Aging and vascular responses to flavanol-rich cocoa.

abstract：OBJECTIVE:We hypothesized that downregulation of the antioxidant thioredoxin system contributes to oxidative stress in angiotensin II-induced hypertension. As oestrogen may protect against oxidative stress, we also evaluated whether the thioredoxin system, particularly in the heart, is differentially regulated between ...

journal_title：Journal of hypertension

authors： Ebrahimian T,He Y,Schiffrin EL,Touyz RM

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:The objective of the present study was to characterize the spectrum of circadian blood pressure changes in type I diabetes at different stages of nephropathy by using two monitorings in each patient in order to avoid intra-individual variability. PATIENTS AND METHODS:A total of 80 type I diabetic subjects a...

journal_title：Journal of hypertension

authors： Lurbe E,Redon J,Pascual JM,Tacons J,Alvarez V

更新日期：2001-08-01 00:00:00

abstract：:We studied 56 patients with essential hypertension to determine whether responses to standardized laboratory mental and physical challenges accurately reflect blood pressure variability during routine daily activities. Four activities were performed in the laboratory: mental arithmetic, a reaction time test, isometric...

journal_title：Journal of hypertension

authors： Floras JS,Hassan MO,Jones JV,Sleight P

更新日期：1987-12-01 00:00:00

abstract：OBJECTIVES:The present study aimed to assess the effect of the specific dipeptidyl peptidase IV (DPPIV) inhibitor sitagliptin on blood pressure and renal function in young prehypertensive (5-week-old) and adult spontaneously hypertensive rats (SHRs; 14-week-old). METHODS:Sitagliptin (40 mg/kg twice daily) was given by...

journal_title：Journal of hypertension

authors： Pacheco BP,Crajoinas RO,Couto GK,Davel AP,Lessa LM,Rossoni LV,Girardi AC

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that apelin protects against angiotensin II (Ang II)-induced cardiovascular fibrosis and vascular remodeling. METHODS AND RESULTS:Wild-type mice administered apelin or apelin along with Ang II exhibited less cardiovascular fibrosis and decreased plasminogen activator inhibitor type-1 (...

journal_title：Journal of hypertension

authors： Siddiquee K,Hampton J,Khan S,Zadory D,Gleaves L,Vaughan DE,Smith LH

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the reproducibility of pulse wave velocity (PWV) and augmentation index (AIx) measured using pulse wave analysis (PWA), prior to its use in large-scale clinical trials. METHODS:Arterial pressure waveforms were recorded and analysed using an established technique (Sphygm...

journal_title：Journal of hypertension

authors： Wilkinson IB,Fuchs SA,Jansen IM,Spratt JC,Murray GD,Cockcroft JR,Webb DJ

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVES:Several genome-wide scans recently accomplished in the ethnic Chinese revealed a number of candidate loci possibly contributing to essential hypertension, and some appeared to be replicable in 2q14-q23 and 5q32. The current study aimed to examine the linkage of qualitative and blood pressure quantitative tra...

journal_title：Journal of hypertension

authors： Ge D,Yang W,Huang J,Yao C,Xu X,Gan W,Zhao J,Liu D,Wang X,Duan X,Hui R,Shen Y,Yao Z,Qiang B,Gu D

更新日期：2003-02-01 00:00:00

abstract：:Plasma atrial natriuretic peptide (ANP) concentrations were measured by both direct radio-immunoassay and with pre-extraction of the peptide from plasma using C18 reverse phase columns. Peptide concentrations were measured in normal subjects (including a group of eight volunteers who received an intravenous infusion o...

journal_title：Journal of hypertension

authors： Richards AM,Tonolo G,McIntyre GD,Leckie BJ,Robertson JI

更新日期：1987-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the association between stroke risk and blood pressure (BP) levels with regard to the usage of antihypertensive medications. METHODS:From the Japan arteriosclerosis longitudinal study, 11,371 participants from the four population-based cohort studies (aged 40-89) were followed up for a mean of 9....

journal_title：Journal of hypertension

authors： Asayama K,Ohkubo T,Yoshida S,Suzuki K,Metoki H,Harada A,Murakami Y,Ohashi Y,Ueshima H,Imai Y,Japan Arteriosclerosis Longitudinal Study (JALS) group.

更新日期：2009-02-01 00:00:00

abstract：:Haemorheological characteristics were measured in a group of 52 patients with essential arterial hypertension (HT), and were compared with those of a group of normotensive subjects. The relationships between the arterial blood pressure (BP), the echocardiographic indices of left ventricular hypertrophy (LVH), and the ...

journal_title：Journal of hypertension

authors： Zannad F,Voisin P,Brunotte F,Bruntz JF,Stoltz JF,Gilgenkrantz JM

更新日期：1988-04-01 00:00:00

abstract：:: Primary aldosteronism is a frequent cause of secondary hypertension requiring a specific pharmacological treatment with mineralocorticoid receptor antagonist or with unilateral adrenalectomy. These treatments have shown to reduce the excess of cardiovascular risk characteristically associated with this disease. In p...

journal_title：Journal of hypertension

authors： Mulatero P,Sechi LA,Williams TA,Lenders JWM,Reincke M,Satoh F,Januszewicz A,Naruse M,Doumas M,Veglio F,Wu VC,Widimsky J

更新日期：2020-06-25 00:00:00

abstract：BACKGROUND:Correlations have been found between oxidative stress and hypertension. OBJECTIVE:To determine whether antioxidants can normalize sympathetic dysfunction at pre- or postsynaptic levels in spontaneously hypertensive rats (SHRs). METHODS AND RESULTS:Untreated SHRs and Wistar-Kyoto (WKY) rats were compared wi...

journal_title：Journal of hypertension

authors： Girouard H,Chulak C,LeJossec M,Lamontagne D,de Champlain J

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:The difference between clinic and ambulatory blood pressure (BP) is a poor estimate of the true white-coat effect (WCE) measured with beat-to-beat recording. METHOD:We investigated whether the difference between clinic and home BP (home WCE) was a better estimate of true WCE than ambulatory WCE. In 73 young...

journal_title：Journal of hypertension

authors： Saladini F,Benetti E,Malipiero G,Casiglia E,Palatini P

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:To examine a possible relationship between baseline albuminuria and effect of losartan versus atenolol on cardiovascular (CV) events in hypertensive patients with left ventricular hypertrophy, the effect of losartan versus atenolol on albuminuria, and whether the benefits of losartan versus atenolol could be...

journal_title：Journal of hypertension

authors： Ibsen H,Wachtell K,Olsen MH,Borch-Johnsen K,Lindholm LH,Mogensen CE,Dahlöf B,Devereux RB,de Faire U,Fyhrquist F,Julius S,Kjeldsen SE,Lederballe-Pedersen O,Nieminen MS,Omvik P,Oparil S,Wan Y,LIFE substudy.

更新日期：2004-09-01 00:00:00

abstract：:Hypertensive disease is known to increase the risks in connection with acute changes in blood pressure due to the presence of pronounced structural as well as functional changes in the cardiovascular system. In the present study the metabolic consequences of fixed haemorrhagic hypotension [mean arterial pressure (MAP)...

journal_title：Journal of hypertension

authors： Wennberg E,Hagberg H,Haljamäe H,Johansson BB

更新日期：1983-10-01 00:00:00

abstract：OBJECTIVES:Evidence about sex differences in blood pressure (BP) at the time of acute stroke presentation is scarce. We aimed to summarize available data on sex differences in BP at the time of acute stroke presentation, including stratification by prior history of hypertension and stroke subtype. METHODS:We performed...

journal_title：Journal of hypertension

authors： Li J,Yang SC,Moullaali TJ,Chen R,Woodward M,Carcel C,Delcourt C,Sandset EC,Anderson C,Chen G,Wang X

更新日期：2019-10-01 00:00:00

abstract：:Genetic factors in essential hypertension: Studies of the epidemiology of blood pressure indicate that genetic factors are part of the pathogenesis of human essential hypertension, raising the possibility of identifying these genes. This may provide unique opportunities to elucidate the pathophysiology of hypertension...

journal_title：Journal of hypertension

authors： Lifton RP,Jeunemaitre X

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:To assess the antihypertensive efficacy and safety of the novel AT1 receptor antagonist, telmisartan, compared with that of enalapril in elderly patients with mild to moderate hypertension. DESIGN:A 26-week, multicenter, double-blind, parallel-group, dosage titration study. METHODS:A total of 278 patients a...

journal_title：Journal of hypertension

authors： Karlberg BE,Lins LE,Hermansson K

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Choice of antihypertensive drugs is also based on the expected burden of adverse events associated with each class of agents, and we have recently identified treatment discontinuation for adverse events as a measure of treatment tolerability frequently reported in randomized controlled trials (RCTs). OBJECT...

journal_title：Journal of hypertension

authors： Thomopoulos C,Parati G,Zanchetti A

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:Retinal blood vessels may develop vasculopathy and apoptosis in response to hypertension. The present study was aimed at testing the role of losartan, a specific antagonist of angiotensin II receptor type 1 receptor in regulation of vascular apoptosis in retinal vasculature with hypertension. METHODS:Losart...

journal_title：Journal of hypertension

authors： Yang D,Zhang M,Huang X,Fang F,Chen B,Wang S,Cai J,Shi X,Qu J,Geng YJ

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Previous work has demonstrated that treatment of hypertensive patients with the angiotensin-converting enzyme inhibitor lisinopril was associated with a reduced incidence of a composite conduction system disease endpoint and also left bundle branch block (LBBB) compared with chlorthalidone therapy. The relat...

journal_title：Journal of hypertension

authors： Okin PM,Kjeldsen SE,Devereux RB

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Losartan is a new angiotensin II type 1 (AT1) receptor antagonist and an antihypertensive drug. Nitric oxide is a vasodilating agent and endothelins are powerful vasoconstrictors, both synthesized by and released from endothelial cells. Angiotensin II promotes the release of endothelins in cultured cells and...

journal_title：Journal of hypertension

authors： Sacerdote A,Cosenzi A,Bocin E,Molino R,Seculin P,Plazzotta N,Luxich E,Bellini G

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:To evaluate whether efficacious counseling methods on sodium restriction can be successfully incorporated into primary care models for the management of hypertension. METHODS:We searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects and Health Te...

journal_title：Journal of hypertension

authors： Ruzicka M,Hiremath S,Steiner S,Helis E,Szczotka A,Baker P,Fodor G

更新日期：2014-07-01 00:00:00

abstract：:Diabetic nephropathy has developed into a worldwide epidemic and is responsible for the majority of end-stage renal disease in most countries. Antihypertensive treatment slows the progression of the disease. In addition, blockade of the renin-angiotensin system reduces the degree of albuminuria and angiotensin II rece...

journal_title：Journal of hypertension

authors： Haller H,Viberti GC,Mimran A,Remuzzi G,Rabelink AJ,Ritz E,Rump LC,Ruilope LM,Katayama S,Ito S,Izzo JL Jr,Januszewicz A

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:To investigate the role of an activated endothelin system in the renal dysfunction observed in chronic heart failure after myocardial infarction. METHODS:In rats with heart failure after myocardial infarction and in sham-operated animals (Sham), we investigated the effect on renal function of long-term oral ...

journal_title：Journal of hypertension

authors： Bauersachs J,Braun C,Fraccarollo D,Widder J,Ertl G,Schilling L,Kirchengast M,Rohmeiss P

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the association of angiotensinogen (AGT) gene with AGT level and hypertension based on the overall genetic variation of the AGT gene in among African-Americans. METHODS:All non-rare single nucleotide polymorphisms (SNPs) in AGT were identified by resequencing 24 individuals. Five tagging SNPs wer...

journal_title：Journal of hypertension

authors： Wu X,Luke A,Rieder M,Lee K,Toth EJ,Nickerson D,Zhu X,Kan D,Cooper RS

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:The oral contraceptive pill (OCP) is widely prescribed throughout the world. Although it is associated with a small but significant increase in blood pressure, the influence of the OCP on large artery stiffness and wave reflection is unclear. The aim of this study was to determine the relationship between us...

journal_title：Journal of hypertension

authors： Hickson SS,Miles KL,McDonnell BJ,Yasmin,Cockcroft JR,Wilkinson IB,McEniery CM,ENIGMA Study Investigators.

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:Microalbuminuria (MA) is a marker of adverse outcome in hypertension. The aim of this study was to investigate the association of MA with cardiovascular risk factors and glomerular hyperfiltration in the early stage of hypertension and to assess its predictive value for the development of sustained hypertensi...

journal_title：Journal of hypertension

authors： Palatini P,Mormino P,Mos L,Mazzer A,Dorigatti F,Zanata G,Longo D,Garbelotto R,De Toni R,Graniero G,Pessina AC,HARVEST Study Group.

更新日期：2005-01-01 00:00:00

abstract：:: The hypertension paradigm has contributed to a dramatic reduction in CVD mortality. This has been achieved by applying average results of population studies to identify a target population and design a common intervention to achieve a BP goal. Progressive lowering of the BP threshold has expanded the fraction of per...

journal_title：Journal of hypertension

authors： Alderman MH,Blumenfeld JD

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to evaluate the effects of acute hyperhomocysteinemia on distensibility and compliance of large peripheral arteries. Isoprostanes generation and antioxidant vitamins were used to assess the role of oxidative stress. DESIGN:A cross-over, double-blind study on distensibility (DC: diste...

journal_title：Journal of hypertension

authors： Arcaro G,Fava C,Dagradi R,Faccini G,Gaino S,Degan M,Lechi C,Lechi A,Minuz P

更新日期：2004-04-01 00:00:00