Abstract:
OBJECTIVES:Local atrial tissue angiotensin II (AngII) level is elevated in atrial fibrillation (AF), but the mechanism is unknown. We hypothesized that atrial myocytes express all components of the renin-angiotensin system (RAS) and investigated whether rapid depolarization alone is sufficient to increase paracrine AngII production by up-regulating RAS component expression. METHODS:In the HL-1 atrial cell line, rapid depolarization was induced by rapid field electrical stimulation (RES) at 1.0 V/cm and 600/min (10 Hz) in atrial HL-1 cells. In a pig model of AF, AF was induced by atrial pacing at 600/min in 10 adult pigs and 10 sham-operated pigs for comparison. RESULTS:In atrial myocytes, RES induced a sustained elevation of intracellular calcium, and up-regulation of angiotensin-converting enzyme (ACE), chymase and angiotensinogen, resulting in increased AngII production. RES-induced AngII production was attenuated by enalapril [ACE inhibitor (ACEI)] and chymostatin (chymase inhibitor). Conditioned medium from RES-stimulated atrial myocytes increased [3H]leucine uptake and atrial natriuretic peptide expression in atrial myocytes, and [3H]proline uptake and collagen type 1 alpha 1 expression in atrial fibroblasts. Both were attenuated by co-incubation with the AngII type 1 receptor blocker (ARB) losartan. In the porcine model, significant structural changes and a similar pattern of changes of RAS components were noted in AF pigs. CONCLUSIONS:Atrial cells expressed all components of RAS and rapid depolarization alone was sufficient to up-regulate RAS components, increase paracrine AngII production and induce atrial structural changes, which are attenuated by ACEI, ARB and chymase inhibitor.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Tsai CT,Lai LP,Hwang JJ,Chen WP,Chiang FT,Hsu KL,Tseng CD,Tseng YZ,Lin JLdoi
10.1097/HJH.0b013e3282f34a4asubject
Has Abstractpub_date
2008-03-01 00:00:00pages
570-82issue
3eissn
0263-6352issn
1473-5598pii
00004872-200803000-00028journal_volume
26pub_type
杂志文章abstract:OBJECTIVE:Homeostasis Model Assessment (HOMA index) is predictive of insulin sensitivity in normal and diabetic patients. This study was designed to see if insulin resistance in hypertensives, measured using the HOMA index, differs, based on salt sensitivity, renin status and sodium intake. METHODS:Fasting insulin and...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00004872-200101000-00013
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:In experimental animal models, exogenous aldosterone excess has been linked to the progression of renal disease. However, the evidence of an increased risk of renal damage in patients affected by primary aldosteronism remains controversial. We aimed at evaluating the association between primary aldosteronism...
journal_title:Journal of hypertension
pub_type: 杂志文章,meta分析
doi:10.1097/HJH.0000000000002216
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Orthostatic hypotension, blood pressure (BP) variability, and arterial stiffness are three markers of cardiovascular risk beyond the average BP. However, the relationships between these three parameters are not well known. AIM:To examine the relationships between orthostatic hypotension, BP variability, and...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002374
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:An increased inter-arm SBP difference (IASBPD) is associated with mortality and cardiovascular events, as well as peripheral vascular disease, which is attributed to subclavian stenosis. The aim of the present study was to investigate the association between the IASBPD and incident chronic kidney disease (CKD...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001931
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVES:Several studies have suggested a positive association between serum lipid levels and blood pressure (BP). This study investigated this association in a large population from 12 European countries. METHODS:Data were taken from the European Study on Cardiovascular Risk Prevention and Management in Usual Daily...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001078
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:Phenotypic transformation of adventitial fibroblasts is important in the pathogenesis of hypertension. This study was designed to determine whether fibronectin type III domain containing 5 (FNDC5) alleviates the phenotypic transformation of adventitial fibroblasts in hypertension and the underlying mechanisms...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001654
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to determine whether pulse pressure is a risk factor for coronary artery disease using data from the MRC trial of treatment of mild hypertension, and whether the effect of anti-hypertensive drug therapy on pulse pressure may be a determinant of outcome in treated patients. METHODS:...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章
doi:10.1097/00004872-199917080-00004
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVES:Human adrenomedullin precursor is converted to glycine-extended adrenomedullin (AM-Gly), an intermediate inactive form of adrenomedullin. Subsequently, AM-Gly is converted to active form of mature adrenomedullin (AM-m). The aim of the present study was to investigate (i) whether sex or age influences plasma ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200104000-00014
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:To determine the benefits and risks of drinking alcohol in treated hypertensives. DESIGN:A prospective study of 6,369 hypertensives (3,161 men) attending primarily hospital clinics in the UK. METHODS:Relative risks both for drinkers compared with non-drinkers and for level of alcohol consumption were calcul...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199509000-00004
更新日期:1995-09-01 00:00:00
abstract:INTRODUCTION:Combination therapy is needed to control blood pressure (BP) in a large number of hypertensive patients with diabetes mellitus. Adherence to treatment is a major clinical problem; therefore, the time duration of the antihypertensive action of a drug determines BP control when a dose is skipped. OBJECTIVES...
journal_title:Journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1097/HJH.0000000000000793
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVES:Lower parental education is associated with higher adolescent blood pressure (BP). We examined the contribution of modifiable risk factors from infancy to adolescence that could potentially explain the link between parental education and SBP and DBP in the offspring. METHODS:In a prospective Chinese birth c...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001003
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Left ventricular mass is associated with body size, obesity and blood pressure. Echocardiography is routinely used to estimate this parameter, which is usually indexed to body surface area to allow comparisons to be made between individuals and groups of different body size. However, in obese subjects, using...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199917040-00016
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVE:Various studies have suggested that a delay in the time between diagnosing hypertension and its correct control (D-C, diagnostic-control time) is linked to a worse prognosis. The aim of this study was to examine the relationship between D-C time and all-cause mortality, or the incidence of cardiovascular even...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001896
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:Patients with essential hypertension exhibit several red blood cell (RBC) ion transport abnormalities, insulin resistance (IR) and increased risk of developing type 2 diabetes. The aims of this study were to assess RBC ion transport activities under basal conditions and to test the in vivo effect of acute hyp...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200307000-00021
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:The use of thiazide diuretics in the treatment of hypertension is widely considered as a first-line treatment, given the efficacy and low cost of this class of drugs. This indication is not unanimous, because thiazides can cause metabolic alterations, and other side effects that reduce compliance and persist...
journal_title:Journal of hypertension
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/HJH.0b013e328353398b
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To clarify the spectrum of the left ventricular responses in hypertension in man by means of coupled analysis of elastances. In the present study we analysed the 'functional' coupling of the left ventricle and the arterial system in terms of the arterial effective elastance (E(a)) divided by a value of end-sy...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract:OBJECTIVE:To investigate the role of an activated endothelin system in the renal dysfunction observed in chronic heart failure after myocardial infarction. METHODS:In rats with heart failure after myocardial infarction and in sham-operated animals (Sham), we investigated the effect on renal function of long-term oral ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200018100-00020
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVE:Some cases of pseudopheochromocytoma have been described among hypertensive patients with obstructive sleep apnea (OSA). This study examined whether a pathological rise of urinary metanephrines is a common feature in hypertensive OSA patients and, in such a case, whether the ventilation treatment during sleep...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001507
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:In this randomized, double-blind, crossover study, the antihypertensive efficacy of amlodipine and nifedipine gastrointestinal therapeutic system (GITS) was compared following missed doses. Design and methods In a randomized crossover design, 42 patients were randomized to receive amlodipine (5-10 mg) or the ...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004872-200202000-00025
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:Bradykinin is a potent cardioprotective hormone, the beneficial role of which in vivo appears to be limited by its rapid metabolism. Inhibitors of peptidases that degrade endogenously formed bradykinin are themselves cardioprotective, presumably by increasing local bradykinin concentrations. As bradykinin-de...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200107000-00015
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVES:The apolipoprotein epsilon 4 allele (APOE/epsilon 4) increases plasma cholesterol level and the risk for the late onset type of Alzheimer's disease. However, the correlation between hypertension and APOE/epsilon 4 has not yet been clarified. To examine the APOE/epsilon 4 effect in the general population of J...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200210000-00021
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVE:The present study was designed to investigate the effect of nicardipine administration upon systolic blood pressure (SBP) and cardiac hypertrophy in spontaneously hypertensive rats (SHR). DESIGN:SBP, heart: and left ventricle: body weight ratios, the cross-sectional area of cardiocytes, and the ultrastructur...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199206000-00002
更新日期:1992-06-01 00:00:00
abstract::The binding of 125I-angiotensin II to human blood cells was investigated. Blood was drawn from healthy volunteers and platelets prepared with minimal contamination of red cells and white blood cells (less than 0.1%). Using thin layer chromatography, degradation of 125I-angiotensin II by platelets could be demonstrated...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198504000-00004
更新日期:1985-04-01 00:00:00
abstract:OBJECTIVE:To determine whether a diuretic can also reverse the clinical, systemic, renal and glomerular haemodynamic and pathological changes caused by nephrosclerosis. METHODS:Three groups of 20-week-old spontaneously hypertensive rats (SHR) were investigated: control male SHR; a similar group, administered 50 mg/l N...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199607000-00004
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:In essential hypertension, the mechanical properties of the radial artery have been shown to be largely unaltered, whereas more controversial and less reliable data have been obtained for the common carotid artery. We therefore examined the distensibility/pressure relationships of the predominantly elastic co...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199715120-00070
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Cerebrovascular myogenic function, which protects the brain from hemorrhagic stroke, is impaired in stroke-prone spontaneously hypertensive rats. Furthermore, myogenic function contributes to very low frequency blood pressure variability and dynamic autoregulation of cerebral blood flow is most effective at ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3282fb81c8
更新日期:2008-06-01 00:00:00
abstract::The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 confirms ischemic heart disease and stroke as the leading cause of death and that hypertension is the main associated risk factor worldwide. How best to respond to the rising prevalence of hypertension in resource-deprived settings is a topic of ongo...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000125
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:To compare noninvasive methods to assess pulse wave velocity (PWV) with the invasive gold standard in terms of absolute values, age-related changes, and relationship with subclinical organ damage. METHODS:Invasive aortic PWV (aoPWVinv) was measured in 915 patients undergoing cardiac catheterization (mean ag...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000518
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:High sleep blood pressure (BP) has been suggested to be an independent risk factor for cardiovascular outcomes. To assess the applicability of sleep BP measured using a timer-equipped home device, we investigated the association between home device-measured sleep BP and large artery stiffness. METHODS:We pe...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002576
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVES:This controlled trial assessed the effect of continuous positive airway pressure (CPAP) on blood pressure (BP) in patients with obstructive sleep apnea (OSA) and resistant hypertension (RH). METHODS:We evaluated 96 patients with resistant hypertension, defined as clinic BP at least 140/90 mmHg despite treat...
journal_title:Journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1097/HJH.0b013e32833b9c63
更新日期:2010-10-01 00:00:00