Soluble dipeptidyl peptidase-4 induces microvascular endothelial dysfunction through proteinase-activated receptor-2 and thromboxane A2 release.

abstract：OBJECTIVE:Microalbuminuria (MA) is a marker of adverse outcome in hypertension. The aim of this study was to investigate the association of MA with cardiovascular risk factors and glomerular hyperfiltration in the early stage of hypertension and to assess its predictive value for the development of sustained hypertensi...

journal_title：Journal of hypertension

authors： Palatini P,Mormino P,Mos L,Mazzer A,Dorigatti F,Zanata G,Longo D,Garbelotto R,De Toni R,Graniero G,Pessina AC,HARVEST Study Group.

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To investigate the association between hypertension and musculoskeletal complaints among men and women selected by a population-based sample. METHODS:A cross-sectional study, with participants selected using a multistage sampling procedure and interviewed at home, was conducted to investigate the association...

journal_title：Journal of hypertension

authors： Kerkhoff AC,Moreira LB,Fuchs FD,Fuchs SC

更新日期：2012-11-01 00:00:00

abstract：AIMS:In order to eventually improve blood pressure (BP) management, the aim of this study was to identify subgroups of type 2 diabetes mellitus (T2DM) patients with distinct trajectories of SBP levels. Identifying subgroups with distinct SBP trajectories helps to better understand the course of SBP levels in T2DM patie...

journal_title：Journal of hypertension

authors： Walraven I,Mast MR,Hoekstra T,Jansen AP,Rauh SP,Rutters FR,van der Heijden AA,Elders PJ,Moll AC,Polak BC,Dekker JM,Nijpels G

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:To determine the suitability of a new logistic curve fitting procedure to measure the diurnal rates of transition from the active to the asleep periods separately. METHOD:We applied this method to 24-h telemetry recordings of systolic, mean, diastolic arterial pressure (SAP, MAP, DAP, respectively), heart ra...

journal_title：Journal of hypertension

authors： Head GA,Lukoshkova EV,Mayorov DN,van den Buuse M

更新日期：2004-11-01 00:00:00

abstract：:: Hypertension is a growing health concern worldwide. Established hypertension is a causative factor of heart failure, which is characterized by increased vascular resistance and intractable uncontrolled blood pressure. Hypertension and heart failure have multiple causes and complex pathophysiology but cellular immuni...

journal_title：Journal of hypertension

authors： Rai A,Narisawa M,Li P,Piao L,Li Y,Yang G,Cheng XW

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:The pteridine cofactor tetrahydrobiopterin (BH4) has emerged as a critical determinant of endothelial nitric oxide synthase (eNOS) activity. When BH4 availability is limited, eNOS does not produce nitric oxide (NO) but instead generates superoxide. BH4 may reverse endothelial dysfunction due to cardiovascular...

journal_title：Journal of hypertension

authors： Kase H,Hashikabe Y,Uchida K,Nakanishi N,Hattori Y

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:Circulating biomarkers of endothelial dysfunction and inflammation are elevated in late pregnancy in women with preeclampsia. We examined plasma levels of inflammatory cytokines and adhesion molecules in early pregnancy, to assess their ability to predict preeclampsia. METHODS:In a prospective longitudinal s...

journal_title：Journal of hypertension

authors： Carty DM,Anderson LA,Freeman DJ,Welsh PI,Brennand JE,Dominiczak AF,Delles C

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:The new arterial hypertension guidelines by the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) changed the definition of isolated diastolic hypertension (IDH). We assessed and compared in a Chinese population the IDH prevalence, newly defined by the 2017 ACC/AHA guidelines versus t...

journal_title：Journal of hypertension

authors： Wu S,Ji C,Shi J,Chen S,Huang Z,Jonas JB

更新日期：2020-10-06 00:00:00

abstract：:We studied 56 patients with essential hypertension to determine whether responses to standardized laboratory mental and physical challenges accurately reflect blood pressure variability during routine daily activities. Four activities were performed in the laboratory: mental arithmetic, a reaction time test, isometric...

journal_title：Journal of hypertension

authors： Floras JS,Hassan MO,Jones JV,Sleight P

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Left ventricular (LV) hypertrophy, arterial hypertension and end-stage renal disease (ESRD) are associated with deranged cardiac parasympathetic regulation and increased cardiovascular risk. These conditions often co-exist but little is known about the relative contribution of LV mass, arterial blood pressur...

journal_title：Journal of hypertension

authors： Mircoli L,Rivera R,Bonforte G,Fedele L,Genovesi S,Surian M,Ferrari AU

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVES:Recent studies have revealed an association between coronary risk factors and both the number and function of bone marrow-derived endothelial progenitor cell (EPC). We investigated the effect of angiotensin II (Ang II) on EPC senescence, leading to the impairment of proliferative activity. METHODS AND RESUL...

journal_title：Journal of hypertension

authors： Imanishi T,Hano T,Nishio I

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Immigration studies can shed light on hypertension development and reveal high-risk populations. To this end, we investigated the association between age at immigration and hypertension occurrence at adolescence among immigrants to Israel. METHODS:We analyzed cross-sectional data on 2 681 294 adolescents as...

journal_title：Journal of hypertension

authors： Peled A,Gordon B,Twig G,Grossman E,Matani D,Derazne E,Afek A

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:To examine the health risks associated with smoking and blood pressure in Chinese hypertensive patients and to compare the benefit of antihypertensive drug treatment with the risk attributable to smoking. METHODS:We used multiple Cox regression to correlate outcome with blood pressure and smoking status in ...

journal_title：Journal of hypertension

authors： Wang JG,Staessen JA,Fagard R,Gong L,Liu L,Systolic Hypertension in China (Syst-China) Trial Collaborative Group.

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:To determine whether the noradrenergic sympathetic hyperinnervation in the spontaneously hypertensive rat (SHR), a genetic model of essential hypertension, is associated with changes in neurotrophin 3 (NT3) concentrations. METHODS:NT3 levels were measured using a sensitive enzyme-linked immunosorbent assay (...

journal_title：Journal of hypertension

authors： Zhang SH,Rush RA

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:A number of potential interactions between angiotensin-converting enzyme inhibitors and lithium have been described in the literature. In the present study, we investigated the effects of a low-dose combination treatment with lithium and captopril on survival and stroke prevention in salt-loaded, stroke-prone...

journal_title：Journal of hypertension

authors： Xu J,Scholz A,Rösch N,Blume A,Unger T,Kreutz R,Culman J,Gohlke P

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVES:We recently demonstrated that glucocorticoid increases the number of angiotensin II type 1 (AT1) receptors and their gene expression in cultured vascular smooth muscle cells. To clarify whether this mechanism participates in glucocorticoid-induced hypertension, we investigated the effect of dexamethasone on ...

journal_title：Journal of hypertension

authors： Sato A,Suzuki H,Nakazato Y,Shibata H,Inagami T,Saruta T

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) both reflects and participates in inflammation, and its circulating concentration marks cardiovascular risk. Here we sought to understand the role of heredity in determining CRP secretion. METHODS:CRP, as well as multiple facets of the metabolic syndrome, were measured in a series o...

journal_title：Journal of hypertension

authors： Wessel J,Moratorio G,Rao F,Mahata M,Zhang L,Greene W,Rana BK,Kennedy BP,Khandrika S,Huang P,Lillie EO,Shih PA,Smith DW,Wen G,Hamilton BA,Ziegler MG,Witztum JL,Schork NJ,Schmid-Schönbein GW,O'Connor DT

更新日期：2007-02-01 00:00:00

abstract：:The effect on blood pressure (BP) of acute and chronic suppression of angiotensin (ANG) II was studied in the two-kidney, one clip hypertensive rat. Conscious, chronically catheterized rats were given a bolus injection of captopril (2.5 mg/kg) followed by a chronic infusion of either dextrose or captopril (1 mg/kg per...

journal_title：Journal of hypertension

authors： Wallace EC,Balmforth AJ,Morton JJ

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVES:To assess the impact of various criteria used to define hypertension in community surveys on estimates of prevalence, treatment and control. In particular, this paper examines the effect of using mean versus minimum values; one, two or three examinations; and three different blood pressure levels. DESIGN:A ...

journal_title：Journal of hypertension

authors： Birkett NJ

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Ambulatory blood pressure (BP) monitoring (ABPM) detects subjects with normal clinic but high ambulatory 24-h BP, that is, masked hypertension. METHODS:One hundred and thirty newly diagnosed obstructive sleep apnea syndrome (OSAS) patients, free of recognized cardiovascular disease were included (111 men, a...

journal_title：Journal of hypertension

authors： Baguet JP,Lévy P,Barone-Rochette G,Tamisier R,Pierre H,Peeters M,Mallion JM,Pépin JL

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVES:This controlled trial assessed the effect of continuous positive airway pressure (CPAP) on blood pressure (BP) in patients with obstructive sleep apnea (OSA) and resistant hypertension (RH). METHODS:We evaluated 96 patients with resistant hypertension, defined as clinic BP at least 140/90 mmHg despite treat...

journal_title：Journal of hypertension

authors： Lozano L,Tovar JL,Sampol G,Romero O,Jurado MJ,Segarra A,Espinel E,Ríos J,Untoria MD,Lloberes P

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:The repair process at the site of injury after percutaneous coronary intervention (PCI) is dominated by neointimal formation composed mainly of smooth muscle cells (SMC). Endothelin-1 (ET-1) is a powerful vasoconstrictor and SMC mitogen. Endothelin-converting enzyme (ECE) is the final key enzyme of endothelin...

journal_title：Journal of hypertension

authors： Shirai N,Naruko T,Ohsawa M,Ikura Y,Sugama Y,Hirayama M,Kitabayashi C,Ehara S,Inoue T,Itoh A,Haze K,Tanzawa K,Yoshiyama M,Yoshikawa J,Ueda M

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:We examined the effects of treatment with soluble epoxide hydrolase inhibitor (sEHi) and epoxyeicosatrienoic acids (EETs) analogue (EET-A), given alone or combined, on blood pressure (BP) and ischemia/reperfusion myocardial injury in rats with angiotensin II (ANG II)-dependent hypertension. METHODS:Ren-2 tra...

journal_title：Journal of hypertension

authors： Červenka L,Husková Z,Kopkan L,Kikerlová S,Sedláková L,Vaňourková Z,Alánová P,Kolář F,Hammock BD,Hwang SH,Imig JD,Falck JR,Sadowski J,Kompanowska-Jezierska E,Neckář J

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To investigate the factors affecting survival in patients with malignant hypertension by analysing the prognosis of all of the patients referred to the City Hospital, Birmingham, with malignant hypertension since 1965. RESULTS:We identified 315 patients with malignant hypertension (211 men, 104 women; mean a...

journal_title：Journal of hypertension

authors： Lip GY,Beevers M,Beevers DG

更新日期：1995-08-01 00:00:00

abstract：AIMS:Myocardial fibrosis is a relevant component of hypertensive heart disease (HHD). Novel cardiovascular magnetic resonance (CMR) imaging techniques have shown potential in quantification of diffuse cardiac fibrosis, with T1 mapping, and estimating preclinical cardiac dysfunction, with strain analysis. Molecular biom...

journal_title：Journal of hypertension

authors： Pichler G,Redon J,Martínez F,Solaz E,Calaforra O,Andrés MS,Lopez B,Díez J,Oberbauer R,Adlbrecht C,Karth GD,Maceira A

更新日期：2020-10-01 00:00:00

abstract：:The European Society of Hypertension and the European Society of Cardiology have started the preparation of the third edition of their joint guidelines on the management of arterial hypertension. The authors have focused on the new edition of the UK NICE guidelines to learn about the difficulties of disentangling evid...

journal_title：Journal of hypertension

authors： Zanchetti A,Mancia G

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:Optimal medication use obscures the impact of physical activity on traditional cardiometabolic risk factors. We evaluated the relationship between step counts and carotid-femoral pulse wave velocity (cfPWV), a summative risk indicator, in patients with type 2 diabetes and/or hypertension. RESEARCH DESIGN AND...

journal_title：Journal of hypertension

authors： Dasgupta K,Rosenberg E,Joseph L,Trudeau L,Garfield N,Chan D,Sherman M,Rabasa-Lhoret R,Daskalopoulou SS

更新日期：2017-05-01 00:00:00

abstract：:Genetic factors in essential hypertension: Studies of the epidemiology of blood pressure indicate that genetic factors are part of the pathogenesis of human essential hypertension, raising the possibility of identifying these genes. This may provide unique opportunities to elucidate the pathophysiology of hypertension...

journal_title：Journal of hypertension

authors： Lifton RP,Jeunemaitre X

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVES:Renal denervation (RDN) can reduce sympathetic activity and blood pressure (BP) in patients with hypertension. The effects on resting and ambulatory heart rate (HR), also regulated by the sympathetic nervous system, are not established. METHODS:Herein, we report 12-month outcomes from the Global SYMPLICITY ...

journal_title：Journal of hypertension

authors： Böhm M,Ukena C,Ewen S,Linz D,Zivanovic I,Hoppe U,Narkiewicz K,Ruilope L,Schlaich M,Negoita M,Schmieder R,Williams B,Zeymer U,Zirlik A,Mancia G,Mahfoud F,Global SYMPLICITY Registry Investigators.

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Left ventricular mass is associated with body size, obesity and blood pressure. Echocardiography is routinely used to estimate this parameter, which is usually indexed to body surface area to allow comparisons to be made between individuals and groups of different body size. However, in obese subjects, using...

journal_title：Journal of hypertension

authors： Whalley GA,Gamble GD,Doughty RN,Culpan A,Plank L,MacMahon S,Sharpe N

更新日期：1999-04-01 00:00:00