Tumor viruses and endogenous retrotransposons in mammary tumorigenesis.

abstract：:It has long been appreciated that the estrogen receptor (ER) plays an important role in the biology of breast cancer. It is an accepted factor predicting favorable disease outcome and treatment response, and as such is generally considered to represent a "good" prognostic marker in breast cancer. In this review we pre...

journal_title：Journal of mammary gland biology and neoplasia

authors： Fuqua SA

更新日期：2001-10-01 00:00:00

abstract：:Originally adapted from the neurosphere assay, the nonadherent mammosphere assay has been utilized to assess early progenitor/stem cell frequency in a given population of mammary epithelial cells. This method has also been used to measure the frequency of tumorsphere initiating cells in both primary mammary tumors as ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Rota LM,Lazzarino DA,Ziegler AN,LeRoith D,Wood TL

更新日期：2012-06-01 00:00:00

abstract：:Various retroviral and lentiviral vectors have been used for up-the-teat intraductal injection to deliver markers, oncogenes, and other genes into mammary epithelial cells in mice. These methods along with the large number of genetically engineered mouse lines have greatly helped us learn normal breast development and...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bu W,Li Y

更新日期：2020-11-09 00:00:00

abstract：:Dynamic interactions between the hormone responsive mammary gland epithelium and surrounding stromal macrophage populations are critical for normal development and function of the mammary gland. Macrophages are versatile cells capable of diverse roles in mammary gland development and maintenance of homeostasis, and th...

journal_title：Journal of mammary gland biology and neoplasia

authors： Sun X,Ingman WV

更新日期：2014-07-01 00:00:00

abstract：:Premalignant breast disease in humans is a concept that admits to a broad range of elements and possible determinants predicting the likelihood of developing breast cancer. Most of these elements are relative, such as the risk of breast cancer for women that is 130 times that of men and peaks at a younger age by about...

journal_title：Journal of mammary gland biology and neoplasia

authors： Page DL,Jensen RA,Simpson JF,Dupont WD

更新日期：2000-10-01 00:00:00

abstract：:We have reported the use of vectors based on avian leukosis virus (ALV) and ALV env pseudotyped lentivirus for stably introducing genes into somatic mammary cells in vivo for tumor modeling. These vectors require tva transgenic mice for viral infection. Here, we report, and described the method for, stably introducing...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bu W,Xin L,Toneff M,Li L,Li Y

更新日期：2009-12-01 00:00:00

abstract：:Mastitis is an inflammation of the mammary gland commonly caused by bacterial infection. The inflammatory process is a normal and necessary immunological response to invading pathogens. The purpose of host inflammatory responses is to eliminate the source of tissue injury, restore immune homeostasis, and return tissue...

journal_title：Journal of mammary gland biology and neoplasia

authors： Aitken SL,Corl CM,Sordillo LM

更新日期：2011-12-01 00:00:00

abstract：:Since the discovery that neural tissue contains a population of stem cells that form neurospheres in vitro, sphere-forming assays have been adapted for use with a number of different tissue types for the quantification of stem cell activity and self-renewal. One tissue type widely used for stem cell investigations is ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Shaw FL,Harrison H,Spence K,Ablett MP,Simões BM,Farnie G,Clarke RB

更新日期：2012-06-01 00:00:00

abstract：:Mammalian cells depend on phospholipid (PL) and fatty acid (FA) transport to maintain membrane structure and organization, and to fuel and regulate cellular functions. In mammary glands of lactating animals, copious milk secretion, including large quantities of lipid in some species, requires adaptation and integratio...

journal_title：Journal of mammary gland biology and neoplasia

authors： McManaman JL

更新日期：2014-03-01 00:00:00

abstract：:Obesity is a preventable risk factor for breast cancer following menopause. Regardless of menopausal status, obese women who develop breast cancer have a worsened prognosis. Breast tissue is comprised of mammary epithelial cells organized into ducts and lobules and surrounded by adipose-rich connective tissue. Studies...

journal_title：Journal of mammary gland biology and neoplasia

authors： Hillers-Ziemer LE,Arendt LM

更新日期：2020-06-01 00:00:00

abstract：:Breast cancer (BC) is a leading cause of death among women with malignant diseases. The selection of adequate therapies for highly invasive and metastatic BCs still represents a major challenge. Novel combinatorial therapeutic approaches are urgently required to enhance the efficiency of BC treatment. Recently, microR...

journal_title：Journal of mammary gland biology and neoplasia

authors： Petrović N,Nakashidze I,Nedeljković M

更新日期：2021-01-21 00:00:00

abstract：:The involvement of molecular mechanisms in a particular process such as embryonic mammary gland development, can be revealed by modulation of one or several factors that purportedly act in that process. If those factors or their inhibitors are soluble, their function can be tested by loading them onto small inert bead...

journal_title：Journal of mammary gland biology and neoplasia

authors： Veltmaat JM

更新日期：2013-06-01 00:00:00

abstract：:Normal mammary gland development is the result of complex interactions between a number of hormones and growth factors. Normal and malignant human mammary epithelial cells are able to synthesize and to respond to various different, locally acting growth factors and growth inhibitors. Among these, the EGF-related pepti...

journal_title：Journal of mammary gland biology and neoplasia

authors： Normanno N,Ciardiello F

更新日期：1997-04-01 00:00:00

abstract：:Human mammary epithelial cells emerge spontaneously from senescence, exhibiting eroding telomeric sequences, and ultimately enter crisis to generate the type of chromosomal abnormalities seen in early stages of breast cancer. In a mouse mammary tumor model, the spontaneous escape of senescence can be observed as an in...

journal_title：Journal of mammary gland biology and neoplasia

authors： Said TK,Medina D

更新日期：2004-01-01 00:00:00

abstract：:The mammary gland is an ectodermal appendage and a defining feature of mammals. Consistent with it being a recent evolutionary novelty, many of the molecules essential for the ontogeny and morphogenesis of various vertebrate organs, including those in the fibroblast growth factor (FGF) signaling pathway, are co-opted ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Kim EJ,Jung HS,Lu P

更新日期：2013-06-01 00:00:00

abstract：:Milk is primarily regarded as a food furnishing essential nutrients for infant growth and development, but milk can also serve as a vehicle for mother to neonate transfer of molecules that regulate development. A wide array of biologically active compounds such as hormones, cytokines and enzymes are present in milk, e...

journal_title：Journal of mammary gland biology and neoplasia

authors： Ellis LA,Mastro AM,Picciano MF

更新日期：1996-07-01 00:00:00

abstract：:The mouse model for breast cancer has developed into a most effective means of dissecting and understanding this devastating disease. The inbred transgenic mouse lends itself to biological, molecular, immunological, and genetic studies. The observation, dissection, transplantation, and subsequent amplification of prec...

journal_title：Journal of mammary gland biology and neoplasia

authors： Young LJ

更新日期：2008-09-01 00:00:00

abstract：:Analysis of genes and proteins involved in lipid biosynthesis in mammary epithelial cells (MECs) is complicated by the presence of adipose tissue in the mammary gland, which may be predominant in whole tissue lysates depending upon developmental stage. We have developed a method based on protocols used to establish pr...

journal_title：Journal of mammary gland biology and neoplasia

authors： Rudolph MC,Wellberg EA,Anderson SM

更新日期：2009-12-01 00:00:00

abstract：:The differentiation and function of mammary epithelial cells is dependent upon the combined action of growth factor/hormone receptors and integrin receptors, which act in concert to control the signals required for normal cell function. It is now becoming clear that integrin receptors also contribute to carcinoma cell...

journal_title：Journal of mammary gland biology and neoplasia

authors： Shaw LM

更新日期：1999-10-01 00:00:00

abstract：:The ability to produce and expel milk is important for the health and survival of all mammals. Nevertheless, our understanding of the molecular events underlying the execution of this process remains incomplete. Whilst impaired mammary gland development and lactational competence remains the subject of focused investi...

journal_title：Journal of mammary gland biology and neoplasia

authors： Stewart TA,Davis FM

更新日期：2020-11-19 00:00:00

abstract：:Breast cancer is a heterogeneous disease comprised of at least five major tumor subtypes that coalesce as the second leading cause of cancer death in women in the United States. Although metastasis clearly represents the most lethal characteristic of breast cancer, our understanding of the molecular mechanisms that go...

journal_title：Journal of mammary gland biology and neoplasia

authors： Parvani JG,Taylor MA,Schiemann WP

更新日期：2011-06-01 00:00:00

abstract：:Transgenic experiments using oocyte micro-injection methodology are often performed in order to target expression of a foreign gene in a specific tissue or, to a lesser extent, to study the regulation of gene expression. However, the isolation of embryonic stem cells in mice and the development of antisense and ribozy...

journal_title：Journal of mammary gland biology and neoplasia

authors： Vilotte JL,L'Huillier P,Mercier JC

更新日期：1998-07-01 00:00:00

abstract：:Exosomes are small extracellular vesicles secreted to the extracellular environment by several cell types, including tumor cells. It has been demonstrated that exosomes have an important role in intercellular communication, but they have recently been implicated in various tumor processes, including the oncogenic tran...

journal_title：Journal of mammary gland biology and neoplasia

authors： Villagrasa A,Álvarez PJ,Osuna A,Garrido JM,Aránega A,Rodríguez-Serrano F

更新日期：2014-12-01 00:00:00

abstract：:Tight junctions (TJs), the most apical components of the cell-cell junctional complexes, play a crucial role in the establishment and maintenance of cell polarity within tissues. In secretory glandular tissues, such as the mammary gland, TJs are crucial for separating apical and basolateral domains. TJs also create th...

journal_title：Journal of mammary gland biology and neoplasia

authors： Itoh M,Bissell MJ

更新日期：2003-10-01 00:00:00

abstract：:Mammary gland involution is a period of intensive tissue remodeling. Over the course of a relatively brief period, a large proportion of the mammary gland epithelium undergoes programmed cell death and is removed by phagocytes. In addition, the gland is cleared of residual milk fat globules as well as milk and adipocy...

journal_title：Journal of mammary gland biology and neoplasia

authors： Atabai K,Sheppard D,Werb Z

更新日期：2007-03-01 00:00:00

abstract：:The insulin-like growth factors (IGFs) signaling via the type I insulin-like growth factor receptor (IGF-1R) regulate multiple aspects of malignancy. The importance of IGF-1R in regulating the malignant phenotype is currently being validated in numerous clinical trials for cancer including breast cancer. This review d...

journal_title：Journal of mammary gland biology and neoplasia

authors： Sachdev D

更新日期：2008-12-01 00:00:00

abstract：:Women are using estrogens for many purposes, such as to prevent pregnancy or miscarriage, or to treat menopausal symptoms. Estrogens also have been used to treat breast cancer which seems puzzling, since there is convincing evidence to support a link between high lifetime estrogen exposure and increased breast cancer ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Hilakivi-Clarke L,de Assis S,Warri A

更新日期：2013-03-01 00:00:00

abstract：:The development and progression of aggressive breast cancer is characterized by genomic instability leading to multiple genetic defects, phenotypic diversity, chemoresistance, and poor outcome. Centrosome abnormalities have been implicated in the origin of chromosomal instability through the development of multipolar ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Salisbury JL,D'Assoro AB,Lingle WL

更新日期：2004-07-01 00:00:00

abstract：:The ErbB receptor tyrosine kinase family has often been associated with increased growth of breast epithelial cells, as well as malignant transformation and progression. In contrast, ErbB4/HER4 exhibits unique attributes from a two step proteolytic cleavage which releases an 80 kilodalton, nuclear localizing, tyrosine...

journal_title：Journal of mammary gland biology and neoplasia

authors： Muraoka-Cook RS,Feng SM,Strunk KE,Earp HS 3rd

更新日期：2008-06-01 00:00:00

abstract：:Postpartum mammary gland involution is a mammalian tissue remodeling event that occurs after pregnancy and lactation to return the gland to the pre-pregnant state. This event is characterized by apoptosis and lysosomal-mediated cell death of the majority of the lactational mammary epithelium, followed by remodeling of...

journal_title：Journal of mammary gland biology and neoplasia

authors： Elder AM,Stoller AR,Black SA,Lyons TR

更新日期：2020-06-01 00:00:00