Abstract:
OBJECTIVE:In some patients with aortic stenosis left-ventricular hypertrophy exceeds what is needed to sustain the hemodynamic load imposed by the aortic stenosis, a condition named inappropriately high left-ventricular mass (iLVM). Although iLVM is associated with increased mortality after aortic valve replacement, prevalence and covariates of iLVM in asymptomatic aortic stenosis are unknown. METHODS:We analyzed baseline data from 1614 patients (67 ± 10 years, 51% hypertensive) recruited in the Simvastatin Ezetimibe in Aortic Stenosis study evaluating placebo-controlled combined simvastatin and ezetimibe treatment in asymptomatic mild-moderate aortic stenosis. iLVM was diagnosed by Doppler echocardiography as LVM greater than 28% of the expected LVM predicted from height, sex and stroke work. RESULTS:iLVM was detected in 268 patients (16.6%), irrespective of concomitant hypertension. Patients with iLVM had higher body weight, LVM and relative wall thickness, higher prevalence of systolic dysfunction (88 vs. 15%) and lower left-ventricular afterload (all P < 0.01) than patients with appropriate LVM in spite of comparable aortic stenosis severity. In multivariate analysis, all these five variables were independently associated with iLVM. The simple coexistence of low stress-corrected midwall shortening and left-ventricular hypertrophy was the best clinical model describing iLVM phenotype (sensitivity 72%, specificity 96%, area under the receiver operating characteristic curve 0.954). CONCLUSION:iLVM is common in asymptomatic mild-moderate aortic stenosis and unrelated to severity of aortic stenosis or presence of hypertension. iLVM was associated with combined concentric geometry and reduced left-ventricular myocardial contractility, suggesting iLVM in asymptomatic aortic stenosis as a marker of more advanced myocardial disease.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Cioffi G,de Simone G,Cramariuc D,Mureddu GF,Gerdts Edoi
10.1097/HJH.0b013e32834f0b00subject
Has Abstractpub_date
2012-02-01 00:00:00pages
421-8issue
2eissn
0263-6352issn
1473-5598journal_volume
30pub_type
临床试验,杂志文章,多中心研究abstract:OBJECTIVES:To evaluate the clinic and ambulatory blood pressure (BP)-lowering efficacy and safety of an aliskiren/amlodipine/hydrochlorothiazide (HCT) triple combination compared with the component dual combinations, in patients with moderate-to-severe hypertension. METHODS:This 8-week, double-blind, randomized, activ...
journal_title:Journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1097/HJH.0b013e328356b8ea
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Hyperactivity of the brain renin-angiotensin (Ang) system has been implicated in the development and maintenance of hypertension. AngIII, one of the main effector peptides of the brain renin-Ang system, exerts a tonic stimulatory control over blood pressure (BP) in hypertensive rats. Aminopepti...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001563
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To investigate whether nondipping and diabetes are independently related to metabolic risk profile and prevalence of target organ damage in a population setting. METHODS:A population-based cohort of 70-year-old men (n = 1057) was examined with 24-h ambulatory blood pressure monitoring, euglycemic hyperinsuli...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200208000-00011
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the mean levels of blood pressure and hypertension (> or = 140 mmHg systolic or > or = 90 mmHg diastolic pressure or on treatment for hypertension) in the adult English population, and to evaluate any changes in the efficacy of hypertension management between 1994 and 2003. DESIGN/METHODS:Cross-s...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000226210.95936.bc
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:Using an aortic constriction model in mice, we studied whether the increase in pressure or the activation of the renin-angiotensin system (RAS) and its main receptors is the main driving force for plaque progression. METHODS:Male ApoE mice underwent sham surgery or placement of a suprarenal silver clip aroun...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000244949.65040.de
更新日期:2006-10-01 00:00:00
abstract::Measurements of exchangeable sodium, arterial pressure and plasma concentrations of active renin, angiotensin II, aldosterone, sodium and potassium were made in 35 hypertensive patients with renal artery stenosis, 30 having unilateral renal arterial lesions. Plasma urea was below 7 mmol/l in 24 of the patients with un...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198310000-00015
更新日期:1983-10-01 00:00:00
abstract:OBJECTIVES:Stroke is elevated in people of black African descent, but evidence for excess subclinical cerebrovascular disease is conflicting, and the role of risk factors in determining any ethnic differences observed unexplored. METHODS:We compared prevalence of brain infarcts, and severe white matter hyperintensitie...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328364f5bc
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:Endothelin is thought to be related to cardiovascular disease. The purpose of this study was to determine whether endothelin levels could be reduced by a calcium antagonist and a 'natural factor'. DESIGN:Since calcium ionophores can induce endothelin-1 messenger RNA synthesis in cultured endothelial cells, t...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199309000-00012
更新日期:1993-09-01 00:00:00
abstract:AIM:Advanced age is associated with vascular endothelial dysfunction, characterized by reductions in the endothelium-dependent vasodilation of the conduit and resistance arteries, in part, from decreased nitric oxide bioavailability. Although vascular smooth muscle function (SMF), assessed by responsiveness to an exoge...
journal_title:Journal of hypertension
pub_type: 杂志文章,meta分析,评审
doi:10.1097/HJH.0000000000000446
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:Mean blood pressure varies moderately with outdoor air temperature in many western populations. Substantial uncertainty exists, however, about the strength of the relationship in other populations and its relevance to age, adiposity, medical treatment, climate and housing conditions. METHODS:To investigate ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32835465b5
更新日期:2012-07-01 00:00:00
abstract::Adequate evaluation of automated sphygmomanometers, in terms of safety, accuracy, mechanical reliability, patient acceptability and ability to record ambulatory blood pressure is essential before these devices are used in clinical practice and in clinical trials. We have evaluated the accuracy and performance of the A...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199007000-00003
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVE:To determine the suitability of a new logistic curve fitting procedure to measure the diurnal rates of transition from the active to the asleep periods separately. METHOD:We applied this method to 24-h telemetry recordings of systolic, mean, diastolic arterial pressure (SAP, MAP, DAP, respectively), heart ra...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200411000-00008
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVES:Night-time blood pressure (BP) - prognostically more important than circadian BP variability - has not been evaluated for quantitative associations with objective sleep quality in large populations. METHODS:The cross-sectional study measured actigraphic sleep parameters and night-time BP for two nights in 1...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001569
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:The primary aim of the Perindopril Protection Against Recurrent Stroke Study (PROGRESS) is to determine the effects of a long-term angiotensin converting enzyme (ACE)-inhibitor-based blood-pressure-lowering regimen on the risk of stroke among patients with a history of stroke or transient ischaemic attack (TI...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1999-11-01 00:00:00
abstract::The response of blood pressure, heart rate and plasma catecholamines to a mental arithmetic and a cold pressor test was studied in 70 patients with mild essential hypertension and in 41 age- and sex-matched normotensives. Each group consisted of three prospectively stratified age classes: 20-29, 30-39 and 40-55 years....
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::Over the last few years, much progress has been made in understanding the genetic basis of primary aldosteronism. This has led to the diagnosis of the familial forms and has aided the understanding of the basis of sporadic forms of the disease. Such information can be exploited to improve the therapeutic approaches us...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/00004872-200404000-00001
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:The present study aimed to characterize the influence of salt intake on the gene expression of the kidney specific chloride channels CLC-K1 and CLC-K2 in the kidneys of salt-resistant and salt-sensitive Dahl rats. DESIGN:For this purpose Dahl salt-resistant (Dahl-R) and Dahl salt-sensitive rats (Dahl-S) were...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200018090-00015
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:We investigated the responses of mean arterial pressure and renal blood flow to intravenous and intrarenal angiotensin II, plasma and kidney angiotensin II concentrations and renal angiotensin receptor subtype 1 protein expression, and renal functional responses to intravenous and intrarenal angiotensin recep...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000174972.46663.5e
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:Excess oxidative stress is one of the major metabolic abnormalities on vascular walls in hypertension and atherosclerosis. In order to further elucidate the endothelial function under oxidative stress, the effect of hydrogen peroxide (H2O2) on expression of two novel endothelium-derived vasorelaxing peptides,...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200018050-00010
更新日期:2000-05-01 00:00:00
abstract::An Na+,K+-ATPase inhibitor possessing inhibitory activity against the specific binding of ouabain to Na+,K+-ATPase has been purified from the plasma of acutely saline-infused hogs. The purification was performed by a combination of Amberlite XAD-2 adsorption chromatography and five steps of high-pressure liquid chroma...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198704000-00014
更新日期:1987-04-01 00:00:00
abstract::Calcium blockers may reduce contractility of vascular smooth muscle as well as that of myocardial cells. Therefore, falls in both total peripheral vascular resistance (TPR) and cardiac output (CO) might be responsible for a fall in blood pressure (BP) caused by calcium blockers in essential hypertension. We have studi...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章
doi:
更新日期:1988-02-01 00:00:00
abstract:OBJECTIVE:To evaluate whether efficacious counseling methods on sodium restriction can be successfully incorporated into primary care models for the management of hypertension. METHODS:We searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects and Health Te...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/HJH.0000000000000182
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:Daily exposure to air-jet stress (AJS) causes sustained elevations of blood pressure in borderline hypertensive rats (BHR). It is known that the renin-angiotensin system is activated during episodes of behavioral stress, and the purpose of this study was to assess the involvement of renin-angiotensin system i...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract:OBJECTIVES:To compare noninvasive methods to assess pulse wave velocity (PWV) with the invasive gold standard in terms of absolute values, age-related changes, and relationship with subclinical organ damage. METHODS:Invasive aortic PWV (aoPWVinv) was measured in 915 patients undergoing cardiac catheterization (mean ag...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000518
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Hypertensive nephrosclerosis is one of the most frequent causes of chronic kidney failure. Proteome analysis potentially improves the pathophysiological understanding and diagnostic precision of this disorder. In the present exploratory study, we investigated experimental nephrosclerosis in the two-kidney, o...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000370
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:The genetic background of orthostatic hypotension, an important risk factor for future cardiovascular morbidity and mortality, was investigated. DESIGN AND METHODS:The study subjects comprised 415 community-dwelling individuals, who were free from any cardiovascular complications, aged 50 years or older (mea...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200204000-00022
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:To validate a computer-based method for measuring the calibre of retinal blood vessels, and use it to determine the effects of ageing and arterial hypertension on the calibres of these vessels and on their ratio. METHODS:Digital eye fundus images covering a 50 degrees field and centred on the optic disc were...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章
doi:10.1097/01.hjh.0000163154.35577.8e
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Sleep-disordered breathing, predominantly obstructive sleep apnea (OSA), is highly prevalent in patients with hypertension. OSA may underlie the progression to resistant hypertension, partly due to increased activation of the sympathetic nervous system. This analysis of patients with and without OSA evaluate...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001142
更新日期:2017-01-01 00:00:00
abstract::The associations of obesity and alcohol consumption with blood pressure and the prevalence of hypertension were studied in 5550 male and female subjects aged 25 to 64 years, surveyed in the National Heart Foundation of Australia 1980 Risk Factor Prevalence Study. Body mass index was significantly and independently ass...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198402000-00015
更新日期:1984-02-01 00:00:00
abstract:AIM:The association between prehypertension (pre-HTN) and abnormal left ventricular (LV) geometric patterns is unclear. We performed a meta-analysis of echocardiographic studies aimed to provide a new piece of information on LV geometric alterations in untreated pre-HTN individuals. DESIGN:Studies were identified by c...
journal_title:Journal of hypertension
pub_type: 杂志文章,meta分析,评审
doi:10.1097/HJH.0000000000002063
更新日期:2019-07-01 00:00:00