Abstract:
OBJECTIVE:To determine whether taurine reduces blood pressure by stimulating the renal kallikrein-kinin system. METHODS:The effects of taurine on blood pressure, urinary kallikrein activity and renal kallikrein gene expression were investigated in Dahl salt-sensitive (Dahl-S) rats. The specificity of the action of taurine was verified by comparison with the action of beta-alanine, a carboxylic analogue of taurine. The effect of co-administration of the specific bradykinin B2 receptor antagonist Hoe 140 was also examined. RESULTS:Administration of taurine (3% in drinking water) for 4 weeks retarded the development of salt (4% sodium chloride diet)-induced hypertension. Systolic blood pressure at the end of the experiment was significantly higher in control rats than in taurine-treated rats. Urinary sodium excretion was not decreased by the reduction in blood pressure. The heart weight:body weight ratio was significantly lower, and urinary volume and kallikrein excretion were significantly higher, in taurine-treated rats. Renal kallikrein gene expression at weeks 1 and 4 was higher in taurine-treated rats. Systolic blood pressure 3 and 4 weeks after the administration of beta-alanine was slightly, but not significantly, lower than that of untreated rats on a high-salt diet, and was accompanied by a significantly lower body weight. Urinary kallikrein excretion decreased with a high-salt diet regardless of beta-alanine administration. Continuous systemic administration of Hoe 140 did not cause any significant alteration in blood pressure in Dahl-S rats that received taurine with a high-salt diet. Taurine also showed a renoprotective effect, as judged by a reduction in proteinuria. CONCLUSION:These results suggest that taurine is an effective antihypertensive agent for salt-induced hypertension. Although taurine activated renal kallikrein, further studies are required to confirm the participation of activated kallikrein in the antihypertensive, cardioprotective and renoprotective effects of taurine.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Ideishi M,Miura S,Sakai T,Sasaguri M,Misumi Y,Arakawa Ksubject
Has Abstractpub_date
1994-06-01 00:00:00pages
653-61issue
6eissn
0263-6352issn
1473-5598journal_volume
12pub_type
杂志文章abstract:OBJECTIVE:To study the association of physician's sex with blood pressure, lipid control, and cardiovascular risk factors in treated hypertensive men and women, stratified for the sex of their physician. METHODS:In a cross-sectional survey of hypertensive patients, 264 primary care physicians (PCPs), 187 men and 77 wo...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32830a4a3b
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:We investigated the responses of mean arterial pressure and renal blood flow to intravenous and intrarenal angiotensin II, plasma and kidney angiotensin II concentrations and renal angiotensin receptor subtype 1 protein expression, and renal functional responses to intravenous and intrarenal angiotensin recep...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000174972.46663.5e
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:Blood pressure (BP) increases both in winter and in the last trimester of pregnancy. Some interaction seems to exist between season and gestational age. The present study observed home BP values during pregnancy with adjustment for seasonal variation and gestational age. METHODS:We observed 10353 home BP mea...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32831364a7
更新日期:2008-12-01 00:00:00
abstract:AIMS:In order to eventually improve blood pressure (BP) management, the aim of this study was to identify subgroups of type 2 diabetes mellitus (T2DM) patients with distinct trajectories of SBP levels. Identifying subgroups with distinct SBP trajectories helps to better understand the course of SBP levels in T2DM patie...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000680
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:Blood pressure (BP) measurement in atrial fibrillation (AF) patients is problematic and automated monitors are regarded as inaccurate. The optimal procedure for validating BP monitors in AF is questionable. This study evaluated the accuracy of a novel professional oscillometric upper-arm cuff device (Microli...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002684
更新日期:2020-10-16 00:00:00
abstract:OBJECTIVE:This study analyzed regional differences in blood pressure (BP) distribution and management in Germany 2008-2011 in a nationwide study. METHODS:The analyses were based on standardized BP measurements and anatomical therapeutic chemical classification-coded medication from the population-based German Health I...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000211
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism-related differences in ACE concentration do not result in differences in angiotensin levels. METHODS AND RESULTS:To investigate whether this relates to differences in the contribution of the ACE C-domain and N-domain, we quantified, u...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3282f465d2
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Genome-wide scans from Italy and China suggest a hypertension-susceptible locus between D2S2278 (nucleotides 11,245,080 - 11,245,358) and D2S168 (nucleotides 11,467,214 - 11,467,422) on chromosome 2. METHODS:We performed a large association study of polymorphisms in this region with blood pressure modulatio...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000166835.70935.3c
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Uncontrolled hypertension notwithstanding the use of at least three drugs or hypertension controlled with at least four drugs, the widely accepted definition of treatment-resistant hypertension (TRH), is considered as a common problem in the hemodialysis population. However, to date there is no estimate of t...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002448
更新日期:2020-09-01 00:00:00
abstract::Reduction of large artery distensibility has several adverse consequences for the cardiovascular system. This paper reviews the evidence obtained by measuring distensibility through quantification of changes in arterial diameter versus blood pressure changes at large elastic and middle size muscle artery sites. Eviden...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/00004872-200210000-00001
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:Hemodialysis patients have a cardiovascular mortality rate of 20-40 times that of the general population. Aldosterone inhibition by spironolactone has exerted beneficial, prognostically significant cardiovascular effects in patients with heart failure maintained on hemodialysis or peritoneal dialysis. Our ai...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章
doi:10.1097/HJH.0b013e32835f955c
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Little data is available concerning the prognostic implications of renal function abnormalities, their evolution over time and the effects of nifedipine on such abnormalities in patients with stable angina pectoris. METHODS:The previously published ACTION trial compared long-acting nifedipine GITS 60 mg onc...
journal_title:Journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1097/HJH.0b013e3281c49d93
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVES:To determine whether vigorous exercise and alcohol restriction have additive and independent effects in reducing blood pressure in sedentary male alcohol drinkers. Also to assess whether 4 weeks of vigorous exercise could offset the fall in high-density lipoprotein cholesterol (HDL-cholesterol) usually obser...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004872-199302000-00012
更新日期:1993-02-01 00:00:00
abstract::Genetic factors in essential hypertension: Studies of the epidemiology of blood pressure indicate that genetic factors are part of the pathogenesis of human essential hypertension, raising the possibility of identifying these genes. This may provide unique opportunities to elucidate the pathophysiology of hypertension...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/00004872-199303000-00002
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:The oral contraceptive pill (OCP) is widely prescribed throughout the world. Although it is associated with a small but significant increase in blood pressure, the influence of the OCP on large artery stiffness and wave reflection is unclear. The aim of this study was to determine the relationship between us...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328346a5af
更新日期:2011-06-01 00:00:00
abstract::The response of blood pressure, heart rate and plasma catecholamines to a mental arithmetic and a cold pressor test was studied in 70 patients with mild essential hypertension and in 41 age- and sex-matched normotensives. Each group consisted of three prospectively stratified age classes: 20-29, 30-39 and 40-55 years....
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract:OBJECTIVE:The pathogenesis of atherosclerosis, a chronic inflammatory disease, is influenced by the renin-angiotensin system and especially by angiotensin II subtype 1 (AT1) receptor activation. Although pro-inflammatory properties of angiotensin II as well as anti-inflammatory effects of AT1 receptor antagonists are w...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000242415.73406.17
更新日期:2006-09-01 00:00:00
abstract::The concentrations of neuropeptide Y immunoreactivity (NPY-ir) were measured in the cortex and cervical, thoracic and lumbar spinal cord of 8-, 18- and 31-week-old normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). This peptide was measured using a highly sensitive and specific radio-immun...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198608000-00012
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:The use of thiazide diuretics in the treatment of hypertension is widely considered as a first-line treatment, given the efficacy and low cost of this class of drugs. This indication is not unanimous, because thiazides can cause metabolic alterations, and other side effects that reduce compliance and persist...
journal_title:Journal of hypertension
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/HJH.0b013e328353398b
更新日期:2012-06-01 00:00:00
abstract::Exogenous sex hormone use, including oral contraceptives, post-menopausal hormonal therapy and anabolic steroids, has been associated with blood pressure changes in both sexes, but little is known about the relationship between blood pressure and endogenous sex hormones. We examined this relationship in men in the Ran...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:Childhood hypertension is an established predictor of adult hypertension and organ damage, an underestimated problem in developing countries. The aim of the study was to assess the prevalence of arterial hypertension, as well as the relationship of blood pressure values and weight class and urinary abnormali...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3283407fe3
更新日期:2011-02-01 00:00:00
abstract:CONTEXT:There is a growing prevalence of cardiovascular disease (CVD) risk factors in West Africa and among its migrants to industrialized countries. Despite this, no study has reviewed CVD risk factor prevalence among West Africans in Africa and industrialized countries. OBJECTIVE:To appraise studies on the prevalenc...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/HJH.0000000000000061
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVES:A previous history of hypertension is overrepresented among patients with ischaemic heart disease. The present study aims at describing the influence of a previous history of hypertension upon the prognosis among patients hospitalized due to acute myocardial infarction. DESIGN:Patients were followed for 1 y...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199210000-00022
更新日期:1992-10-01 00:00:00
abstract::The effect of xipamide on the intracellular concentration and transmembrane fluxes of Na+ and K+ was studied in 12 normal male subjects, using a double-blind cross-over design. After a run-in period on placebo for 1 week, the subjects were treated with either placebo (n = 6) or xipamide 20 mg once a day (n = 6) for 16...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004872-198808000-00007
更新日期:1988-08-01 00:00:00
abstract::This study determined the influence of baroreflex sensitivity (BRS) on the rate of urinary sodium excretion and plasma renin activity (PRA) in response to a saline infusion in conscious male rabbits specifically bred for high (Group I; n = 7) and low (Group II; n = 10) BRS and in seven control animals. Only Group II s...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199109000-00005
更新日期:1991-09-01 00:00:00
abstract:OBJECTIVES:To examine the health risks associated with smoking and blood pressure in Chinese hypertensive patients and to compare the benefit of antihypertensive drug treatment with the risk attributable to smoking. METHODS:We used multiple Cox regression to correlate outcome with blood pressure and smoking status in ...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章
doi:10.1097/00004872-200102000-00004
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:To assess the dilatory effectiveness of nitric oxide donors in resistance arteries of patients with arterial hypertension in comparison with that in those of normotensive controls. BACKGROUND:Endothelium-dependent vasodilation has been demonstrated to be impaired in arterial hypertension. Besides disturbance...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199607000-00014
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:Normotensive rats fed a high fructose diet (HFD) develop hypertriglyceridemia, hyperinsulinemia and hypertension. The glomerular changes observed in the kidneys of these animals are similar to those observed in diabetic rats. The aim of this study was to evaluate whether lacidipine could be effective not only...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199917070-00013
更新日期:1999-07-01 00:00:00
abstract::Two formulations of felodipine, conventional and extended release (ER) tablets, were compared in a double-blind, crossover study of patients whose blood pressure was not being controlled using metoprolol 100 mg once daily. Nineteen patients with a supine diastolic blood pressure greater than or equal to 95 mmHg after ...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.1097/00004872-198908000-00008
更新日期:1989-08-01 00:00:00
abstract:OBJECTIVE:To determine the degree to which hypertension is a risk factor for macrovascular and microvascular complications in type 2 diabetes. DESIGN:Observational prospective study. SUBJECTS:Newly diagnosed Type 2 diabetic patients recruited into the UK Prospective Diabetes Study (n = 3648; mean age 52 years), 40% o...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199303000-00013
更新日期:1993-03-01 00:00:00