Plasma arginine-vasopressin levels during infusion of synthetic atrial natriuretic peptide on different sodium intakes in man.

Abstract:

:The mechanisms involved in the diuretic action of the recently discovered group of atrial natriuretic peptides (ANP) are not entirely clear. To determine whether the diuresis and the changes in blood pressure produced by alpha-human ANP (alpha-hANP) involved a concomitant modification of circulating arginine-vasopressin (arg-VP), we evaluated the effects of synthetic alpha-hANP on plasma alpha-hANP, arg-VP, electrolytes, protein, haematocrit, blood pressure and urinary sodium and water excretion in 10 normal subjects on daily sodium intakes of 16, 140 and 310 mmol, respectively. Plasma alpha-hANP levels before and during a 45-min alpha-hANP infusion (0.09 micrograms/kg per min) tended to be slightly, though not significantly, higher on 'normal' or high sodium intake than on low sodium intake. Alpha-human ANP produced a fall in diastolic blood pressure (P less than 0.001) and to a lesser extent mean blood pressure, and a rise in heart rate (P less than 0.001) at all levels of sodium intake. The induction of diuresis, natriuresis and plasma volume contraction caused by alpha-hANP was greater on a high sodium intake than on 'normal' or low sodium intakes (P less than 0.001). Plasma arg-VP concentrations were lower (P less than 0.05) on a high than on a low sodium intake, but were not altered by an alpha-hANP infusion. The data indicate that in healthy humans circulating arg-VP may tend to decrease in response to a high salt diet. However, marked changes in plasma alpha-hANP concentrations have, regardless of sodium intake, no relevant influence on circulating arg-VP.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Gnädinger MP,Weidmann P,Rascher W,Lang RE,Hellmüller B,Uehlinger DE

doi

10.1097/00004872-198610000-00016

subject

Has Abstract

pub_date

1986-10-01 00:00:00

pages

623-9

issue

5

eissn

0263-6352

issn

1473-5598

journal_volume

4

pub_type

杂志文章
  • Renal prostaglandin E in the hypotensive mechanism of MK-421 in conscious rats.

    abstract::To assess the role of renal prostaglandin E in the hypotensive mechanism of MK-421, we evaluated the effects of chronic infusion of MK-421 (6 mg/kg/day i.p.) on systolic blood pressure and urinary prostaglandin E excretion in conscious rats in states of sodium repletion or depletion and also during chronic infusion of...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198412000-00007

    authors: Yasujima M,Abe K,Tanno M,Kasai Y,Sato K,Tajima J,Kudo K,Tsunoda K,Yoshinaga K

    更新日期:1984-12-01 00:00:00

  • Drug compliance among hypertensive patients in Tabuk, Saudi Arabia.

    abstract:OBJECTIVE:To estimate the compliance rate and associated factors among a population of hypertensive subjects registered in hospitals and primary health care centres. DESIGN:A prospective study carried out on a sample of hypertensive subjects. METHOD:Compliance with treatment by the study sample was measured using the...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199715050-00013

    authors: Khalil SA,Elzubier AG

    更新日期:1997-05-01 00:00:00

  • Insulin increases forearm vascular resistance in obese, insulin-resistant hypertensives.

    abstract:OBJECTIVE:To determine whether acutely lowering insulin levels with somatostatin in obese, insulin-resistant hypertensive individuals reduces arterial pressure and forearm vascular resistance; and whether these changes are reversed by restoring insulin levels during continuing somatostatin infusion. SUBJECTS:Subjects ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Gudbjörnsdottir S,Elam M,Sellgren J,Anderson EA

    更新日期:1996-01-01 00:00:00

  • Blood pressure in four and five-year-old children: the effects of environment and other factors in it's measurement--the Brompton study.

    abstract::Systolic blood pressure was measured on a total of 1855 occasions in 1307 children aged four and five years, and compared with values obtained since birth in the same children. There was a rapid rise in blood pressure in the first month of life. The mean blood pressure then only rose from 93 mmHg at six months to 98 m...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198410000-00009

    authors: de Swiet M,Fayers PM,Shinebourne EA

    更新日期:1984-10-01 00:00:00

  • Interleukin-4 deficiency induces mild preeclampsia in mice.

    abstract:OBJECTIVE:Inflammation is necessary for successful pregnancy; however, excessive inflammation plays a central role in the development of the pregnancy-specific hypertensive disorder preeclampsia. Numerous anti-inflammatory cytokines are decreased in women with preeclampsia but the role of individual cytokines in blood ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328360ae6c

    authors: Chatterjee P,Kopriva SE,Chiasson VL,Young KJ,Tobin RP,Newell-Rogers K,Mitchell BM

    更新日期:2013-07-01 00:00:00

  • Spironolactone improves endothelial and cardiac autonomic function in non heart failure hemodialysis patients.

    abstract:OBJECTIVES:Hemodialysis patients have a cardiovascular mortality rate of 20-40 times that of the general population. Aldosterone inhibition by spironolactone has exerted beneficial, prognostically significant cardiovascular effects in patients with heart failure maintained on hemodialysis or peritoneal dialysis. Our ai...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1097/HJH.0b013e32835f955c

    authors: Flevari P,Kalogeropoulou S,Drakou A,Leftheriotis D,Panou F,Lekakis J,Kremastinos D,Vlahakos DV

    更新日期:2013-06-01 00:00:00

  • Ischemic renal disease: an emerging cause of chronic renal failure and end-stage renal disease.

    abstract::Ischemic renal disease (IRD) is defined as a clinically important reduction in glomerular filtration rate or loss of renal parenchyma caused by hemodynamically significant renal artery stenosis. IRD is a common and often overlooked clinical entity that presents itself in the setting of extrarenal arteriosclerotic vasc...

    journal_title:Journal of hypertension

    pub_type: 社论,评审

    doi:10.1097/00004872-199715120-00001

    authors: Preston RA,Epstein M

    更新日期:1997-12-01 00:00:00

  • Relationship between exercise systolic blood pressure and left ventricular geometry in overweight, mildly hypertensive patients.

    abstract:OBJECTIVE:To examine the association between the graded exercise systolic blood pressure (SBP) response and left ventricular (LV) geometric structure in patients with untreated mild hypertension. PARTICIPANTS:The study included 80 sedentary, overweight patients (43 female and 37 male) with unmedicated high normal bloo...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200402000-00026

    authors: Pierson LM,Bacon SL,Sherwood A,Hinderliter AL,Babyak M,Gullette EC,Waugh R,Blumenthal JA

    更新日期:2004-02-01 00:00:00

  • Isolation of T-cell clones with specificity for arterial antigen from spontaneously hypertensive rats.

    abstract:OBJECTIVE:It has been postulated that hypertension in the spontaneously hypertensive rat (SHR) results from autoimmune damage to the SHR vasculature. The objective of this study was to isolate autoreactive T-cells specific for arterial antigens, and to characterize these cells. DESIGN:The presence of autoreactive T-ce...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199312000-00002

    authors: Ofosu-Appiah W,Ruggiero C,Huang LY

    更新日期:1993-12-01 00:00:00

  • Persistence of antihypertensive efficacy after missed doses: comparison of amlodipine and nifedipine gastrointestinal therapeutic system.

    abstract:OBJECTIVE:In this randomized, double-blind, crossover study, the antihypertensive efficacy of amlodipine and nifedipine gastrointestinal therapeutic system (GITS) was compared following missed doses. Design and methods In a randomized crossover design, 42 patients were randomized to receive amlodipine (5-10 mg) or the ...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004872-200202000-00025

    authors: Elliott HL,Elawad M,Wilkinson R,Singh SP

    更新日期:2002-02-01 00:00:00

  • Contrasting associations between aldosterone synthase gene polymorphisms and essential hypertension in blacks and in whites.

    abstract:BACKGROUND:Genetic variability in the gene for aldosterone synthase--a key enzyme in the production of aldosterone--can affect sodium homeostasis and thereby blood pressure. The possibility of impaired aldosterone production for the development of hypertension is of particular relevance in black Afro-Caribbeans exposed...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200301000-00018

    authors: Zhu H,Sagnella GA,Dong Y,Miller MA,Onipinla A,Markandu ND,MacGregor GA

    更新日期:2003-01-01 00:00:00

  • Protection of retinal vasculature by losartan against apoptosis and vasculopathy in rats with spontaneous hypertension.

    abstract:OBJECTIVES:Retinal blood vessels may develop vasculopathy and apoptosis in response to hypertension. The present study was aimed at testing the role of losartan, a specific antagonist of angiotensin II receptor type 1 receptor in regulation of vascular apoptosis in retinal vasculature with hypertension. METHODS:Losart...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328333663f

    authors: Yang D,Zhang M,Huang X,Fang F,Chen B,Wang S,Cai J,Shi X,Qu J,Geng YJ

    更新日期:2010-03-01 00:00:00

  • Radio-immunoassay for plasma alpha human atrial natriuretic peptide: a comparison of direct and pre-extracted methods.

    abstract::Plasma atrial natriuretic peptide (ANP) concentrations were measured by both direct radio-immunoassay and with pre-extraction of the peptide from plasma using C18 reverse phase columns. Peptide concentrations were measured in normal subjects (including a group of eight volunteers who received an intravenous infusion o...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198704000-00015

    authors: Richards AM,Tonolo G,McIntyre GD,Leckie BJ,Robertson JI

    更新日期:1987-04-01 00:00:00

  • Multiparametric carotid and cardiac ultrasound compared with clinical risk scores for the prediction of angiographic coronary artery disease: a multicenter prospective study.

    abstract:OBJECTIVE:Cardiovascular risk prediction is deemed fundamental and the assessment of organ damage is emerging as a potentially 'downstream' picture of individual risk. Our aim was to assess the feasibility and value of prediction of coronaropathy [coronary artery disease (CAD)] of integrated cardiovascular ultrasound e...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1097/HJH.0000000000000543

    authors: Moreo A,Gaibazzi N,Faggiano P,Mohammed M,Carerj S,Mureddu G,Pigazzani F,Muiesan L,Salvetti M,Cesana F,Faden G,Facchetti R,Giannattasio C,Rigo F

    更新日期:2015-06-01 00:00:00

  • Dietary sodium and pulse pressure in normotensive and essential hypertensive subjects.

    abstract:OBJECTIVES:To assess the influence of sodium intake on the two components of arterial blood pressure [mean blood pressure (MBP) and pulse pressure] and left ventricular mass (LVM) in normotensive subjects and never-treated hypertensive patients. METHODS:Blood pressure, LVM (M-mode echocardiography) and sodium excretio...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200404000-00011

    authors: du Cailar G,Mimran A,Fesler P,Ribstein J,Blacher J,Safar ME

    更新日期:2004-04-01 00:00:00

  • Polymorphisms in human connexin40 gene promoter are associated with increased risk of hypertension in men.

    abstract:OBJECTIVE:Gap junctions, formed by connexins (Cx), are important in the regulation of vascular tone. Previously, we reported two closely linked polymorphisms (-44G --> A and +71A --> G) within regulatory regions of the gene for Cx40, a major connexin in the vascular wall and the kidney. In the present study, we examine...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000200512.40818.47

    authors: Firouzi M,Kok B,Spiering W,Busjahn A,Bezzina CR,Ruijter JM,Koeleman BP,Schipper M,Groenewegen WA,Jongsma HJ,de Leeuw PW

    更新日期:2006-02-01 00:00:00

  • Prevalence, awareness, treatment and control of hypertension in Portugal: the PAP study.

    abstract:BACKGROUND:The objective of this study was to estimate the prevalence and distribution of hypertension and to determine the status of hypertension awareness, treatment and control in the Portuguese adult population. METHODS:This study was conducted in 2003, and a multistage cluster sampling method was used to select a...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000179908.51187.de

    authors: Macedo ME,Lima MJ,Silva AO,Alcantara P,Ramalhinho V,Carmona J

    更新日期:2005-09-01 00:00:00

  • The association between blood pressure and lipid levels in Europe: European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice.

    abstract:OBJECTIVES:Several studies have suggested a positive association between serum lipid levels and blood pressure (BP). This study investigated this association in a large population from 12 European countries. METHODS:Data were taken from the European Study on Cardiovascular Risk Prevention and Management in Usual Daily...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001078

    authors: Borghi C,Rodriguez-Artalejo F,De Backer G,Dallongeville J,Medina J,Guallar E,Perk J,Banegas JR,Tubach F,Roy C,Halcox JP

    更新日期:2016-11-01 00:00:00

  • Early sexual experience and hypertension in US adults: results from the National Health and Nutrition Examination Survey 2001-2016.

    abstract:OBJECTIVES:We examined whether the early initiation of sexual activity is associated with hypertension in US adults, and whether the timing of first menstruation is meaningful in regard of this association. We also assessed the effect modification by ethnicity. METHODS:Using data from 2001 to 2016 National Health and ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001821

    authors: Ngueta G,Ndjaboue R

    更新日期:2018-12-01 00:00:00

  • Neonatal sympathectomy of normotensive Wistar-Kyoto and spontaneously hypertensive rats with 6-hydroxydopamine: effects on resistance vessel structure and sensitivity to calcium.

    abstract::6-Hydroxydopamine (6-OHDA) was injected on alternate days from birth to 3 weeks of age into spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) control rats. The effects of this neonatal treatment on cardiovascular structure and mesenteric resistance vessel calcium sensitivity was studied in young (6 ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198608000-00010

    authors: Nyborg NC,Korsgaard N,Mulvany MJ

    更新日期:1986-08-01 00:00:00

  • Arterial stiffness in atherosclerotic renovascular hypertension.

    abstract:OBJECTIVE:Arterial stiffness is an independent cardiovascular risk factor. Aging, high blood pressure and increased renin-angiotensin system activity contribute to increased arterial stiffness in patients with atherosclerotic renovascular hypertension (aRVH). A literature search failed to identify any study related to ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000324

    authors: Fodor L,Premužić V,Ivković V,Perkov D,Laganović M,Vrkić TZ,Dika Z,Zivko M,Jelaković B

    更新日期:2014-11-01 00:00:00

  • Hypertension susceptibility genes on chromosome 2p24-p25 in a general Japanese population.

    abstract:BACKGROUND:Genome-wide scans from Italy and China suggest a hypertension-susceptible locus between D2S2278 (nucleotides 11,245,080 - 11,245,358) and D2S168 (nucleotides 11,467,214 - 11,467,422) on chromosome 2. METHODS:We performed a large association study of polymorphisms in this region with blood pressure modulatio...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000166835.70935.3c

    authors: Kamide K,Kokubo Y,Yang J,Tanaka C,Hanada H,Takiuchi S,Inamoto N,Banno M,Kawano Y,Okayama A,Tomoike H,Miyata T

    更新日期:2005-05-01 00:00:00

  • Prevalence, awareness, treatment and control of hypertension in four Middle East countries.

    abstract:OBJECTIVE:We report the prevalence, awareness, treatment, and control of hypertension across four Middle Eastern countries (Iran, Occupied Palestinian Territory, Saudi Arabia, and United Arab Emirates), using a standardized and uniform method. METHODS:The Prospective Urban Rural Epidemiology study enrolled participant...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001326

    authors: Yusufali AM,Khatib R,Islam S,Alhabib KF,Bahonar A,Swidan HM,Khammash U,Alshamiri MQ,Rangarajan S,Yusuf S

    更新日期:2017-07-01 00:00:00

  • Twenty-four-hour ambulatory blood pressure in adult women with urinary tract infection in childhood.

    abstract:OBJECTIVE:To study 24-h ambulatory blood pressure (BP) and development of hypertension over four decades in women with childhood urinary tract infection (UTI) associated with renal damage. METHODS:A population-based group of 111 women was followed from their first UTI in childhood. The cohort was investigated at a med...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000234

    authors: Gebäck C,Hansson S,Himmelmann A,Sandberg T,Sixt R,Jodal U

    更新日期:2014-08-01 00:00:00

  • A search for endogenous Na+,K+-ATPase inhibitor in acutely volume-expanded hog plasma led to lysophosphatidylcholine gamma-stearoyl.

    abstract::An Na+,K+-ATPase inhibitor possessing inhibitory activity against the specific binding of ouabain to Na+,K+-ATPase has been purified from the plasma of acutely saline-infused hogs. The purification was performed by a combination of Amberlite XAD-2 adsorption chromatography and five steps of high-pressure liquid chroma...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198704000-00014

    authors: Tamura M,Inagami T,Kinoshita T,Kuwano H

    更新日期:1987-04-01 00:00:00

  • Longing for clinical excellence: a critical outlook into the NICE recommendations on hypertension management--is nice always good?

    abstract::The European Society of Hypertension and the European Society of Cardiology have started the preparation of the third edition of their joint guidelines on the management of arterial hypertension. The authors have focused on the new edition of the UK NICE guidelines to learn about the difficulties of disentangling evid...

    journal_title:Journal of hypertension

    pub_type: 社论

    doi:10.1097/HJH.0b013e328351b4e4

    authors: Zanchetti A,Mancia G

    更新日期:2012-04-01 00:00:00

  • Pathways from parental educational attainment to adolescent blood pressure.

    abstract:OBJECTIVES:Lower parental education is associated with higher adolescent blood pressure (BP). We examined the contribution of modifiable risk factors from infancy to adolescence that could potentially explain the link between parental education and SBP and DBP in the offspring. METHODS:In a prospective Chinese birth c...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001003

    authors: Kwok MK,Schooling CM,Subramanian SV,Leung GM,Kawachi I

    更新日期:2016-09-01 00:00:00

  • Central haemodynamics in normal pregnancy: a prospective longitudinal study.

    abstract:OBJECTIVE:To conduct a longitudinal evaluation of the central haemodynamic adaptations of normal pregnancy. METHODS:This was a prospective longitudinal study involving healthy, normotensive women who were having an uncomplicated, singleton pregnancy. Brachial and central SBP, DBP, mean arterial pressure (MAP), brachia...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001768

    authors: O' Callaghan KM,Hennessy Á,Malvisi L,Kiely M

    更新日期:2018-10-01 00:00:00

  • An age-related decline in endothelial function is not associated with alterations in L-arginine transport in humans.

    abstract:OBJECTIVES:Endothelial dysfunction is established in aged individuals; however, the mechanism(s) are not fully elucidated. We have previously identified l-arginine transport as a potential rate-limiting factor in nitric oxide (NO) production in heart-failure patients, characterized with endothelial dysfunction. We ther...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004872-200402000-00016

    authors: Ahlers BA,Parnell MM,Chin-Dusting JP,Kaye DM

    更新日期:2004-02-01 00:00:00

  • High sodium intake of children through 'hidden' food sources and its association with the Mediterranean diet: the GRECO study.

    abstract:OBJECTIVES:Sodium is the mineral that has been, mainly, linked to hypertension and cardiovascular disease. It is found naturally in many foods, but is also used in the food industry and manufacturing. Identification of total sodium intake, as well as 'hidden' sodium intake from food sources early in life is necessary. ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328345ef35

    authors: Magriplis E,Farajian P,Pounis GD,Risvas G,Panagiotakos DB,Zampelas A

    更新日期:2011-06-01 00:00:00