Abstract:
OBJECTIVE:To evaluate the wave reflection characteristics in the aortic arch and common carotid artery of ex-preterm adolescents and assess their relationship to central blood pressure in a cohort followed prospectively since birth. METHODS:Central blood pressures, pulse wave velocity, augmentation index, microvascular reactive hyperemia, arterial distensibility, compliance and stiffness index, and also aortic and carotid wave intensity were measured in 18-year-olds born extremely preterm at below 28 weeks' gestation (n = 76) and term-born controls (n = 42). RESULTS:Compared with controls, ex-preterm adolescents had higher central systolic (111 ± 11 vs. 105 ± 10 mmHg; P < 0.001) and diastolic blood pressures (73 ± 7 vs. 67 ± 7 mmHg; P < 0.001). Although conventional measures of arterial function and biomechanics such as pulse wave velocity and augmentation index were no different between groups, wave intensity analysis revealed elevated backward compression wave area (-0.39 ± 0.21 vs. -0.29 ± 0.17 W/m/s × 10; P = 0.03), backward compression wave pressure change (9.0 ± 3.5 vs. 6.6 ± 2.5 mmHg; P = 0.001) and reflection index (0.44 ± 0.15 vs. 0.32 ± 0.08; P < 0.001) in the aorta of ex-preterm adolescents compared with controls. These changes were less pronounced in the carotid artery. On multivariable analysis, forward and backward compression wave areas were the only biomechanical variables associated with central systolic pressure. CONCLUSIONS:Ex-preterm adolescents demonstrate elevated wave reflection indices in the aortic arch, which correlate with central systolic pressure. Wave intensity analysis may provide a sensitive novel marker of evolving vascular dysfunction in ex-preterm survivors.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Kowalski RR,Beare R,Mynard JP,Cheong JLY,Doyle LW,Smolich JJ,Cheung MMHdoi
10.1097/HJH.0000000000001719subject
Has Abstractpub_date
2018-07-01 00:00:00pages
1514-1523issue
7eissn
0263-6352issn
1473-5598journal_volume
36pub_type
杂志文章abstract:OBJECTIVES:Treatment modifications--addition, uptitration, switching, and downtitration--are necessary to address issues such as unattained blood pressure goals, adverse drug events, drug cost, or patient dissatisfaction which lead to treatment discontinuation. This study assessed the patterns of treatment modification...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000806
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the prognostic significance of cardiovascular risk factors including 24-h ambulatory blood pressure level and rhythm for all-cause mortality in type 2 diabetic patients. METHODS:In a prospective observational study, 104 patients with type 2 diabetes were followed: 51 patients with diabetic nephro...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3282f06428
更新日期:2007-12-01 00:00:00
abstract::The cardiovascular responses to selective alpha 1- and alpha 2-adrenoceptor antagonism (with prazosin and idazoxan, respectively) were assessed in rats 4 weeks after unilateral nephro-adrenalectomy, contralateral adrenal enucleation and the provision of a 1% NaCl solution as drinking fluid (AEN rats) and in sham-opera...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract:OBJECTIVE:To determine adrenocorticotrophin dose-response relationships for increase of blood pressure and metabolic parameters of the Sprague-Dawley rat. METHODS:We injected 120 male Sprague-Dawley rats twice daily subcutaneously for 10 days with 0.5, 1, 5, 50, 100, 200 or 500 microg/kg synthetic adrenocorticotrophin...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199816050-00006
更新日期:1998-05-01 00:00:00
abstract::Blood pressure was measured in 864 young people aged 16-24 years, 8 years after both of their parents had their blood pressures measured as part of the screening phase of the Medical Research Council Mild Hypertension Trial. Only 29% of offspring with a conventional 'family history of hypertension', defined in terms o...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:Insulin-mediated vasodilation has been shown to be impaired with hypertension and aggravated by dietary sodium restriction. Whether vascular insulin resistance in this setting could be improved by antihypertensive therapy was unknown. Therefore, we determined the effect of therapy with an angiotensin-converti...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004872-200101000-00015
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To investigate whether the clinic-daytime blood pressure difference can provide information on vascular reactivity to stress comparable to that of simple noninvasive stimuli such as a cold pressor test and isometric exercise, and whether there is any relationship between this blood pressure difference and non...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199917030-00005
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVE:Reversibility of the systemic and renal alterations induced by N(omega)-nitro-L-arginine-methyl ester(L-NAME) was assessed by treatment with irbesartan and enalapril (30 and 10 mg/kg per 24 h, respectively) alone or in combination. DESIGN:L-NAME (20 mg/kg per 24 h) was given to rats for 6 weeks and treatment...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200111000-00015
更新日期:2001-11-01 00:00:00
abstract::Former guidelines on hypertension never made a commitment to the detection of microalbuminuria for screening or follow-up of hypertensive patients. On the other hand, growing evidence support the contributory role of microalbuminuria in the prediction of absolute cardiovascular risk in hypertension and document the po...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/00004872-200307000-00001
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:Cardiac hypertrophy arises as an adaptive response to increased afterload. Studies in knockout mice have shown that catecholamines, but not alpha1-adrenergic receptors, are necessary for such an adaptation to occur. However, whether beta-adrenergic receptors are critical for the development of cardiac hypertr...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000203843.41937.2a
更新日期:2006-03-01 00:00:00
abstract::The effects of essential fatty acid deficiency (EFAD) on vascular reactivity to vasoconstrictor stimuli were studied in rat autoperfused hindquarters. Weanling male Sprague-Dawley rats (aged 21 days) were fed diets containing 8% (weight/weight) of stearax plus 2% safflower oil (control diet) or 10% stearax (EFAD diet)...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1988-02-01 00:00:00
abstract:OBJECTIVE:To evaluate autonomic nervous function by power-spectral analysis of heart-rate variability in salt-sensitive and non-salt-sensitive patients with essential hypertension under the conditions of low and high salt intakes. DESIGN AND METHODS:The blood pressures, heart rates, and electrocardiogram R-R intervals...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199715070-00004
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Apoptosis or programmed cell death could be greater than normal in various cardiovascular disorders, particularly in the heart. Apoptosis might contribute to remodeling of blood vessels in hypertension and could participate in regulation of vascular hypertrophy/hyperplasia. OBJECTIVE:To investigate apoptosi...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199715120-00011
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVES:To assess whether the association between birth weight and blood pressure (BP) increases with age using three different statistical methods. METHODS:A representative sample of 1232 study participants born between 1974-1978 in Limache, Chile were assessed in 2000-2002, of whom 796 were reassessed in 2010-201...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000912
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:Reflection of the finger pulse wave form is a valid measure of arterial stiffness, which may be continuously assessed during sleep. We investigated the relationships between sleep, sleep-disordered breathing, hypertension, and pulse propagation time (PPT) in patients with suspected sleep apnea. METHODS:The ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001111
更新日期:2016-12-01 00:00:00
abstract::Seventeen essential hypertensive patients with normal renal function were treated with a new non-sulphydryl orally active angiotensin converting enzyme (ACE) inhibitor, benazepril, 10 mg given once or twice daily, according to diastolic blood pressure levels, for 6 weeks. In all patients, changes in blood pressure, sy...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199011000-00003
更新日期:1990-11-01 00:00:00
abstract:OBJECTIVES:Patients with chronic renal failure are restricted to mild physical activity and tend to a lack of exercise. However, there have been few reports regarding the influence of chronic exercise on the progression of renal disease. Similarly, there are few animal models concerned with the effect of exercise train...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200110000-00024
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:To find an objective, sensitive method for quantifying microvascular alterations associated with level of blood pressure and age. DESIGN:A prospective cross-sectional study. SUBJECTS AND METHODS:Seventy-four previously untreated hypertensive patients, referred to a hospital outpatients department, and 26 no...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:In this randomized, double-blind, crossover study, the antihypertensive efficacy of amlodipine and nifedipine gastrointestinal therapeutic system (GITS) was compared following missed doses. Design and methods In a randomized crossover design, 42 patients were randomized to receive amlodipine (5-10 mg) or the ...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004872-200202000-00025
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE:Patients with essential hypertension exhibit several red blood cell (RBC) ion transport abnormalities, insulin resistance (IR) and increased risk of developing type 2 diabetes. The aims of this study were to assess RBC ion transport activities under basal conditions and to test the in vivo effect of acute hyp...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200307000-00021
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:The pteridine cofactor tetrahydrobiopterin (BH4) has emerged as a critical determinant of endothelial nitric oxide synthase (eNOS) activity. When BH4 availability is limited, eNOS does not produce nitric oxide (NO) but instead generates superoxide. BH4 may reverse endothelial dysfunction due to cardiovascular...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000173520.13976.7d
更新日期:2005-07-01 00:00:00
abstract::Over the last few years, much progress has been made in understanding the genetic basis of primary aldosteronism. This has led to the diagnosis of the familial forms and has aided the understanding of the basis of sporadic forms of the disease. Such information can be exploited to improve the therapeutic approaches us...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/00004872-200404000-00001
更新日期:2004-04-01 00:00:00
abstract::The plasma concentration of atrial natriuretic peptide (ANP) and the density and affinity of binding sites for ANP in platelets was investigated in patients with essential hypertension. Severe hypertensives were studied whilst still on medication. All subjects were ambulatory and were investigated after 3 days on a 13...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198807000-00008
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:There is a need for an easily accessible biomarker of sympathetic nervous activation in essential hypertension, but none exists. Heart rate (HR) has been suggested, but requires validation, now doubly important as an elevated HR in hypertension has emerged as an independent cardiovascular risk factor. METHO...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002407
更新日期:2020-08-01 00:00:00
abstract::Elevated large artery stiffness and pulse pressure have emerged as important risk factors for cardiovascular disease. The genders differ in large artery biomechanical properties throughout the lifespan with females displaying higher stiffness than males during the prepubertal years and a dramatic increase after menopa...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/HJH.0b013e328344da5e
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:An increased inter-arm SBP difference (IASBPD) is associated with mortality and cardiovascular events, as well as peripheral vascular disease, which is attributed to subclavian stenosis. The aim of the present study was to investigate the association between the IASBPD and incident chronic kidney disease (CKD...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001931
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Endogenous ouabain, an endogenous digitalis-like steroid, is synthesized in the adrenal glands and possibly in the hypothalamus. In vitro and in vivo, endogenous ouabain triggers growth and proliferation of cardiomyocytes. OBJECTIVE:We therefore investigated the association between left ventricular structur...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32832e49a8
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVES:Renal tubular sodium handling was measured in healthy subjects submitted to acute and chronic salt-repletion/salt-depletion protocols. The goal was to compare the changes in proximal and distal sodium handling induced by the two procedures using the lithium clearance technique. METHODS:In nine subjects, acu...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004872-200018110-00018
更新日期:2000-11-01 00:00:00
abstract::Current opinions on the relationships between erythrocyte sodium-lithium countertransport kinetics and primary hypertension, hyperlipidaemia and diabetic nephropathy are reviewed. Problems associated with the assay are analysed. Some possible mechanisms that could modify the kinetics of ion exchange are examined. The ...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/00004872-199816010-00002
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND AND AIM:The prevalence and associated risks of white-coat hypertension (WCH) are still a matter of debate. We aimed to assess differences in prevalence and associated conditions of WCH defined on the basis of the normality of all daytime, night-time, and 24-h blood pressure (BP), only daytime, or only 24-h B...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001493
更新日期:2017-12-01 00:00:00