Obesity and daytime pulse pressure are predictors of left ventricular hypertrophy in true normotensive individuals.

abstract：OBJECTIVE:It has been shown that angiotensin-converting enzyme inhibition or angiotensin receptor blockade may improve endothelial dysfunction, an early manifestation of atherosclerosis, in patients with diabetes. Whether this protective effect is mediated through blood pressure-lowering effects or other specific mecha...

journal_title：Journal of hypertension

authors： Flammer AJ,Hermann F,Wiesli P,Schwegler B,Chenevard R,Hürlimann D,Sudano I,Gay S,Neidhart M,Riesen W,Ruschitzka F,Lüscher TF,Noll G,Lehmann R

更新日期：2007-04-01 00:00:00

abstract：:Twenty-four adolescent boys with a positive and 40 boys with a negative parental history of hypertension (PH+ and PH-, respectively) were studied at rest and during exercise on a bicycle ergometer at work loads ranging from 25 to 150 W. Each group was divided into fit and unfit categories on the basis of oxygen consum...

journal_title：Journal of hypertension

authors： Molineux D,Steptoe A

更新日期：1988-05-01 00:00:00

abstract：OBJECTIVE:To determine whether taurine reduces blood pressure by stimulating the renal kallikrein-kinin system. METHODS:The effects of taurine on blood pressure, urinary kallikrein activity and renal kallikrein gene expression were investigated in Dahl salt-sensitive (Dahl-S) rats. The specificity of the action of tau...

journal_title：Journal of hypertension

authors： Ideishi M,Miura S,Sakai T,Sasaguri M,Misumi Y,Arakawa K

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVE:The objective of the study was to investigate interarm differences of blood pressure (BP) and its determinants, and to clarify whether both arms are equally good in assessing BP and target organ damage in the general population. METHODS:We studied a representative sample of Finnish adult population with 484 ...

journal_title：Journal of hypertension

authors： Johansson JK,Puukka PJ,Jula AM

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to evaluate the influence of renal sympathetic nerves on the production of interleukin (IL)-6 in the kidney of normotensive Wistar rats and spontaneously hypertensive rats (SHR). DESIGN:In acute studies, the left kidney was exposed and the renal nerves were electrically stimulated to...

journal_title：Journal of hypertension

authors： Nakamura A,Kohsaka T,Johns EJ

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVES:Night-time blood pressure (BP) - prognostically more important than circadian BP variability - has not been evaluated for quantitative associations with objective sleep quality in large populations. METHODS:The cross-sectional study measured actigraphic sleep parameters and night-time BP for two nights in 1...

journal_title：Journal of hypertension

authors： Oume M,Obayashi K,Asai Y,Ogura M,Takeuchi K,Tai Y,Kurumatani N,Saeki K

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:Orthostatic hypotension is a common condition associated with adverse cardiovascular and cognitive prognosis. Screening for orthostatic hypotension consists of blood pressure measurements in supine (or sitting) and standing position during clinical consultations. As orthostatic hypotension is a poorly reprodu...

journal_title：Journal of hypertension

authors： Cremer A,Rousseau AL,Boulestreau R,Kuntz S,Tzourio C,Gosse P

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:We aim to synthesize effects of repeated administration (≥3 days) of inorganic nitrate on blood pressure and arterial stiffness measures. METHODS:We conducted a systematic review and meta-analysis of randomized controlled trials with at least 3 days treatment of inorganic nitrate on blood pressure and arteri...

journal_title：Journal of hypertension

authors： Li D,Nishi SK,Jovanovski E,Zurbau A,Komishon A,Mejia SB,Khan TA,Sievenpiper JL,Milicic D,Jenkins A,Vuksan V

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE AND METHODS:The vasoactive properties of P1,P4-diadenosine tetraphosphate (Ap4A) were studied by measuring the effects of perfusion pressure of a rat isolated perfused kidney. RESULTS:The vasoconstrictive response to Ap4A was mediated to a large extent to a P2X receptor which could be shown by inhibition wit...

journal_title：Journal of hypertension

authors： van der Giet M,Jankowski J,Schlüter H,Zidek W,Tepel M

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVES:Endothelial dysfunction is established in aged individuals; however, the mechanism(s) are not fully elucidated. We have previously identified l-arginine transport as a potential rate-limiting factor in nitric oxide (NO) production in heart-failure patients, characterized with endothelial dysfunction. We ther...

journal_title：Journal of hypertension

authors： Ahlers BA,Parnell MM,Chin-Dusting JP,Kaye DM

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:There have been very few studies on life prognosis of cardiovascular disease according to blood pressure stratification in the Japanese. Therefore, in Japan, although treatment of hypertension is possible, albeit at times difficult, due to the availability of various antihypertensive medications, the appropr...

journal_title：Journal of hypertension

authors： Takagi S,Saitoh S,Nakano M,Hayashi Y,Obara F,Onishi H,Shimamoto K

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Left-ventricular hypertrophy (LVH) is a marker of organ damage in hypertension and helps stratifying cardiovascular risk. Initial left-ventricular mass (LVM) is also a predictor of progression to hypertension, independently of initial blood pressure (BP) and other confounders. OBJECTIVES:To evaluate whether...

journal_title：Journal of hypertension

authors： Izzo R,de Simone G,Devereux RB,Giudice R,De Marco M,Cimmino CS,Vasta A,De Luca N,Trimarco B

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:To detect the existence of a possible relationship between arterial hypertension and adrenergic reactivity to pressure stimuli, and changes in left ventricular diastolic function (LVDF). PATIENTS:Fifty-nine young subjects with borderline arterial hypertension and ten sex- and age-matched controls were invest...

journal_title：Journal of hypertension

authors： Covi G,Sheiban I,Gelmini GP,Zenorini C,Mileto A,Girelli A,Lechi A

更新日期：1992-03-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to examine the reproducibility of arterial baroreflex sensitivity (BRS) provided by the spontaneous baroreflex method at rest and during laboratory tests. METHODS:Twenty healthy volunteers were studied 24 h apart, in the same laboratory and under the same environmental condit...

journal_title：Journal of hypertension

authors： Iellamo F,Legramante JM,Raimondi G,Castrucci F,Massaro M,Peruzzi G

更新日期：1996-09-01 00:00:00

abstract：OBJECTIVES:Current evidence demonstrates that both genetic and environmental factors influence blood pressure. The sympathetic nervous system is a key player in blood pressure control and functional genetic variants of the beta-2 adrenergic receptor (B2AR) have been identified and implicated in the pathogenesis of hype...

journal_title：Journal of hypertension

authors： Binder A,Garcia E,Wallace C,Gbenga K,Ben-Shlomo Y,Yarnell J,Brown P,Caulfield M,Skrabal F,Kotanko P,Munroe P

更新日期：2006-03-01 00:00:00

abstract：:The effect of haemorrhagic hypotension on plasma catecholamine levels was studied in anesthetized normotensive and DOCA-salt hypertensive rats. The basal levels of plasma norepinephrine (NE) were significantly higher in DOCA-salt hypertensive rats than in normotensive rats. Moreover, the elevations in plasma NE and ep...

journal_title：Journal of hypertension

authors： Drolet G,Bouvier M,de Champlain J

更新日期：1989-03-01 00:00:00

abstract：OBJECTIVES:The present study was designed to examine whether or not excessive Zn intake affects systemic blood pressure (BP) levels in a normotensive state. METHODS:Systolic BP (SBP) and mean arterial pressure (MAP) before and after administration of the nitric oxide synthase (NOS) inhibitor, N-nitro-L-arginine methyl...

journal_title：Journal of hypertension

authors： Yanagisawa H,Sato M,Nodera M,Wada O

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:The effect of brief, prehypertensive therapy by angiotensin-converting enzyme inhibition (ACEi) with perindopril on the structure and function of large arteries was studied in rats. METHODS:Spontaneously hypertensive rats (SHR) received perindopril (3 mg/kg per day) between the ages of either 6 and 10 weeks ...

journal_title：Journal of hypertension

authors： Ng K,Butlin M,Avolio AP

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:To investigate whether combined treatment with lisinopril, an angiotensin-converting enzyme (ACE) inhibitor and exercise training would have an additive effect in enhancing the capillary supply of the left ventricular (LV) myocardium in spontaneously hypertensive rats (SHR). DESIGN:Twelve-week-old male SHR ...

journal_title：Journal of hypertension

authors： Ziada AM,Hassan MO,Tahlilkar KI,Inuwa IM

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Beta-blockers are not recommended as the initial therapy for hypertension. Reports on associations between use of beta-blockers and stroke severity are inconclusive. We assessed associations between prestroke use of beta-blockers and stroke severity, poststroke disability and death in a large group of hypert...

journal_title：Journal of hypertension

authors： Koton S,Tanne D,Grossman E

更新日期：2017-04-01 00:00:00

abstract：INTRODUCTION:Chronic kidney disease (CKD) in which the disease cannot be attributed to any known cause is named CKD of uncertain aetiology (CKDu). The main aims of this analysis were to estimate the prevalence of hypertension and to identify the associated factors in a rural community vulnerable to CKDu and to identify...

journal_title：Journal of hypertension

authors： Senanayake S,Ruwanpathirana T,Gunawardena N

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of hypertension and diabetes mellitus on vascular albumin permeability and hypertrophy in 11-week-old Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) with and without 3 weeks of streptozotocin-induced diabetes. METHODS:Vascular albumin permeability was measured as...

journal_title：Journal of hypertension

authors： Hulthén UL,Rumble J,Cooper ME,Johnston CI

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:High sleep blood pressure (BP) has been suggested to be an independent risk factor for cardiovascular outcomes. To assess the applicability of sleep BP measured using a timer-equipped home device, we investigated the association between home device-measured sleep BP and large artery stiffness. METHODS:We pe...

journal_title：Journal of hypertension

authors： Tabara Y,Matsumoto T,Murase K,Setoh K,Kawaguchi T,Kosugi S,Nakayama T,Hirai T,Wakamura T,Chin K,Matsuda F,Nagahama study group.

更新日期：2020-12-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) plays a pivotal role in modulation of vascular function and it is also involved in the pathophysiology of several cardiovascular diseases. We provide an updated overview of the current appraisal of ANP vascular effects in both animal models and humans. We describe the physiological imp...

journal_title：Journal of hypertension

authors： Rubattu S,Calvieri C,Pagliaro B,Volpe M

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the association of angiotensinogen (AGT) gene with AGT level and hypertension based on the overall genetic variation of the AGT gene in among African-Americans. METHODS:All non-rare single nucleotide polymorphisms (SNPs) in AGT were identified by resequencing 24 individuals. Five tagging SNPs wer...

journal_title：Journal of hypertension

authors： Wu X,Luke A,Rieder M,Lee K,Toth EJ,Nickerson D,Zhu X,Kan D,Cooper RS

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVES:Patients with end-stage renal-disease under hemodialysis have increased cardiovascular risk and experience severe blood pressure (BP) fluctuations during the dialysis session and the subsequent interdialytic period. BP variability (BPV) may be an additional risk factor for cardiovascular events and prelimina...

journal_title：Journal of hypertension

authors： Karpetas A,Loutradis C,Bikos A,Tzanis G,Koutroumpas G,Lazaridis AA,Mavromatidis K,Liakopoulos V,Papagianni A,Zebekakis P,Ruilope LM,Parati G,Sarafidis PA

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:Recently, the nanomechanical properties (i.e. stiffness) of endothelial cells have been identified as crucial for appropriate endothelial function. One major determinant of endothelial stiffness is the endothelial sodium channel (EnNaC). EnNaC-dependent stiffening leads to reduced nitric oxide release, which...

journal_title：Journal of hypertension

authors： Lenders M,Hofschröer V,Schmitz B,Kasprzak B,Rohlmann A,Missler M,Pavenstädt H,Oberleithner H,Brand SM,Kusche-Vihrog K,Brand E

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:Circulating biomarkers of endothelial dysfunction and inflammation are elevated in late pregnancy in women with preeclampsia. We examined plasma levels of inflammatory cytokines and adhesion molecules in early pregnancy, to assess their ability to predict preeclampsia. METHODS:In a prospective longitudinal s...

journal_title：Journal of hypertension

authors： Carty DM,Anderson LA,Freeman DJ,Welsh PI,Brennand JE,Dominiczak AF,Delles C

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Besides its capacity to regulate organ and tissue growth, the insulin-like growth factor I exerts biologic actions that resemble those of insulin. Tissue access of the factor depends on the distribution of the circulating bound factor between its binding protein 3 that remains within the intravascular space ...

journal_title：Journal of hypertension

authors： Laviades C,Gil MJ,Monreal I,González A,Díez J

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:To search for a genetic marker of the sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase (SERCA) II gene in spontaneously hypertensive rats (SHRs) and to investigate differences in blood pressure and intracellular Ca2+ among some substrains of SHRs and Wistar-Kyoto (WKY) rats related to their SERCA II genot...

journal_title：Journal of hypertension

authors： Ohno Y,Matsuo K,Suzuki H,Tanase H,Ikeshima H,Takano T,Saruta T

更新日期：1996-03-01 00:00:00