No effect of ultraviolet radiation on blood pressure and other cardiovascular risk factors.

Abstract:

OBJECTIVES:Recent epidemiological studies have reported inverse associations between vitamin D status and blood pressure. The study aim is to determine if exposure to ultraviolet B radiation, which synthesizes vitamin D, lowers blood pressure, compared with ultraviolet A radiation. METHODS:Men and women (n = 119) with low vitamin D levels [serum 25-hydroxyvitamin D [25(OH)D] <50 nmol/l], completed a randomized clinical trial carried out during winter. Blood pressure was measured for 12-14 h with an ambulatory monitor at baseline and 12 weeks. In between, participants received 24 whole body exposures of either ultraviolet B (n = 58) or ultraviolet A (n = 61) over 12 weeks. RESULTS:Mean (SD) 25(OH)D increased from 43.7 (9.7) to 92.6 (16.9) nmol/l in the ultraviolet B arm after 12 weeks, and from 45.4 (9.2) to 64.9 (11.3) nmol/l in the ultraviolet A arm. However, mean blood pressure, which was similar for the ultraviolet B and ultraviolet A at baseline (134.9/79.2 vs. 132.9/77.8 mmHg; P = 0.59 and 0.56, respectively), did not change from baseline to 12 weeks in either group. The mean change [95% confidence interval (CI)] in blood pressure over this period in the ultraviolet B group compared with the ultraviolet A group was -2.2 (-7.8, 3.3) mmHg for systolic (P = 0.42) and -2.7 (-6.5, 1.0) mmHg for diastolic (P = 0.15). CONCLUSION:Exposure to ultraviolet B did not lower blood pressure. Our results suggest that if vitamin D protects against cardiovascular disease, it involves some mechanism other than blood pressure.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Scragg R,Wishart J,Stewart A,Ofanoa M,Kerse N,Dyall L,Lawes CM

doi

10.1097/HJH.0b013e328349666d

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

1749-56

issue

9

eissn

0263-6352

issn

1473-5598

journal_volume

29

pub_type

杂志文章,随机对照试验
  • Relationship between exercise systolic blood pressure and left ventricular geometry in overweight, mildly hypertensive patients.

    abstract:OBJECTIVE:To examine the association between the graded exercise systolic blood pressure (SBP) response and left ventricular (LV) geometric structure in patients with untreated mild hypertension. PARTICIPANTS:The study included 80 sedentary, overweight patients (43 female and 37 male) with unmedicated high normal bloo...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200402000-00026

    authors: Pierson LM,Bacon SL,Sherwood A,Hinderliter AL,Babyak M,Gullette EC,Waugh R,Blumenthal JA

    更新日期:2004-02-01 00:00:00

  • Long-term effects of antihypertensive therapy on cardiovascular events and new-onset diabetes mellitus in high-risk hypertensive patients in Japan.

    abstract:OBJECTIVE:During the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial, patients with hypertension who received amlodipine had similar cardiovascular risks as those who received candesartan. We conducted a post-trial study, the Candesartan Antihypertensive Survival Evaluation in Japan 10-year fol...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001780

    authors: Liu J,Yasuno S,Oba K,Konda M,Ichihara C,Kitao H,Kuwabara Y,Ueshima K

    更新日期:2018-09-01 00:00:00

  • Antihypertensive effect of a renin inhibitor in marmosets with a segmental renal infarction.

    abstract::Hypertension was induced in marmosets by ligating the minor branch of one renal artery. The blood pressure (BP), measured by a tail-cuff method, increased to hypertensive levels within 4-5 weeks and the maximum increases occurred after 4-15 weeks (BP, mean +/- s.e.m. was 120 +/- 3 and 152 +/- 6 mmHg before and 10 week...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198712000-00015

    authors: Neisius D,Wood JM

    更新日期:1987-12-01 00:00:00

  • Cardiovascular autonomic profile in women with constitutional hypotension.

    abstract:BACKGROUND:Constitutional hypotension (CHT) is defined as a SBP below 105 mmHg. As autonomic-related symptoms are frequently reported in CHT, these symptoms suggest that the cardiovascular autonomic control is perturbed in individuals with CHT. METHODS:We investigated the autonomic cardiovascular control of 15 women w...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001790

    authors: Jacob G,Barbic F,Glago M,Dipaola F,Porta A,Furlan R

    更新日期:2018-10-01 00:00:00

  • Role of endothelium in the mechanical response of the carotid arterial wall to calcium blockade in spontaneously hypertensive and Wistar-Kyoto rats.

    abstract:OBJECTIVES:Calcium blockade has been reported to inhibit the contraction of the vascular smooth muscle and the liberation of vasoactive substances by endothelial cells. We tested the effects of calcium blockade on the mechanical properties of the carotid artery in normotensive Wistar-Kyoto (WKY) rats and spontaneously ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199301000-00009

    authors: Lévy BI,el Fertak L,Pieddeloup C,Barouki F,Safar ME

    更新日期:1993-01-01 00:00:00

  • Cardiac magnetic resonance-derived fibrosis, strain and molecular biomarkers of fibrosis in hypertensive heart disease.

    abstract:AIMS:Myocardial fibrosis is a relevant component of hypertensive heart disease (HHD). Novel cardiovascular magnetic resonance (CMR) imaging techniques have shown potential in quantification of diffuse cardiac fibrosis, with T1 mapping, and estimating preclinical cardiac dysfunction, with strain analysis. Molecular biom...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002504

    authors: Pichler G,Redon J,Martínez F,Solaz E,Calaforra O,Andrés MS,Lopez B,Díez J,Oberbauer R,Adlbrecht C,Karth GD,Maceira A

    更新日期:2020-10-01 00:00:00

  • Rapid increases in infant adiposity and overweight/obesity in childhood are associated with higher central and brachial blood pressure in early adulthood.

    abstract:BACKGROUND:Small size at birth and greater BMI in childhood are associated with greater brachial blood pressure (BP) in later life. Aortic (central) BP differs from brachial BP and is more predictive of organ damage and cardiovascular events; the relationship between BMI in childhood and central BP is not known. METHO...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000269

    authors: Howe LD,Chaturvedi N,Lawlor DA,Ferreira DL,Fraser A,Davey Smith G,Tilling K,Hughes AD

    更新日期:2014-09-01 00:00:00

  • Aldosterone induces arterial stiffness in absence of oxidative stress and endothelial dysfunction.

    abstract:AIMS:Monocyte/macrophages participate in inflammatory responses that may play an important role in mineralocorticoid-induced vascular damage. We hypothesized that monocyte/macrophages modulate aldosterone effects on oxidative stress, endothelial function, and ultimately vascular stiffness. METHODS:Adult heterozygous o...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328330a963

    authors: Leibovitz E,Ebrahimian T,Paradis P,Schiffrin EL

    更新日期:2009-11-01 00:00:00

  • Weight status change from childhood to early adulthood and the risk of adult hypertension.

    abstract:OBJECTIVE:Overweight/obesity in childhood is suggested to increase risk of hypertension later in life. However, few studies have assessed the effect of trajectories of weight status from childhood to adulthood on adult hypertension. The present study aimed to assess the relationship between weight status change from ch...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002016

    authors: Hou Y,Wang M,Yang L,Zhao M,Yan Y,Xi B

    更新日期:2019-06-01 00:00:00

  • Systemic and regional haemodynamic effects of renal denervation in spontaneously hypertensive rats.

    abstract::Systemic and regional haemodynamic effects of renal denervation were evaluated in adult (six-month-old) male spontaneously hypertensive rats (SHR) using the Fick procedure and electromagnetic flowmetry technique. Renal denervation (bilateral, 10% phenol in ethanol), performed five to eight days before the experiment, ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198312000-00010

    authors: Lee JY,Walsh GM

    更新日期:1983-12-01 00:00:00

  • Interstrain restriction fragment length polymorphism of c-fos and c-src oncogene loci in spontaneously hypertensive and normotensive rats.

    abstract::Interstrain restriction fragment length polymorphism was detected after Southern blot hybridization of spontaneously hypertensive (SHR) and control (WKY) rat DNA digested by Bam HI restrictase with a v-fos probe. The SHR genome was characterized by an additional minor band of 4.0 kb. Other restriction fragment length ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Kotelevtsev YV,Brashishkite DA,Spitkovski DD,Kiselev FL,Postnov YV

    更新日期:1988-10-01 00:00:00

  • Left ventricular mass correlates with fat-free mass but not fat mass in adults.

    abstract:BACKGROUND:Left ventricular mass is associated with body size, obesity and blood pressure. Echocardiography is routinely used to estimate this parameter, which is usually indexed to body surface area to allow comparisons to be made between individuals and groups of different body size. However, in obese subjects, using...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199917040-00016

    authors: Whalley GA,Gamble GD,Doughty RN,Culpan A,Plank L,MacMahon S,Sharpe N

    更新日期:1999-04-01 00:00:00

  • Noninvasive estimation of central blood pressure and the augmentation index in the seated position: a validation study of two commercially available methods.

    abstract:OBJECTIVES:The aim of this study was to examine the utility of the generalized transfer function (GTF) and the late systolic shoulder of the radial pressure waveform (SBP2) for estimating seated central systolic blood pressure (c-SBP) and seated c-augmentation index (c-AIx). METHODS:In 199 participants (182 cardiovasc...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32835c1d45

    authors: Hirata K,Kojima I,Momomura S

    更新日期:2013-03-01 00:00:00

  • Superior hypertension control with betablockade in the European Sleep Apnea Database.

    abstract:AIMS:Arterial hypertension is highly prevalent and difficult to control in patients with obstructive sleep apnea (OSA). High sympathoadrenergic activity is a hallmark physiological phenomenon in OSA. We hypothesized that an antihypertensive drug with inhibitory properties on this activity, such as beta blockers (BBs), ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002629

    authors: Svedmyr S,Hedner J,Zou D,Parati G,Ryan S,Hein H,Pepin JL,Tkáčová R,Marrone O,Schiza S,Basoglu OK,Grote L,European Sleep Apnea Database (ESADA) study group.

    更新日期:2021-02-01 00:00:00

  • Atrial natriuretic peptide behaviour and myocyte hypertrophic profile in combined pressure and volume-induced cardiac hypertrophy.

    abstract:OBJECTIVE:To investigate cardiomyocyte hypertrophy and hormonal profile in cardiac hypertrophy resulting from sequentially applied overloads. METHODS:We studied Sprague-Dawley rats with renovascular hypertension (RV), where pressure overload predominates, or deoxycorticosterone acetate (DOCA)-salt (DS), where volume o...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3282435b1e

    authors: Cavallero S,González GE,Puyó AM,Rosón MI,Pérez S,Morales C,Hertig CM,Gelpi RJ,Fernández BE

    更新日期:2007-09-01 00:00:00

  • Regional variations in hypertension prevalence and management in Germany: results from the German Health Interview and Examination Survey (DEGS1).

    abstract:OBJECTIVE:This study analyzed regional differences in blood pressure (BP) distribution and management in Germany 2008-2011 in a nationwide study. METHODS:The analyses were based on standardized BP measurements and anatomical therapeutic chemical classification-coded medication from the population-based German Health I...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000211

    authors: Diederichs C,Neuhauser H

    更新日期:2014-07-01 00:00:00

  • Effects of blood pressure-lowering drugs in heart failure: a systematic review and meta-analysis of randomized controlled trials.

    abstract::: We aimed to combine evidence from all heart failure trials that have investigated the effects of drugs with blood pressure (BP)-lowering properties to assess the extent to which such drugs reduce BP in heart failure, the association between the net change in BP between treatment arms and cause-specific outcomes and ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,meta分析

    doi:10.1097/HJH.0000000000002094

    authors: Pinho-Gomes AC,Azevedo L,Bidel Z,Nazarzadeh M,Canoy D,Copland E,Salam A,Rodgers A,Kotecha D,Rahimi K

    更新日期:2019-09-01 00:00:00

  • Control of systemic and pulmonary blood pressure by nitric oxide formed through neuronal nitric oxide synthase.

    abstract::Nitric oxide formed by neuronal nitric oxide synthase (nNOS) in the brain, autonomic inhibitory (nitrergic) nerves, and heart plays important roles in the control of blood pressure. Activation of nitrergic nerves innervating the systemic vasculature elicits vasodilatation, decreases peripheral resistance, and lowers b...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/HJH.0b013e32832e8ddf

    authors: Toda N,Ayajiki K,Okamura T

    更新日期:2009-10-01 00:00:00

  • Effects of glucose and insulin on the development of oxidative stress and hypertension in animal models of type 1 and type 2 diabetes.

    abstract:OBJECTIVES:To investigate whether glucose or insulin is the cause of increases in oxidative stress and blood pressure in insulin-resistant animals, and to evaluate the effects of alpha-lipoic acid (LA) on the production of the superoxide anion (O2-) in the aorta and blood pressure elevations in various models of diabet...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000160215.78973.ba

    authors: El Midaoui A,de Champlain J

    更新日期:2005-03-01 00:00:00

  • The impact of age on vascular smooth muscle function in humans.

    abstract:AIM:Advanced age is associated with vascular endothelial dysfunction, characterized by reductions in the endothelium-dependent vasodilation of the conduit and resistance arteries, in part, from decreased nitric oxide bioavailability. Although vascular smooth muscle function (SMF), assessed by responsiveness to an exoge...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/HJH.0000000000000446

    authors: Montero D,Pierce GL,Stehouwer CD,Padilla J,Thijssen DH

    更新日期:2015-03-01 00:00:00

  • Endothelium-dependent and cyclooxygenase-dependent cutaneous vasodilatation is blunted in young men with hypertensive parents.

    abstract:BACKGROUND:Across ethnicities, offspring of hypertensive parents (OH) have higher risk of hypertension than offspring of normotensive parents (ON). Sympathetic hyperactivity and reduced nitric oxide availability have been reported in normotensive OH; but the role of vasodilator cyclooxygenase (COX) products is unclear....

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001794

    authors: Hirst A,Marshall JM

    更新日期:2018-11-01 00:00:00

  • Prognostic significance of acute hypertensive response in ischemic stroke or transient ischemic attack patients and its relationship with left ventricular myocardial function.

    abstract:OBJECTIVES:Acute hypertensive response (AHR) in acute stroke is associated with adverse outcomes; however, the underlying pathophysiology of the association is poorly understood and its prognostic impact in ischemic stroke remains unclear. We aimed to investigate the prognostic significance of AHR in patients with isch...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002171

    authors: Yi JE,Chang Y,Song TJ,Shin GJ,Kim YJ

    更新日期:2019-12-01 00:00:00

  • Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project.

    abstract:OBJECTIVE:To study the association between polymorphisms in the angiotensin converting enzyme (ACE) gene and angiotensinogen (AGT) gene and hypertension and/or type 2 diabetes in a community population. PATIENTS AND METHODS:The insertion (I)/deletion (D) polymorphism of the ACE gene and the M235T polymorphism of the A...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199917110-00010

    authors: Bengtsson K,Orho-Melander M,Lindblad U,Melander O,Bøg-Hansen E,Ranstam J,Råstam L,Groop L

    更新日期:1999-11-01 00:00:00

  • Association between renal function and outcomes after percutaneous transluminal renal angioplasty in hypertensive patients with renal artery stenosis.

    abstract:OBJECTIVE:We investigated the impact of renal function on outcomes after percutaneous transluminal angioplasty. METHODS:A total of 139 hypertensive patients with atherosclerotic renal artery stenosis (mean age, 70 years, 80.6% men) who underwent renal percutaneous transluminal angioplasty were included. Renal function...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001499

    authors: Iwashima Y,Fukuda T,Horio T,Hayashi SI,Kusunoki H,Kishida M,Nakamura S,Kamide K,Kawano Y,Yoshihara F

    更新日期:2018-01-01 00:00:00

  • Marinobufagenin, an endogenous ligand of alpha-1 sodium pump, is a marker of congestive heart failure severity.

    abstract:BACKGROUND:A reduced cardiac output in chronic heart failure (CHF) evokes renal NaCl and water retention, and, therefore, activates mechanisms promoting natriuresis. Atrial natriuretic peptide (ANP) is one such factor. We hypothesized that another NaCl sensitive endogenous natriuretic factor, i.e., marinobufagenin (MBG...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200206000-00032

    authors: Fridman AI,Matveev SA,Agalakova NI,Fedorova OV,Lakatta EG,Bagrov AY

    更新日期:2002-06-01 00:00:00

  • Expression of cardiac angiotensin II AT1 receptor genes in rat hearts is regulated by steroids but not by angiotensin II.

    abstract:OBJECTIVE:To examine the regulation by angiotensin II and by steroids of the expression of the angiotensin II AT1a and AT1b receptor genes in rat hearts. METHODS:Endogenous levels of angiotensin II in the rats were increased either by unilateral 0.2-mm renal artery clips or by subcutaneous infusions of frusemide (12 m...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Della Bruna R,Ries S,Himmelstoss C,Kurtz A

    更新日期:1995-07-01 00:00:00

  • Haemorrhage increases the pressor effect of angiotensin-(1-7) but not of angiotensin II at the rat rostral ventrolateral medulla.

    abstract:OBJECTIVE:To evaluate the effects of angiotensins acting at the rostral ventrolateral medulla (RVLM) on the cardiovascular adjustments following haemorrhage. DESIGN:Changes in mean arterial pressure (MAP) and heart rate (HR) produced by micro-injections of angiotensin II (Ang II) and angiotensin (Ang)-(1-7) and differ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199917080-00014

    authors: Lima DX,Campagnole-Santos MJ,Fontes MA,Khosla MC,Santos RA

    更新日期:1999-08-01 00:00:00

  • Prevalence of episodes of ST-segment depression among mild-to-moderate hypertensive patients in northern Italy: the Cardioscreening Study.

    abstract:OBJECTIVES:To assess the prevalence of episodes of ST-segment depression in a population of consecutive patients with mild-to-moderate essential hypertension who are free of clinical signs of coronary artery disease. METHODS:The study involved 28 Italian centers that enrolled 414 hypertensive patients (aged 50-70 year...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00004872-199816050-00016

    authors: Stramba-Badiale M,Bonazzi O,Casadei G,Dal Palù C,Magnani B,Zanchetti A

    更新日期:1998-05-01 00:00:00

  • Diurnal blood pressure loads are associated with lower cognitive performances in controlled-hypertensive elderly individuals.

    abstract:INTRODUCTION:Hypertension in midlife adults is associated with cognitive decline later in life. In individuals treated for hypertension, blood pressure (BP) loads have been associated with end organ damages. This study examines whether BP load inversely correlates with performance in cognitive tasks in normotensive or ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002155

    authors: Noriega de la Colina A,Wu R,Desjardins-Crépeau L,Badji A,Lamarre-Cliche M,Doyon J,Bherer L,Girouard H

    更新日期:2019-11-01 00:00:00

  • Low sodium diet inhibits the local counter-regulator effect of angiotensin-(1-7) on angiotensin II.

    abstract:OBJECTIVE:The heptapeptide angiotensin-(1-7) [Ang-(1-7)] has been identified as a versatile, endogenous inhibitor of the renin-angiotensin system (RAS). As the therapeutic response to exogenous RAS inhibitors, such as AT1 receptor antagonists, is altered by changes in salt intake, we investigated the effect of a low, n...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200412000-00018

    authors: Roks AJ,Nijholt J,van Buiten A,van Gilst WH,de Zeeuw D,Henning RH

    更新日期:2004-12-01 00:00:00