Relationship between blood pressure, cholesterolemia and serum apolipoprotein B in a large population sample: the Brisighella Heart Study.

Abstract:

OBJECTIVE:The objective is to evaluate the relationship between cholesterolemia, serum apolipoprotein B (apoB) level and blood pressure in a large sample of general population. METHODS:The Brisighella Heart Study (BHS) is a prospective, population-based longitudinal epidemiological investigation. For this study, we analysed the data sampled in the 2008 BHS population survey, excluding those participants treated with antihypertensive and/or lipid lowering drugs (N: 2473). RESULTS:In a sex, BMI, smoking habit, physical activity level and serum creatinine adjusted model, low-density lipoprotein-cholesterol (LDL-C) appears to be significantly related to SBP (P < 0.001), DBP (P = 0.026), and pulse pressure (PP) (P < 0.001). In individuals aged less than 52 years, LDL-C was significantly associated to SBP and DBP (P < 0.001), but not PP. In the same model, apoB appears to be mildly but significantly related to SBP (P < 0.001), DBP (P < 0.001), and PP (P < 0.001). In individuals aged less than 52 years, apoB was significantly associated to SBP (P < 0.001), DBP (P < 0.001), and PP (P < 0.001). In individuals aged 52 or more, nor LDL-C neither apoB were significantly associated to blood pressure. Including in the same model LDL-C and apoB, apoB excluded the predicting role of LDL-C as it regards the blood pressure either in the whole population sample and in the younger individuals. CONCLUSION:On the basis of our observation, either serum LDL-C and apoB are significantly related to the blood pressure level in a large sample of individuals untreated with antihypertensive and lipid-lowering drugs. This association is stronger in younger individuals than in elderly. ApoB seems to be a stronger predictor of either SBP, DBP and PP than LDL-C.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Cicero AF,D'Addato S,Veronesi M,Rosticci M,Santi F,Dormi A,Borghi C,Brisighella Heart Study Group.

doi

10.1097/HJH.0b013e32834f6b11

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

492-6

issue

3

eissn

0263-6352

issn

1473-5598

journal_volume

30

pub_type

杂志文章
  • Management of cardiovascular risk factors in advanced type 2 diabetic nephropathy: a comparative analysis in nephrology, diabetology and primary care settings.

    abstract:OBJECTIVES:Advanced diabetic nephropathy (DN) is characterized by a marked development of cardiovascular and renal disease. These patients are frequently managed by different health professionals with the consequence that the quality of care may differ substantially. To compare the management of cardiovascular risk fac...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.hjh.0000239303.93872.31

    authors: Minutolo R,Sasso FC,Chiodini P,Cianciaruso B,Carbonara O,Zamboli P,Tirino G,Pota A,Torella R,Conte G,De Nicola L

    更新日期:2006-08-01 00:00:00

  • High sodium intake of children through 'hidden' food sources and its association with the Mediterranean diet: the GRECO study.

    abstract:OBJECTIVES:Sodium is the mineral that has been, mainly, linked to hypertension and cardiovascular disease. It is found naturally in many foods, but is also used in the food industry and manufacturing. Identification of total sodium intake, as well as 'hidden' sodium intake from food sources early in life is necessary. ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328345ef35

    authors: Magriplis E,Farajian P,Pounis GD,Risvas G,Panagiotakos DB,Zampelas A

    更新日期:2011-06-01 00:00:00

  • Simultaneous radioimmunoassay of six angiotensin peptides in arterial and venous plasma of man.

    abstract::Using antibodies raised against angiotensin I and II, and high-performance liquid chromatography (HPLC) of plasma extracts, we have quantified six angiotensin peptides in venous (cubital vein) and arterial (brachial) plasma of normal male subjects. The concentrations of venous plasma (fmol/ml, mean +/- s.d., n = 29) f...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199002000-00011

    authors: Campbell DJ,Kladis A

    更新日期:1990-02-01 00:00:00

  • Angiotensin converting enzyme inhibition prevents proto-oncogene expression in the vascular wall after injury.

    abstract:OBJECTIVES:Angiotensin converting enzyme (ACE) inhibitors reduce neointimal hyperplasia after balloon denudation, but the mechanisms are not completely understood. It has been demonstrated that nuclear oncogenes are induced in the vascular wall in the hours immediately after injury, and that the same genes are induced ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Van Belle E,Bauters C,Wernert N,Delcayre C,McFadden EP,Dupuis B,Lablanche JM,Bertrand ME,Swynghedauw B

    更新日期:1995-01-01 00:00:00

  • Variant on chromosome 9p is associated with left ventricular mass: results from two cohorts of essential hypertensive individuals.

    abstract:OBJECTIVES:It is well known that among hypertensive patients, an increased left ventricular mass (LVM) is a powerful predictor of cardiovascular morbidity and mortality. However, the mechanisms underlying LVM in hypertension are not completely understood, as the absolute value of blood pressure and other risk factors a...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3283581f7e

    authors: Menni C,Boffi L,Cesana F,Viviani Anselmi C,Nava S,Bertola F,Blasio AM,Roncarati R,Trimarco V,Marino M,Trimarco B,Grassi G,Giannattasio C,Mancia G

    更新日期:2012-11-01 00:00:00

  • Does albuminuria predict cardiovascular outcome on treatment with losartan versus atenolol in hypertension with left ventricular hypertrophy? A LIFE substudy.

    abstract:OBJECTIVES:To examine a possible relationship between baseline albuminuria and effect of losartan versus atenolol on cardiovascular (CV) events in hypertensive patients with left ventricular hypertrophy, the effect of losartan versus atenolol on albuminuria, and whether the benefits of losartan versus atenolol could be...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004872-200409000-00026

    authors: Ibsen H,Wachtell K,Olsen MH,Borch-Johnsen K,Lindholm LH,Mogensen CE,Dahlöf B,Devereux RB,de Faire U,Fyhrquist F,Julius S,Kjeldsen SE,Lederballe-Pedersen O,Nieminen MS,Omvik P,Oparil S,Wan Y,LIFE substudy.

    更新日期:2004-09-01 00:00:00

  • Influence of serum selenium concentrations on hypertension: the Lipid Analytic Cologne cross-sectional study.

    abstract:AIMS:Selenium is an antioxidant micronutrient with potential associations with hypertension. Few studies have investigated the association of serum selenium concentrations with blood pressure and hypertension in countries with low dietary selenium intake such as Germany, with inconsistent findings. METHODS:We undertoo...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32835414df

    authors: Berthold HK,Michalke B,Krone W,Guallar E,Gouni-Berthold I

    更新日期:2012-07-01 00:00:00

  • Apolipoprotein E polymorphism affects carotid artery atherosclerosis in smoking hypertensive men.

    abstract:OBJECTIVE:Smoking is a risk factor for increased carotid artery intima-media thickness (IMT). The apolipoprotein E (apoE) 4 allele has been associated with cardiovascular diseases, but the role of apoE in regard to intima-media thickness (IMT) has remained controversial. The objective was to investigate whether there i...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200212000-00015

    authors: Karvonen J,Kauma H,Kervinen K,Ukkola O,Rantala M,Päivänsalo M,Savolainen MJ,Kesäniemi YA

    更新日期:2002-12-01 00:00:00

  • The impact of age on vascular smooth muscle function in humans.

    abstract:AIM:Advanced age is associated with vascular endothelial dysfunction, characterized by reductions in the endothelium-dependent vasodilation of the conduit and resistance arteries, in part, from decreased nitric oxide bioavailability. Although vascular smooth muscle function (SMF), assessed by responsiveness to an exoge...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/HJH.0000000000000446

    authors: Montero D,Pierce GL,Stehouwer CD,Padilla J,Thijssen DH

    更新日期:2015-03-01 00:00:00

  • Transforming growth factor beta1 and additional renoprotective effect of combination ACE inhibitor and angiotensin II receptor blocker in hypertensive subjects with minor renal abnormalities: a 24-week randomized controlled trial.

    abstract:OBJECTIVE:To verify the benefit of renin-angiotensin system blockade in hypertension, the effects of 24 weeks' losartan and ramipril treatment, both alone and in combination, on urinary albumin excretion (UAE) and circulating transforming growth factor beta1 (TGF beta1) have been evaluated in hypertensive subjects with...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.hjh.0000160225.01845.26

    authors: Scaglione R,Argano C,Corrao S,Di Chiara T,Licata A,Licata G

    更新日期:2005-03-01 00:00:00

  • Relationship between baroreflex sensitivity, renin suppression and natriuresis in salt-sensitive rabbits.

    abstract::This study determined the influence of baroreflex sensitivity (BRS) on the rate of urinary sodium excretion and plasma renin activity (PRA) in response to a saline infusion in conscious male rabbits specifically bred for high (Group I; n = 7) and low (Group II; n = 10) BRS and in seven control animals. Only Group II s...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199109000-00005

    authors: Weinstock M,Borosh M,Kafri O,Kaczmarczyk G

    更新日期:1991-09-01 00:00:00

  • Differential stimulation of synaptosomal norepinephrine uptake by high salt diet in Dahl rats.

    abstract::We have studied the norepinephrine (NE) uptake processes directly in synaptosomes isolated from the hypothalamus of both Dahl salt-sensitive (DS) and Dahl salt-resistant (DR) rats. Both DS and DR rats were divided into two dietary groups, one high salt diet group and one low salt diet group. NE uptake was highly sodiu...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198410000-00003

    authors: Rho JH,Hough K

    更新日期:1984-10-01 00:00:00

  • Weight status change from childhood to early adulthood and the risk of adult hypertension.

    abstract:OBJECTIVE:Overweight/obesity in childhood is suggested to increase risk of hypertension later in life. However, few studies have assessed the effect of trajectories of weight status from childhood to adulthood on adult hypertension. The present study aimed to assess the relationship between weight status change from ch...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002016

    authors: Hou Y,Wang M,Yang L,Zhao M,Yan Y,Xi B

    更新日期:2019-06-01 00:00:00

  • Controlled analysis of blood pressure sensitivity to sodium intake: interactions with hypertension type.

    abstract:OBJECTIVE:The contribution of salt intake to the pathogenesis of hypertension holds longstanding interest. Recent studies employed the sensitivity of blood pressure (BP) to salt intake as an intermediate phenotype. The validity of this approach relative to the homogeneity of sodium-sensitive hypertension was investigat...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00004872-200305000-00020

    authors: Hurwitz S,Fisher ND,Ferri C,Hopkins PN,Williams GH,Hollenberg NK

    更新日期:2003-05-01 00:00:00

  • Nitric oxide synthase upregulation and the predelivery blood pressure decrease in spontaneously hypertensive rats.

    abstract:OBJECTIVE:The pregnant spontaneously hypertensive rat (SHR) exhibits a decrease in arterial blood pressure shortly before delivery; however, the mechanisms are unknown. Nitric oxide may be involved. DESIGN:Blood pressure in stroke-prone SHR (SHRSP) and Wistar-Kyoto control rats (WKY) was telemetrically measured. Four ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200202000-00015

    authors: Gompf H,Luft FC,Morano I

    更新日期:2002-02-01 00:00:00

  • Vascular stiffness determined from a nocturnal digital pulse wave signal: association with sleep, sleep-disordered breathing, and hypertension.

    abstract:OBJECTIVES:Reflection of the finger pulse wave form is a valid measure of arterial stiffness, which may be continuously assessed during sleep. We investigated the relationships between sleep, sleep-disordered breathing, hypertension, and pulse propagation time (PPT) in patients with suspected sleep apnea. METHODS:The ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001111

    authors: Svedmyr S,Zou D,Sommermeyer D,Ficker JH,Randerath W,Fietze I,Sanner B,Hedner J,Grote L

    更新日期:2016-12-01 00:00:00

  • Within-visit BP variability, cardiovascular risk factors, and BP control in central and eastern Europe: findings from the BP-CARE study.

    abstract:INTRODUCTION AND OBJECTIVE:Blood pressure variability (BPV) within 24 h or between visits has been found to represent an independent risk factor for cardiovascular disease. The present study was aimed at determining whether a clinical significance can be given also to the BP variations occurring within a single clinica...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000700

    authors: Grassi G,Seravalle G,Maloberti A,Facchetti R,Cuspidi C,Bombelli M,Laurent S,Redon J,Mancia G

    更新日期:2015-11-01 00:00:00

  • Hypertension: evolving from standardized to individualized care.

    abstract::: The hypertension paradigm has contributed to a dramatic reduction in CVD mortality. This has been achieved by applying average results of population studies to identify a target population and design a common intervention to achieve a BP goal. Progressive lowering of the BP threshold has expanded the fraction of per...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002375

    authors: Alderman MH,Blumenfeld JD

    更新日期:2020-07-01 00:00:00

  • Female sexual dysfunction in essential hypertension: a common problem being uncovered.

    abstract:OBJECTIVES:Female sexual dysfunction (FSD) is increasingly attracting more scientific and public interest, and represents a poorly investigated issue in patients with essential hypertension. We evaluated the prevalence of sexual dysfunction in hypertensive women compared with normotensive women according to age, hypert...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000251898.40002.5b

    authors: Doumas M,Tsiodras S,Tsakiris A,Douma S,Chounta A,Papadopoulos A,Kanellakopoulou K,Giamarellou H

    更新日期:2006-12-01 00:00:00

  • Are coronary revascularization and myocardial infarction a homogeneous combined endpoint in hypertension trials? The Losartan Intervention For Endpoint reduction in hypertension study.

    abstract:OBJECTIVE:Construction of prognostically relevant endpoints for clinical trials in hypertension has increasingly included coronary revascularization with myocardial infarction (MI) as manifestations of coronary artery disease. However, whether coronary revascularization and MI predict other cardiovascular events simila...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:

    authors: Cicala S,de Simone G,Gerdts E,Dahlöf B,Lindholm LH,Kjeldsen SE,Devereux RB

    更新日期:2010-06-01 00:00:00

  • High-salt diet increases plasma adiponectin levels independent of blood pressure in hypertensive rats: the role of the renin-angiotensin-aldosterone system.

    abstract:BACKGROUND:High sodium intake is associated with increased risk of end-organ damage, independent of blood pressure (BP) levels. The protective peptide adiponectin may play a role in the pathogenesis of hypertension and particularly in salt-loaded conditions. Furthermore, increased adiponectin levels were observed in sa...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3283325eee

    authors: Kamari Y,Shimoni N,Koren F,Peleg E,Sharabi Y,Grossman E

    更新日期:2010-01-01 00:00:00

  • Visit-to-visit variability of blood pressure and death, end-stage renal disease, and cardiovascular events in patients with chronic kidney disease.

    abstract:OBJECTIVES:Visit-to-visit variability of blood pressure (VVV of BP) is an important independent risk factor for premature death and cardiovascular events, but relatively little is known about this phenomenon in patients with chronic kidney disease (CKD) not yet on dialysis. METHODS:We conducted a retrospective study i...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000779

    authors: Chang TI,Tabada GH,Yang J,Tan TC,Go AS

    更新日期:2016-02-01 00:00:00

  • Health-related quality of life and blood pressure 12 months after renal denervation.

    abstract:AIM:To examine the effect of renal denervation (RDN) on blood pressure (BP) and health-related quality of life (QoL) in patients with resistant hypertension, pseudoresistant hypertension due to a white-coat effect and in patients with uncontrolled masked hypertension. METHODS:Using the Medical Outcomes Study 36-Item S...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000698

    authors: Lambert GW,Hering D,Marusic P,Thorp A,Sata Y,Lee R,Duval J,Hammond L,Head GA,Esler MD,Lambert EA,Dixon JB,Dhar AK,Barton DA,Schlaich MP

    更新日期:2015-11-01 00:00:00

  • Can we trust automatic sphygmomanometer validations?

    abstract::Hypertension is a leading risk factor for mortality. Detecting, treating and monitoring hypertensive patients require accurate blood pressure measurements. Protocols for validation of automatic sphygmomanometers exist, but quality control of validations is limited to peer review of published reports, which has severe ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/HJH.0b013e32833e1011

    authors: Turner MJ

    更新日期:2010-12-01 00:00:00

  • Longitudinal changes in cortical thinning associated with hypertension.

    abstract:BACKGROUND:Cross-sectional studies of the association between hypertension (HTN) and brain atrophy have shown reductions in prefrontal, temporal, and hippocampal volumes, and have identified thinner cortices across the cortical mantle. METHOD:In the current study, we followed 96 participants enrolled in the Baltimore ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000531

    authors: Gonzalez CE,Pacheco J,Beason-Held LL,Resnick SM

    更新日期:2015-06-01 00:00:00

  • Long-term chronic baroreflex activation: persistent efficacy in patients with heart failure and reduced ejection fraction.

    abstract:AIMS:Baroreflex activation therapy (BAT) has recently been shown to reduce muscle sympathetic nerve activity and hospitalization rate while improving clinical variables through 6 months of therapy in patients with heart failure and reduced ejection fraction (HFrEF). The objective of the present study is to extend the i...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1097/HJH.0000000000000603

    authors: Gronda E,Seravalle G,Trevano FQ,Costantino G,Casini A,Alsheraei A,Lovett EG,Vanoli E,Mancia G,Grassi G

    更新日期:2015-08-01 00:00:00

  • Parathyroidectomy in the Lyon hypertensive rat: cardiovascular reactivity and aortic responsiveness.

    abstract::We have studied the effect of parathyroidectomy on the systolic blood pressure, cardiovascular reactivity and the contractile response of isolated aorta to norepinephrine in the genetically hypertensive Lyon rat strain (LH), parathyroidectomized hypertensive Lyon rats (LH-PTX) and parathyroidectomized hypertensive Lyo...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199012000-00007

    authors: Pernot F,Schleiffer R,Vincent M,Sassard J,Gairard A

    更新日期:1990-12-01 00:00:00

  • Increased aortic wave reflection contributes to higher systolic blood pressure in adolescents born preterm.

    abstract:OBJECTIVE:To evaluate the wave reflection characteristics in the aortic arch and common carotid artery of ex-preterm adolescents and assess their relationship to central blood pressure in a cohort followed prospectively since birth. METHODS:Central blood pressures, pulse wave velocity, augmentation index, microvascula...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001719

    authors: Kowalski RR,Beare R,Mynard JP,Cheong JLY,Doyle LW,Smolich JJ,Cheung MMH

    更新日期:2018-07-01 00:00:00

  • High-normal blood pressure and abnormal left ventricular geometric patterns: a meta-analysis.

    abstract:AIM:The association between prehypertension (pre-HTN) and abnormal left ventricular (LV) geometric patterns is unclear. We performed a meta-analysis of echocardiographic studies aimed to provide a new piece of information on LV geometric alterations in untreated pre-HTN individuals. DESIGN:Studies were identified by c...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/HJH.0000000000002063

    authors: Cuspidi C,Sala C,Tadic M,Gherbesi E,Facchetti R,Grassi G,Mancia G

    更新日期:2019-07-01 00:00:00

  • Effect of nicardipine treatment upon cardiac hypertrophy in spontaneously hypertensive rats: a morphometric and ultrastructural study.

    abstract:OBJECTIVE:The present study was designed to investigate the effect of nicardipine administration upon systolic blood pressure (SBP) and cardiac hypertrophy in spontaneously hypertensive rats (SHR). DESIGN:SBP, heart: and left ventricle: body weight ratios, the cross-sectional area of cardiocytes, and the ultrastructur...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199206000-00002

    authors: Ferrante F,Bronzetti E,Ciriaco E,Felici L,Amenta F

    更新日期:1992-06-01 00:00:00