Subtype diagnosis, treatment, complications and outcomes of primary aldosteronism and future direction of research: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension.

abstract：OBJECTIVE:The inverse association between socioeconomic status (SES) and cardiovascular disease (CVD) risk is well documented. Aortic stiffness assessed by aortic pulse wave velocity (PWV) is a strong predictor of CVD events. However, no previous study has examined the effect of SES on arterial stiffening over time. Th...

journal_title：Journal of hypertension

authors： Trudel X,Shipley MJ,McEniery CM,Wilkinson IB,Brunner EJ

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:The genes responsible for obesity are also candidate genes for obesity-related conditions, such as hypertension and type 2 diabetes. A functional polymorphism in the uncoupling protein 2 (UCP2) promoter has been reported to be associated with obesity in Caucasians. To clarify the contribution of this polymor...

journal_title：Journal of hypertension

authors： Ji Q,Ikegami H,Fujisawa T,Kawabata Y,Ono M,Nishino M,Ohishi M,Katsuya T,Rakugi H,Ogihara T

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:Unlike the 2018 European Society of Cardiology/European Society of Hypertension (ESC/ESH) guideline, the 2017 American College of Cardiology/American Heart Association (ACC/AHA) guideline has recommended a shift in hypertension definition from blood pressure (BP) 140/90-130/80 mmHg. Further, they proposed so...

journal_title：Journal of hypertension

authors： Gijón-Conde T,Sánchez-Martínez M,Graciani A,Cruz JJ,López-García E,Ortolá R,Rodríguez-Artalejo F,Banegas JR

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:This study tests the hypothesis that the transient receptor potential vanilloid subtype 1 channel induced neuropeptide secretion and depressor response are mediated by, at least in part, activation of endoplasmic reticulum associated Ca release receptors, leading to increased cytosolic Ca in dorsal root gangl...

journal_title：Journal of hypertension

authors： Huang W,Wang H,Galligan JJ,Wang DH

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVES:Whether the C-344T polymorphism of the aldosterone synthase gene is important for blood pressure control remains controversial. It has been proposed that an association between this polymorphism and blood pressure might be evident in elderly subjects. The aim of the present study was to test this hypothesis ...

journal_title：Journal of hypertension

authors： Casiglia E,Tikhonoff V,Mazza A,Rynkiewicz A,Limon J,Caffi S,Guglielmi F,Martini B,Basso G,Winnicki M,Pessina AC,Somers VK

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Inflammatory processes may play a pivotal role in the pathogenesis of cerebrovascular injury in salt-loaded, stroke-prone, spontaneously hypertensive rats (SHRSP). Thromboxane A2 (TP) receptor stimulation by 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha) is involved in the process of vascular inflammation. O...

journal_title：Journal of hypertension

authors： Ishizuka T,Niwa A,Tabuchi M,Nagatani Y,Ooshima K,Higashino H

更新日期：2007-04-01 00:00:00

abstract：AIMS:Monocyte/macrophages participate in inflammatory responses that may play an important role in mineralocorticoid-induced vascular damage. We hypothesized that monocyte/macrophages modulate aldosterone effects on oxidative stress, endothelial function, and ultimately vascular stiffness. METHODS:Adult heterozygous o...

journal_title：Journal of hypertension

authors： Leibovitz E,Ebrahimian T,Paradis P,Schiffrin EL

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:In order to optimize cardiovascular risk assessment, we compared the association of common carotid artery intima-media thickness (CCA-IMT) with carotid and/or iliofemoral (C/IF) plaques according to the presence or absence of cardiovascular disease (CVD) and belonging to a high cardiovascular risk group. DES...

journal_title：Journal of hypertension

authors： Tartière JM,Henry OF,Safar H,Bureau JM,Girerd X,Safar ME,Blacher J

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that in the stroke-prone spontaneously hypertensive rat (SHRSP), the pressor effect of selective dietary chloride loading depends on a positive external sodium balance. METHODS:In 43 male SHRSP fed a Japanese style diet containing a low normal amount of NaCl (0.4%), we compared the eff...

journal_title：Journal of hypertension

authors： Schmidlin O,Tanaka M,Sebastian A,Morris RC Jr

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Hyperactivity of the brain renin-angiotensin (Ang) system has been implicated in the development and maintenance of hypertension. AngIII, one of the main effector peptides of the brain renin-Ang system, exerts a tonic stimulatory control over blood pressure (BP) in hypertensive rats. Aminopepti...

journal_title：Journal of hypertension

authors： Marc Y,Hmazzou R,Balavoine F,Flahault A,Llorens-Cortes C

更新日期：2018-03-01 00:00:00

abstract：:The effects of rilmenidine [(N-dicyclopropylmethyl) amino-2-oxazoline; S 3341], an alpha 2 agonist, on the hypertensive rat heart have been compared with those of propranolol, using a model of deoxycorticosterone acetate (DOCA)-salt hypertension. One week after nephrectomy and initial treatment with DOCA-salt, which w...

journal_title：Journal of hypertension

authors： Callens-el Amrani F,Paolaggi F,Swynghedauw B

更新日期：1989-12-01 00:00:00

abstract：OBJECTIVE:To characterize the in vivo vascular properties of the spontaneously hypertensive rat (SHR) renal vascular bed by examining vascular conductance/resistance responsiveness to vasoactive agents in vivo and determining whether the filtration surface area of glomerular capillaries is reduced. DESIGN AND METHODS:...

journal_title：Journal of hypertension

authors： Kett MM,Bergström G,Alcorn D,Bertram JF,Anderson WP

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Anandamide (AEA), one of the endocannabinoid compounds, has an important regulatory function by serving as an autocrine/paracrine or endocrine factor throughout the body via activation of the cannabinoid receptor 1 (CB1) and/or the transient receptor potential vanilloid type 1 (TRPV1) channels. However, the ...

journal_title：Journal of hypertension

authors： Li J,Wang DH

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVES:Several studies have suggested a positive association between serum lipid levels and blood pressure (BP). This study investigated this association in a large population from 12 European countries. METHODS:Data were taken from the European Study on Cardiovascular Risk Prevention and Management in Usual Daily...

journal_title：Journal of hypertension

authors： Borghi C,Rodriguez-Artalejo F,De Backer G,Dallongeville J,Medina J,Guallar E,Perk J,Banegas JR,Tubach F,Roy C,Halcox JP

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of angiotensin II on cyclooxygenase-2 (COX-2) expression in aortic adventitial fibroblasts from normotensive [Wistar-Kyoto (WKY)] rats and spontaneously hypertensive rats (SHRs). METHODS:Protein expression was determined by western blot, mRNA levels by real-time PCR, transcriptional...

journal_title：Journal of hypertension

authors： Beltrán AE,Briones AM,García-Redondo AB,Rodríguez C,Miguel M,Alvarez Y,Alonso MJ,Martínez-González J,Salaices M

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:The objective of the present study was to assess the regression of left ventricular hypertrophy (LVH) during antihypertensive treatment, and its relationship with the changes in microalbuminuria. INDIVIDUALS AND METHODS:One hundred and sixty-eight previously untreated patients with echocardiographic LVH, 46 ...

journal_title：Journal of hypertension

authors： Rodilla E,Pascual JM,Costa JA,Martin J,Gonzalez C,Redon J

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:The role of circadian rhythm of energy and macronutrient intake in influencing cardiometabolic risk factors is increasingly recognized. However, little is known of the association between time of energy intake and blood pressure. We examined the association between time-of-day of energy intake and subsequent...

journal_title：Journal of hypertension

authors： Almoosawi S,Prynne CJ,Hardy R,Stephen AM

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:Hypertension and fractures related to osteoporosis are major public health problems that often coexist. This study examined the associations between exposure to different antihypertensive drug classes and the risk of hip fracture in hypertensive patients. METHOD:We included 59 246 individuals, 50 years and o...

journal_title：Journal of hypertension

authors： Bokrantz T,Schiöler L,Boström KB,Kahan T,Mellström D,Ljungman C,Hjerpe P,Hasselström J,Manhem K

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:Scarce data exist on blood pressure (BP) and secondary effects in young athletes. Hence, we aimed to study prevalence of high BP (≥140/90 mmHg) and the association to arterial compliance, left ventricle mass and left atrium volume. METHODS:A Norwegian preparticipation cardiac screening of male professional ...

journal_title：Journal of hypertension

authors： Berge HM,Gjerdalen GF,Andersen TE,Solberg EE,Steine K

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVES:High blood pressure is known to be associated with higher cardiovascular risk. The emphasis has shifted over time from diastolic pressure to systolic pressure and variability in blood pressure. This study examined the impact of transient and sustained diastolic hypertension on later mortality. METHODS:In th...

journal_title：Journal of hypertension

authors： Peters R,Wells F,Bulpitt C,Beckett N

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Blood pressure (BP) recovery after orthostatic hypotension might be important to prevent cerebral hypoperfusion episodes in older adults, and be related to better clinical outcome. The objective was to study the relationship between BP recovery and clinical outcome, that is physical and cognitive performance,...

journal_title：Journal of hypertension

authors： Mol A,Slangen LRN,van Wezel RJA,Maier AB,Meskers CGM

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:To compare the anti-hypertensive effect of combination therapy versus a single drug regimen schedule (dose-titration or switching to a different drug class) in type 2 diabetic hypertensive patients with inadequate blood pressure (BP) control on monotherapy. DESIGN:Prospective, randomized, open-fashion, paral...

journal_title：Journal of hypertension

authors： Ruilope LM,de la Sierra A,Moreno E,Fernández R,Garrido J,de la Figuera M,de la Cámara AG,Coca A,Luque-Otero M

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:Reduction in capillary density or rarefaction is a hallmark of essential hypertension. We measured the retinal capillary density using noninvasive optical coherence tomographic angiography (OCT-A) in adults with treated systemic hypertension and determined possible correlations with ambulatory blood pressure ...

journal_title：Journal of hypertension

authors： Chua J,Chin CWL,Hong J,Chee ML,Le TT,Ting DSW,Wong TY,Schmetterer L

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:Stroke is elevated in people of black African descent, but evidence for excess subclinical cerebrovascular disease is conflicting, and the role of risk factors in determining any ethnic differences observed unexplored. METHODS:We compared prevalence of brain infarcts, and severe white matter hyperintensitie...

journal_title：Journal of hypertension

authors： Shibata D,Tillin T,Beauchamp N,Heasman J,Hughes AD,Park C,Gedroyc W,Chaturvedi N

更新日期：2013-12-01 00:00:00

abstract：INTRODUCTION:Combination therapy is needed to control blood pressure (BP) in a large number of hypertensive patients with diabetes mellitus. Adherence to treatment is a major clinical problem; therefore, the time duration of the antihypertensive action of a drug determines BP control when a dose is skipped. OBJECTIVES...

journal_title：Journal of hypertension

authors： Redon J,Pichler G,Missed Dose Study Group.

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:To compare the effects of the angiotensin II receptor antagonist candesartan with the angiotensin-converting enzyme inhibitor enalapril on myocardial fibrosis evaluated by echoreflectivity analysis. METHODS:Hypertensive patients (n = 196) with echocardigraphically documented left ventricular hypertrophy were...

journal_title：Journal of hypertension

authors： Ciulla MM,Paliotti R,Esposito A,Cuspidi C,Muiesan ML,Rosei EA,Magrini F,Zanchetti A

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:Studies in genetically hypertensive rats and their normotensive Wistar-Kyoto control rats have revealed a linkage of a chromosomal region containing the angiotensin converting enzyme (ACE) gene with blood pressure. This led to the hypothesis that ACE is a possible candidate gene for primary hypertension in hu...

journal_title：Journal of hypertension

authors： Schmidt S,van Hooft IM,Grobbee DE,Ganten D,Ritz E

更新日期：1993-04-01 00:00:00

abstract：OBJECTIVE:To test whether angiotensin II (Ang II) through the Ang II type 2 receptor (AT2R), downregulates RhoA/Rho kinase, which plays a role in AT1 receptor (AT1R)-mediated function. METHODS:In vitro studies were performed in A10 vascular smooth muscle cells (VSMC) and in vivo studies in mesenteric arteries from Wis...

journal_title：Journal of hypertension

authors： Savoia C,Tabet F,Yao G,Schiffrin EL,Touyz RM

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVES:Retinal blood vessels may develop vasculopathy and apoptosis in response to hypertension. The present study was aimed at testing the role of losartan, a specific antagonist of angiotensin II receptor type 1 receptor in regulation of vascular apoptosis in retinal vasculature with hypertension. METHODS:Losart...

journal_title：Journal of hypertension

authors： Yang D,Zhang M,Huang X,Fang F,Chen B,Wang S,Cai J,Shi X,Qu J,Geng YJ

更新日期：2010-03-01 00:00:00

abstract：:The postulated antihypertensive effect of dietary fish oil and the influence of dietary sodium on this effect were evaluated in young stroke-prone spontaneously hypertensive rats (SHRSP) by direct intra-arterial measurement of blood pressure. Weaning rats were fed synthetic diets containing olive oil or eicosapentaeno...

journal_title：Journal of hypertension

authors： Howe PR,Lungershausen YK,Rogers PF,Gerkens JF,Head RJ,Smith RM

更新日期：1991-07-01 00:00:00