High-normal blood pressure and abnormal left ventricular geometric patterns: a meta-analysis.

abstract：OBJECTIVE:The pteridine cofactor tetrahydrobiopterin (BH4) has emerged as a critical determinant of endothelial nitric oxide synthase (eNOS) activity. When BH4 availability is limited, eNOS does not produce nitric oxide (NO) but instead generates superoxide. BH4 may reverse endothelial dysfunction due to cardiovascular...

journal_title：Journal of hypertension

authors： Kase H,Hashikabe Y,Uchida K,Nakanishi N,Hattori Y

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVES:To determine whether 'slow pressor' hypertension from systemic angiotensin (Ang II) infusion was associated with renal vascular structural remodeling of the renal resistance vessels and glomerulus. METHODS:Ang II (4.5-10 ng/kg per min) or vehicle was infused for 10 days. Renal resistance vascular lumen chan...

journal_title：Journal of hypertension

authors： Edgley AJ,Kett MM,Anderson WP

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:Endothelial dysfunction and arterial stiffness are early vascular alterations, linked to oxidative stress and inflammation, with prognostic significance in essential hypertensive patients. P2X7 receptors (P2X7R), responding to extracellular ATP, are encoded by a highly polymorphic gene and modulate inflammato...

journal_title：Journal of hypertension

authors： Ghiadoni L,Rossi C,Duranti E,Santini E,Bruno RM,Salvati A,Taddei S,Solini A

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Left ventricular mass is associated with body size, obesity and blood pressure. Echocardiography is routinely used to estimate this parameter, which is usually indexed to body surface area to allow comparisons to be made between individuals and groups of different body size. However, in obese subjects, using...

journal_title：Journal of hypertension

authors： Whalley GA,Gamble GD,Doughty RN,Culpan A,Plank L,MacMahon S,Sharpe N

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:In this randomized, double-blind, crossover study, the antihypertensive efficacy of amlodipine and nifedipine gastrointestinal therapeutic system (GITS) was compared following missed doses. Design and methods In a randomized crossover design, 42 patients were randomized to receive amlodipine (5-10 mg) or the ...

journal_title：Journal of hypertension

authors： Elliott HL,Elawad M,Wilkinson R,Singh SP

更新日期：2002-02-01 00:00:00

abstract：:Thirty-two patients with mildly elevated blood pressure (BP), but without target organ damage, attended a BP measuring clinic where duplicate BP measurements were made on 12 visits. During visits 1-3, BP showed a systematic decrease which varied from patient to patient. During visits 4-12, no further systematic change...

journal_title：Journal of hypertension

authors： Watson RD,Lumb R,Young MA,Stallard TJ,Davies P,Littler WA

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:Small size at birth and greater BMI in childhood are associated with greater brachial blood pressure (BP) in later life. Aortic (central) BP differs from brachial BP and is more predictive of organ damage and cardiovascular events; the relationship between BMI in childhood and central BP is not known. METHO...

journal_title：Journal of hypertension

authors： Howe LD,Chaturvedi N,Lawlor DA,Ferreira DL,Fraser A,Davey Smith G,Tilling K,Hughes AD

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:There is ongoing discussion on how best to screen for diabetes mellitus. Previous studies suggest that an abnormal oral glucose tolerance test (OGTT) is better than fasting glucose levels in predicting cardiovascular mortality, which is largely determined by macrovascular complications in type 2 diabetes. We ...

journal_title：Journal of hypertension

authors： Schneider MP,Ott C,Ritt M,Raff U,Schlaich MP,Schmieder RE

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea (OSA) has several negative effects on the heart including increase in myocardial end-systolic stress, venous return and sympathetic activity, all potential stimuli of left ventricular (LV) hypertrophy. The impact of the severity of OSA on LV geometry is unknown. We hypothesized that O...

journal_title：Journal of hypertension

authors： Cioffi G,Russo TE,Stefenelli C,Selmi A,Furlanello F,Cramariuc D,Gerdts E,de Simone G

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVES:To study the relation between the blood pressure and the neurocognitive function within the full adult age range in a large population sample. DESIGN:A cross-sectional study of 936 healthy adults who were recruited from a register of family practices, stratified for age (24-81 years), sex, and occupational ...

journal_title：Journal of hypertension

authors： van Boxtel MP,Gaillard C,Houx PJ,Buntinx F,de Leeuw PW,Jolles J

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:To determine whether a diuretic can also reverse the clinical, systemic, renal and glomerular haemodynamic and pathological changes caused by nephrosclerosis. METHODS:Three groups of 20-week-old spontaneously hypertensive rats (SHR) were investigated: control male SHR; a similar group, administered 50 mg/l N...

journal_title：Journal of hypertension

authors： Ono Y,Ono H,Frohlich ED

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:To determine whether kidney stone disease (KSD) and hypertension (HTN) share a common familial component that is determined by a specific urinary biochemical abnormality. DESIGN:Familial aggregation study. PATIENTS:Two hundred and twelve KSD patients, aged 18-50 years, collected a 24-h urine sample to measu...

journal_title：Journal of hypertension

authors： Tisler A,Pierratos A,Honey JD,Bull SB,Logan AG

更新日期：1999-12-01 00:00:00

abstract：:An Na+,K+-ATPase inhibitor possessing inhibitory activity against the specific binding of ouabain to Na+,K+-ATPase has been purified from the plasma of acutely saline-infused hogs. The purification was performed by a combination of Amberlite XAD-2 adsorption chromatography and five steps of high-pressure liquid chroma...

journal_title：Journal of hypertension

authors： Tamura M,Inagami T,Kinoshita T,Kuwano H

更新日期：1987-04-01 00:00:00

abstract：OBJECTIVES:Renal denervation (RDN) can reduce sympathetic activity and blood pressure (BP) in patients with hypertension. The effects on resting and ambulatory heart rate (HR), also regulated by the sympathetic nervous system, are not established. METHODS:Herein, we report 12-month outcomes from the Global SYMPLICITY ...

journal_title：Journal of hypertension

authors： Böhm M,Ukena C,Ewen S,Linz D,Zivanovic I,Hoppe U,Narkiewicz K,Ruilope L,Schlaich M,Negoita M,Schmieder R,Williams B,Zeymer U,Zirlik A,Mancia G,Mahfoud F,Global SYMPLICITY Registry Investigators.

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Cross-sectional evidence indicates that eating frequency correlates with blood pressure, hypertension, and related target organ damage. The aim of the present study was to prospectively assess eating frequency as a predictor of arteriosclerosis progression and new onset hypertension over a follow-up period o...

journal_title：Journal of hypertension

authors： Karatzi K,Georgiopoulos G,Yannakoulia M,Efthimiou E,Voidonikola P,Mitrakou A,Manios E,Alevizaki M,Papamichael C,Stamatelopoulos K

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:Recently, the nanomechanical properties (i.e. stiffness) of endothelial cells have been identified as crucial for appropriate endothelial function. One major determinant of endothelial stiffness is the endothelial sodium channel (EnNaC). EnNaC-dependent stiffening leads to reduced nitric oxide release, which...

journal_title：Journal of hypertension

authors： Lenders M,Hofschröer V,Schmitz B,Kasprzak B,Rohlmann A,Missler M,Pavenstädt H,Oberleithner H,Brand SM,Kusche-Vihrog K,Brand E

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The prognostic role of endothelial dysfunction, as evaluated by flow-mediated vasodilatation of the brachial artery, has been demonstrated in patients at very high risk. We aimed to investigate whether flow-mediated vasodilatation predicts cardiovascular events in uncomplicated hypertensive patients. METHOD...

journal_title：Journal of hypertension

authors： Muiesan ML,Salvetti M,Paini A,Monteduro C,Galbassini G,Poisa P,Porteri E,Agabiti-Rosei C,Paderno V,Belotti E,Rizzoni D,Castellano M,Agabiti-Rosei E

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Endogenous ouabain, an endogenous digitalis-like steroid, is synthesized in the adrenal glands and possibly in the hypothalamus. In vitro and in vivo, endogenous ouabain triggers growth and proliferation of cardiomyocytes. OBJECTIVE:We therefore investigated the association between left ventricular structur...

journal_title：Journal of hypertension

authors： Kuznetsova T,Manunta P,Casamassima N,Messaggio E,Jin Y,Thijs L,Richart T,Fagard RH,Bianchi G,Staessen JA

更新日期：2009-09-01 00:00:00

abstract：:Arterial aging is associated with a progressive increase in aortic stiffening, which results in a rise in central aortic pressures. Traditionally, blood pressure (BP)-lowering therapy has been directed at brachial rather than central pressures. However, a key contemporary question is whether this strategy is optimal i...

journal_title：Journal of hypertension

authors： Williams B

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:To validate a computer-based method for measuring the calibre of retinal blood vessels, and use it to determine the effects of ageing and arterial hypertension on the calibres of these vessels and on their ratio. METHODS:Digital eye fundus images covering a 50 degrees field and centred on the optic disc were...

journal_title：Journal of hypertension

authors： Pose-Reino A,Gomez-Ulla F,Hayik B,Rodriguez-Fernández M,Carreira-Nouche MJ,Mosquera-González A,González-Penedo M,Gude F

更新日期：2005-04-01 00:00:00

abstract：INTRODUCTION:Chronic kidney disease (CKD) in which the disease cannot be attributed to any known cause is named CKD of uncertain aetiology (CKDu). The main aims of this analysis were to estimate the prevalence of hypertension and to identify the associated factors in a rural community vulnerable to CKDu and to identify...

journal_title：Journal of hypertension

authors： Senanayake S,Ruwanpathirana T,Gunawardena N

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:The interaction between trophoblasts and maternal endothelium is important for placental vascular modeling. Failure of uterine spiral artery transformation is linked to the etiopathology of preeclampsia. Antihypertensive medications used to control hypertension in early pregnancy can alter placental and circ...

journal_title：Journal of hypertension

authors： Xu B,Charlton F,Makris A,Hennessy A

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:Blood pressure (BP) control is the most established practice for preventing the progression of chronic kidney disease (CKD). We examined the BP control and nocturnal dipping pattern changes in hypertensive patients with CKD and their effects on target organ damages. METHODS:We recruited 378 hypertensive CKD ...

journal_title：Journal of hypertension

authors： Cha RH,Lee H,Lee JP,Kang E,Song YR,Kim YS,Kim SG

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:To determine the effects of angiotensin II (AII) (1-8) on cytosolic free calcium concentrations in the absence and in the presence of the selective angiotensin subtype 1 (AT1) receptor antagonist losartan and of the selective angiotensin subtype 2-receptor antagonist P-186 in human peripheral blood mononuclea...

journal_title：Journal of hypertension

authors： Lijnen P,Fagard R,Petrov V

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:To investigate the association between hypertension and musculoskeletal complaints among men and women selected by a population-based sample. METHODS:A cross-sectional study, with participants selected using a multistage sampling procedure and interviewed at home, was conducted to investigate the association...

journal_title：Journal of hypertension

authors： Kerkhoff AC,Moreira LB,Fuchs FD,Fuchs SC

更新日期：2012-11-01 00:00:00

abstract：:The treatment of essential hypertension continues to be carried out by drugs, combined with the adaptation of life style. The development of various types of antihypertensive drugs has not only greatly improved the management of hypertension, but also offered significant methodological sophistication of the pharmacolo...

journal_title：Journal of hypertension

authors： van Zwieten PA

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:Traditional cardiovascular risk factors do not fully account for ethnic differences in cardiovascular disease. We tested if arterial function indices, particularly augmentation index (AIx), and their determinants from childhood could underlie such ethnic variability among young British adults in the 'DASH' lo...

journal_title：Journal of hypertension

authors： Faconti L,Silva MJ,Molaodi OR,Enayat ZE,Cassidy A,Karamanos A,Nanino E,Read UM,Dall P,Stansfield B,Harding S,Cruickshank KJ

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:To investigate the characteristics and expression of transforming growth factor (TGF)-beta receptor subtypes on vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. METHODS:The effects of TGF-beta 1 on DNA synthesis were evaluated by [3H]-th...

journal_title：Journal of hypertension

authors： Fukuda N,Kubo A,Izumi Y,Soma M,Kanmatsuse K

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVE:This study evaluated the impact of prolonged circulatory unloading and subsequent left ventricular (LV) mass decrease on LV myocardial performance. Five-week head-down tilt (-6°) bed rest (HDTBR) was used as a model of prolonged circulatory unloading. METHODS:Ten young healthy male volunteers (age 23 ± 2 yea...

journal_title：Journal of hypertension

authors： Kozàkovà M,Malshi E,Morizzo C,Pedri S,Santini F,Biolo G,Pagani M,Palombo C

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Hypertensive disorders during pregnancy are an important risk to mother and fetus, frequently necessitating antihypertensive treatment. Data describing the safety of in-utero exposure to antihypertensive treatment is conflicting with many studies suffering from significant methodological issues. METHOD:We c...

journal_title：Journal of hypertension

authors： Fitton CA,Fleming M,Aucott L,Pell JP,Mackay DF,McLay JS

更新日期：2020-10-09 00:00:00