Involvement of thromboxane A2 receptor in the cerebrovascular damage of salt-loaded, stroke-prone rats.

abstract：OBJECTIVE:Using an aortic constriction model in mice, we studied whether the increase in pressure or the activation of the renin-angiotensin system (RAS) and its main receptors is the main driving force for plaque progression. METHODS:Male ApoE mice underwent sham surgery or placement of a suprarenal silver clip aroun...

journal_title：Journal of hypertension

authors： Johansson ME,Wickman A,Skøtt O,Gan LM,Bergström G

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:The objective of this study was to estimate the prevalence and distribution of hypertension and to determine the status of hypertension awareness, treatment and control in the Portuguese adult population. METHODS:This study was conducted in 2003, and a multistage cluster sampling method was used to select a...

journal_title：Journal of hypertension

authors： Macedo ME,Lima MJ,Silva AO,Alcantara P,Ramalhinho V,Carmona J

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVES:Recent epidemiological studies have reported inverse associations between vitamin D status and blood pressure. The study aim is to determine if exposure to ultraviolet B radiation, which synthesizes vitamin D, lowers blood pressure, compared with ultraviolet A radiation. METHODS:Men and women (n = 119) with...

journal_title：Journal of hypertension

authors： Scragg R,Wishart J,Stewart A,Ofanoa M,Kerse N,Dyall L,Lawes CM

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:There is a need for an easily accessible biomarker of sympathetic nervous activation in essential hypertension, but none exists. Heart rate (HR) has been suggested, but requires validation, now doubly important as an elevated HR in hypertension has emerged as an independent cardiovascular risk factor. METHO...

journal_title：Journal of hypertension

authors： Esler M,Lambert G,Esler D,Ika Sari C,Guo L,Jennings G

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:The prognostic importance of the nocturnal blood pressure (BP) fall and early-morning surge were scarcely investigated in patients with resistant hypertension (RHT). We investigated them in a prospective cohort of 1726 RHT individuals. METHODS:The nocturnal fall and morning surge were calculated from the bas...

journal_title：Journal of hypertension

authors： Cardoso CRL,Salles GF

更新日期：2021-01-11 00:00:00

abstract：OBJECTIVE:To test the hypothesis that insulin differently modifies vasoconstriction and recovery from vasoconstriction induced by endogenously released versus circulating norepinephrine, and to investigate the time-dependency of its effect METHODS:Healthy male subjects were studied. Norepinephrine was infused for 10 m...

journal_title：Journal of hypertension

authors： van Veen S,Chang PC

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:International recommendations have classified brachial blood pressure (BP) in subgroups enabling better cardiovascular risk stratification. Central BP is an independent predictor of cardiovascular risk, differing from brachial BP through the predominant influence of arterial stiffness and wave reflections. C...

journal_title：Journal of hypertension

authors： Safar ME,Blacher J,Protogerou A,Achimastos A

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To examine the association of blood pressure (BP) with cardiovascular mortality in real-world settings and investigate whether that association varied by use of antihypertensive medication at baseline. METHODS:Data from 27 728 Japanese men and women, aged 40-79 years, free of stroke, coronary heart disease, ...

journal_title：Journal of hypertension

authors： Yamagishi K,Sawachi S,Tamakoshi A,Iso H,JACC Study Group.

更新日期：2019-07-01 00:00:00

abstract：:Seventeen essential hypertensive patients with normal renal function were treated with a new non-sulphydryl orally active angiotensin converting enzyme (ACE) inhibitor, benazepril, 10 mg given once or twice daily, according to diastolic blood pressure levels, for 6 weeks. In all patients, changes in blood pressure, sy...

journal_title：Journal of hypertension

authors： Valvo E,Casagrande P,Bedogna V,Antiga L,Alberti D,Zamboni M,Perobelli L,Dal Santo F,Maschio G

更新日期：1990-11-01 00:00:00

abstract：OBJECTIVE:In clonal animal cells, certain angiotensin receptor blockers (ARB) activate the peroxisome proliferator-activated receptor-gamma (PPARgamma). The aim of this work was to validate that observation in human cells and humans. METHODS:We investigated the induction of in-vitro adipogenesis and the activation of ...

journal_title：Journal of hypertension

authors： Janke J,Schupp M,Engeli S,Gorzelniak K,Boschmann M,Sauma L,Nystrom FH,Jordan J,Luft FC,Sharma AM

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:The major advantage of dual inhibitors of neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE) is their ability to lower blood pressure irrespective of renin or volume status. The aim of this study was to determine whether dual NEP/ACE inhibition produces different effects on cardiovascular str...

journal_title：Journal of hypertension

authors： Farina NK,Johnston CI,Burrell LM

更新日期：2000-06-01 00:00:00

abstract：AIM:Since canine hereditary essential hypertension has been previously reported in a colony of Siberian husky dogs, we tested the suitability of this model for use in studies on the platelet defect identified in humans with essential hypertension. METHODS:Platelet aggregation and dense granule ATP secretion were measu...

journal_title：Journal of hypertension

authors： Thomas JS,McConnell MF,Bell TG,Padgett GA

更新日期：1992-12-01 00:00:00

abstract：OBJECTIVES:The interaction between trophoblasts and maternal endothelium is important for placental vascular modeling. Failure of uterine spiral artery transformation is linked to the etiopathology of preeclampsia. Antihypertensive medications used to control hypertension in early pregnancy can alter placental and circ...

journal_title：Journal of hypertension

authors： Xu B,Charlton F,Makris A,Hennessy A

更新日期：2014-05-01 00:00:00

abstract：:This study determined the influence of baroreflex sensitivity (BRS) on the rate of urinary sodium excretion and plasma renin activity (PRA) in response to a saline infusion in conscious male rabbits specifically bred for high (Group I; n = 7) and low (Group II; n = 10) BRS and in seven control animals. Only Group II s...

journal_title：Journal of hypertension

authors： Weinstock M,Borosh M,Kafri O,Kaczmarczyk G

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Increased arterial stiffness is associated with cardiovascular morbidity and mortality among hypertensive patients. OBJECTIVES:To assess the relationship between ambulatory arterial stiffness index (AASI) and subclinical left ventricular (LV) systolic dysfunction assessed by 2-D speckle-tracking echocardiog...

journal_title：Journal of hypertension

authors： Ahmed TAN,Shams-Eddin H,Fathy MA,El-Naggar HM,Kishk YT

更新日期：2020-05-01 00:00:00

abstract：:: Phaeochromocytoma and paraganglioma (PPGL) are chromaffin cell tumours that require timely diagnosis because of their potentially serious cardiovascular and sometimes life- threatening sequelae. Tremendous progress in biochemical testing, imaging, genetics and pathophysiological understanding of the tumours has far-...

journal_title：Journal of hypertension

authors： Lenders JWM,Kerstens MN,Amar L,Prejbisz A,Robledo M,Taieb D,Pacak K,Crona J,Zelinka T,Mannelli M,Deutschbein T,Timmers HJLM,Castinetti F,Dralle H,Widimský J,Gimenez-Roqueplo AP,Eisenhofer G

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Losartan is a new angiotensin II type 1 (AT1) receptor antagonist and an antihypertensive drug. Nitric oxide is a vasodilating agent and endothelins are powerful vasoconstrictors, both synthesized by and released from endothelial cells. Angiotensin II promotes the release of endothelins in cultured cells and...

journal_title：Journal of hypertension

authors： Sacerdote A,Cosenzi A,Bocin E,Molino R,Seculin P,Plazzotta N,Luxich E,Bellini G

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Bradykinin is a potent cardioprotective hormone, the beneficial role of which in vivo appears to be limited by its rapid metabolism. Inhibitors of peptidases that degrade endogenously formed bradykinin are themselves cardioprotective, presumably by increasing local bradykinin concentrations. As bradykinin-de...

journal_title：Journal of hypertension

authors： Taylor-McCabe KJ,Erşahin C,Simmons WH

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:Cardiovascular risk prediction is deemed fundamental and the assessment of organ damage is emerging as a potentially 'downstream' picture of individual risk. Our aim was to assess the feasibility and value of prediction of coronaropathy [coronary artery disease (CAD)] of integrated cardiovascular ultrasound e...

journal_title：Journal of hypertension

authors： Moreo A,Gaibazzi N,Faggiano P,Mohammed M,Carerj S,Mureddu G,Pigazzani F,Muiesan L,Salvetti M,Cesana F,Faden G,Facchetti R,Giannattasio C,Rigo F

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:To investigate whether the combination of exercise training with the angiotensin-converting enzyme inhibitor lisinopril will have an additional beneficial effect on left ventricular function in spontaneously hypertensive rats. DESIGN:Twelve-week-old male rats were assigned to treadmill running (Ht-Ex; 20 m/...

journal_title：Journal of hypertension

authors： Ziada AM

更新日期：2009-06-01 00:00:00

abstract：:A10 vascular smooth muscle cells were placed in a flow chamber and exposed to the circulation of foetal calf serum at different rates and pressures. Under unidirectional laminar flow, physiological flow rates and pressures had almost no effect on internal sodium content. Indeed, pressure values greater than 150 mmHg w...

journal_title：Journal of hypertension

authors： Rosati C,Garay R

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Angiotensin II causes hypertension not only by direct constriction of vascular smooth muscle, but also by facilitating the release of noradrenaline from sympathetic terminals and by enhancing vascular noradrenaline sensitivity. AT1 receptor antagonists attenuate all these actions, but display some evidence o...

journal_title：Journal of hypertension

authors： Dendorfer A,Dominiak P,Tempel K,Raasch W

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:We demonstrated in a previous cross-sectional study that arterial compliance is elevated in postmenopausal women taking estrogen-containing hormonal therapy, which may partially account for the reduction in cardiovascular risk observed. OBJECTIVE:To investigate the effects of withdrawal and recommencement o...

journal_title：Journal of hypertension

authors： Waddell TK,Rajkumar C,Cameron JD,Jennings GL,Dart AM,Kingwell BA

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:We aim to synthesize effects of repeated administration (≥3 days) of inorganic nitrate on blood pressure and arterial stiffness measures. METHODS:We conducted a systematic review and meta-analysis of randomized controlled trials with at least 3 days treatment of inorganic nitrate on blood pressure and arteri...

journal_title：Journal of hypertension

authors： Li D,Nishi SK,Jovanovski E,Zurbau A,Komishon A,Mejia SB,Khan TA,Sievenpiper JL,Milicic D,Jenkins A,Vuksan V

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:To compare retinal arterial bifurcation geometry in normotensive and hypertensive subjects. DESIGN:A retrospective observational study. METHODS:Fluorescein angiograms of normotensive (n = 13) and hypertensive (n = 12) subjects aged 30-80 years with uni-ocular retinal pathology were compared. Quantification ...

journal_title：Journal of hypertension

authors： Stanton AV,Wasan B,Cerutti A,Ford S,Marsh R,Sever PP,Thom SA,Hughes AD

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:To determine adrenocorticotrophin dose-response relationships for increase of blood pressure and metabolic parameters of the Sprague-Dawley rat. METHODS:We injected 120 male Sprague-Dawley rats twice daily subcutaneously for 10 days with 0.5, 1, 5, 50, 100, 200 or 500 microg/kg synthetic adrenocorticotrophin...

journal_title：Journal of hypertension

authors： Turner SW,Wen C,Li M,Fraser TB,Whitworth JA

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVES:Human adrenomedullin precursor is converted to glycine-extended adrenomedullin (AM-Gly), an intermediate inactive form of adrenomedullin. Subsequently, AM-Gly is converted to active form of mature adrenomedullin (AM-m). The aim of the present study was to investigate (i) whether sex or age influences plasma ...

journal_title：Journal of hypertension

authors： Nishikimi T,Horio T,Kohmoto Y,Yoshihara F,Nagaya N,Inenaga T,Saito M,Teranishi M,Nakamura M,Ohrui M,Kawano Y,Matsuo H,Ishimitsu T,Takishita S,Matsuoka H,Kangawa K

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:In this randomized, double-blind, crossover study, the antihypertensive efficacy of amlodipine and nifedipine gastrointestinal therapeutic system (GITS) was compared following missed doses. Design and methods In a randomized crossover design, 42 patients were randomized to receive amlodipine (5-10 mg) or the ...

journal_title：Journal of hypertension

authors： Elliott HL,Elawad M,Wilkinson R,Singh SP

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVES:We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). METHODS:We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HA...

journal_title：Journal of hypertension

authors： Parthasarathy HK,Alhashmi K,McMahon AD,Struthers AD,McInnes GT,Ford I,Connell JM,MacDonald TM

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:The existence and localization of renin in situ was examined in human arteries under non-pathological conditions. DESIGN:Biochemical and immunohistochemical procedures were adopted to examine the existence of renin in human gastroepiploic arteries using an antibody raised against human recombinant renin or a...

journal_title：Journal of hypertension

authors： Okamura T,Aimi Y,Kimura H,Murakami K,Toda N

更新日期：1992-01-01 00:00:00