Determining mammosphere-forming potential: application of the limiting dilution analysis.

abstract：:With improved screening methods, the numbers of abnormal breast lesions diagnosed in women have been increasing over time. However, it remains unclear whether these breast lesions will develop into invasive cancers. To more effectively predict the outcome of breast lesions and determine a more appropriate course of tr...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bernard S,Myers M,Fang WB,Zinda B,Smart C,Lambert D,Zou A,Fan F,Cheng N

更新日期：2018-12-01 00:00:00

abstract：:The Hedgehog pathway is critical for many developmental processes, including the formation of several epidermal appendages. In the mammary gland strict regulation of the Hedgehog pathway is required for normal development. Alterations in Hedgehog signaling result in defects in both the embryonic and postnatal mammary ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Hatsell S,Frost AR

更新日期：2007-09-01 00:00:00

abstract：:The ErbB receptor tyrosine kinase family has often been associated with increased growth of breast epithelial cells, as well as malignant transformation and progression. In contrast, ErbB4/HER4 exhibits unique attributes from a two step proteolytic cleavage which releases an 80 kilodalton, nuclear localizing, tyrosine...

journal_title：Journal of mammary gland biology and neoplasia

authors： Muraoka-Cook RS,Feng SM,Strunk KE,Earp HS 3rd

更新日期：2008-06-01 00:00:00

abstract：:Estrogens are important for the development of the mammary gland and strongly associated with oncogenesis in this tissue. The biological effects of estrogens are mediated through the estrogen receptor (ER), a member of the nuclear receptor superfamily. The estrogen/ER signaling pathway plays a central role in mammary ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bocchinfuso WP,Korach KS

更新日期：1997-10-01 00:00:00

abstract：:Milk production is highly dependent on the optimal development of the mammary epithelium. It is therefore essential to better understand mammary epithelial cell growth and maintenance from the related epithelial lineage during the animal life. Here, we characterized the epithelial lineage at puberty, lactation and dry...

journal_title：Journal of mammary gland biology and neoplasia

authors： Finot L,Chanat E,Dessauge F

更新日期：2019-06-01 00:00:00

abstract：:Breast cancer (BC) is a leading cause of death among women with malignant diseases. The selection of adequate therapies for highly invasive and metastatic BCs still represents a major challenge. Novel combinatorial therapeutic approaches are urgently required to enhance the efficiency of BC treatment. Recently, microR...

journal_title：Journal of mammary gland biology and neoplasia

authors： Petrović N,Nakashidze I,Nedeljković M

更新日期：2021-01-21 00:00:00

abstract：:Carcinogenesis is a complex process during which cells undergo genetic and epigenetic alterations. These changes can lead tumor cells to acquire characteristics that enable movement from the primary site of origin when conditions become unfavorable. Such characteristics include gain of front-rear polarity, increased m...

journal_title：Journal of mammary gland biology and neoplasia

authors： Howe EN,Cochrane DR,Richer JK

更新日期：2012-03-01 00:00:00

abstract：:Estrogen receptor-α (ERα) and transforming growth factor (TGF)-β signaling pathways are major regulators during mammary gland development, function and tumorigenesis. Predominantly, they have opposing roles in proliferation and apoptosis. While ERα signaling supports growth and differentiation and is antiapoptotic, ma...

journal_title：Journal of mammary gland biology and neoplasia

authors： Band AM,Laiho M

更新日期：2011-06-01 00:00:00

abstract：:The relationship between maternal dietary intakes of energy or fat maternal body composition and the milk fat concentration is an important element in understanding the role of breast-milk in infant nutrition. In most studies in both developing and developed countries, no relation between maternal energy intake and mi...

journal_title：Journal of mammary gland biology and neoplasia

authors： Villalpando S,del Prado M

更新日期：1999-07-01 00:00:00

abstract：:The development and progression of aggressive breast cancer is characterized by genomic instability leading to multiple genetic defects, phenotypic diversity, chemoresistance, and poor outcome. Centrosome abnormalities have been implicated in the origin of chromosomal instability through the development of multipolar ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Salisbury JL,D'Assoro AB,Lingle WL

更新日期：2004-07-01 00:00:00

abstract：:Women are using estrogens for many purposes, such as to prevent pregnancy or miscarriage, or to treat menopausal symptoms. Estrogens also have been used to treat breast cancer which seems puzzling, since there is convincing evidence to support a link between high lifetime estrogen exposure and increased breast cancer ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Hilakivi-Clarke L,de Assis S,Warri A

更新日期：2013-03-01 00:00:00

abstract：:Normal mammary gland development is the result of complex interactions between a number of hormones and growth factors. Normal and malignant human mammary epithelial cells are able to synthesize and to respond to various different, locally acting growth factors and growth inhibitors. Among these, the EGF-related pepti...

journal_title：Journal of mammary gland biology and neoplasia

authors： Normanno N,Ciardiello F

更新日期：1997-04-01 00:00:00

abstract：:We review the role of Neuregulin 3 (Nrg3) and Erbb receptor signalling in embryonic mammary gland development. Neuregulins are growth factors that bind and activate its cognate Erbb receptor tyrosine kinases, which form a signalling network with established roles in breast development and breast cancer. Studies have s...

journal_title：Journal of mammary gland biology and neoplasia

authors： Kogata N,Zvelebil M,Howard BA

更新日期：2013-06-01 00:00:00

abstract：:The involvement of molecular mechanisms in a particular process such as embryonic mammary gland development, can be revealed by modulation of one or several factors that purportedly act in that process. If those factors or their inhibitors are soluble, their function can be tested by loading them onto small inert bead...

journal_title：Journal of mammary gland biology and neoplasia

authors： Veltmaat JM

更新日期：2013-06-01 00:00:00

abstract：:Elucidating cell hierarchy in the mammary gland is fundamental for understanding the mechanisms governing its normal development and malignant transformation. There is relatively little information on cell hierarchy in the bovine mammary gland, despite its agricultural potential and relevance to breast cancer research...

journal_title：Journal of mammary gland biology and neoplasia

authors： Rauner G,Barash I

更新日期：2016-06-01 00:00:00

abstract：:Breast cancer development is a multi-step process in which genetic and molecular heterogeneity occurs at multiple stages. Ductal carcinoma arises from pre-invasive lesions such as atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS), which progress to invasive and metastatic cancer. The feasibility of...

journal_title：Journal of mammary gland biology and neoplasia

authors： Behbod F,Gomes AM,Machado HL

更新日期：2018-12-01 00:00:00

abstract：:As their name implies, the myoepithelial cells found at the epithelial-mesenchymal interface of the human mammary gland disclose features suggestive of a dual epithelial-like and muscle-like differentiation, i.e. they co-express various keratins and vimentin intermediate filaments, as well as smooth muscle-related ant...

journal_title：Journal of mammary gland biology and neoplasia

authors： Jolicoeur F

更新日期：2005-07-01 00:00:00

abstract：:Colony stimulating factor 1 (CSF-1), a major regulator of the mononuclear phagocytic lineage, is expressed in more than 70% of human breast cancers and its expression is correlated with poor prognosis. Studies of CSF-1 null mutant mice demonstrated that CSF-1 plays an important role in normal mammary ductal developmen...

journal_title：Journal of mammary gland biology and neoplasia

authors： Lin EY,Gouon-Evans V,Nguyen AV,Pollard JW

更新日期：2002-04-01 00:00:00

abstract：:Mouse modeling of human breast cancer has developed tremendously over the past ten years. Human breast cancer is characterized by enormous biological diversity and, collectively, the new models have come much closer to encompassing this diversity. They have provided a deeper understanding of the fundamental events tha...

journal_title：Journal of mammary gland biology and neoplasia

authors： Allred DC,Medina D

更新日期：2008-09-01 00:00:00

abstract：:The ability to produce and expel milk is important for the health and survival of all mammals. Nevertheless, our understanding of the molecular events underlying the execution of this process remains incomplete. Whilst impaired mammary gland development and lactational competence remains the subject of focused investi...

journal_title：Journal of mammary gland biology and neoplasia

authors： Stewart TA,Davis FM

更新日期：2020-11-19 00:00:00

abstract：:The insulin-like growth factors (IGFs) signaling via the type I insulin-like growth factor receptor (IGF-1R) regulate multiple aspects of malignancy. The importance of IGF-1R in regulating the malignant phenotype is currently being validated in numerous clinical trials for cancer including breast cancer. This review d...

journal_title：Journal of mammary gland biology and neoplasia

authors： Sachdev D

更新日期：2008-12-01 00:00:00

abstract：:We have reported the use of vectors based on avian leukosis virus (ALV) and ALV env pseudotyped lentivirus for stably introducing genes into somatic mammary cells in vivo for tumor modeling. These vectors require tva transgenic mice for viral infection. Here, we report, and described the method for, stably introducing...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bu W,Xin L,Toneff M,Li L,Li Y

更新日期：2009-12-01 00:00:00

abstract：:Transgenic experiments using oocyte micro-injection methodology are often performed in order to target expression of a foreign gene in a specific tissue or, to a lesser extent, to study the regulation of gene expression. However, the isolation of embryonic stem cells in mice and the development of antisense and ribozy...

journal_title：Journal of mammary gland biology and neoplasia

authors： Vilotte JL,L'Huillier P,Mercier JC

更新日期：1998-07-01 00:00:00

abstract：:Increased glucose requirements of the gravid uterus during late pregnancy and even greater requirements of the lactating mammary glands necessitate major adjustments in glucose production and utilization in maternal liver, adipose tissue, skeletal muscle, and other tissues. In ruminants, which at all times rely princi...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bell AW,Bauman DE

更新日期：1997-07-01 00:00:00

abstract：:Inflammation of the adipose tissues occurs in association with obesity. This inflammatory process leads to the induction of cyclooxygenase-2 (COX-2) expression and a consequent elevation in prostaglandin (PG) production, which, together with proinflammatory cytokines, induce aromatase expression and estrogen synthesis...

journal_title：Journal of mammary gland biology and neoplasia

authors： Vona-Davis L,Rose DP

更新日期：2013-12-01 00:00:00

abstract：:Insulin-like growth factor-I and -II (IGF-I and IGF-II) and/or the type I insulin-like growth factor receptor (IGF-IR) have been implicated in a number of human tumors including breast cancer. However, despite being implicated in breast cancer for approximately 25 years and given that transgenic technology has been av...

journal_title：Journal of mammary gland biology and neoplasia

authors： Jones RA,Moorehead RA

更新日期：2008-12-01 00:00:00

abstract：:The differentiation and function of mammary epithelial cells is dependent upon the combined action of growth factor/hormone receptors and integrin receptors, which act in concert to control the signals required for normal cell function. It is now becoming clear that integrin receptors also contribute to carcinoma cell...

journal_title：Journal of mammary gland biology and neoplasia

authors： Shaw LM

更新日期：1999-10-01 00:00:00

abstract：:T cell immunity in breast cancer is suggested to play a role in tumor dormancy, a period of stability which can correspond to the time interval between primary treatment and tumor recurrence. Bone marrow in breast cancer patients seems to be particularly important because it is highly enriched with cancer specific mem...

journal_title：Journal of mammary gland biology and neoplasia

authors： Schirrmacher V,Feuerer M,Beckhove P,Ahlert T,Umansky V

更新日期：2002-04-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT) and its reversion via mesenchymal to epithelial transition (MET), represent a stepwise cycle of epithelial plasticity that allows for normal tissue remodelling and diversification during development. In particular, epithelial-mesenchymal plasticity is central to many aspects ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Godde NJ,Galea RC,Elsum IA,Humbert PO

更新日期：2010-06-01 00:00:00

abstract：:Various retroviral and lentiviral vectors have been used for up-the-teat intraductal injection to deliver markers, oncogenes, and other genes into mammary epithelial cells in mice. These methods along with the large number of genetically engineered mouse lines have greatly helped us learn normal breast development and...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bu W,Li Y

更新日期：2020-11-09 00:00:00