Blood pressure is the major driving force for plaque formation in aortic-constricted ApoE-/- mice.

abstract：BACKGROUND:Sleep-disordered breathing, predominantly obstructive sleep apnea (OSA), is highly prevalent in patients with hypertension. OSA may underlie the progression to resistant hypertension, partly due to increased activation of the sympathetic nervous system. This analysis of patients with and without OSA evaluate...

journal_title：Journal of hypertension

authors： Linz D,Mancia G,Mahfoud F,Narkiewicz K,Ruilope L,Schlaich M,Kindermann I,Schmieder RE,Ewen S,Williams B,Böhm M,Global SYMPLICITY Registry Investigators.

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:Advanced diabetic nephropathy (DN) is characterized by a marked development of cardiovascular and renal disease. These patients are frequently managed by different health professionals with the consequence that the quality of care may differ substantially. To compare the management of cardiovascular risk fac...

journal_title：Journal of hypertension

authors： Minutolo R,Sasso FC,Chiodini P,Cianciaruso B,Carbonara O,Zamboli P,Tirino G,Pota A,Torella R,Conte G,De Nicola L

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:Metabolic syndrome (MetS) is associated with insulin resistance and increases the cardiovascular risk. Oxidative stress constitutes a potential mechanism that links insulin resistance and cardiovascular disease. The aim of this study was to analyze the relationship of NADPH oxidase activation with insulin res...

journal_title：Journal of hypertension

authors： Fortuño A,Bidegain J,San José G,Robador PA,Landecho MF,Beloqui O,Díez J,Zalba G

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Apoptosis or programmed cell death could be greater than normal in various cardiovascular disorders, particularly in the heart. Apoptosis might contribute to remodeling of blood vessels in hypertension and could participate in regulation of vascular hypertrophy/hyperplasia. OBJECTIVE:To investigate apoptosi...

journal_title：Journal of hypertension

authors： Sharifi AM,Schiffrin EL

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:To assess the trends in blood pressure (BP) and in body mass index (BMI) in the hypertensive and normotensive population in Finland during 1982-1997. DESIGN:Four independent cross-sectional standardized population surveys were conducted in 1982, 1987, 1992 and 1997. SETTING:The provinces of North Karelia an...

journal_title：Journal of hypertension

authors： Kastarinen MJ,Nissinen AM,Vartiainen EA,Jousilahti PJ,Korhonen HJ,Puska PM,Tuomilehto

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:Despite the widespread use of multivitamin supplements, little is known regarding their effects on blood pressure (BP) and the development of hypertension. We, therefore, sought to prospectively investigate how multivitamin use was associated with incident hypertension among middle-aged and older women. METH...

journal_title：Journal of hypertension

authors： Rautiainen S,Wang L,Lee IM,Manson JE,Gaziano JM,Buring JE,Sesso HD

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to examine the reproducibility of arterial baroreflex sensitivity (BRS) provided by the spontaneous baroreflex method at rest and during laboratory tests. METHODS:Twenty healthy volunteers were studied 24 h apart, in the same laboratory and under the same environmental condit...

journal_title：Journal of hypertension

authors： Iellamo F,Legramante JM,Raimondi G,Castrucci F,Massaro M,Peruzzi G

更新日期：1996-09-01 00:00:00

abstract：:Precapillary resistance arteries from spontaneously hypertensive rats (SHR) and Wistar-Kyoto normotensive rats (WKY) were found to contain three inositol lipids and to produce five inositol phosphate peaks. These were assessed by a highly sensitive procedure which involved the separation of radiolabelled inositol-cont...

journal_title：Journal of hypertension

authors： Durkin H,Ollerenshaw JD,Heagerty AM

更新日期：1990-06-01 00:00:00

abstract：:Recent evidence suggests that a considerable proportion of plasma angiotensin is generated not in blood but in peripheral tissues. Through the measurement of angiotensin peptides and renin in the plasma of 11 anephric subjects, we have investigated whether kidney-derived renin, or some other tissue mechanism for angio...

journal_title：Journal of hypertension

authors： Campbell DJ,Kladis A,Skinner SL,Whitworth JA

更新日期：1991-03-01 00:00:00

abstract：OBJECTIVE:In patients with type 2 diabetes mellitus (T2DM), blocking of the renin-angiotensin-aldosterone system (RAAS) has demonstrated efficacy in lowering blood pressure (BP) and urinary albumin excretion rate (UAER). Nonetheless, not all patients successfully respond to RAAS blockade with a reduction in BP and UAER...

journal_title：Journal of hypertension

authors： Weir MR,Hollenberg NK,Remuzzi G,Zappe DH,Meng X,Parving HH

更新日期：2011-10-01 00:00:00

abstract：:If ambulatory blood pressure measurement is not possible because the upper-arm circumference is so great that even the largest cuff provided with the monitor will not encircle the arm, satisfactory measurements can be obtained by applying a cuff to the forearm. ...

journal_title：Journal of hypertension

authors： O'Brien E

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:The rostral ventrolateral medulla (RVLM) of the brainstem and the paraventricular nucleus (PVN) of the hypothalamus play crucial roles in central cardiovascular regulation. In hypertensive rats, an imbalance of excitatory and inhibitory inputs to the RVLM enhances central sympathetic outflow. Increased react...

journal_title：Journal of hypertension

authors： Nishihara M,Hirooka Y,Matsukawa R,Kishi T,Sunagawa K

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Sitagliptin, a new antidiabetic drug that inhibits dipeptidyl peptidase (DPP)-4 enzyme activity, has been reported to possess neuroprotective property. We tested the protective effects of sitagliptin against chronic cerebral hypoperfusion (CHP) in mice after bilateral carotid artery stenosis (BCAS). METHOD:...

journal_title：Journal of hypertension

authors： Tsai TH,Sun CK,Su CH,Sung PH,Chua S,Zhen YY,Leu S,Chang HW,Yang JL,Yip HK

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to evaluate the 24-h urinary sodium excretion in children of 10-12 years at a school in the north of Portugal and to examine the influence on salt intake and blood pressure of three different educational interventions for 6 months. METHODS:Blood pressure (BP) and sodium excretion in ...

journal_title：Journal of hypertension

authors： Cotter J,Cotter MJ,Oliveira P,Cunha P,Polónia J

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Dopamine receptors induce natriuresis in kidney. Previous studies have shown interactions between different subtypes of dopamine receptors in renal proximal tubule (RPT) cells. We hypothesize that D3 receptors have an interaction with D4 receptors in RPT cells from normotensive rats (Wistar-Kyoto, WKY) and s...

journal_title：Journal of hypertension

authors： Chen X,Liu Y,Wang WE,Chen C,Ren H,Zheng S,Zhou L,Zeng C

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:Blood pressure (BP) variability (BPV) may offer independent prognostic information. However, data supporting this notion are inconsistent, and this may be due to the wide variety of methodologies used for measuring BPV. A systematic analysis on the effect of BPV methodologies on BPV itself has never been und...

journal_title：Journal of hypertension

authors： Veloudi P,Sharman JE

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:Experimental data show that ouabain is a modulator of the sodium-potassium pump, which plays an important role in sodium homeostasis and blood pressure regulation. We investigated the distribution of plasma ouabain in the general population in relation to blood pressure and other determinants of sodium homeos...

journal_title：Journal of hypertension

authors： Wang JG,Staessen JA,Messaggio E,Nawrot T,Fagard R,Hamlyn JM,Bianchi G,Manunta P

更新日期：2003-08-01 00:00:00

abstract：:Neutrophils possess a plasma-membrane-bound reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase which catalyzes superoxide (O2-) formation and is activated by a variety of stimuli. Recently, neutrophils of patients with essential hypertension (EHT) have been reported to generate O2- at rates up to four...

journal_title：Journal of hypertension

authors： Seifert R,Hilgenstock G,Fassbender M,Distler A

更新日期：1991-02-01 00:00:00

abstract：OBJECTIVE:Based on results of in vitro studies, it has been hypothesized that blockade of the renin-angiotensin system (RAS) promotes the recruitment and differentiation of pre-adipocytes and that increased formation of small insulin-sensitive adipocytes counteracts ectopic deposition of lipids, thereby improving insul...

journal_title：Journal of hypertension

authors： Furuhashi M,Ura N,Takizawa H,Yoshida D,Moniwa N,Murakami H,Higashiura K,Shimamoto K

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:The screening for primary aldosteronism is based on the aldosterone-renin ratio calculated with the plasma renin activity (PRA) value as denominator. A direct measurement of active renin (DRA) is being used as an alternative to PRA, but its diagnostic performance remains unclear. METHOD:We, therefore compar...

journal_title：Journal of hypertension

authors： Rossi GP,Barisa M,Belfiore A,Desideri G,Ferri C,Letizia C,Maccario M,Morganti A,Palumbo G,Patalano A,Roman E,Seccia TM,Pessina AC,Mantero F,PAPY study Investigators.

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:Abnormal vascular reactivity contributes to the pathophysiology of hypertension and hypertension-related organ damage. As the dietary content of fatty acids may affect the vascular responses, we investigated the relationship of endothelium-independent and endothelium-dependent vasodilation with the fatty acid...

journal_title：Journal of hypertension

authors： Colussi G,Catena C,Dialti V,Mos L,Sechi LA

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVES:We examined whether the Rho/Rho-kinase pathway is involved in the pathogenesis of nephrosclerosis in severely hypertensive rats and assessed the effects of long-term treatment with a Rho-kinase inhibitor, fasudil, on kidney function, histological findings, gene expressions, and survival. We also attempted to...

journal_title：Journal of hypertension

authors： Nishikimi T,Koshikawa S,Ishikawa Y,Akimoto K,Inaba C,Ishimura K,Ono H,Matsuoka H

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:To validate a computer-based method for measuring the calibre of retinal blood vessels, and use it to determine the effects of ageing and arterial hypertension on the calibres of these vessels and on their ratio. METHODS:Digital eye fundus images covering a 50 degrees field and centred on the optic disc were...

journal_title：Journal of hypertension

authors： Pose-Reino A,Gomez-Ulla F,Hayik B,Rodriguez-Fernández M,Carreira-Nouche MJ,Mosquera-González A,González-Penedo M,Gude F

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVES:Recent studies in homogenized hearts suggest that chymase rather than angiotensin converting enzyme (ACE) is responsible for cardiac angiotensin I to angiotensin II conversion. We investigated in intact rat hearts whether (i) enzymes other than ACE contribute to angiotensin I to angiotensin II conversion and...

journal_title：Journal of hypertension

authors： de Lannoy LM,Schuijt MP,Saxena PR,Schalekamp MA,Danser AH

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:To examine the interaction of sodium intake with genetic variations of the angiotensinogen gene and hypertension. DESIGN:A community-based case-reference study. SETTING:Two rural Japanese communities. PARTICIPANTS:Non-overweight and non-drinking Japanese men and women: 229 hypertensives and 229 age-, sex- ...

journal_title：Journal of hypertension

authors： Iso H,Harada S,Shimamoto T,Sato S,Kitamura A,Sankai T,Tanigawa T,Iida M,Komachi Y

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to investigate possible inter-relationships between connective tissue growth factor (CTGF) and aldosterone in vascular and renal damage associated with hypertension. METHOD:Spontaneously hypertensive rats (SHR) were treated with two doses (100 and 30 mg/kg per day) of the min...

journal_title：Journal of hypertension

authors： de las Heras N,Ruiz-Ortega M,Miana M,Rupérez M,Sanz-Rosa D,Aragoncillo P,Mezzano S,Cachofeiro V,Egido J,Lahera V

更新日期：2007-03-01 00:00:00

abstract：:Blood pressure was measured in 864 young people aged 16-24 years, 8 years after both of their parents had their blood pressures measured as part of the screening phase of the Medical Research Council Mild Hypertension Trial. Only 29% of offspring with a conventional 'family history of hypertension', defined in terms o...

journal_title：Journal of hypertension

authors： Watt GC,Foy CJ,Holton DW,Edwards HE

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVES:To assess the expression of early cardiac genes, implicated in the hypertrophic growth response of the adult heart, in peripheral blood mononuclear cells in patients with essential hypertension and its relationship to ambulatory blood pressure monitoring (ABPM) parameters and to echocardiographic left ventri...

journal_title：Journal of hypertension

authors： Kontaraki JE,Marketou ME,Zacharis EA,Parthenakis FI,Vardas PE

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:Blood pressure (BP) control is the most established practice for preventing the progression of chronic kidney disease (CKD). We examined the BP control and nocturnal dipping pattern changes in hypertensive patients with CKD and their effects on target organ damages. METHODS:We recruited 378 hypertensive CKD ...

journal_title：Journal of hypertension

authors： Cha RH,Lee H,Lee JP,Kang E,Song YR,Kim YS,Kim SG

更新日期：2017-03-01 00:00:00

abstract：:Recent investigations have delineated the renal microvascular responsiveness to pressure, by using isolated afferent arterioles, juxtamedullary nephrons, and isolated perfused hydronephrotic kidneys. Both afferent arterioles and interlobular arteries (ILA) manifest pressure-dependent vasoconstrictor responses to eleva...

journal_title：Journal of hypertension

authors： Hayashi K,Epstein M,Saruta T

更新日期：1996-12-01 00:00:00