Abstract:
:The concentrations of neuropeptide Y immunoreactivity (NPY-ir) were measured in the cortex and cervical, thoracic and lumbar spinal cord of 8-, 18- and 31-week-old normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). This peptide was measured using a highly sensitive and specific radio-immunoassay (RIA) developed in our laboratory. The concentrations of NPY-ir in the cortex, cervical and thoracic spinal cord were significantly different between the two strains, with the levels being consistently lower in the SHR strain independent of age. While there was no obvious change in the levels of NPY-ir in the cortex with increasing age, there was a general trend for the levels to fall in all three spinal cord regions. The rate of decrease of NPY-ir in the thoracic spinal cord appeared greater in the SHR compared with the WKY rats. These biochemical differences observed in the cortex and thoracic spinal cord of SHR and WKY rats may be related to the behavioural and blood pressure differences observed in these strains.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Maccarrone C,Jarrott Bdoi
10.1097/00004872-198608000-00012subject
Has Abstractpub_date
1986-08-01 00:00:00pages
471-5issue
4eissn
0263-6352issn
1473-5598journal_volume
4pub_type
杂志文章abstract:OBJECTIVE:Studies were undertaken to clarify the pathophysiologic significance of endogenous endothelin in the control of blood pressure and renal hemodynamics in spontaneously hypertensive rats (SHR). DESIGN:The technique of passive immunization was used to neutralize endogenous endothelin in order to estimate the co...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract:OBJECTIVE:Visceral artery fibromuscular dysplasia (VA FMD) manifestations range from asymptomatic to life-threatening. The aim of the study is to evaluate the prevalence and clinical characteristics of VA FMD. METHODS:A total of 232 FMD patients enrolled into ongoing ARCADIA-POL study were included in this analysis. A...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002327
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to define the relationship between physical activity and the magnitude of the percentage fall in blood pressure at night (nocturnal dip). METHODS:We simultaneously monitored 24-h ambulatory blood pressure and measured physical activity by actigraphy in 434 patients. Blood pressure w...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200018040-00008
更新日期:2000-04-01 00:00:00
abstract:AIMS:Arterial hypertension is highly prevalent and difficult to control in patients with obstructive sleep apnea (OSA). High sympathoadrenergic activity is a hallmark physiological phenomenon in OSA. We hypothesized that an antihypertensive drug with inhibitory properties on this activity, such as beta blockers (BBs), ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002629
更新日期:2021-02-01 00:00:00
abstract::Fenoldopam, a dopamine-1 (D1) agonist, was administered by a 6-h intravenous infusion to patients with refractory hypertension [diastolic blood pressure (DBP) greater than 115 mmHg while on triple therapy] in order to achieve a fall in DBP of 30 mmHg. The evolution of blood pressure, heart rate, glomerular filtration ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198808000-00010
更新日期:1988-08-01 00:00:00
abstract:OBJECTIVES:To discuss changes during the past decades in the prevalence and in the patterns of detection, treatment and control of arterial hypertension in the general Belgian population aged 25-64 years. DESIGN:Data from two cross-sectional cardiovascular disease risk factor surveys of the general population aged 25-...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199816030-00004
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:Aldosterone is produced in the ventricle of patients with hypertension. The present study was designed to examine whether adrenocorticotropic hormone (ACTH) and cortisol are also produced from the heart in patients with essential hypertension. METHODS:The study population consisted of 57 patients with essent...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200502000-00024
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:To ascertain the relationships between the kinetic properties of erythrocyte Na+-H+ exchange [maximum kinetic energy (Vmax), Michaelis constant (Km) for internal H+ and Hill's coefficient], Na+-Li+ (Vmax and Km for external Na+), and metabolic parameters in normotensive controls and hypertensive subjects. MA...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract::Left ventricular hypertrophy (LVH), despite its adaptive nature, increases cardiovascular morbidity and mortality. Novel approaches for protection against pathological heart remodelling are presented in this supplement. Melatonin diminishes myocardial fibrosis in rats exposed to continuous light and N-nitro-L-arginine...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000388487.43460.db
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to investigate possible inter-relationships between connective tissue growth factor (CTGF) and aldosterone in vascular and renal damage associated with hypertension. METHOD:Spontaneously hypertensive rats (SHR) were treated with two doses (100 and 30 mg/kg per day) of the min...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3280112ce5
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:We investigated to what extent anthropometric and lifestyle factors contributed to the classification of Chinese individuals into groups with white-coat, masked and sustained hypertension (HT). METHODS:We measured the office and ambulatory blood pressure (BP) in 694 Chinese enrolled in the JingNing populatio...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3282efeee7
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Elevated plasma glucocorticoid level is an independent predictor of increased mortality risk in chronic heart failure, but local biosynthesis and pathophysiological roles of glucocorticoids in the heart remain unclear. METHODS:Dahl salt-sensitive rats on high-salt diet and mice with transthoracic aortic ban...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328326cb04
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Obstructive sleep apnea (OSA) may lead to the development of hypertension and therapy with continuous positive airway pressure (CPAP) can promote reduction in blood pressure. OBJECTIVE:The objective of this study is to review systematically the effects of CPAP on blood pressure in patients with OSA. METHOD...
journal_title:Journal of hypertension
pub_type: 杂志文章,meta分析,评审
doi:10.1097/HJH.0000000000000250
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:The existence and localization of renin in situ was examined in human arteries under non-pathological conditions. DESIGN:Biochemical and immunohistochemical procedures were adopted to examine the existence of renin in human gastroepiploic arteries using an antibody raised against human recombinant renin or a...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199201000-00008
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Comprehensive studies have confirmed that particulate matter air pollution could trigger myocardial infarction, heart failure and reduce heart rate variability; however, its effect on blood pressure (BP) remains controversial. Therefore, we did a systematic review and meta-analysis to investigate the associa...
journal_title:Journal of hypertension
pub_type: 杂志文章,meta分析,评审
doi:10.1097/HJH.0000000000000342
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:Considering the growing body of evidence that indicates the contribution of superoxide anions (O2) and other reactive oxygen species (ROS) to the development of hypertension, we assessed whether animal models of hypertension have a benefic effect with tempol, a superoxide dismutase mimetic, to help augment th...
journal_title:Journal of hypertension
pub_type: 杂志文章,meta分析,评审
doi:10.1097/HJH.0000000000000422
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Excess dietary sodium has been linked to the development of hypertension and other cardiovascular diseases. In humans, the effects of sodium consumption on endothelial function have not been separated from the effects on blood pressure. The present study was designed to determine if dietary sodium intake aff...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32835c6ca8
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To verify the benefit of renin-angiotensin system blockade in hypertension, the effects of 24 weeks' losartan and ramipril treatment, both alone and in combination, on urinary albumin excretion (UAE) and circulating transforming growth factor beta1 (TGF beta1) have been evaluated in hypertensive subjects with...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.hjh.0000160225.01845.26
更新日期:2005-03-01 00:00:00
abstract::Genetic factors in essential hypertension: Studies of the epidemiology of blood pressure indicate that genetic factors are part of the pathogenesis of human essential hypertension, raising the possibility of identifying these genes. This may provide unique opportunities to elucidate the pathophysiology of hypertension...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/00004872-199303000-00002
更新日期:1993-03-01 00:00:00
abstract:OBJECTIVE:To investigate the role of the renal medulla in early hypertension in spontaneously hypertensive rats (SHR), and to explore whether the attenuated increase of pressure induced by enalapril treatment is affected by chemical medullectomy. DESIGN:Forty-four male SHR were studied from 5 to 18 weeks of age: 22 re...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199211000-00006
更新日期:1992-11-01 00:00:00
abstract:OBJECTIVES:The goal of this study was to compare the cardiovascular responses to behavioural stressors of three groups of adolescents who differed in blood pressure status across assessments. DESIGN:Casual blood pressure of adolescents who were identified as having elevated blood pressure during a school screen was re...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200101000-00003
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:Elevated blood pressure (BP) is associated with cardiovascular mortality. BP variability (BPV) is also associated with cardiovascular mortality. However, most studies evaluated hypertensive patients with a relatively short follow-up. We investigated in male workers the association between BPV and long-term al...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002447
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the prognostic significance of cardiovascular risk factors including 24-h ambulatory blood pressure level and rhythm for all-cause mortality in type 2 diabetic patients. METHODS:In a prospective observational study, 104 patients with type 2 diabetes were followed: 51 patients with diabetic nephro...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3282f06428
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:A recent editorial published by Verma and Strauss, entitled 'Angiotensin receptor blockers and myocardial infarction', examined, through a partial analysis of individual trials, the use of angiotensin receptor blockers (ARBs) in a variety of clinical settings. This editorial was reported widely in the lay pr...
journal_title:Journal of hypertension
pub_type: 杂志文章,meta分析,评审
doi:10.1097/01.hjh.0000194114.12228.16
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:To assess the contribution of the sympathetic nervous system to the hypertension in patients with longstanding essential hypertension. DESIGN:Overall sympathetic function, presynaptic adrenoceptors and neuronal re-uptake were examined after withdrawal of medication for at least 3 weeks in eight patients with...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVES:To investigate the mechanism of angiotensin II-induced apoptosis in cultured cardiomyocytes by determining which receptor subtype is involved, and what is the relationship between intracellular Ca2+ changes and apoptosis. DESIGN AND METHODS:Neonatal rat cardiomyocytes were pretreated with either the AT1 ant...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200109000-00022
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:Transport activities of cardiac sodium-calcium exchange and sarcoplasmic reticulum calcium ATPase were measured biochemically in spontaneously hypertensive rats (SHR) with hypertrophied myocardium and in normotensive Wistar-Kyoto (WKY) rats and it was tested whether possible differences have consequences for ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199511000-00014
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVE:We examined the effects of treatment with soluble epoxide hydrolase inhibitor (sEHi) and epoxyeicosatrienoic acids (EETs) analogue (EET-A), given alone or combined, on blood pressure (BP) and ischemia/reperfusion myocardial injury in rats with angiotensin II (ANG II)-dependent hypertension. METHODS:Ren-2 tra...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001708
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:Studies have shown that famine exposure during early life may increase the risk of cardiovascular disease (CVD), hypertension, and diabetes during adulthood. We aimed to assess whether exposure to the Chinese famine (1959-1961) modifies the association between hypertension and CVD. METHODS:We investigated da...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001496
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:Left atrial (LA) enlargement is an index of adverse cardiovascular events. We sought to investigate any possible correlation between haemodynamic load, neurohumoral factors and LA size in the early stages of essential hypertension. METHODS:We studied 94 consecutive middle-aged subjects, with newly diagnosed ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000222768.15100.00
更新日期:2006-05-01 00:00:00