EGF-related peptides in the pathophysiology of the mammary gland.

abstract：:The involvement of molecular mechanisms in a particular process such as embryonic mammary gland development, can be revealed by modulation of one or several factors that purportedly act in that process. If those factors or their inhibitors are soluble, their function can be tested by loading them onto small inert bead...

journal_title：Journal of mammary gland biology and neoplasia

authors： Veltmaat JM

更新日期：2013-06-01 00:00:00

abstract：:Estrogen receptor-α (ERα) and transforming growth factor (TGF)-β signaling pathways are major regulators during mammary gland development, function and tumorigenesis. Predominantly, they have opposing roles in proliferation and apoptosis. While ERα signaling supports growth and differentiation and is antiapoptotic, ma...

journal_title：Journal of mammary gland biology and neoplasia

authors： Band AM,Laiho M

更新日期：2011-06-01 00:00:00

abstract：:Mouse modeling of human breast cancer has developed tremendously over the past ten years. Human breast cancer is characterized by enormous biological diversity and, collectively, the new models have come much closer to encompassing this diversity. They have provided a deeper understanding of the fundamental events tha...

journal_title：Journal of mammary gland biology and neoplasia

authors： Allred DC,Medina D

更新日期：2008-09-01 00:00:00

abstract：:Estrogens are important for the development of the mammary gland and strongly associated with oncogenesis in this tissue. The biological effects of estrogens are mediated through the estrogen receptor (ER), a member of the nuclear receptor superfamily. The estrogen/ER signaling pathway plays a central role in mammary ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bocchinfuso WP,Korach KS

更新日期：1997-10-01 00:00:00

abstract：:Dynamic interactions between the hormone responsive mammary gland epithelium and surrounding stromal macrophage populations are critical for normal development and function of the mammary gland. Macrophages are versatile cells capable of diverse roles in mammary gland development and maintenance of homeostasis, and th...

journal_title：Journal of mammary gland biology and neoplasia

authors： Sun X,Ingman WV

更新日期：2014-07-01 00:00:00

abstract：:The relationship between maternal dietary intakes of energy or fat maternal body composition and the milk fat concentration is an important element in understanding the role of breast-milk in infant nutrition. In most studies in both developing and developed countries, no relation between maternal energy intake and mi...

journal_title：Journal of mammary gland biology and neoplasia

authors： Villalpando S,del Prado M

更新日期：1999-07-01 00:00:00

abstract：:The Hedgehog pathway is critical for many developmental processes, including the formation of several epidermal appendages. In the mammary gland strict regulation of the Hedgehog pathway is required for normal development. Alterations in Hedgehog signaling result in defects in both the embryonic and postnatal mammary ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Hatsell S,Frost AR

更新日期：2007-09-01 00:00:00

abstract：:The mouse model for breast cancer has developed into a most effective means of dissecting and understanding this devastating disease. The inbred transgenic mouse lends itself to biological, molecular, immunological, and genetic studies. The observation, dissection, transplantation, and subsequent amplification of prec...

journal_title：Journal of mammary gland biology and neoplasia

authors： Young LJ

更新日期：2008-09-01 00:00:00

abstract：:Postpartum mammary gland involution is a mammalian tissue remodeling event that occurs after pregnancy and lactation to return the gland to the pre-pregnant state. This event is characterized by apoptosis and lysosomal-mediated cell death of the majority of the lactational mammary epithelium, followed by remodeling of...

journal_title：Journal of mammary gland biology and neoplasia

authors： Elder AM,Stoller AR,Black SA,Lyons TR

更新日期：2020-06-01 00:00:00

abstract：:Various retroviral and lentiviral vectors have been used for up-the-teat intraductal injection to deliver markers, oncogenes, and other genes into mammary epithelial cells in mice. These methods along with the large number of genetically engineered mouse lines have greatly helped us learn normal breast development and...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bu W,Li Y

更新日期：2020-11-09 00:00:00

abstract：:Analysis of genes and proteins involved in lipid biosynthesis in mammary epithelial cells (MECs) is complicated by the presence of adipose tissue in the mammary gland, which may be predominant in whole tissue lysates depending upon developmental stage. We have developed a method based on protocols used to establish pr...

journal_title：Journal of mammary gland biology and neoplasia

authors： Rudolph MC,Wellberg EA,Anderson SM

更新日期：2009-12-01 00:00:00

abstract：:Colony stimulating factor 1 (CSF-1), a major regulator of the mononuclear phagocytic lineage, is expressed in more than 70% of human breast cancers and its expression is correlated with poor prognosis. Studies of CSF-1 null mutant mice demonstrated that CSF-1 plays an important role in normal mammary ductal developmen...

journal_title：Journal of mammary gland biology and neoplasia

authors： Lin EY,Gouon-Evans V,Nguyen AV,Pollard JW

更新日期：2002-04-01 00:00:00

abstract：:The mammary gland is an ectodermal appendage and a defining feature of mammals. Consistent with it being a recent evolutionary novelty, many of the molecules essential for the ontogeny and morphogenesis of various vertebrate organs, including those in the fibroblast growth factor (FGF) signaling pathway, are co-opted ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Kim EJ,Jung HS,Lu P

更新日期：2013-06-01 00:00:00

abstract：:Elucidating cell hierarchy in the mammary gland is fundamental for understanding the mechanisms governing its normal development and malignant transformation. There is relatively little information on cell hierarchy in the bovine mammary gland, despite its agricultural potential and relevance to breast cancer research...

journal_title：Journal of mammary gland biology and neoplasia

authors： Rauner G,Barash I

更新日期：2016-06-01 00:00:00

abstract：:With improved screening methods, the numbers of abnormal breast lesions diagnosed in women have been increasing over time. However, it remains unclear whether these breast lesions will develop into invasive cancers. To more effectively predict the outcome of breast lesions and determine a more appropriate course of tr...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bernard S,Myers M,Fang WB,Zinda B,Smart C,Lambert D,Zou A,Fan F,Cheng N

更新日期：2018-12-01 00:00:00

abstract：:Mammary gland involution, characterized by extensive apoptosis and structural remodelling of the gland, is the process by which the gland is returned to the pre-pregnant state. A key advantage of the mammary gland is the ability to synchronize involution through forced weaning, thus allowing the dissection of biochemi...

journal_title：Journal of mammary gland biology and neoplasia

authors： Sutherland KD,Lindeman GJ,Visvader JE

更新日期：2007-03-01 00:00:00

abstract：:Localised breast cancer can be cured by surgery and adjuvant treatments, but mortality remains high as some tumours metastasize early. Perlecan is a basement membrane (BM) protein involved in tumour development and progression. Here, mRNA and protein expression of perlecan, and mRNA expression of matrix degrading enzy...

journal_title：Journal of mammary gland biology and neoplasia

authors： Jansson M,Billing O,Herdenberg C,Lundin C,Tolockiene E,Nazemroaya A,Sund M

更新日期：2020-03-01 00:00:00

abstract：:Human mammary epithelial cells emerge spontaneously from senescence, exhibiting eroding telomeric sequences, and ultimately enter crisis to generate the type of chromosomal abnormalities seen in early stages of breast cancer. In a mouse mammary tumor model, the spontaneous escape of senescence can be observed as an in...

journal_title：Journal of mammary gland biology and neoplasia

authors： Said TK,Medina D

更新日期：2004-01-01 00:00:00

abstract：:Tight junctions (TJs), the most apical components of the cell-cell junctional complexes, play a crucial role in the establishment and maintenance of cell polarity within tissues. In secretory glandular tissues, such as the mammary gland, TJs are crucial for separating apical and basolateral domains. TJs also create th...

journal_title：Journal of mammary gland biology and neoplasia

authors： Itoh M,Bissell MJ

更新日期：2003-10-01 00:00:00

abstract：:Carcinogenesis is a complex process during which cells undergo genetic and epigenetic alterations. These changes can lead tumor cells to acquire characteristics that enable movement from the primary site of origin when conditions become unfavorable. Such characteristics include gain of front-rear polarity, increased m...

journal_title：Journal of mammary gland biology and neoplasia

authors： Howe EN,Cochrane DR,Richer JK

更新日期：2012-03-01 00:00:00

abstract：:Originally adapted from the neurosphere assay, the nonadherent mammosphere assay has been utilized to assess early progenitor/stem cell frequency in a given population of mammary epithelial cells. This method has also been used to measure the frequency of tumorsphere initiating cells in both primary mammary tumors as ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Rota LM,Lazzarino DA,Ziegler AN,LeRoith D,Wood TL

更新日期：2012-06-01 00:00:00

abstract：:Breast development occurs through well-defined stages representing 'windows of susceptibility' to adverse environmental exposures that potentially modify breast cancer risk. Systematic characterization of morphology and transcriptome during normal breast development lays the foundation of our understanding of cancer e...

journal_title：Journal of mammary gland biology and neoplasia

authors： Gopalakrishnan K,Teitelbaum SL,Wetmur J,Manservisi F,Falcioni L,Panzacchi S,Gnudi F,Belpoggi F,Chen J

更新日期：2018-09-01 00:00:00

abstract：:With the discovery of an activated Notch oncogene as a causative agent in mouse mammary tumor virus induced breast cancer in mice, the potential role for Notch signaling in normal and pathological mammary development was revealed. Subsequently, Notch receptors have been found to regulate normal development in many org...

journal_title：Journal of mammary gland biology and neoplasia

authors： Callahan R,Egan SE

更新日期：2004-04-01 00:00:00

abstract：:Milk is primarily regarded as a food furnishing essential nutrients for infant growth and development, but milk can also serve as a vehicle for mother to neonate transfer of molecules that regulate development. A wide array of biologically active compounds such as hormones, cytokines and enzymes are present in milk, e...

journal_title：Journal of mammary gland biology and neoplasia

authors： Ellis LA,Mastro AM,Picciano MF

更新日期：1996-07-01 00:00:00

abstract：:Breast cancer is one of the most common cancers of women in the Western world. Despite modest achievements in the treatment of this disease, there is a substantial unmet medical need to reduce the occurrence of new breast cancers. In several prospective, placebo-controlled trials, the antiestrogen tamoxifen has been s...

journal_title：Journal of mammary gland biology and neoplasia

authors： Strassmer-Weippl K,Goss PE

更新日期：2003-01-01 00:00:00

abstract：:We have reported the use of vectors based on avian leukosis virus (ALV) and ALV env pseudotyped lentivirus for stably introducing genes into somatic mammary cells in vivo for tumor modeling. These vectors require tva transgenic mice for viral infection. Here, we report, and described the method for, stably introducing...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bu W,Xin L,Toneff M,Li L,Li Y

更新日期：2009-12-01 00:00:00

abstract：:The microenvironment of a tumor has emerged recently as a critical contributor to the development of cancer. Within this environment, fibroblasts and immune cells are the cell lineages that seem to be active mediators of tumour development. The activated fibroblasts that are also present during wound healing and chron...

journal_title：Journal of mammary gland biology and neoplasia

authors： Unsworth A,Anderson R,Britt K

更新日期：2014-07-01 00:00:00

abstract：:Tumor spread involves degradation of various components of the extracellular matrix and blood vessel wall. Among these is heparan sulfate proteoglycan, which plays a key role in the self-assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Expression of an endoglycosidase (he...

journal_title：Journal of mammary gland biology and neoplasia

authors： Zcharia E,Metzger S,Chajek-Shaul T,Friedmann Y,Pappo O,Aviv A,Elkin M,Pecker I,Peretz T,Vlodavsky I

更新日期：2001-07-01 00:00:00

abstract：:This article illustrates the most common benign and malignant lesions in the breast, and is intended for the biologist working in the area of breast cancer and breast biology, not for the practicing pathologist. The atlas covers benign proliferative lesions, atypical lesions, variants of in situ cancer, the main types...

journal_title：Journal of mammary gland biology and neoplasia

authors： Mallon E,Osin P,Nasiri N,Blain I,Howard B,Gusterson B

更新日期：2000-04-01 00:00:00

abstract：:The ability to produce and expel milk is important for the health and survival of all mammals. Nevertheless, our understanding of the molecular events underlying the execution of this process remains incomplete. Whilst impaired mammary gland development and lactational competence remains the subject of focused investi...

journal_title：Journal of mammary gland biology and neoplasia

authors： Stewart TA,Davis FM

更新日期：2020-11-19 00:00:00