Cytokine networks that mediate epithelial cell-macrophage crosstalk in the mammary gland: implications for development and cancer.

abstract：:The microenvironment of a tumor has emerged recently as a critical contributor to the development of cancer. Within this environment, fibroblasts and immune cells are the cell lineages that seem to be active mediators of tumour development. The activated fibroblasts that are also present during wound healing and chron...

journal_title：Journal of mammary gland biology and neoplasia

authors： Unsworth A,Anderson R,Britt K

更新日期：2014-07-01 00:00:00

abstract：:Carcinogenesis is a complex process during which cells undergo genetic and epigenetic alterations. These changes can lead tumor cells to acquire characteristics that enable movement from the primary site of origin when conditions become unfavorable. Such characteristics include gain of front-rear polarity, increased m...

journal_title：Journal of mammary gland biology and neoplasia

authors： Howe EN,Cochrane DR,Richer JK

更新日期：2012-03-01 00:00:00

abstract：:Premalignant breast disease in humans is a concept that admits to a broad range of elements and possible determinants predicting the likelihood of developing breast cancer. Most of these elements are relative, such as the risk of breast cancer for women that is 130 times that of men and peaks at a younger age by about...

journal_title：Journal of mammary gland biology and neoplasia

authors： Page DL,Jensen RA,Simpson JF,Dupont WD

更新日期：2000-10-01 00:00:00

abstract：:Various retroviral and lentiviral vectors have been used for up-the-teat intraductal injection to deliver markers, oncogenes, and other genes into mammary epithelial cells in mice. These methods along with the large number of genetically engineered mouse lines have greatly helped us learn normal breast development and...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bu W,Li Y

更新日期：2020-11-09 00:00:00

abstract：:The differentiation and function of mammary epithelial cells is dependent upon the combined action of growth factor/hormone receptors and integrin receptors, which act in concert to control the signals required for normal cell function. It is now becoming clear that integrin receptors also contribute to carcinoma cell...

journal_title：Journal of mammary gland biology and neoplasia

authors： Shaw LM

更新日期：1999-10-01 00:00:00

abstract：:The centrosome is the major microtubule organizing center of the cell and as such it plays an important role in cytoskeletal organization and in the formation of the bipolar mitotic spindle. Centrosome defects, characterized by abnormal size, number, and microtubule nucleation capacity, are distinguishing features of ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Salisbury JL

更新日期：2001-04-01 00:00:00

abstract：:The neuroendocrine hormone prolactin (PRL) stimulates breast growth and differentiation during puberty, pregnancy, and lactation. Despite extensive and convincing data indicating that PRL significantly contributes to the pathogenesis and progression of rodent mammary carcinoma, parallel observations for human breast c...

journal_title：Journal of mammary gland biology and neoplasia

authors： Clevenger CV,Plank TL

更新日期：1997-01-01 00:00:00

abstract：:The Hedgehog pathway is critical for many developmental processes, including the formation of several epidermal appendages. In the mammary gland strict regulation of the Hedgehog pathway is required for normal development. Alterations in Hedgehog signaling result in defects in both the embryonic and postnatal mammary ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Hatsell S,Frost AR

更新日期：2007-09-01 00:00:00

abstract：:Breast cancer is one of the most common cancers of women in the Western world. Despite modest achievements in the treatment of this disease, there is a substantial unmet medical need to reduce the occurrence of new breast cancers. In several prospective, placebo-controlled trials, the antiestrogen tamoxifen has been s...

journal_title：Journal of mammary gland biology and neoplasia

authors： Strassmer-Weippl K,Goss PE

更新日期：2003-01-01 00:00:00

abstract：:Mammalian cells depend on phospholipid (PL) and fatty acid (FA) transport to maintain membrane structure and organization, and to fuel and regulate cellular functions. In mammary glands of lactating animals, copious milk secretion, including large quantities of lipid in some species, requires adaptation and integratio...

journal_title：Journal of mammary gland biology and neoplasia

authors： McManaman JL

更新日期：2014-03-01 00:00:00

abstract：:Colony stimulating factor 1 (CSF-1), a major regulator of the mononuclear phagocytic lineage, is expressed in more than 70% of human breast cancers and its expression is correlated with poor prognosis. Studies of CSF-1 null mutant mice demonstrated that CSF-1 plays an important role in normal mammary ductal developmen...

journal_title：Journal of mammary gland biology and neoplasia

authors： Lin EY,Gouon-Evans V,Nguyen AV,Pollard JW

更新日期：2002-04-01 00:00:00

abstract：:Inflammation of the adipose tissues occurs in association with obesity. This inflammatory process leads to the induction of cyclooxygenase-2 (COX-2) expression and a consequent elevation in prostaglandin (PG) production, which, together with proinflammatory cytokines, induce aromatase expression and estrogen synthesis...

journal_title：Journal of mammary gland biology and neoplasia

authors： Vona-Davis L,Rose DP

更新日期：2013-12-01 00:00:00

abstract：:The One Health concept promotes integrated evaluation of human, animal, and environmental health questions to expedite advances benefiting all species. A recognition of the multi-species impact of mastitis as a painful condition with welfare implications leads us to suggest that mastitis is an ideal target for a One H...

journal_title：Journal of mammary gland biology and neoplasia

authors： Hughes K,Watson CJ

更新日期：2018-06-01 00:00:00

abstract：:Estrogen receptor-α (ERα) and transforming growth factor (TGF)-β signaling pathways are major regulators during mammary gland development, function and tumorigenesis. Predominantly, they have opposing roles in proliferation and apoptosis. While ERα signaling supports growth and differentiation and is antiapoptotic, ma...

journal_title：Journal of mammary gland biology and neoplasia

authors： Band AM,Laiho M

更新日期：2011-06-01 00:00:00

abstract：:Mammary gland involution, characterized by extensive apoptosis and structural remodelling of the gland, is the process by which the gland is returned to the pre-pregnant state. A key advantage of the mammary gland is the ability to synchronize involution through forced weaning, thus allowing the dissection of biochemi...

journal_title：Journal of mammary gland biology and neoplasia

authors： Sutherland KD,Lindeman GJ,Visvader JE

更新日期：2007-03-01 00:00:00

abstract：:Estrogens are important for the development of the mammary gland and strongly associated with oncogenesis in this tissue. The biological effects of estrogens are mediated through the estrogen receptor (ER), a member of the nuclear receptor superfamily. The estrogen/ER signaling pathway plays a central role in mammary ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bocchinfuso WP,Korach KS

更新日期：1997-10-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT) and its reversion via mesenchymal to epithelial transition (MET), represent a stepwise cycle of epithelial plasticity that allows for normal tissue remodelling and diversification during development. In particular, epithelial-mesenchymal plasticity is central to many aspects ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Godde NJ,Galea RC,Elsum IA,Humbert PO

更新日期：2010-06-01 00:00:00

abstract：:Tight junctions (TJs), the most apical components of the cell-cell junctional complexes, play a crucial role in the establishment and maintenance of cell polarity within tissues. In secretory glandular tissues, such as the mammary gland, TJs are crucial for separating apical and basolateral domains. TJs also create th...

journal_title：Journal of mammary gland biology and neoplasia

authors： Itoh M,Bissell MJ

更新日期：2003-10-01 00:00:00

abstract：:Insulin-like growth factor-I and -II (IGF-I and IGF-II) and/or the type I insulin-like growth factor receptor (IGF-IR) have been implicated in a number of human tumors including breast cancer. However, despite being implicated in breast cancer for approximately 25 years and given that transgenic technology has been av...

journal_title：Journal of mammary gland biology and neoplasia

authors： Jones RA,Moorehead RA

更新日期：2008-12-01 00:00:00

abstract：:The potential role of smoking in breast cancer risk has been the subject of over 100 publications, numerous scientific reviews, and animated debate. Tobacco exposure is a well-established cause of lung cancer, and is thought to account for nearly one third of all cancer deaths. Tobacco smoke contains thousands of chem...

journal_title：Journal of mammary gland biology and neoplasia

authors： Reynolds P

更新日期：2013-03-01 00:00:00

abstract：:Breast cancer is a heterogeneous disease comprised of at least five major tumor subtypes that coalesce as the second leading cause of cancer death in women in the United States. Although metastasis clearly represents the most lethal characteristic of breast cancer, our understanding of the molecular mechanisms that go...

journal_title：Journal of mammary gland biology and neoplasia

authors： Parvani JG,Taylor MA,Schiemann WP

更新日期：2011-06-01 00:00:00

abstract：:The Notch receptor protein and its signaling pathway have been well conserved throughout evolution and appear to be pivotal components in cell fate decisions during development. Recent studies suggest that, depending on the cellular and developmental context, Notch signaling may also affect cell proliferation and prog...

journal_title：Journal of mammary gland biology and neoplasia

authors： Callahan R,Raafat A

更新日期：2001-01-01 00:00:00

abstract：:It has long been appreciated that the estrogen receptor (ER) plays an important role in the biology of breast cancer. It is an accepted factor predicting favorable disease outcome and treatment response, and as such is generally considered to represent a "good" prognostic marker in breast cancer. In this review we pre...

journal_title：Journal of mammary gland biology and neoplasia

authors： Fuqua SA

更新日期：2001-10-01 00:00:00

abstract：:The development and progression of aggressive breast cancer is characterized by genomic instability leading to multiple genetic defects, phenotypic diversity, chemoresistance, and poor outcome. Centrosome abnormalities have been implicated in the origin of chromosomal instability through the development of multipolar ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Salisbury JL,D'Assoro AB,Lingle WL

更新日期：2004-07-01 00:00:00

abstract：:Breast cancer development is a multi-step process in which genetic and molecular heterogeneity occurs at multiple stages. Ductal carcinoma arises from pre-invasive lesions such as atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS), which progress to invasive and metastatic cancer. The feasibility of...

journal_title：Journal of mammary gland biology and neoplasia

authors： Behbod F,Gomes AM,Machado HL

更新日期：2018-12-01 00:00:00

abstract：:Breast cancer (BC) is a leading cause of death among women with malignant diseases. The selection of adequate therapies for highly invasive and metastatic BCs still represents a major challenge. Novel combinatorial therapeutic approaches are urgently required to enhance the efficiency of BC treatment. Recently, microR...

journal_title：Journal of mammary gland biology and neoplasia

authors： Petrović N,Nakashidze I,Nedeljković M

更新日期：2021-01-21 00:00:00

abstract：:The IGFBP family comprises six proteins with high affinity for the IGFs and several lower affinity IGFBP-related proteins. Their production in the breast is controlled by hormones, other local regulators and in tumors relates to the estrogen receptor status. Their functional activity can also be affected by various po...

journal_title：Journal of mammary gland biology and neoplasia

authors： Perks CM,Holly JM

更新日期：2000-01-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) receptor expression and signal transduction in human breast cancer are reviewed as a function of estrogen receptor (ER) expression. ER+ breast cancer cells are generally resistant to the inhibitory effects of TGF-beta. The only known exception appears to be MCF-7 early passag...

journal_title：Journal of mammary gland biology and neoplasia

authors： Brattain MG,Ko Y,Banerji SS,Wu G,Willson JK

更新日期：1996-10-01 00:00:00

abstract：:Calcium is an important nutrient that is secreted into milk in quantities that put a considerable stress upon maternal calcium homeostasis. Here we summarize the evidence that two important entities, the extracellular calcium-sensing receptor (CaR) and parathyroid hormone-related protein (PTHrP) are involved in a feed...

journal_title：Journal of mammary gland biology and neoplasia

authors： VanHouten JN

更新日期：2005-04-01 00:00:00

abstract：:Increased glucose requirements of the gravid uterus during late pregnancy and even greater requirements of the lactating mammary glands necessitate major adjustments in glucose production and utilization in maternal liver, adipose tissue, skeletal muscle, and other tissues. In ruminants, which at all times rely princi...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bell AW,Bauman DE

更新日期：1997-07-01 00:00:00