Abstract：
BACKGROUND:Obstructive sleep apnea (OSA) has several negative effects on the heart including increase in myocardial end-systolic stress, venous return and sympathetic activity, all potential stimuli of left ventricular (LV) hypertrophy. The impact of the severity of OSA on LV geometry is unknown. We hypothesized that OSA is related to concentric LV geometry. METHODS:One hundred and fifty-seven patients with suspected OSA underwent echocardiography, ambulatory 24-h blood pressure and ECG monitoring. On the basis of the severity of OSA, patients were divided into controls, mild OSA and moderate/severe OSA (apnea-hypopnea index <5, 5-15 and >15/h, respectively). Patients with LV hypertrophy were defined as LV mass at least 49.2 g/m2.7 for men and at least 46.7 for women. Relative wall thickness of at least 0.43 identified patients with concentric LV geometry. RESULTS:Patients with moderate/severe OSA (n = 86) had a higher body mass index and a higher prevalence of paroxysmal atrial fibrillation than those (n = 51) with mild OSA and controls (n = 20). Prevalence of hypertension, diabetes, obesity, LV mass and blood pressure did not differ between the groups. Relative wall thickness was positively related to apnea-hypopnea index (r = 0.30; P = 0.003) and the prevalence of concentric LV geometry was 20% in controls, 12% in mild OSA and 58% in moderate/severe OSA (P < 0.001). In logistic regression analysis concentric LV geometry was associated with moderate/severe OSA [odds ratio (OR) 7.6, P < 0.001], low stress-corrected midwall shortening (OR 3.38, P = 0.004), and higher body mass index (OR 1.09, P = 0.03). CONCLUSIONS:Moderate/severe OSA is associated with high prevalence of concentric LV geometry. This increased prevalence may in part explain the increased rate of cardiovascular events in these patients.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Cioffi G,Russo TE,Stefenelli C,Selmi A,Furlanello F,Cramariuc D,Gerdts E,de Simone Gdoi
10.1097/hjh.0b013e328336c90asubject
Has Abstractpub_date
2010-05-01 00:00:00pages
1074-82issue
5eissn
0263-6352issn
1473-5598journal_volume
28pub_type
杂志文章abstract：:Ischemic renal disease (IRD) is defined as a clinically important reduction in glomerular filtration rate or loss of renal parenchyma caused by hemodynamically significant renal artery stenosis. IRD is a common and often overlooked clinical entity that presents itself in the setting of extrarenal arteriosclerotic vasc...
journal_title：Journal of hypertension
pub_type： 社论,评审
doi：10.1097/00004872-199715120-00001
更新日期：1997-12-01 00:00:00
abstract：BACKGROUND:Hypertension is a complex trait with an ill-defined genetic predisposition, in which adrenergic mechanisms seem to be involved even at the early stages. Chromogranin A is a pro-hormone stored and released with catecholamines by exocytosis; its fragment catestatin, formed in vivo, inhibits further catecholami...
journal_title：Journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1097/00004872-200207000-00020
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVES:Brachial artery flow-mediated dilation (FMD) is a popular technique to examine endothelial function in humans. Identifying volunteer and methodological factors related to variation in FMD is important to improve measurement accuracy and applicability. METHODS:Volunteer-related and methodology-related parame...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000001012
更新日期：2016-09-01 00:00:00
abstract：:The activity of renal Na-K-ATPase was compared in hypertension-prone (SBH) and hypertension-resistant (SBN) Sabra rats on regular sodium intake and 2-3 weeks after a high sodium diet. ATPase activity was determined in single nephron segments by a micromethod. The activity profile was found to be similar in the two sub...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：
更新日期：1983-06-01 00:00:00
abstract：BACKGROUND:Constitutional hypotension (CHT) is defined as a SBP below 105 mmHg. As autonomic-related symptoms are frequently reported in CHT, these symptoms suggest that the cardiovascular autonomic control is perturbed in individuals with CHT. METHODS:We investigated the autonomic cardiovascular control of 15 women w...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000001790
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:The platelet GPIIIa plays a pivotal role in platelet aggregation. Previous studies showed an association between the GPIIIa Pl(A1/A2) polymorphism and coronary thrombosis, while there is only contrasting evidence about its role in stroke. We explored the possibility that this polymorphism represents a risk fa...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e328013cd67
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVE:Using an aortic constriction model in mice, we studied whether the increase in pressure or the activation of the renin-angiotensin system (RAS) and its main receptors is the main driving force for plaque progression. METHODS:Male ApoE mice underwent sham surgery or placement of a suprarenal silver clip aroun...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/01.hjh.0000244949.65040.de
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVE:To introduce a new method, the smoothness index, for assessing the homogeneity of 24 h blood pressure reduction by antihypertensive treatment and to compare it with the trough : peak ratio; and to assess the ability of both indices to predict a reduction in the left ventricular mass index induced by treatment...
journal_title：Journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1097/00004872-199816110-00016
更新日期：1998-11-01 00:00:00
abstract：:Reduction of large artery distensibility has several adverse consequences for the cardiovascular system. This paper reviews the evidence obtained by measuring distensibility through quantification of changes in arterial diameter versus blood pressure changes at large elastic and middle size muscle artery sites. Eviden...
journal_title：Journal of hypertension
pub_type： 杂志文章,评审
doi：10.1097/00004872-200210000-00001
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:Excess dietary sodium has been linked to the development of hypertension and other cardiovascular diseases. In humans, the effects of sodium consumption on endothelial function have not been separated from the effects on blood pressure. The present study was designed to determine if dietary sodium intake aff...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e32835c6ca8
更新日期：2013-03-01 00:00:00
abstract：:Two formulations of felodipine, conventional and extended release (ER) tablets, were compared in a double-blind, crossover study of patients whose blood pressure was not being controlled using metoprolol 100 mg once daily. Nineteen patients with a supine diastolic blood pressure greater than or equal to 95 mmHg after ...
journal_title：Journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验,评审
doi：10.1097/00004872-198908000-00008
更新日期：1989-08-01 00:00:00
abstract：OBJECTIVE:To gain insight into the mechanisms which contribute to the development of vascular hypertrophy in the spontaneously hypertensive rat (SHR). DESIGN:These experiments were performed under conditions which most closely mimic the growth of smooth muscle in blood vessels, i.e. once cell-cell contact has been ach...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：DESIGN:Because of uncertainties regarding the complete antihypertensive mechanism of action of beta-adrenoceptor antagonists, the present study determined whether vagal afferent neurons of humans and rats possess beta-adrenoceptors. Such a location would provide an appropriate target for beta-blockers to modulate neuro...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-199506000-00009
更新日期：1995-06-01 00:00:00
abstract：BACKGROUND:Activated coagulation Factor XII (FXIIa) infusion increases peripheral resistance (TPR) and mean arterial pressure (MAP) of Brown Norway but not plasma kininogen deficient Brown Norway Katholiek (BNK) rats. FXIIa concentrations are elevated in hypertensive end-stage renal disease patients receiving conventio...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000000192
更新日期：2014-07-01 00:00:00
abstract：CONTEXT:There is a growing prevalence of cardiovascular disease (CVD) risk factors in West Africa and among its migrants to industrialized countries. Despite this, no study has reviewed CVD risk factor prevalence among West Africans in Africa and industrialized countries. OBJECTIVE:To appraise studies on the prevalenc...
journal_title：Journal of hypertension
pub_type： 杂志文章,评审
doi：10.1097/HJH.0000000000000061
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVES:Several studies have suggested a positive association between serum lipid levels and blood pressure (BP). This study investigated this association in a large population from 12 European countries. METHODS:Data were taken from the European Study on Cardiovascular Risk Prevention and Management in Usual Daily...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000001078
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Wide pulse pressure is a potent risk factor for atherosclerotic disease, and hypertension is induced by habitual alcohol drinking. This concise study investigated whether age affects the relationship between alcohol drinking and pulse pressure. METHODS:The participants were 99 661 male workers (20-69 years ...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e3280895b69
更新日期：2007-05-01 00:00:00
abstract：OBJECTIVE:Guidelines recommend lower threshold and goal blood pressure (BP) for patients with proteinuria. BP reduction could be accompanied by a different fall in proteinuria depending of the antihypertensive drug. The objective was to compare proteinuria reduction when BP is lowered to the same level with different d...
journal_title：Journal of hypertension
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1097/00004872-200204000-00032
更新日期：2002-04-01 00:00:00
abstract：OBJECTIVES:To determine prevalence, awareness, treatment, and control of hypertension, and its risk factors in an urban Korean population. DESIGN AND SETTING:A cross-sectional survey in Ansan-city, Korea. SUBJECTS AND METHODS:Population-based samples of people aged 18-92 years in Ansan-city, Korea, were selected, yie...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-200109000-00002
更新日期：2001-09-01 00:00:00
abstract：OBJECTIVE:Endothelial dysfunction and arterial stiffness are early vascular alterations, linked to oxidative stress and inflammation, with prognostic significance in essential hypertensive patients. P2X7 receptors (P2X7R), responding to extracellular ATP, are encoded by a highly polymorphic gene and modulate inflammato...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e3283653ff5
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVE:Epidemiological studies suggest that intrauterine growth restriction (IUGR) due to maternal undernutrition during pregnancy represents a major risk factor for hypertension and diabetes in adult age. However, placental insufficiency, rather than maternal malnutrition, is the main cause of IUGR in the Western w...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-199917090-00002
更新日期：1999-09-01 00:00:00
abstract：OBJECTIVE:To examine the changes in plasma brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP) and blood pressure in patients with essential hypertension on a low, normal and high sodium intake. DESIGN AND METHODS:Twelve patients with mild-to-moderate essential hypertension were studied. Plasma, urinary ...
journal_title：Journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:In the BEtter control of BP in hypertensive pAtients monitored Using the HOTMAN sYstem study, we investigated whether utilizing noninvasive monitoring of hemodynamic parameters combined with a drug selection algorithm (integrated hemodynamic management - IHM) compared with conventional drug selection may imp...
journal_title：Journal of hypertension
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1097/HJH.0000000000000749
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:We examined the relationship between brachial-ankle pulse wave velocity and the development of cardiovascular disease in a general Japanese population. METHODS:A total of 2916 community-dwelling Japanese individuals without history of cardiovascular disease aged at least 40 years were followed up for an aver...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e32835c5c23
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVES:Recently, the nanomechanical properties (i.e. stiffness) of endothelial cells have been identified as crucial for appropriate endothelial function. One major determinant of endothelial stiffness is the endothelial sodium channel (EnNaC). EnNaC-dependent stiffening leads to reduced nitric oxide release, which...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000000736
更新日期：2015-12-01 00:00:00
abstract：:Hypertensive disease is known to increase the risks in connection with acute changes in blood pressure due to the presence of pronounced structural as well as functional changes in the cardiovascular system. In the present study the metabolic consequences of fixed haemorrhagic hypotension [mean arterial pressure (MAP)...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-198310000-00005
更新日期：1983-10-01 00:00:00
abstract：:The associations of obesity and alcohol consumption with blood pressure and the prevalence of hypertension were studied in 5550 male and female subjects aged 25 to 64 years, surveyed in the National Heart Foundation of Australia 1980 Risk Factor Prevalence Study. Body mass index was significantly and independently ass...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-198402000-00015
更新日期：1984-02-01 00:00:00
abstract：OBJECTIVES:We evaluated the predictive power of home blood pressure and clinic blood pressure based on the long-term cardiovascular outcome in hypertensive patients with and without impaired glucose metabolism (IGM). METHOD:The multicentre Hypertension Objective Treatment Based on Measurement by Electrical Devices Blo...
journal_title：Journal of hypertension
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1097/HJH.0b013e328361732c
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:High sleep blood pressure (BP) has been suggested to be an independent risk factor for cardiovascular outcomes. To assess the applicability of sleep BP measured using a timer-equipped home device, we investigated the association between home device-measured sleep BP and large artery stiffness. METHODS:We pe...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000002576
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:To investigate whether a dietary supplement of vitamin B6 could attenuate the elevation of systolic blood pressure (SBP) in Zucker obese or spontaneously hypertensive rats, or rats ingesting sucrose. METHODS:Zucker obese rats (fa/fa), Sprague-Dawley rats with sucrose-induced elevation of SBP, spontaneously h...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-199603000-00013
更新日期：1996-03-01 00:00:00
