Abstract:
AIM:To investigate same day repeated measures and diurnal variation of arterial stiffness, cardiac output (CO), stroke volume (SV) and total peripheral resistance (TPR) during the third trimester of normal pregnancy. METHODOLOGY:Pulse wave velocity (PWV) and augmentation index (AIx) were recorded using the Arteriograph, while CO, SV and TPR were recorded using noninvasive cardiac output monitoring. The measurements were obtained in the third trimester of pregnancy from 21 healthy pregnant women at four time points (morning, afternoon, evening and midnight) over a 24-h period. Triplicate measurements of 67 women were obtained at 5-min intervals to assess repeatability between measurements within a patient. RESULTS:Diurnal measurements of arterial stiffness for brachial AIx, aortic AIx and PWV were not statistically significantly different at any of the four time points. Estimated means (SD) for PWV at the four stated time points were 7.81 (2.05), 8.45 (1.68), 7.87 (1.74) and 7.64 m/s (1.15), respectively (P = 0.267). Estimates for AIx at those time points were 10.22 (15.62), 4.44 (10.07), 6.49 (10.92) and 8.40% (8.16), respectively (P = 0.295). Similarly, mean arterial pressure, SV, SV index and TPR did not show any evidence of diurnal variation. However, we observed that the mean CO, cardiac index (CI) and heart rate (HR) varied from morning to midnight; the mean CO, HR and CI increased significantly in the afternoon compared with the corresponding mean morning measurements in a similar fashion to HR. Mean (SD) CO estimates at the four stated time points were 5.90 (1.33), 6.38 (1.49), 6.18 (1.43) and 5.80 ml/min (1.19), respectively, (P < 0.001), whereas mean CI estimates were 3.65 (0.58), 3.93 (0.68), 3.81 (0.65), and 3.57 (0.48), respectively, (P < 0.001), and mean HR estimates were 95 (12), 98 (13), 95 (12) and 88 (12.98), respectively (P < 0.001). Triplicate measurements of 61 women in our repeatability study showed moderate-to-high correlation between observations on the same woman for all Arteriograph and noninvasive cardiac output monitoring variables (estimates of intraclass correlation ranged from 0.49 to 0.91). CONCLUSION:With the exception of CO, CI and HR which showed a diurnal variation, measurements of most haemodynamic parameters did not change significantly from morning to midnight, suggesting there was no evidence of systematic differences in the mean values of these variables at these time points. Multiple consecutive noninvasive measurements of vascular stiffness, CO, SV and TPR were highly correlated confirming repeatability of measurements in the third trimester of uncomplicated pregnancy, so these haemodynamic measurements do not need to be undertaken at a specific time period of the day.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Osman MW,Leone F,Nath M,Khalil A,Webb DR,Robinson TG,Mousa HAdoi
10.1097/HJH.0000000000001482subject
Has Abstractpub_date
2017-12-01 00:00:00pages
2436-2442issue
12eissn
0263-6352issn
1473-5598journal_volume
35pub_type
杂志文章abstract:BACKGROUND:In arteries, agonists such as acetylcholine release an endothelium-derived hyperpolarizing factor (EDHF) that is neither nitric oxide nor prostacyclin. OBJECTIVES:To examine the responses to acetylcholine in segments of forearm veins from patients with chronic renal failure who either had never received dia...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200310000-00021
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:The optimal time to initiate antihypertensive therapy among patients with acute ischemic stroke remains uncertain. We tested the effects of blood pressure reduction among patients with acute ischemic stroke according to time from onset to initiation of antihypertensive treatment. METHODS:We randomly assigned...
journal_title:Journal of hypertension
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/HJH.0000000000001288
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:We have recently shown that mean pulse pressure is higher in patients with transient myocardial ischemia. Pulse pressure elevation might be an important consequence of increased arterial stiffness. The aim of this study was to prove if arterial stiffness is changed in patients with transient myocardial ischem...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000244959.92856.7e
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:We aim to synthesize effects of repeated administration (≥3 days) of inorganic nitrate on blood pressure and arterial stiffness measures. METHODS:We conducted a systematic review and meta-analysis of randomized controlled trials with at least 3 days treatment of inorganic nitrate on blood pressure and arteri...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002524
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:This study was designed to evaluate the capacity of norepinephrine (NE) to induce hypertrophic remodeling of small arteries in rats, and to determine the involvement of endothelin (ET) to initiate and maintain it. DESIGN AND RESULTS:Treatment with NE (2.5 microg/kg per min) for 14 or 28 days produced a simil...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200110000-00014
更新日期:2001-10-01 00:00:00
abstract::The associations of obesity and alcohol consumption with blood pressure and the prevalence of hypertension were studied in 5550 male and female subjects aged 25 to 64 years, surveyed in the National Heart Foundation of Australia 1980 Risk Factor Prevalence Study. Body mass index was significantly and independently ass...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198402000-00015
更新日期:1984-02-01 00:00:00
abstract:OBJECTIVE:To find an objective, sensitive method for quantifying microvascular alterations associated with level of blood pressure and age. DESIGN:A prospective cross-sectional study. SUBJECTS AND METHODS:Seventy-four previously untreated hypertensive patients, referred to a hospital outpatients department, and 26 no...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::The mechanisms involved in the diuretic action of the recently discovered group of atrial natriuretic peptides (ANP) are not entirely clear. To determine whether the diuresis and the changes in blood pressure produced by alpha-human ANP (alpha-hANP) involved a concomitant modification of circulating arginine-vasopress...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198610000-00016
更新日期:1986-10-01 00:00:00
abstract:OBJECTIVES:To establish whether safety and feasibility of dobutamine and dipyridamole stress echocardiography are affected by history of hypertension. METHODS:Data on 2200 consecutive pharmacologic stress echocardiography (959 dobutamine and 1241 dipyridamole) performed between October 1990 and February 2001 at a sing...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200207000-00030
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVES:Scarce data exist on blood pressure (BP) and secondary effects in young athletes. Hence, we aimed to study prevalence of high BP (≥140/90 mmHg) and the association to arterial compliance, left ventricle mass and left atrium volume. METHODS:A Norwegian preparticipation cardiac screening of male professional ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32835eb5fe
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:To investigate methods to diagnose renal artery stenosis (RAS) among the general hypertensive population. METHODS:We studied the value of clinical and biochemical characteristics at the outpatient clinic to identify subjects with a renal artery narrowing of more than 50% of the luminal surface among 1047 hyp...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
abstract::This study was designed to assess the contribution of thromboxane (Tx) A2 to the pathogenesis of renal dysfunction in rats with angiotensin II (Ang II)-salt hypertension. Hypertension was induced in rats drinking 0.15 mol/l NaCl by infusion of Ang II (125 ng/min, intraperitoneally) for 12 days. Relative to values in w...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199001000-00012
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Cross-sectional evidence indicates that eating frequency correlates with blood pressure, hypertension, and related target organ damage. The aim of the present study was to prospectively assess eating frequency as a predictor of arteriosclerosis progression and new onset hypertension over a follow-up period o...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000822
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:Traditional cardiovascular risk factors do not fully account for ethnic differences in cardiovascular disease. We tested if arterial function indices, particularly augmentation index (AIx), and their determinants from childhood could underlie such ethnic variability among young British adults in the 'DASH' lo...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001066
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:Recent studies have shown that the heptapeptide angiotensin-(1-7) [Ang-(1-7)] exerts important vasoactive actions and can act as an endogenous physiological antagonist of angiotensin II (Ang II) within the renin-angiotensin system (RAS). The present study was performed to evaluate the effects, first, of chron...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32832f0d06
更新日期:2009-10-01 00:00:00
abstract::The present study investigated the roles of insulin on central cardiovascular regulation. When rats were fed with a high-salt diet for 4 weeks, hypothalamic and pituitary contents of insulin-like immunoreactive substance (ILI) significantly decreased. The plasma concentration of ILI remained unaltered, however. Intrac...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199106000-00006
更新日期:1991-06-01 00:00:00
abstract:OBJECTIVE:To estimate the compliance rate and associated factors among a population of hypertensive subjects registered in hospitals and primary health care centres. DESIGN:A prospective study carried out on a sample of hypertensive subjects. METHOD:Compliance with treatment by the study sample was measured using the...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199715050-00013
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVES:Recent studies in homogenized hearts suggest that chymase rather than angiotensin converting enzyme (ACE) is responsible for cardiac angiotensin I to angiotensin II conversion. We investigated in intact rat hearts whether (i) enzymes other than ACE contribute to angiotensin I to angiotensin II conversion and...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200105000-00017
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVES:High blood pressure is known to be associated with higher cardiovascular risk. The emphasis has shifted over time from diastolic pressure to systolic pressure and variability in blood pressure. This study examined the impact of transient and sustained diastolic hypertension on later mortality. METHODS:In th...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32835a4dd8
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Genetic variability in the gene for aldosterone synthase--a key enzyme in the production of aldosterone--can affect sodium homeostasis and thereby blood pressure. The possibility of impaired aldosterone production for the development of hypertension is of particular relevance in black Afro-Caribbeans exposed...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200301000-00018
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:The acute effects of estrogen on hemodynamic responses were studied with emphasis on the sympathoadrenal system and peripheral circulation. DESIGN:Eleven healthy postmenopausal women recruited from the population-based study BEDA were included in this randomized, double-blind, cross-over, placebo-controlled ...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004872-200302000-00031
更新日期:2003-02-01 00:00:00
abstract::Fish and fish oils have been reported to reduce blood pressure in normotensives and untreated hypertensives. The present study examined the effect of dietary supplementation with fish oil on blood pressure in 20 treated hypertensives with controlled blood pressures who continued their usual antihypertensive drug treat...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004872-199004000-00007
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND:Results from previous studies suggested that a blunted response of renal plasma flow (RPF) to angiotensin II infusion during a high-sodium diet (a phenotype associated with nonmodulation) is an intermediate phenotype for essential hypertension. OBJECTIVE:To determine whether RPF traits used to investigate n...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199715050-00003
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:Homeostasis Model Assessment (HOMA index) is predictive of insulin sensitivity in normal and diabetic patients. This study was designed to see if insulin resistance in hypertensives, measured using the HOMA index, differs, based on salt sensitivity, renin status and sodium intake. METHODS:Fasting insulin and...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00004872-200101000-00013
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:To examine a possible relationship between baseline albuminuria and effect of losartan versus atenolol on cardiovascular (CV) events in hypertensive patients with left ventricular hypertrophy, the effect of losartan versus atenolol on albuminuria, and whether the benefits of losartan versus atenolol could be...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004872-200409000-00026
更新日期:2004-09-01 00:00:00
abstract::We have examined the mechanisms mediating the release of renin elicited in man by reduction of renal perfusion pressure. Fifteen patients with essential hypertension and six normotensive subjects were investigated during diagnostic renal arteriography. Renal neural receptors were inhibited by propranolol (10 mg i.v.) ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198502000-00007
更新日期:1985-02-01 00:00:00
abstract:OBJECTIVE:To clarify the spectrum of the left ventricular responses in hypertension in man by means of coupled analysis of elastances. In the present study we analysed the 'functional' coupling of the left ventricle and the arterial system in terms of the arterial effective elastance (E(a)) divided by a value of end-sy...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract:OBJECTIVES:We aimed to determine the association of nonalcoholic fatty liver disease (NAFLD) with central and peripheral blood pressure (BP), in a general adolescent population and to examine whether associations are independent of adiposity. METHODS:Using cross-sectional data from a subsample (N = 1904) of a UK birth...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000445
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:The objective is to evaluate the relationship between cholesterolemia, serum apolipoprotein B (apoB) level and blood pressure in a large sample of general population. METHODS:The Brisighella Heart Study (BHS) is a prospective, population-based longitudinal epidemiological investigation. For this study, we an...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32834f6b11
更新日期:2012-03-01 00:00:00
abstract::This paper describes the kinetics of the Na(+)-K+ pump and the Na(+)-K(+)-Cl- cotransport in sodium-loaded erythrocytes and of the Na(+)-K(+)-Cl- cotransport in erythrocyte inside-out vesicles (IOV) from Milan hypertensive (MHS) and normotensive (MNS) rats in order to evaluate the possible role of intracellular factor...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199108000-00003
更新日期:1991-08-01 00:00:00