Genotypes of sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase II gene in substrains of spontaneously hypertensive rats.

abstract：BACKGROUND:A cardiac angiotensin II-generating system has been suspected to be involved in various cardiac pathological conditions. Both angiotensin converting enzyme and human chymase can convert angiotensin I to angiotensin II. OBJECTIVE:To clarify the relative contributions of these two enzymatic pathways to angiot...

journal_title：Journal of hypertension

authors： Ohmichi N,Iwai N,Kinoshita M

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:The repair process at the site of injury after percutaneous coronary intervention (PCI) is dominated by neointimal formation composed mainly of smooth muscle cells (SMC). Endothelin-1 (ET-1) is a powerful vasoconstrictor and SMC mitogen. Endothelin-converting enzyme (ECE) is the final key enzyme of endothelin...

journal_title：Journal of hypertension

authors： Shirai N,Naruko T,Ohsawa M,Ikura Y,Sugama Y,Hirayama M,Kitabayashi C,Ehara S,Inoue T,Itoh A,Haze K,Tanzawa K,Yoshiyama M,Yoshikawa J,Ueda M

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:Reversibility of the systemic and renal alterations induced by N(omega)-nitro-L-arginine-methyl ester(L-NAME) was assessed by treatment with irbesartan and enalapril (30 and 10 mg/kg per 24 h, respectively) alone or in combination. DESIGN:L-NAME (20 mg/kg per 24 h) was given to rats for 6 weeks and treatment...

journal_title：Journal of hypertension

authors： Jover B,Herizi A,Casellas D,Mimran A

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVES:Previous studies have demonstrated that the time rate of blood pressure (BP) variation was associated with early carotid atherosclerosis, independent of peripheral and central BP levels. We evaluated the association between the rate of BP variation, derived from ambulatory BP monitoring (ABPM) data analysis,...

journal_title：Journal of hypertension

authors： Manios E,Stamatelopoulos K,Tsivgoulis G,Barlas G,Koroboki E,Tsagalis G,Michas F,Vemmos K,Zakopoulos N

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:The effects of salt intake on renal regulation have been investigated for decades. To find new pathways and to demonstrate the utility of oligonucleotide expression arrays, we studied whole kidneys. METHODS:Eight Sprague-Dawley rats were divided into two groups. One group received a 6% salt (by weight) diet...

journal_title：Journal of hypertension

authors： Barta P,Monti J,Maass PG,Gorzelniak K,Müller DN,Dechend R,Luft FC,Hübner N,Sharma AM

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVE:We examined the effects of a calcium antagonist and an angiotensin converting enzyme (ACE) inhibitor on contractile and non-contractile protein metabolism and cardiac function in a monocrotaline-induced right ventricular hypertrophy model, in order to define the effects of these drugs on cardiac hypertrophy. ...

journal_title：Journal of hypertension

authors： Tanaka K,Honda M,Kuramochi T,Hashimoto M,Masumura S,Mansoor AM,Ishikawa S,Morioka S

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Poor adherence to treatment is one of the major problems in the treatment of hypertension. Self blood pressure measurement may help patients to improve their adherence to treatment. METHOD:In this prospective, randomized, controlled study coordinated by a university hospital, a total of 228 mild-to-moderate...

journal_title：Journal of hypertension

authors： van Onzenoort HA,Verberk WJ,Kroon AA,Kessels AG,Nelemans PJ,van der Kuy PH,Neef C,de Leeuw PW

更新日期：2010-03-01 00:00:00

abstract：AIM:Advanced age is associated with vascular endothelial dysfunction, characterized by reductions in the endothelium-dependent vasodilation of the conduit and resistance arteries, in part, from decreased nitric oxide bioavailability. Although vascular smooth muscle function (SMF), assessed by responsiveness to an exoge...

journal_title：Journal of hypertension

authors： Montero D,Pierce GL,Stehouwer CD,Padilla J,Thijssen DH

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of hypertension and diabetes mellitus on vascular albumin permeability and hypertrophy in 11-week-old Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) with and without 3 weeks of streptozotocin-induced diabetes. METHODS:Vascular albumin permeability was measured as...

journal_title：Journal of hypertension

authors： Hulthén UL,Rumble J,Cooper ME,Johnston CI

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:To investigate the role of the renal medulla in early hypertension in spontaneously hypertensive rats (SHR), and to explore whether the attenuated increase of pressure induced by enalapril treatment is affected by chemical medullectomy. DESIGN:Forty-four male SHR were studied from 5 to 18 weeks of age: 22 re...

journal_title：Journal of hypertension

authors： Bergström G,Bohman SO,Folkow B,Göthberg G,Rudenstam J,Karlström G

更新日期：1992-11-01 00:00:00

abstract：DESIGN AND METHODS:Levels of dietary and serum potassium are thought to correlate inversely with vascular resistance and blood pressure. This study examined renal vascular resistance in perfused rat kidneys partially preconstricted with 10 micromol/ phenylephrine, quantifying changes in the resistance when levels of po...

journal_title：Journal of hypertension

authors： Murphy ME,Cohen DB

更新日期：1999-10-01 00:00:00

abstract：:Hypertensive disease is known to increase the risks in connection with acute changes in blood pressure due to the presence of pronounced structural as well as functional changes in the cardiovascular system. In the present study the metabolic consequences of fixed haemorrhagic hypotension [mean arterial pressure (MAP)...

journal_title：Journal of hypertension

authors： Wennberg E,Hagberg H,Haljamäe H,Johansson BB

更新日期：1983-10-01 00:00:00

abstract：OBJECTIVE:Blood pressure (BP) load, defined as the percentage of abnormally elevated BP readings, is usually provided on the report of ambulatory BP monitoring. However, the usefulness of BP load is still uncertain. In the present study, we examined whether BP load would be associated, independently of BP level, with t...

journal_title：Journal of hypertension

authors： Liu M,Li Y,Wei FF,Zhang L,Han JL,Wang JG

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Sleep-disordered breathing, predominantly obstructive sleep apnea (OSA), is highly prevalent in patients with hypertension. OSA may underlie the progression to resistant hypertension, partly due to increased activation of the sympathetic nervous system. This analysis of patients with and without OSA evaluate...

journal_title：Journal of hypertension

authors： Linz D,Mancia G,Mahfoud F,Narkiewicz K,Ruilope L,Schlaich M,Kindermann I,Schmieder RE,Ewen S,Williams B,Böhm M,Global SYMPLICITY Registry Investigators.

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:To determine whether automated blood pressure measuring devices can measure blood pressure accurately in patients with atrial fibrillation. DESIGN:Comparison of the accuracy of two electronic sphygmomanometers [Takeda UA-751 (Takeda) and Copal UA-251 (Copal)] and two ambulatory blood pressure monitors [Accut...

journal_title：Journal of hypertension

authors： Stewart MJ,Gough K,Padfield PL

更新日期：1995-03-01 00:00:00

abstract：:The hormonal and hypotensive effects of a single oral 10 mg dose of enalapril (MK-421), were assessed by a double-blind randomized trial in 12 subjects with essential hypertension, during a 100 and 40 mmol/day sodium intake. Peak serum MK-421 appeared 1 h following oral dosage. The bioactive conversion product of MK-4...

journal_title：Journal of hypertension

authors： Jackson B,Cubela R,Johnston CI

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:Fibromuscular dysplasia (FMD) and atherosclerotic renal artery stenosis (ARAS) are the most common causes of renovascular hypertension. So far, FMD is believed to cause hypertension via similar mechanisms as in ARAS, that is, a decrease in renal blood flow, which subsequently leads to increased renin secreti...

journal_title：Journal of hypertension

authors： van Twist DJ,Houben AJ,de Haan MW,de Leeuw PW,Kroon AA

更新日期：2017-04-01 00:00:00

abstract：:A unique tissue kallikrein-binding protein was identified and partially characterized in the brain and serum of Sprague-Dawley rats and in the serum-free conditioned media of mouse anterior pituitary cells (AtT 20) and rodent neuroblastoma x glioma hybrids (NG108-15). Kallikrein and kallikrein-binding protein(s) form ...

journal_title：Journal of hypertension

authors： Chao J,Chao L

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:To examine a possible involvement of a regulatory protein of Na+/H+ exchanger (NHE) in the increased renal NHE activity in spontaneously hypertensive rats (SHR), we investigated mRNA expression of inhibitory members of the NHE regulatory protein family, NHERF1 and NHERF2, in the kidney. DESIGN:Prehypertensiv...

journal_title：Journal of hypertension

authors： Kobayashi K,Monkawa T,Hayashi M,Saruta T

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:It has been shown that nitric oxide (NO) plays an important role in the central control of arterial pressure and sympathetic nerve activity. The aim of this study was to determine whether NO can regulate sympathetic nerve activity by an action on pressor neurons within the rostral part of the ventrolateral me...

journal_title：Journal of hypertension

authors： Hirooka Y,Polson JW,Dampney RA

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Angiotensin II causes hypertension not only by direct constriction of vascular smooth muscle, but also by facilitating the release of noradrenaline from sympathetic terminals and by enhancing vascular noradrenaline sensitivity. AT1 receptor antagonists attenuate all these actions, but display some evidence o...

journal_title：Journal of hypertension

authors： Dendorfer A,Dominiak P,Tempel K,Raasch W

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:To evaluate endothelium-dependent vascular function in obstructive sleep apnoea patients. DESIGN AND METHODS:Forearm blood flow and vascular resistance were studied in eight normotensives and eight obstructive sleep apnoea patients and also in eight normotensive and eight hypertensive controls after graded b...

journal_title：Journal of hypertension

authors： Carlson JT,Rångemark C,Hedner JA

更新日期：1996-05-01 00:00:00

abstract：:Hypertension is the most prevalent chronic medical condition and a major risk factor for cardiovascular morbidity and mortality. In the majority of hypertensive cases, the underlying cause of hypertension cannot be easily identified because of the heterogeneous, polygenic and multi-factorial nature of hypertension. Me...

journal_title：Journal of hypertension

authors： Nikolic SB,Sharman JE,Adams MJ,Edwards LM

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:When assessing arterial stiffness, heart rate (HR) and blood pressure (BP) are potential confounders. It appears that the HR/BP dependences of pulse wave velocity (PWV) and distensibility are different, even though both assess arterial stiffness. This study aims to compare aortic PWV as measured using pulse ...

journal_title：Journal of hypertension

authors： Spronck B,Tan I,Reesink KD,Georgevsky D,Delhaas T,Avolio AP,Butlin M

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:To determine prevalence, awareness, treatment, and control of hypertension, and its risk factors in an urban Korean population. DESIGN AND SETTING:A cross-sectional survey in Ansan-city, Korea. SUBJECTS AND METHODS:Population-based samples of people aged 18-92 years in Ansan-city, Korea, were selected, yie...

journal_title：Journal of hypertension

authors： Jo I,Ahn Y,Lee J,Shin KR,Lee HK,Shin C

更新日期：2001-09-01 00:00:00

abstract：:BMI represents an internal metabolic and physiological environment that plays a key role in development of high blood pressure (BP) for many Americans. African-American women have a higher prevalence of high BP and being overweight than men or other ethnic groups. This study examines the genetic-environmental interact...

journal_title：Journal of hypertension

authors： Taylor J,Sun YV,Chu J,Mosley TH,Kardia SL

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Recent reports have demonstrated increased cardiac risk, and an association with essential hypertension in patients with panic disorder. The cause is not known, but possibly involves sympathetic nervous activation. In this study, we evaluated the arterial baroreflex control of vascular sympathetic nervous ou...

journal_title：Journal of hypertension

authors： Lambert EA,Thompson J,Schlaich M,Laude D,Elghozi JL,Esler MD,Lambert GW

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine whether antioxidant therapy could relieve hypertension and retard the progression of renal damage in advanced-stage hypertensive rats. METHODS:Twenty-four-week-old spontaneously hypertensive stroke-prone rats were treated for 8 weeks with the superoxide dismutase mimeti...

journal_title：Journal of hypertension

authors： Sugama I,Kohagura K,Yamazato M,Nakamura T,Shinzato T,Ohya Y

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Widely evaluated regarding the genetic make-up of essential hypertension are the renin-angiotensin-aldosterone system (RAAS) genes polymorphisms, whereas results are often not reproducible. METHOD:We thus focused on a large Fangshan population to explore association of thirteen polymorphisms in five genes o...

journal_title：Journal of hypertension

authors： Niu W,Qi Y,Hou S,Zhai X,Zhou W,Qiu C

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Essential hypertension is characterized by an impairment of endothelium-dependent vasodilatation. OBJECTIVE:To test whether antihypertensive treatment with the angiotensin converting enzyme inhibitor lisinopril can improve vasodilatation in response to endothelium-dependent agonists in essential hypertensiv...

journal_title：Journal of hypertension

authors： Taddei S,Virdis A,Ghiadoni L,Mattei P,Salvetti A

更新日期：1998-04-01 00:00:00