Gender differences in artery wall biomechanical properties throughout life.


:Elevated large artery stiffness and pulse pressure have emerged as important risk factors for cardiovascular disease. The genders differ in large artery biomechanical properties throughout the lifespan with females displaying higher stiffness than males during the prepubertal years and a dramatic increase after menopause. Males on the other hand experience an increase in arterial stiffness postpuberty and a linear increase thereafter, suggesting that females have intrinsically stiffer large arteries than males, but that such effects are mitigated by sex steroids during the reproductive years. This review discusses anthropometric and sex steroid influences on gender differences in large artery stiffness and pressure dynamics from childhood to senescence. In particular, the sex-specific effects of estrogen, progesterone and testosterone on vascular structure and function and how these influence arterial stiffness are explored. These factors may contribute in part to the observed gender differences in the pathophysiology and clinical manifestations of cardiovascular disease.


J Hypertens


Journal of hypertension


Rossi P,Francès Y,Kingwell BA,Ahimastos AA




Has Abstract


2011-06-01 00:00:00












  • Rapid increases in infant adiposity and overweight/obesity in childhood are associated with higher central and brachial blood pressure in early adulthood.

    abstract:BACKGROUND:Small size at birth and greater BMI in childhood are associated with greater brachial blood pressure (BP) in later life. Aortic (central) BP differs from brachial BP and is more predictive of organ damage and cardiovascular events; the relationship between BMI in childhood and central BP is not known. METHO...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Howe LD,Chaturvedi N,Lawlor DA,Ferreira DL,Fraser A,Davey Smith G,Tilling K,Hughes AD

    更新日期:2014-09-01 00:00:00

  • Frailty and the relationship between blood pressure and mortality in elderly patients with type 2 diabetes (Zwolle Outpatient Diabetes project Integrating Available Care-34).

    abstract:OBJECTIVE:We aimed to investigate whether adjustment for frailty influences the relationship of blood pressure with mortality in elderly patients with type 2 diabetes mellitus (T2DM). METHODS:Patients aged 60 years and older (n = 858) were selected from a prospective observational cohort study of primary care patients...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: van Hateren KJ,Hendriks SH,Groenier KH,Bakker SJ,Bilo HJ,Kleefstra N,Landman GW

    更新日期:2015-06-01 00:00:00

  • A randomized and controlled study of noninvasive hemodynamic monitoring as a guide to drug treatment of uncontrolled hypertensive patients.

    abstract:BACKGROUND:In the BEtter control of BP in hypertensive pAtients monitored Using the HOTMAN sYstem study, we investigated whether utilizing noninvasive monitoring of hemodynamic parameters combined with a drug selection algorithm (integrated hemodynamic management - IHM) compared with conventional drug selection may imp...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Fadl Elmula FE,Rebora P,Talvik A,Salerno S,Miszkowska-Nagórna E,Liu X,Heinpalu-Kuum M,Comotti T,Larstorp AC,Rostrup M,Świerblewska E,Valsecchi MG,Kjeldsen SE,Viigimaa M,Narkiewicz K,Parati G,Laurent S,BEtter control of

    更新日期:2015-12-01 00:00:00

  • Moxonidine-induced central sympathoinhibition improves prognosis in rats with hypertensive heart failure.

    abstract:OBJECTIVES:Enhanced central sympathetic outflow is an indicator of the prognosis of heart failure. Although the central sympatholytic drug moxonidine is an established therapeutic strategy for hypertension, its benefits for hypertensive heart failure are poorly understood. In the present study, we investigated the effe...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Honda N,Hirooka Y,Ito K,Matsukawa R,Shinohara K,Kishi T,Yasukawa K,Utsumi H,Sunagawa K

    更新日期:2013-11-01 00:00:00

  • C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loc

    abstract:BACKGROUND:C-reactive protein (CRP) both reflects and participates in inflammation, and its circulating concentration marks cardiovascular risk. Here we sought to understand the role of heredity in determining CRP secretion. METHODS:CRP, as well as multiple facets of the metabolic syndrome, were measured in a series o...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Wessel J,Moratorio G,Rao F,Mahata M,Zhang L,Greene W,Rana BK,Kennedy BP,Khandrika S,Huang P,Lillie EO,Shih PA,Smith DW,Wen G,Hamilton BA,Ziegler MG,Witztum JL,Schork NJ,Schmid-Schönbein GW,O'Connor DT

    更新日期:2007-02-01 00:00:00

  • Diurnal blood pressure loads are associated with lower cognitive performances in controlled-hypertensive elderly individuals.

    abstract:INTRODUCTION:Hypertension in midlife adults is associated with cognitive decline later in life. In individuals treated for hypertension, blood pressure (BP) loads have been associated with end organ damages. This study examines whether BP load inversely correlates with performance in cognitive tasks in normotensive or ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Noriega de la Colina A,Wu R,Desjardins-Crépeau L,Badji A,Lamarre-Cliche M,Doyon J,Bherer L,Girouard H

    更新日期:2019-11-01 00:00:00

  • Insulin resistance in hypertensives: effect of salt sensitivity, renin status and sodium intake.

    abstract:OBJECTIVE:Homeostasis Model Assessment (HOMA index) is predictive of insulin sensitivity in normal and diabetic patients. This study was designed to see if insulin resistance in hypertensives, measured using the HOMA index, differs, based on salt sensitivity, renin status and sodium intake. METHODS:Fasting insulin and...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Raji A,Williams GH,Jeunemaitre X,Hopkins PN,Hunt SC,Hollenberg NK,Seely EW

    更新日期:2001-01-01 00:00:00

  • Acetylcholine and norepinephrine concentrations in the heart of spontaneously hypertensive rats: a parasympathetic role in hypertension.

    abstract::To determine the role of the parasympathetic system in the development of essential hypertension, the concentrations of acetylcholine (ACh) as a parasympathetic marker and norepinephrine (NE) as a sympathetic marker were measured simultaneously in the heart of spontaneously hypertensive rats (SHR) at 4, 10 and 27 week...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Tsuboi H,Ohno O,Ogawa K,Ito T,Hashimoto H,Okumura K,Satake T

    更新日期:1987-06-01 00:00:00

  • Hypertension in blacks: insights from Africa.

    abstract::Although the consequences of hypertension are universal, blacks (African-Americans or indigenous Africans) have been the subject of a differential approach to causation, outcome, and treatment. Blacks have a greater propensity to salt sensitivity and suppressed plasma renin suggesting a predisposition to sodium retent...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Rayner BL,Spence JD

    更新日期:2017-02-01 00:00:00

  • Prevalence of episodes of ST-segment depression among mild-to-moderate hypertensive patients in northern Italy: the Cardioscreening Study.

    abstract:OBJECTIVES:To assess the prevalence of episodes of ST-segment depression in a population of consecutive patients with mild-to-moderate essential hypertension who are free of clinical signs of coronary artery disease. METHODS:The study involved 28 Italian centers that enrolled 414 hypertensive patients (aged 50-70 year...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: Stramba-Badiale M,Bonazzi O,Casadei G,Dal Palù C,Magnani B,Zanchetti A

    更新日期:1998-05-01 00:00:00

  • Downregulation of glomerular and vascular atrial natriuretic factor receptor subtypes by angiotensin II.

    abstract::We have previously reported that pressor doses of angiotensin II induce atrial natriuretic factor (ANF) release. Since the number of glomerular and vascular ANF receptors may vary inversely with plasma ANF levels, we investigated whether they are modified by angiotensin II. Male rats were infused intraperitoneally for...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Gauquelin G,Schiffrin EL,Garcia R

    更新日期:1991-12-01 00:00:00

  • Glucose level is a major determinant of carotid intima-media thickness in patients with hypertension and hyperglycemia.

    abstract:BACKGROUND:A causal relationship has been established between hyperglycemia and cardiovascular diseases, but no threshold has been retained to determine a 'glycemia-associated' cardiovascular risk. Carotid intima-media thickness (CIMT) is an independent predictor for cardiovascular events. High blood pressure is a majo...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Tropeano AI,Boutouyrie P,Katsahian S,Laloux B,Laurent S

    更新日期:2004-11-01 00:00:00

  • Finding genes that cause human hypertension.

    abstract::Genetic factors in essential hypertension: Studies of the epidemiology of blood pressure indicate that genetic factors are part of the pathogenesis of human essential hypertension, raising the possibility of identifying these genes. This may provide unique opportunities to elucidate the pathophysiology of hypertension...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审


    authors: Lifton RP,Jeunemaitre X

    更新日期:1993-03-01 00:00:00

  • Arterial hypertension in urban Africa: an epidemiological study on a representative sample of Dakar inhabitants in Senegal.

    abstract:OBJECTIVE:To assess the prevalence and risk markers of arterial hypertension in the context of a rapidly growing urbanization in Africa. DESIGN:A cross-sectional study was performed on a representative sample of inhabitants of Pikine, an urban suburb of Dakar, Senegal. METHODS:Blood pressure was measured by properly ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Astagneau P,Lang T,Delarocque E,Jeannee E,Salem G

    更新日期:1992-09-01 00:00:00

  • Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis.

    abstract:OBJECTIVE:The aim of this study was to determine the reproducibility of pulse wave velocity (PWV) and augmentation index (AIx) measured using pulse wave analysis (PWA), prior to its use in large-scale clinical trials. METHODS:Arterial pressure waveforms were recorded and analysed using an established technique (Sphygm...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wilkinson IB,Fuchs SA,Jansen IM,Spratt JC,Murray GD,Cockcroft JR,Webb DJ

    更新日期:1998-12-01 00:00:00

  • Central haemodynamics in normal pregnancy: a prospective longitudinal study.

    abstract:OBJECTIVE:To conduct a longitudinal evaluation of the central haemodynamic adaptations of normal pregnancy. METHODS:This was a prospective longitudinal study involving healthy, normotensive women who were having an uncomplicated, singleton pregnancy. Brachial and central SBP, DBP, mean arterial pressure (MAP), brachia...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: O' Callaghan KM,Hennessy Á,Malvisi L,Kiely M

    更新日期:2018-10-01 00:00:00

  • Effect of postural changes on cardiovascular responses to static exercise in hypertensive human beings.

    abstract:OBJECTIVE:In hypertensive patients, exaggerated increases in vascular resistance and arterial blood pressure have been reported on changing posture from supine to upright. In this study we tested the hypothesis that in hypertensive subjects, upright posture induces an increase in the vasoconstrictor and pressor respons...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Legramante JM,Massaro M,Raimondi G,Castrucci F,Cassarino S,Peruzzi G,Iellamo F

    更新日期:1999-01-01 00:00:00

  • Hormone replacement improves hemodynamic profile and left ventricular geometry in hypertensive and normotensive postmenopausal women.

    abstract:BACKGROUND:Postmenopausal estrogen replacement, with or without progestins, has been related to lower cardiovascular risks. OBJECTIVE:We investigated whether the actions of estrogen on vascular resistance contribute to this cardioprotective effect. DESIGN AND METHODS:In a 6-month double-blind study, pre- and post-tre...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Light KC,Hinderliter AL,West SG,Grewen KM,Steege JF,Sherwood A,Girdler SS

    更新日期:2001-02-01 00:00:00

  • Time-of-day of energy intake: association with hypertension and blood pressure 10 years later in the 1946 British Birth Cohort.

    abstract:OBJECTIVES:The role of circadian rhythm of energy and macronutrient intake in influencing cardiometabolic risk factors is increasingly recognized. However, little is known of the association between time of energy intake and blood pressure. We examined the association between time-of-day of energy intake and subsequent...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Almoosawi S,Prynne CJ,Hardy R,Stephen AM

    更新日期:2013-05-01 00:00:00

  • Blood pressure reduction in acute ischemic stroke according to time to treatment: a subgroup analysis of the China Antihypertensive Trial in Acute Ischemic Stroke trial.

    abstract:OBJECTIVE:The optimal time to initiate antihypertensive therapy among patients with acute ischemic stroke remains uncertain. We tested the effects of blood pressure reduction among patients with acute ischemic stroke according to time from onset to initiation of antihypertensive treatment. METHODS:We randomly assigned...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Xu T,Zhang Y,Bu X,Wang D,Sun Y,Chen CS,Wang J,Peng H,Ju Z,Peng Y,Xu T,Li Q,Geng D,Zhang J,Li D,Zhang F,Guo L,Wang X,Cui Y,Li Y,Ma D,Zhang D,Yang G,Gao Y,Yuan X,Chen J,He J,CATIS investigators.

    更新日期:2017-06-01 00:00:00

  • Is it time to measure microalbuminuria in hypertension?

    abstract::Former guidelines on hypertension never made a commitment to the detection of microalbuminuria for screening or follow-up of hypertensive patients. On the other hand, growing evidence support the contributory role of microalbuminuria in the prediction of absolute cardiovascular risk in hypertension and document the po...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审


    authors: Volpe M,Cosentino F,Ruilope LM

    更新日期:2003-07-01 00:00:00

  • Use of the oral contraceptive pill is associated with increased large artery stiffness in young women: the ENIGMA study.

    abstract:BACKGROUND:The oral contraceptive pill (OCP) is widely prescribed throughout the world. Although it is associated with a small but significant increase in blood pressure, the influence of the OCP on large artery stiffness and wave reflection is unclear. The aim of this study was to determine the relationship between us...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Hickson SS,Miles KL,McDonnell BJ,Yasmin,Cockcroft JR,Wilkinson IB,McEniery CM,ENIGMA Study Investigators.

    更新日期:2011-06-01 00:00:00

  • The effect of losartan on global and focal cerebral perfusion and on renal function in hypertensives in mild early ischaemic stroke.

    abstract:BACKGROUND:Secondary prevention of stroke with antihypertensive drugs is now standard practice, but it is unclear how soon after a cerebrovascular event antihypertensive therapy should be initiated or re-started. Due to impaired cerebral autoregulation, changes in systemic blood pressure may be reflected in cerebral pe...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nazir FS,Overell JR,Bolster A,Hilditch TE,Reid JL,Lees KR

    更新日期:2004-05-01 00:00:00

  • Pulse wave velocity is increased in patients with transient myocardial ischemia.

    abstract:OBJECTIVE:We have recently shown that mean pulse pressure is higher in patients with transient myocardial ischemia. Pulse pressure elevation might be an important consequence of increased arterial stiffness. The aim of this study was to prove if arterial stiffness is changed in patients with transient myocardial ischem...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Baulmann J,Homsi R,Uen S,Düsing R,Fimmers R,Vetter H,Mengden T

    更新日期:2006-10-01 00:00:00

  • Simvastatin improves endothelial function in spontaneously hypertensive rats through a superoxide dismutase mediated antioxidant effect.

    abstract:BACKGROUND:Hydroxymethylglutaryl coenzyme A (HMGCoA) reductase inhibitors have beneficial effects beyond their cholesterol-lowering properties. The antioxidant mechanism of HMGCoA reductase inhibitors is not completely understood. OBJECTIVES:To elucidate the antioxidant effect of simvastatin. METHODS:We studied the i...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Carneado J,Alvarez de Sotomayor M,Perez-Guerrero C,Jimenez L,Herrera MD,Pamies E,Martin-Sanz MD,Stiefel P,Miranda M,Bravo L,Marhuenda E

    更新日期:2002-03-01 00:00:00

  • Reduction of endothelin levels by the dihydropyridine calcium antagonist nisoldipine and a 'natural factor' in cultured human endothelial cells.

    abstract:OBJECTIVE:Endothelin is thought to be related to cardiovascular disease. The purpose of this study was to determine whether endothelin levels could be reduced by a calcium antagonist and a 'natural factor'. DESIGN:Since calcium ionophores can induce endothelin-1 messenger RNA synthesis in cultured endothelial cells, t...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Liu JJ,Casley D,Wojta J,Gallicchio M,Dauer R,Buxton BF,Johnston CI

    更新日期:1993-09-01 00:00:00

  • Sodium-lithium countertransport: physiology and function.

    abstract::Current opinions on the relationships between erythrocyte sodium-lithium countertransport kinetics and primary hypertension, hyperlipidaemia and diabetic nephropathy are reviewed. Problems associated with the assay are analysed. Some possible mechanisms that could modify the kinetics of ion exchange are examined. The ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审


    authors: West IC,Rutherford PA,Thomas TH

    更新日期:1998-01-01 00:00:00

  • Homozygosity for angiotensinogen 235T variant increases the risk of myocardial infarction in patients with multi-vessel coronary artery disease.

    abstract:OBJECTIVE:Molecular variants of the angiotensinogen (AGT) and the angiotensin II type 1 receptor (ATR) genes have been associated with the risk of coronary artery disease (CAD) and myocardial infarction (MI), but data so far available are conflicting. The primary object of the paper is to verify this possible associati...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Olivieri O,Stranieri C,Girelli D,Pizzolo F,Grazioli S,Russo C,Pignatti PF,Corrocher R

    更新日期:2001-05-01 00:00:00

  • Does the association between birth weight and blood pressure increase with age? A longitudinal study in young adults.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Bustos P,Amigo H,Bangdiwala SI,Pizarro T,Rona RJ

    更新日期:2016-06-01 00:00:00

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    abstract::We have examined the mechanisms mediating the release of renin elicited in man by reduction of renal perfusion pressure. Fifteen patients with essential hypertension and six normotensive subjects were investigated during diagnostic renal arteriography. Renal neural receptors were inhibited by propranolol (10 mg i.v.) ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章


    authors: Guazzi MD,Barbier P,Loaldi A,Montorsi P,Polese A,Tosi E,Fiorentini C

    更新日期:1985-02-01 00:00:00