当前位置： SCI文献检索 > JOURNAL OF HYPERTENSION期刊下所有文献 > Prevalence of and risk factors for primary aldosteronism among patients with resistant hypertension in China.

Prevalence of and risk factors for primary aldosteronism among patients with resistant hypertension in China.

Abstract：

OBJECTIVES:It is estimated that there are more than 16 million adults with drug-resistant hypertension in China. Nevertheless, the prevalence of and risk factors for primary aldosteronism, a highly curable condition among adults with drug-resistant hypertension, has not been fully investigated. METHODS:Between January 2010 and October 2011, a multicenter epidemiologic study was conducted among 1656 patients with resistant hypertension in 11 provinces of China. Serum aldosterone and plasma renin activity were measured in every participant and aldosterone-to-renin ratio (ARR) was calculated. Patients with ARR more than 20 underwent an intravenous (i.v.) sodium infusion test, and diagnosis of primary aldosteronism was established by the presence of unsuppressed postinfusion aldosterone (>8 ng/dl). Patients with biochemically proved primary aldosteronism then underwent adrenal computed tomography (CT) scanning and adrenal vein sampling (AVS) for subtype classification. RESULTS:Among the 1656 patients, 494 (29.8%) had ARR greater than 20 and underwent i.v. sodium infusion. Of these 494, 118 were diagnosed as primary aldosteronism, yielding a prevalence of 7.1% (95% confidential interval 5.9-8.3%). Seventy of the 118 patients were categorized into unilateral (39) and bilateral (31) by AVS. Generalized additive regression analysis revealed that among all the factors investigated (age of hypertension onset, BMI, family history of hypertension, cigarette smoking, alcohol consumption, diabetes, serum potassium, hyperlipidemia, and creatinine), only age of hypertension onset and serum potassium were independently associated with the presence of primary aldosteronism. CONCLUSION:The prevalence of primary aldosteronism among Chinese patients with resistant hypertension is relatively lower than that reported previously for other ethnic populations. The screening for primary aldosteronism should be focused on those with early onset hypertension and/or hypokalemia.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Sang X,Jiang Y,Wang W,Yan L,Zhao J,Peng Y,Gu W,Chen G,Liu W,Ning G

doi

10.1097/HJH.0b013e328360ddf6

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

1465-71; discussion 1471-2

issue

eissn

0263-6352

issn

1473-5598

pii

00004872-201307000-00017

journal_volume

pub_type

杂志文章

在线工具

Prevalence of and risk factors for primary aldosteronism among patients with resistant hypertension in China.