Abstract:
:Breast cancer (BC) is a leading cause of death among women with malignant diseases. The selection of adequate therapies for highly invasive and metastatic BCs still represents a major challenge. Novel combinatorial therapeutic approaches are urgently required to enhance the efficiency of BC treatment. Recently, microRNAs (miRNAs) emerged as key regulators of the complex mechanisms that govern BC therapeutic resistance and susceptibility. In the present review we aim to critically examine how miRNAs influence BC response to therapies, or how to use miRNAs as a basis for new therapeutic approaches. We summarized recent findings in this rapidly evolving field, emphasizing the challenges still ahead for the successful implementation of miRNAs into BC treatment while providing insights for future BC management.The goal of this review was to propose miRNAs, that might simultaneously improve the efficacy of all four therapies that are the backbone of current BC management (radio-, chemo-, targeted, and hormone therapy). Among the fifty-nine described miRNAs, miR-21 and miR-16 emerged as the most promising, closely followed by miR-205, miR-451, miR-182, and miRNAs from the let-7 family. miR-21 inhibition might be the best choice for future improvement of invasive BC treatment.New therapeutic strategies of miRNA-based agents alongside current standard treatment modalities could greatly benefit BC patients. This review represents a guideline on how to navigate this elaborate puzzle.
journal_name
J Mammary Gland Biol Neoplasiajournal_title
Journal of mammary gland biology and neoplasiaauthors
Petrović N,Nakashidze I,Nedeljković Mdoi
10.1007/s10911-021-09478-3subject
Has Abstractpub_date
2021-01-21 00:00:00eissn
1083-3021issn
1573-7039pii
10.1007/s10911-021-09478-3pub_type
杂志文章,评审abstract::Since breast cancer and its associated metastasis are a global health problem and a major cause of mortality among women, research efforts to understand the development, morphogenesis, and functioning of the mammary gland are a high priority. Myriad signaling pathways, transcription factors, and associated transcripti...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1007/s10911-007-9043-7
更新日期:2007-09-01 00:00:00
abstract::Nuclear Factor-kappaB (NF-kappaB) has been implicated in the lobuloalveolar development of the mammary gland. In breast cancer its activation has been linked to tumor progression via stimulation of cell proliferation, pro-survival, and angiogenesis pathways and metastasis. Whether NF-kappaB activation in the immune sy...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1007/s10911-006-9013-5
更新日期:2006-01-01 00:00:00
abstract::Ductal development in the pubertal mouse mammary gland is characterized by dramatic morphological changes in the epithelium driven by proliferation of cap and body cells in the terminal endbuds. Recent experiments revealed a coincident and abundant apoptosis in the body cells of these structures. The cells undergoing ...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1023/a:1018733426625
更新日期:1999-04-01 00:00:00
abstract::The Notch receptor protein and its signaling pathway have been well conserved throughout evolution and appear to be pivotal components in cell fate decisions during development. Recent studies suggest that, depending on the cellular and developmental context, Notch signaling may also affect cell proliferation and prog...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1023/a:1009512414430
更新日期:2001-01-01 00:00:00
abstract::We review the role of Neuregulin 3 (Nrg3) and Erbb receptor signalling in embryonic mammary gland development. Neuregulins are growth factors that bind and activate its cognate Erbb receptor tyrosine kinases, which form a signalling network with established roles in breast development and breast cancer. Studies have s...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1007/s10911-013-9286-4
更新日期:2013-06-01 00:00:00
abstract::T cell immunity in breast cancer is suggested to play a role in tumor dormancy, a period of stability which can correspond to the time interval between primary treatment and tumor recurrence. Bone marrow in breast cancer patients seems to be particularly important because it is highly enriched with cancer specific mem...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1023/a:1020308104613
更新日期:2002-04-01 00:00:00
abstract::Mammalian cells depend on phospholipid (PL) and fatty acid (FA) transport to maintain membrane structure and organization, and to fuel and regulate cellular functions. In mammary glands of lactating animals, copious milk secretion, including large quantities of lipid in some species, requires adaptation and integratio...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1007/s10911-014-9318-8
更新日期:2014-03-01 00:00:00
abstract::With improved screening methods, the numbers of abnormal breast lesions diagnosed in women have been increasing over time. However, it remains unclear whether these breast lesions will develop into invasive cancers. To more effectively predict the outcome of breast lesions and determine a more appropriate course of tr...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章
doi:10.1007/s10911-018-9407-1
更新日期:2018-12-01 00:00:00
abstract::Insulin-like growth factor-I and -II (IGF-I and IGF-II) and/or the type I insulin-like growth factor receptor (IGF-IR) have been implicated in a number of human tumors including breast cancer. However, despite being implicated in breast cancer for approximately 25 years and given that transgenic technology has been av...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1007/s10911-008-9097-1
更新日期:2008-12-01 00:00:00
abstract::The ErbB receptor tyrosine kinase family has often been associated with increased growth of breast epithelial cells, as well as malignant transformation and progression. In contrast, ErbB4/HER4 exhibits unique attributes from a two step proteolytic cleavage which releases an 80 kilodalton, nuclear localizing, tyrosine...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1007/s10911-008-9080-x
更新日期:2008-06-01 00:00:00
abstract::We have reported the use of vectors based on avian leukosis virus (ALV) and ALV env pseudotyped lentivirus for stably introducing genes into somatic mammary cells in vivo for tumor modeling. These vectors require tva transgenic mice for viral infection. Here, we report, and described the method for, stably introducing...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章
doi:10.1007/s10911-009-9154-4
更新日期:2009-12-01 00:00:00
abstract::Transforming growth factor beta (TGF-beta) receptor expression and signal transduction in human breast cancer are reviewed as a function of estrogen receptor (ER) expression. ER+ breast cancer cells are generally resistant to the inhibitory effects of TGF-beta. The only known exception appears to be MCF-7 early passag...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1007/BF02017392
更新日期:1996-10-01 00:00:00
abstract::Inflammation of the adipose tissues occurs in association with obesity. This inflammatory process leads to the induction of cyclooxygenase-2 (COX-2) expression and a consequent elevation in prostaglandin (PG) production, which, together with proinflammatory cytokines, induce aromatase expression and estrogen synthesis...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1007/s10911-013-9299-z
更新日期:2013-12-01 00:00:00
abstract::The IGFBP family comprises six proteins with high affinity for the IGFs and several lower affinity IGFBP-related proteins. Their production in the breast is controlled by hormones, other local regulators and in tumors relates to the estrogen receptor status. Their functional activity can also be affected by various po...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1023/a:1009519400591
更新日期:2000-01-01 00:00:00
abstract::Breast development occurs through well-defined stages representing 'windows of susceptibility' to adverse environmental exposures that potentially modify breast cancer risk. Systematic characterization of morphology and transcriptome during normal breast development lays the foundation of our understanding of cancer e...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章
doi:10.1007/s10911-018-9401-7
更新日期:2018-09-01 00:00:00
abstract::The mouse model for breast cancer has developed into a most effective means of dissecting and understanding this devastating disease. The inbred transgenic mouse lends itself to biological, molecular, immunological, and genetic studies. The observation, dissection, transplantation, and subsequent amplification of prec...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1007/s10911-008-9088-2
更新日期:2008-09-01 00:00:00
abstract::The neuroendocrine hormone prolactin (PRL) stimulates breast growth and differentiation during puberty, pregnancy, and lactation. Despite extensive and convincing data indicating that PRL significantly contributes to the pathogenesis and progression of rodent mammary carcinoma, parallel observations for human breast c...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1023/a:1026325630359
更新日期:1997-01-01 00:00:00
abstract::The potential role of smoking in breast cancer risk has been the subject of over 100 publications, numerous scientific reviews, and animated debate. Tobacco exposure is a well-established cause of lung cancer, and is thought to account for nearly one third of all cancer deaths. Tobacco smoke contains thousands of chem...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1007/s10911-012-9269-x
更新日期:2013-03-01 00:00:00
abstract::Male breast cancer is a rare disease and clinical or epidemiological data are available from only a relatively few cases. Nonetheless, both similarities and discrepancies are apparent between breast cancer in men and women. For example, lobular and mucinous carcinomas are seldom seen in men. Tumors in men more often d...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1023/a:1009546811429
更新日期:2000-07-01 00:00:00
abstract::The One Health concept promotes integrated evaluation of human, animal, and environmental health questions to expedite advances benefiting all species. A recognition of the multi-species impact of mastitis as a painful condition with welfare implications leads us to suggest that mastitis is an ideal target for a One H...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1007/s10911-018-9395-1
更新日期:2018-06-01 00:00:00
abstract::Various retroviral and lentiviral vectors have been used for up-the-teat intraductal injection to deliver markers, oncogenes, and other genes into mammary epithelial cells in mice. These methods along with the large number of genetically engineered mouse lines have greatly helped us learn normal breast development and...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章
doi:10.1007/s10911-020-09469-w
更新日期:2020-11-09 00:00:00
abstract::The microenvironment of a tumor has emerged recently as a critical contributor to the development of cancer. Within this environment, fibroblasts and immune cells are the cell lineages that seem to be active mediators of tumour development. The activated fibroblasts that are also present during wound healing and chron...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1007/s10911-014-9326-8
更新日期:2014-07-01 00:00:00
abstract::Most of the development and functional differentiation in the mammary gland occur after birth. Epigenetics is defined as the stable alterations in gene expression potential that arise during development and proliferation. Epigenetic changes are mediated at the biochemical level by the chromatin conformation initiated ...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1007/s10911-010-9170-4
更新日期:2010-03-01 00:00:00
abstract::Wild-type p53 is a tumor suppressor gene that plays a central role in maintaining the genetic integrity of the cell by preventing cells with damaged DNA from further proliferation. Mutation and deletion of p53 are the most common genetic defects seen in clinical cancer. About 40% of breast carcinomas show high levels ...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1007/BF02013640
更新日期:1996-04-01 00:00:00
abstract::Estrogen receptor-α (ERα) and transforming growth factor (TGF)-β signaling pathways are major regulators during mammary gland development, function and tumorigenesis. Predominantly, they have opposing roles in proliferation and apoptosis. While ERα signaling supports growth and differentiation and is antiapoptotic, ma...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1007/s10911-011-9203-7
更新日期:2011-06-01 00:00:00
abstract::Available evidence indicates that mammary gland secretions first evolved in synapsids that laid parchment-shelled eggs. Unlike the rigid-shelled eggs of birds and some other sauropsids, parchment-shelled eggs lose water very rapidly when exposed to ambient air of lower vapor pressure, whether due to differences in rel...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1023/a:1022848632125
更新日期:2002-07-01 00:00:00
abstract::The differentiation and function of mammary epithelial cells is dependent upon the combined action of growth factor/hormone receptors and integrin receptors, which act in concert to control the signals required for normal cell function. It is now becoming clear that integrin receptors also contribute to carcinoma cell...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1023/a:1018766317055
更新日期:1999-10-01 00:00:00
abstract::Localised breast cancer can be cured by surgery and adjuvant treatments, but mortality remains high as some tumours metastasize early. Perlecan is a basement membrane (BM) protein involved in tumour development and progression. Here, mRNA and protein expression of perlecan, and mRNA expression of matrix degrading enzy...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章
doi:10.1007/s10911-020-09447-2
更新日期:2020-03-01 00:00:00
abstract::As their name implies, the myoepithelial cells found at the epithelial-mesenchymal interface of the human mammary gland disclose features suggestive of a dual epithelial-like and muscle-like differentiation, i.e. they co-express various keratins and vimentin intermediate filaments, as well as smooth muscle-related ant...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1007/s10911-005-9581-9
更新日期:2005-07-01 00:00:00
abstract::With the discovery of an activated Notch oncogene as a causative agent in mouse mammary tumor virus induced breast cancer in mice, the potential role for Notch signaling in normal and pathological mammary development was revealed. Subsequently, Notch receptors have been found to regulate normal development in many org...
journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1023/B:JOMG.0000037159.63644.81
更新日期:2004-04-01 00:00:00