Nifedipine inhibited angiotensin II-induced monocyte chemoattractant protein 1 expression: involvement of inhibitor of nuclear factor kappa B kinase and nuclear factor kappa B-inducing kinase.

Abstract:

OBJECTIVE:The effect of nifedipine, a 1,4-dihydropyridine calcium antagonist, on the expression of monocyte chemoattractant protein 1 (MCP-1) induced by angiotensin II (Ang II) was examined using vascular smooth muscle cells (VSMC) isolated from rat thoracic aorta. METHODS AND RESULTS:Ang II increased the expression of MCP-1 messenger RNA accompanied by an increase in nuclear factor kappa B (NF-kappaB) binding activity to the cis DNA element in the promoter region of MCP-1. Ang II also decreased the cytosolic level of the inhibitor of NF-kappaB (IkappaB) and increased the phosphorylation of IkappaB subunits, IkappaBalpha and IkappaBbeta, as well as the phosphorylation of IkappaB kinase (IKK) subunits, IKKalpha and IKKbeta, suggesting that Ang II enhanced the breakdown of IkappaB. Nifedipine decreased MCP-1 mRNA expression, together with NF-kappaB binding activity to the promoter region of MCP-1 induced by Ang II. Nifedipine also attenuated the decrease in the cytosolic level of IkappaB, and the phosphorylation of IkappaB and IKK subunits induced by Ang II. Moreover, Ang II increased the phosphorylation of NF-kappaB-inducing kinase (NIK), and this increase was significantly inhibited by nifedipine. CONCLUSION:As NIK is reported to activate IKK, our results suggest that nifedipine attenuates the effect of Ang II on MCP-1 expression in VSMC by regulating the activity of NF-kappaB through NIK, IKK and IkappaB.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Wu L,Iwai M,Li Z,Li JM,Mogi M,Horiuchi M

doi

10.1097/01.hjh.0000198031.30095.d1

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

123-30

issue

1

eissn

0263-6352

issn

1473-5598

pii

00004872-200601000-00020

journal_volume

24

pub_type

杂志文章
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    更新日期:2020-05-01 00:00:00

  • Elastic properties of ascending aorta and ventricular-arterial coupling in women with previous pregnancy complicated by HELLP syndrome.

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    authors: Sciatti E,Orabona R,Prefumo F,Vizzardi E,Bonadei I,Valcamonico A,Metra M,Frusca T

    更新日期:2019-02-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/00004872-199816010-00012

    authors: Simon G,Csiky B

    更新日期:1998-01-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Casals-Stenzel J,Tree M,Brown JJ,Fraser R,Lever AF,Millar JA,Morton JJ,Robertson JI,Reid JL,Hamilton C

    更新日期:1983-06-01 00:00:00

  • Severe obstructive sleep apnea elicits concentric left ventricular geometry.

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    pub_type: 杂志文章

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    authors: Cioffi G,Russo TE,Stefenelli C,Selmi A,Furlanello F,Cramariuc D,Gerdts E,de Simone G

    更新日期:2010-05-01 00:00:00

  • Determinants of blood pressure treatment and control in obese people: evidence from the general population.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

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    authors: Czernichow S,Castetbon K,Salanave B,Vernay M,Barry Y,Batty GD,Hercberg S,Blacher J

    更新日期:2012-12-01 00:00:00

  • The vascular response to vasodilators is related to the membrane content of polyunsaturated fatty acids in hypertensive patients.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000495

    authors: Colussi G,Catena C,Dialti V,Mos L,Sechi LA

    更新日期:2015-05-01 00:00:00

  • The aldosterone-renin ratio based on the plasma renin activity and the direct renin assay for diagnosing aldosterone-producing adenoma.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32833d2192

    authors: Rossi GP,Barisa M,Belfiore A,Desideri G,Ferri C,Letizia C,Maccario M,Morganti A,Palumbo G,Patalano A,Roman E,Seccia TM,Pessina AC,Mantero F,PAPY study Investigators.

    更新日期:2010-09-01 00:00:00

  • Effects of angiotensin converting enzyme inhibition on endothelium-dependent vasodilatation in essential hypertensive patients.

    abstract:BACKGROUND:Essential hypertension is characterized by an impairment of endothelium-dependent vasodilatation. OBJECTIVE:To test whether antihypertensive treatment with the angiotensin converting enzyme inhibitor lisinopril can improve vasodilatation in response to endothelium-dependent agonists in essential hypertensiv...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199816040-00006

    authors: Taddei S,Virdis A,Ghiadoni L,Mattei P,Salvetti A

    更新日期:1998-04-01 00:00:00

  • Management of high blood pressure in children and adolescents: recommendations of the European Society of Hypertension.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章,实务指引

    doi:10.1097/HJH.0b013e32832f4f6b

    authors: Lurbe E,Cifkova R,Cruickshank JK,Dillon MJ,Ferreira I,Invitti C,Kuznetsova T,Laurent S,Mancia G,Morales-Olivas F,Rascher W,Redon J,Schaefer F,Seeman T,Stergiou G,Wühl E,Zanchetti A,European Society of Hypertension.

    更新日期:2009-09-01 00:00:00

  • Angiotension receptor blockers reduce the risk of dementia.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000086

    authors: Chiu WC,Ho WC,Lin MH,Lee HH,Yeh YC,Wang JD,Chen PC,Health Data Analysis in Taiwan (hDATa) Research Group.

    更新日期:2014-04-01 00:00:00

  • Diurnal variation and repeatability of arterial stiffness and cardiac output measurements in the third trimester of uncomplicated pregnancy.

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    pub_type: 杂志文章

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    authors: Osman MW,Leone F,Nath M,Khalil A,Webb DR,Robinson TG,Mousa HA

    更新日期:2017-12-01 00:00:00

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    authors: Salam A,Atkins E,Sundström J,Hirakawa Y,Ettehad D,Emdin C,Neal B,Woodward M,Chalmers J,Berge E,Yusuf S,Rahimi K,Rodgers A,Blood Pressure Lowering Treatment Trialists’ Collaboration.

    更新日期:2019-01-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002113

    authors: Chung J,Kim HL,Lim WH,Seo JB,Kim SH,Zo JH,Kim MA

    更新日期:2019-10-01 00:00:00

  • Ca2+-activated K+ channels mediate relaxation of forearm veins in chronic renal failure.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

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    authors: Martinez-León JB,Segarra G,Medina P,Vila JM,Lluch P,Peiró M,Otero E,Lluch S

    更新日期:2003-10-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002245

    authors: Bokrantz T,Schiöler L,Boström KB,Kahan T,Mellström D,Ljungman C,Hjerpe P,Hasselström J,Manhem K

    更新日期:2020-01-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001896

    authors: Martín-Fernández M,Vinyoles E,Real J,Soldevila N,Muñoz MÁ,Del-Val JL,Verdú JM,Domingo M,Mundet X

    更新日期:2019-02-01 00:00:00

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    更新日期:2013-07-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200106000-00006

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    更新日期:2001-06-01 00:00:00

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    pub_type: 杂志文章

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    authors: Taylor-McCabe KJ,Erşahin C,Simmons WH

    更新日期:2001-07-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2007-03-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章

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    更新日期:2013-03-01 00:00:00

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    pub_type: 临床试验,杂志文章

    doi:

    authors: Stewart MJ,Gough K,Padfield PL

    更新日期:1995-03-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/00004872-200203000-00028

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    更新日期:2002-03-01 00:00:00

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    pub_type: 杂志文章,评审

    doi:10.1097/00004872-200307000-00001

    authors: Volpe M,Cosentino F,Ruilope LM

    更新日期:2003-07-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002651

    authors: van der Linden EL,Couwenhoven BN,Beune EJAJ,Daams JG,van den Born BH,Agyemang C

    更新日期:2021-02-01 00:00:00

  • Preventing microalbuminuria in patients with diabetes: rationale and design of the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) study.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/01.hjh.0000202820.56201.e6

    authors: Haller H,Viberti GC,Mimran A,Remuzzi G,Rabelink AJ,Ritz E,Rump LC,Ruilope LM,Katayama S,Ito S,Izzo JL Jr,Januszewicz A

    更新日期:2006-02-01 00:00:00

  • Comparative effects of candesartan and hydrochlorothiazide on blood pressure, insulin sensitivity, and sympathetic drive in obese hypertensive individuals: results of the CROSS study.

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    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Grassi G,Seravalle G,Dell'Oro R,Trevano FQ,Bombelli M,Scopelliti F,Facchini A,Mancia G,CROSS Study.

    更新日期:2003-09-01 00:00:00

  • Effects of deoxycorticosterone on arterial wall properties in two-kidney rats.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198610000-00007

    authors: Cox RH

    更新日期:1986-10-01 00:00:00