Gender differences in artery wall biomechanical properties throughout life.


:Elevated large artery stiffness and pulse pressure have emerged as important risk factors for cardiovascular disease. The genders differ in large artery biomechanical properties throughout the lifespan with females displaying higher stiffness than males during the prepubertal years and a dramatic increase after menopause. Males on the other hand experience an increase in arterial stiffness postpuberty and a linear increase thereafter, suggesting that females have intrinsically stiffer large arteries than males, but that such effects are mitigated by sex steroids during the reproductive years. This review discusses anthropometric and sex steroid influences on gender differences in large artery stiffness and pressure dynamics from childhood to senescence. In particular, the sex-specific effects of estrogen, progesterone and testosterone on vascular structure and function and how these influence arterial stiffness are explored. These factors may contribute in part to the observed gender differences in the pathophysiology and clinical manifestations of cardiovascular disease.


J Hypertens


Journal of hypertension


Rossi P,Francès Y,Kingwell BA,Ahimastos AA




Has Abstract


2011-06-01 00:00:00












  • A common polymorphism of uncoupling protein 2 gene is associated with hypertension.

    abstract:OBJECTIVES:The genes responsible for obesity are also candidate genes for obesity-related conditions, such as hypertension and type 2 diabetes. A functional polymorphism in the uncoupling protein 2 (UCP2) promoter has been reported to be associated with obesity in Caucasians. To clarify the contribution of this polymor...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Ji Q,Ikegami H,Fujisawa T,Kawabata Y,Ono M,Nishino M,Ohishi M,Katsuya T,Rakugi H,Ogihara T

    更新日期:2004-01-01 00:00:00

  • Oxidative stress in the rostral ventrolateral medulla modulates excitatory and inhibitory inputs in spontaneously hypertensive rats.

    abstract:OBJECTIVES:The rostral ventrolateral medulla (RVLM) of the brainstem and the paraventricular nucleus (PVN) of the hypothalamus play crucial roles in central cardiovascular regulation. In hypertensive rats, an imbalance of excitatory and inhibitory inputs to the RVLM enhances central sympathetic outflow. Increased react...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Nishihara M,Hirooka Y,Matsukawa R,Kishi T,Sunagawa K

    更新日期:2012-01-01 00:00:00

  • Plasma arginine-vasopressin levels during infusion of synthetic atrial natriuretic peptide on different sodium intakes in man.

    abstract::The mechanisms involved in the diuretic action of the recently discovered group of atrial natriuretic peptides (ANP) are not entirely clear. To determine whether the diuresis and the changes in blood pressure produced by alpha-human ANP (alpha-hANP) involved a concomitant modification of circulating arginine-vasopress...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Gnädinger MP,Weidmann P,Rascher W,Lang RE,Hellmüller B,Uehlinger DE

    更新日期:1986-10-01 00:00:00

  • A gene expression analysis in rat kidney following high and low salt intake.

    abstract:BACKGROUND:The effects of salt intake on renal regulation have been investigated for decades. To find new pathways and to demonstrate the utility of oligonucleotide expression arrays, we studied whole kidneys. METHODS:Eight Sprague-Dawley rats were divided into two groups. One group received a 6% salt (by weight) diet...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Barta P,Monti J,Maass PG,Gorzelniak K,Müller DN,Dechend R,Luft FC,Hübner N,Sharma AM

    更新日期:2002-06-01 00:00:00

  • Lacidipine reduces high blood pressure and the target organ damage induced by high fructose diet in rats.

    abstract:OBJECTIVE:Normotensive rats fed a high fructose diet (HFD) develop hypertriglyceridemia, hyperinsulinemia and hypertension. The glomerular changes observed in the kidneys of these animals are similar to those observed in diabetic rats. The aim of this study was to evaluate whether lacidipine could be effective not only...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Cosenzi A,Bernobich E,Plazzotta N,Seculin P,Odoni G,Bellini G

    更新日期:1999-07-01 00:00:00

  • The relationship between body weight and plasma viscosity in hypertensive diabetic Nigerians.

    abstract::Plasma viscosity and fibrinogen concentrations were measured in 70 diabetics (35 hypertensive and 35 normotensive) and compared with those of 35 age- and sex-matched normotensive healthy subjects in relation to body weight. The body weight, body mass index, blood pressure (systolic and diastolic), mean arterial pressu...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Memeh CU

    更新日期:1990-08-01 00:00:00

  • Effect of D3 dopamine receptor on dopamine D4 receptor expression and function in renal proximal tubule cells from Wistar-Kyoto rats and spontaneously hypertensive rats.

    abstract:BACKGROUND:Dopamine receptors induce natriuresis in kidney. Previous studies have shown interactions between different subtypes of dopamine receptors in renal proximal tubule (RPT) cells. We hypothesize that D3 receptors have an interaction with D4 receptors in RPT cells from normotensive rats (Wistar-Kyoto, WKY) and s...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Chen X,Liu Y,Wang WE,Chen C,Ren H,Zheng S,Zhou L,Zeng C

    更新日期:2016-08-01 00:00:00

  • Parity as predictor of early hypertension during menopausal transition.

    abstract:OBJECTIVES:Studies regarding the effects of parity on blood pressure in later life produced conflicting results. The aim of our study is to analyse whether parity influences the prevalence of hypertension in perimenopausal and postmenopausal women. METHODS:One thousand perimenopausal and postmenopausal women (mean age...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Giubertoni E,Bertelli L,Bartolacelli Y,Origliani G,Modena MG

    更新日期:2013-03-01 00:00:00

  • Accuracy of self-monitored blood pressure for diagnosing hypertension in primary care.

    abstract:OBJECTIVE:To assess the diagnostic accuracy of recommendations for self-monitoring blood pressure (BP) for diagnosing hypertension in primary care. METHODS:Two hundred and forty-seven consecutive participants with raised (≥130 mmHg systolic) BP measured by their general practitioner from four primary care practices in...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Nunan D,Thompson M,Heneghan CJ,Perera R,McManus RJ,Ward A

    更新日期:2015-04-01 00:00:00

  • Treatment-resistant hypertension in the hemodialysis population: a 44-h ambulatory blood pressure monitoring-based study.

    abstract:BACKGROUND:Uncontrolled hypertension notwithstanding the use of at least three drugs or hypertension controlled with at least four drugs, the widely accepted definition of treatment-resistant hypertension (TRH), is considered as a common problem in the hemodialysis population. However, to date there is no estimate of t...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Mallamaci F,Torino C,Sarafidis P,Ekart R,Loutradis C,Siamopoulos K,Del Giudice A,Aucella F,Morosetti M,Raptis V,Bikos A,Papagianni A,Balafa O,Pappas E,Tripepi R,Marino C,Tripepi G,Ferro C,Malyszko J,Dekker FW,Jage

    更新日期:2020-09-01 00:00:00

  • Diurnal blood pressure loads are associated with lower cognitive performances in controlled-hypertensive elderly individuals.

    abstract:INTRODUCTION:Hypertension in midlife adults is associated with cognitive decline later in life. In individuals treated for hypertension, blood pressure (BP) loads have been associated with end organ damages. This study examines whether BP load inversely correlates with performance in cognitive tasks in normotensive or ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Noriega de la Colina A,Wu R,Desjardins-Crépeau L,Badji A,Lamarre-Cliche M,Doyon J,Bherer L,Girouard H

    更新日期:2019-11-01 00:00:00

  • Estimating population salt intake in India using spot urine samples.

    abstract:OBJECTIVE:To compare estimates of mean population salt intake in North and South India derived from spot urine samples versus 24-h urine collections. METHODS:In a cross-sectional survey, participants were sampled from slum, urban and rural communities in North and in South India. Participants provided 24-h urine colle...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Petersen KS,Johnson C,Mohan S,Rogers K,Shivashankar R,Thout SR,Gupta P,He FJ,MacGregor GA,Webster J,Santos JA,Krishnan A,Maulik PK,Reddy KS,Gupta R,Prabhakaran D,Neal B

    更新日期:2017-11-01 00:00:00

  • Genetic linkage analysis in hypertension: principles and practice.

    abstract:BACKGROUND:Primary hypertension is a hereditary disorder characterized by a complex etiological interplay of multiple genetic and environmental factors, until now defying attempts at identifying pathogenetically important genes. The marriage of classical genetics and molecular techniques is now offering a powerful set ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审


    authors: Lindpaintner K

    更新日期:1992-02-01 00:00:00

  • Effect of neonatal sympathectomy on the development of structural vascular changes in angiotensin II-treated rats.

    abstract:BACKGROUND:In a previous study, we found that neonatal sympathectomy prevented the development of angiotensin II (ANG II)-induced hypertension but not the development of structural changes in small mesenteric arteries. OBJECTIVES:To investigate further the dissociation between hypertension and structural vascular chan...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Simon G,Csiky B

    更新日期:1998-01-01 00:00:00

  • Effects of deoxycorticosterone on arterial wall properties in two-kidney rats.

    abstract::The contribution of deoxycorticosterone acetate (DOCA) and salt to arterial pressure and hypertension-related arterial wall changes was assessed in Wistar rats. One group of two-kidney DOCA-treated animals was given a high salt diet and another group a low salt diet. After 16 weeks of treatment, the animals on low sal...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Cox RH

    更新日期:1986-10-01 00:00:00

  • Association between coffee consumption and markers of inflammation and cardiovascular function during mental stress.

    abstract:BACKGROUND:Coffee is widely consumed in the Western diet and therefore has important implications for public health. Research findings pertaining to the effects of coffee consumption on cardiovascular health are conflicting, and the role of caffeine is not clear. OBJECTIVE:To examine the relationship between coffee in...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Hamer M,Williams ED,Vuononvirta R,Gibson EL,Steptoe A

    更新日期:2006-11-01 00:00:00

  • What is the plasma cofactor required by diuretics for direct vascular relaxant effect in vitro?

    abstract:OBJECTIVE:To determine the plasma cofactor which is required by diuretics (hydrochlorothiazide, chlorthalidone, indapamide, and furosemide) for direct vasorelaxant effects in vitro. DESIGN:A randomized, double-blind, vehicle-control design was used to avoid experimenter bias. METHODS:We plotted concentration-response...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Abrahams Z,Pang MY,Lam EK,Wright JM

    更新日期:1998-06-01 00:00:00

  • Benefit and harm of low-dose aspirin in well-treated hypertensives at different baseline cardiovascular risk.

    abstract:BACKGROUND:The effects of aspirin in subjects without cardiovascular disease are controversial. In the intensively treated patients of the Hypertension Optimal Treatment (HOT) Study, randomization to low-dose aspirin (75 mg daily) versus placebo significantly reduced cardiovascular events (-15%) and myocardial infarcti...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Zanchetti A,Hansson L,Dahlöf B,Julius S,Ménard J,Warnold I,Wedel H,HOT Study Group.

    更新日期:2002-11-01 00:00:00

  • Heritability of plasma leptin levels: a twin study.

    abstract:OBJECTIVE:To examine the influence of genetic factors on plasma leptin levels. SUBJECTS AND METHODS:We measured plasma leptin levels, body mass index and body fat distribution in healthy young female monozygotic (n = 19) and dizygotic (n = 14) twins. The twin zygosity was verified by determination of short tandem repe...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Narkiewicz K,Szczech R,Winnicki M,Chrostowska M,Pawlowski R,Lysiak-Szydlowska W,Choe I,Kato M,Sivitz WI,Krupa-Wojciechowska B,Somers VK

    更新日期:1999-01-01 00:00:00

  • Acute effects of transdermal estrogen on hemodynamic and vascular reactivity in elderly postmenopausal healthy women.

    abstract:OBJECTIVE:The acute effects of estrogen on hemodynamic responses were studied with emphasis on the sympathoadrenal system and peripheral circulation. DESIGN:Eleven healthy postmenopausal women recruited from the population-based study BEDA were included in this randomized, double-blind, cross-over, placebo-controlled ...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Manhem K,Brandin L,Ghanoum B,Rosengren A,Gustafsson H

    更新日期:2003-02-01 00:00:00

  • Computerized measurement of retinal blood vessel calibre: description, validation and use to determine the influence of ageing and hypertension.

    abstract:OBJECTIVE:To validate a computer-based method for measuring the calibre of retinal blood vessels, and use it to determine the effects of ageing and arterial hypertension on the calibres of these vessels and on their ratio. METHODS:Digital eye fundus images covering a 50 degrees field and centred on the optic disc were...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Pose-Reino A,Gomez-Ulla F,Hayik B,Rodriguez-Fernández M,Carreira-Nouche MJ,Mosquera-González A,González-Penedo M,Gude F

    更新日期:2005-04-01 00:00:00

  • Prospective comparison of therapeutical attitudes in hypertensive type 2 diabetic patients uncontrolled on monotherapy. A randomized trial: the EDICTA study.

    abstract:OBJECTIVE:To compare the anti-hypertensive effect of combination therapy versus a single drug regimen schedule (dose-titration or switching to a different drug class) in type 2 diabetic hypertensive patients with inadequate blood pressure (BP) control on monotherapy. DESIGN:Prospective, randomized, open-fashion, paral...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ruilope LM,de la Sierra A,Moreno E,Fernández R,Garrido J,de la Figuera M,de la Cámara AG,Coca A,Luque-Otero M

    更新日期:1999-12-01 00:00:00

  • Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography.

    abstract:OBJECTIVE:Reduction in capillary density or rarefaction is a hallmark of essential hypertension. We measured the retinal capillary density using noninvasive optical coherence tomographic angiography (OCT-A) in adults with treated systemic hypertension and determined possible correlations with ambulatory blood pressure ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Chua J,Chin CWL,Hong J,Chee ML,Le TT,Ting DSW,Wong TY,Schmetterer L

    更新日期:2019-03-01 00:00:00

  • Fibronectin type III domain containing 5 attenuates NLRP3 inflammasome activation and phenotypic transformation of adventitial fibroblasts in spontaneously hypertensive rats.

    abstract:OBJECTIVE:Phenotypic transformation of adventitial fibroblasts is important in the pathogenesis of hypertension. This study was designed to determine whether fibronectin type III domain containing 5 (FNDC5) alleviates the phenotypic transformation of adventitial fibroblasts in hypertension and the underlying mechanisms...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Ling L,Chen D,Tong Y,Zang YH,Ren XS,Zhou H,Qi XH,Chen Q,Li YH,Kang YM,Zhu GQ

    更新日期:2018-05-01 00:00:00

  • Weight status change from childhood to early adulthood and the risk of adult hypertension.

    abstract:OBJECTIVE:Overweight/obesity in childhood is suggested to increase risk of hypertension later in life. However, few studies have assessed the effect of trajectories of weight status from childhood to adulthood on adult hypertension. The present study aimed to assess the relationship between weight status change from ch...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Hou Y,Wang M,Yang L,Zhao M,Yan Y,Xi B

    更新日期:2019-06-01 00:00:00

  • Antihypertensive effect of a renin inhibitor in marmosets with a segmental renal infarction.

    abstract::Hypertension was induced in marmosets by ligating the minor branch of one renal artery. The blood pressure (BP), measured by a tail-cuff method, increased to hypertensive levels within 4-5 weeks and the maximum increases occurred after 4-15 weeks (BP, mean +/- s.e.m. was 120 +/- 3 and 152 +/- 6 mmHg before and 10 week...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Neisius D,Wood JM

    更新日期:1987-12-01 00:00:00

  • The use of single-pill combinations as first-line treatment for hypertension: translating guidelines into clinical practice.

    abstract::: The 2008 European Society of Cardiology/European Society of Hypertension guidelines recommend the first-line prescription of two antihypertensive drugs in single-pill combinations (SPCs), also known as fixed-dose combinations, for the treatment of most patients with hypertension. This recommendation is based on a la...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Campana E,Cunha V,Glaveckaite S,Gruev I,Lamirault G,Lehmann E,Masi S,Mfeukeu Kuate L,Mishshenko L,Ona DID,Oo MZ,Tautu OGF,Vachulova A,Vintila AM,Wolf J,Zvartau N,Narkiewicz K,Laurent S

    更新日期:2020-12-01 00:00:00

  • Increased vascular reactivity induced by essential fatty acid deficiency in rat autoperfused hindquarters.

    abstract::The effects of essential fatty acid deficiency (EFAD) on vascular reactivity to vasoconstrictor stimuli were studied in rat autoperfused hindquarters. Weanling male Sprague-Dawley rats (aged 21 days) were fed diets containing 8% (weight/weight) of stearax plus 2% safflower oil (control diet) or 10% stearax (EFAD diet)...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Kudo K,Dusting GJ,Loiacono RE,Sinclair AJ

    更新日期:1988-02-01 00:00:00

  • Aortic dilatation in Marfan syndrome: role of arterial stiffness and fibrillin-1 variants.

    abstract:OBJECTIVE:Marfan syndrome (MFS) is an autosomal dominant genetic disorder characterized by aortic root dilation and dissection and an abnormal fibrillin-1 synthesis. In this observational study, we evaluated aortic stiffness in MFS and its association with ascending aorta diameters and fibrillin-1 genotype. METHODS:A ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Salvi P,Grillo A,Marelli S,Gao L,Salvi L,Viecca M,Di Blasio AM,Carretta R,Pini A,Parati G

    更新日期:2018-01-01 00:00:00

  • The predictive role of CHA2DS2-VASc score between venous thromboembolism and ischemic stroke: a large-scale cohort study.

    abstract:PURPOSE:This study aimed to explore the predictive role of CHA2DS2-VASc score between venous thromboembolism (VTE) and ischemic stroke. METHODS:The current study was analyzed from the in-patient claims data of the Taiwan National Health Insurance Research Database. We identified the patients diagnosed with VTE (for St...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Hu WS,Lin CL

    更新日期:2018-03-01 00:00:00