The sympathetic nervous system in hypertension: assessment by blood pressure variability and ganglionic blockade.

abstract：OBJECTIVES:It is estimated that there are more than 16 million adults with drug-resistant hypertension in China. Nevertheless, the prevalence of and risk factors for primary aldosteronism, a highly curable condition among adults with drug-resistant hypertension, has not been fully investigated. METHODS:Between January...

journal_title：Journal of hypertension

authors： Sang X,Jiang Y,Wang W,Yan L,Zhao J,Peng Y,Gu W,Chen G,Liu W,Ning G

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Enhanced mechanical forces, e.g. in arterial hypertension, stimulate the formation of reactive oxygen species (ROS) by the NAD(P)H oxidase. Since bone marrow derived endothelial progenitor cells (EPCs) contribute to vascular remodeling and repair, we investigated whether renovascular hypertension stimulates ...

journal_title：Journal of hypertension

authors： Salguero G,Akin E,Templin C,Kotlarz D,Doerries C,Landmesser U,Grote K,Schieffer B

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:To investigate the association of serum uric acid level with the risk for hypertension and Type 2 diabetes. DESIGN:Prospective cohort study. SETTING:Work site in Osaka, Japan. PARTICIPANTS:A total of 6,356 Japanese men, aged 35-60 years with systolic blood pressure < 140 mmHg and diastolic blood pressure <...

journal_title：Journal of hypertension

authors： Taniguchi Y,Hayashi T,Tsumura K,Endo G,Fujii S,Okada K

更新日期：2001-07-01 00:00:00

abstract：:The effect of xipamide on the intracellular concentration and transmembrane fluxes of Na+ and K+ was studied in 12 normal male subjects, using a double-blind cross-over design. After a run-in period on placebo for 1 week, the subjects were treated with either placebo (n = 6) or xipamide 20 mg once a day (n = 6) for 16...

journal_title：Journal of hypertension

authors： Lijnen P,Hespel P,Fagard R,Staessen J,Goossens W,Lissens W,Amery A

更新日期：1988-08-01 00:00:00

abstract：OBJECTIVES:The apolipoprotein epsilon 4 allele (APOE/epsilon 4) increases plasma cholesterol level and the risk for the late onset type of Alzheimer's disease. However, the correlation between hypertension and APOE/epsilon 4 has not yet been clarified. To examine the APOE/epsilon 4 effect in the general population of J...

journal_title：Journal of hypertension

authors： Katsuya T,Baba S,Ishikawa K,Mannami T,Fu Y,Inamoto N,Asai T,Fukuda M,Higaki J,Ogata J,Ogihara T

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVES:To provide estimates of the global burden of disease attributable to non-optimal blood pressure by age and sex for adults aged > or = 30 years, by WHO subregion. METHODS:Estimates of attributable burden were made using population impact fractions, which used data on mean systolic blood pressure levels, dise...

journal_title：Journal of hypertension

authors： Lawes CM,Vander Hoorn S,Law MR,Elliott P,MacMahon S,Rodgers A

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:Overweight/obesity in childhood is suggested to increase risk of hypertension later in life. However, few studies have assessed the effect of trajectories of weight status from childhood to adulthood on adult hypertension. The present study aimed to assess the relationship between weight status change from ch...

journal_title：Journal of hypertension

authors： Hou Y,Wang M,Yang L,Zhao M,Yan Y,Xi B

更新日期：2019-06-01 00:00:00

abstract：:Medical records were examined for 1935 patients who presented sequentially to a hypertension clinic between 1971 and 1981. Patients were classified according to whether they were on a beta-blocker, methyldopa, a potassium-losing diuretic, or whether they had discontinued any of these treatments. Age-standardized morta...

journal_title：Journal of hypertension

authors： Franks PJ,Hartley K,Bulpitt PF,Bulpitt CJ,Dollery CT

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVE:Treating hypertension in those aged at least 80 years is now recommended; however, the best antihypertensive to choose remains unexplored. Calcium channel blocker (CCB) use has been associated with a decreased risk of incident dementia in a younger hypertensive group but with an increased risk of cognitive de...

journal_title：Journal of hypertension

authors： Peters R,Booth A,Peters J

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:We aimed to investigate whether blood pressure (BP) in the subacute stage of ischemic stroke affects subsequent vascular events after acute ischemic stroke. METHODS:From a prospective stroke registry database, consecutive ischemic stroke patients arriving within 48 h of onset were identified. The mean and S...

journal_title：Journal of hypertension

authors： Kang J,Kim BJ,Yang MH,Jang MS,Han MK,Lee JS,Gorelick PB,Lee J,Bae HJ

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:The interaction between trophoblasts and maternal endothelium is important for placental vascular modeling. Failure of uterine spiral artery transformation is linked to the etiopathology of preeclampsia. Antihypertensive medications used to control hypertension in early pregnancy can alter placental and circ...

journal_title：Journal of hypertension

authors： Xu B,Charlton F,Makris A,Hennessy A

更新日期：2014-05-01 00:00:00

abstract：:We have demonstrated high concentrations of inactive renin in mouse amniotic fluid compared with mouse plasma and other organs. Its molecular weight was similar to that of prorenin from the mouse submaxillary gland (42 000 daltons). The activated renin had a Km value of 1.48 greater than M which is identical to that o...

journal_title：Journal of hypertension

authors： Jacobsen J,Poulsen K

更新日期：1984-10-01 00:00:00

abstract：BACKGROUND:Nitric oxide is involved in the regulation of vascular basal tone and blood pressure. Polymorphisms of NOS3, the gene that codes for endothelial nitric oxide synthase, have been associated with essential hypertension. OBJECTIVE:To look for linkage and association of three di-allelic polymorphisms (Glu298Asp...

journal_title：Journal of hypertension

authors： Persu A,Vinck WJ,El Khattabi O,Janssen RG,Paulussen AD,Devuyst O,Vlietinck R,Fagard RH

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:The objective of this study was to estimate the prevalence and distribution of hypertension and to determine the status of hypertension awareness, treatment and control in the Portuguese adult population. METHODS:This study was conducted in 2003, and a multistage cluster sampling method was used to select a...

journal_title：Journal of hypertension

authors： Macedo ME,Lima MJ,Silva AO,Alcantara P,Ramalhinho V,Carmona J

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Dopamine receptors induce natriuresis in kidney. Previous studies have shown interactions between different subtypes of dopamine receptors in renal proximal tubule (RPT) cells. We hypothesize that D3 receptors have an interaction with D4 receptors in RPT cells from normotensive rats (Wistar-Kyoto, WKY) and s...

journal_title：Journal of hypertension

authors： Chen X,Liu Y,Wang WE,Chen C,Ren H,Zheng S,Zhou L,Zeng C

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:Reduction in capillary density or rarefaction is a hallmark of essential hypertension. We measured the retinal capillary density using noninvasive optical coherence tomographic angiography (OCT-A) in adults with treated systemic hypertension and determined possible correlations with ambulatory blood pressure ...

journal_title：Journal of hypertension

authors： Chua J,Chin CWL,Hong J,Chee ML,Le TT,Ting DSW,Wong TY,Schmetterer L

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:The present study aimed to characterize the influence of salt intake on the gene expression of the kidney specific chloride channels CLC-K1 and CLC-K2 in the kidneys of salt-resistant and salt-sensitive Dahl rats. DESIGN:For this purpose Dahl salt-resistant (Dahl-R) and Dahl salt-sensitive rats (Dahl-S) were...

journal_title：Journal of hypertension

authors： Castrop H,Krämer BK,Riegger GA,Kurtz A,Wolf K

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVES:Hemodialysis patients have a cardiovascular mortality rate of 20-40 times that of the general population. Aldosterone inhibition by spironolactone has exerted beneficial, prognostically significant cardiovascular effects in patients with heart failure maintained on hemodialysis or peritoneal dialysis. Our ai...

journal_title：Journal of hypertension

authors： Flevari P,Kalogeropoulou S,Drakou A,Leftheriotis D,Panou F,Lekakis J,Kremastinos D,Vlahakos DV

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVES:The role of the baroreflex function in the pathogenesis of hemodialysis-associated hypotension is controversial. Complex demodulation technique (CDM), providing continuous assessment of the amplitude of cardiovascular oscillation over time, is particularly suitable to assess dynamic changes in autonomic nerv...

journal_title：Journal of hypertension

authors： Sapoznikov D,Backenroth R,Rubinger D

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:Different radiologists may show considerable variation in their interpretation of renal angiograms. We therefore wished to establish the reliability of their interpretation. DESIGN:Assessment of the intra- and inter-observer agreement of the interpretation of renal angiograms. SETTING:Tertiary referral univ...

journal_title：Journal of hypertension

authors： Schreij G,de Haan MW,Oei TK,Koster D,de Leeuw PW

更新日期：1999-12-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH), despite its adaptive nature, increases cardiovascular morbidity and mortality. Novel approaches for protection against pathological heart remodelling are presented in this supplement. Melatonin diminishes myocardial fibrosis in rats exposed to continuous light and N-nitro-L-arginine...

journal_title：Journal of hypertension

authors： Simko F,Pechanova O

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:It has been suggested that non-invasive aortic stiffness measurements can be used as an indicator of atherosclerosis. The relationships of arterial stiffness with arterial wall hypertrophy and atherosclerosis however, have rarely been investigated in large-scale studies. The present study reports the associat...

journal_title：Journal of hypertension

authors： Zureik M,Temmar M,Adamopoulos C,Bureau JM,Courbon D,Thomas F,Bean K,Touboul PJ,Ducimetière P,Benetos A

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Recently, an apparently novel, specific endothelin-1 inactivating metalloendopeptidase (ET-1 peptidase) has been isolated from the rat kidney. In this study we attempted to determine whether the same or a similar peptidase is present in the human kidney, and whether the enzyme is excreted into the urine. The ...

journal_title：Journal of hypertension

authors： Janas J,Sitkiewicz D,Januszewicz A,Szczesniak C,Grenda R,Janas RM

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVE:To investigate cardiomyocyte hypertrophy and hormonal profile in cardiac hypertrophy resulting from sequentially applied overloads. METHODS:We studied Sprague-Dawley rats with renovascular hypertension (RV), where pressure overload predominates, or deoxycorticosterone acetate (DOCA)-salt (DS), where volume o...

journal_title：Journal of hypertension

authors： Cavallero S,González GE,Puyó AM,Rosón MI,Pérez S,Morales C,Hertig CM,Gelpi RJ,Fernández BE

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Cathepsin L (CTSL1) catalyzes the formation of peptides that influence blood pressure (BP). Naturally occurring genetic variation or targeted ablation of the Ctsl1 locus in mice yield cardiovascular pathology. Here, we searched for genetic variation across the human CTSL1 locus and probed its functional effe...

journal_title：Journal of hypertension

authors： Mbewe-Campbell N,Wei Z,Zhang K,Friese RS,Mahata M,Schork AJ,Rao F,Chiron S,Biswas N,Kim HS,Mahata SK,Waalen J,Nievergelt CM,Hook VY,O'Connor DT

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Hypertension-induced renal injury is characterized by inflammation, fibrosis and proteinuria. Previous studies have demonstrated that N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) inhibits renal damage following diabetes mellitus and antiglomerular basement membrane nephritis. However, its effects on low-renin hyperten...

journal_title：Journal of hypertension

authors： Rhaleb NE,Pokharel S,Sharma U,Carretero OA

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:p63RhoGEF, a guanine nucleotide exchange factor, has been reported 'in vitro' as key mediator of the angiotensin II-induced RhoA/Rho kinase activation leading to vasoconstriction and cardiovascular remodeling. We assessed p63RhoGEF gene and protein expression and RhoA/Rho kinase activity in essential hyperten...

journal_title：Journal of hypertension

authors： Calò LA,Davis PA,Pagnin E,Dal Maso L,Maiolino G,Seccia TM,Pessina AC,Rossi GP

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Although an exaggerated systolic blood pressure (SBP) response to exercise is a predictor of future hypertension and cardiovascular mortality, the underlying mechanisms are not fully understood. We tested the hypothesis that an exaggerated SBP response is associated with carotid atherosclerosis in a cross-sec...

journal_title：Journal of hypertension

authors： Jae SY,Fernhall B,Heffernan KS,Kang M,Lee MK,Choi YH,Hong KP,Ahn ES,Park WH

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Recent cross-sectional studies have suggested that higher serum sodium levels may be a marker of elevated blood pressure. It is unclear whether serum sodium levels are related to the risk of developing hypertension in the community. METHODS:We investigated the association of serum sodium with longitudinal b...

journal_title：Journal of hypertension

authors： Lago RM,Pencina MJ,Wang TJ,Lanier KJ,D'Agostino RB,Kannel WB,Vasan RS

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:To validate a computer-based method for measuring the calibre of retinal blood vessels, and use it to determine the effects of ageing and arterial hypertension on the calibres of these vessels and on their ratio. METHODS:Digital eye fundus images covering a 50 degrees field and centred on the optic disc were...

journal_title：Journal of hypertension

authors： Pose-Reino A,Gomez-Ulla F,Hayik B,Rodriguez-Fernández M,Carreira-Nouche MJ,Mosquera-González A,González-Penedo M,Gude F

更新日期：2005-04-01 00:00:00