Mammary gland development and tumorigenesis in estrogen receptor knockout mice.

abstract：:The mouse has emerged as a primary animal model for human breast cancer because the mammary glands of the two species are very similar in structure and function. In this regard the TDLU and LA have similar morphology. The mouse, infected by MMTV, develops "spontaneous" tumors with specific but limited tumor phenotypes...

journal_title：Journal of mammary gland biology and neoplasia

authors： Cardiff RD,Wellings SR

更新日期：1999-01-01 00:00:00

abstract：:The mammary gland is an ectodermal appendage and a defining feature of mammals. Consistent with it being a recent evolutionary novelty, many of the molecules essential for the ontogeny and morphogenesis of various vertebrate organs, including those in the fibroblast growth factor (FGF) signaling pathway, are co-opted ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Kim EJ,Jung HS,Lu P

更新日期：2013-06-01 00:00:00

abstract：:T cell immunity in breast cancer is suggested to play a role in tumor dormancy, a period of stability which can correspond to the time interval between primary treatment and tumor recurrence. Bone marrow in breast cancer patients seems to be particularly important because it is highly enriched with cancer specific mem...

journal_title：Journal of mammary gland biology and neoplasia

authors： Schirrmacher V,Feuerer M,Beckhove P,Ahlert T,Umansky V

更新日期：2002-04-01 00:00:00

abstract：:Estrogen receptor-α (ERα) and transforming growth factor (TGF)-β signaling pathways are major regulators during mammary gland development, function and tumorigenesis. Predominantly, they have opposing roles in proliferation and apoptosis. While ERα signaling supports growth and differentiation and is antiapoptotic, ma...

journal_title：Journal of mammary gland biology and neoplasia

authors： Band AM,Laiho M

更新日期：2011-06-01 00:00:00

abstract：:Ductal development in the pubertal mouse mammary gland is characterized by dramatic morphological changes in the epithelium driven by proliferation of cap and body cells in the terminal endbuds. Recent experiments revealed a coincident and abundant apoptosis in the body cells of these structures. The cells undergoing ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Humphreys RC

更新日期：1999-04-01 00:00:00

abstract：:We review the role of Neuregulin 3 (Nrg3) and Erbb receptor signalling in embryonic mammary gland development. Neuregulins are growth factors that bind and activate its cognate Erbb receptor tyrosine kinases, which form a signalling network with established roles in breast development and breast cancer. Studies have s...

journal_title：Journal of mammary gland biology and neoplasia

authors： Kogata N,Zvelebil M,Howard BA

更新日期：2013-06-01 00:00:00

abstract：:Mammalian cells depend on phospholipid (PL) and fatty acid (FA) transport to maintain membrane structure and organization, and to fuel and regulate cellular functions. In mammary glands of lactating animals, copious milk secretion, including large quantities of lipid in some species, requires adaptation and integratio...

journal_title：Journal of mammary gland biology and neoplasia

authors： McManaman JL

更新日期：2014-03-01 00:00:00

abstract：:Human mammary epithelial cells emerge spontaneously from senescence, exhibiting eroding telomeric sequences, and ultimately enter crisis to generate the type of chromosomal abnormalities seen in early stages of breast cancer. In a mouse mammary tumor model, the spontaneous escape of senescence can be observed as an in...

journal_title：Journal of mammary gland biology and neoplasia

authors： Said TK,Medina D

更新日期：2004-01-01 00:00:00

abstract：:Dynamic interactions between the hormone responsive mammary gland epithelium and surrounding stromal macrophage populations are critical for normal development and function of the mammary gland. Macrophages are versatile cells capable of diverse roles in mammary gland development and maintenance of homeostasis, and th...

journal_title：Journal of mammary gland biology and neoplasia

authors： Sun X,Ingman WV

更新日期：2014-07-01 00:00:00

abstract：:Exosomes are small extracellular vesicles secreted to the extracellular environment by several cell types, including tumor cells. It has been demonstrated that exosomes have an important role in intercellular communication, but they have recently been implicated in various tumor processes, including the oncogenic tran...

journal_title：Journal of mammary gland biology and neoplasia

authors： Villagrasa A,Álvarez PJ,Osuna A,Garrido JM,Aránega A,Rodríguez-Serrano F

更新日期：2014-12-01 00:00:00

abstract：:Milk production is highly dependent on the optimal development of the mammary epithelium. It is therefore essential to better understand mammary epithelial cell growth and maintenance from the related epithelial lineage during the animal life. Here, we characterized the epithelial lineage at puberty, lactation and dry...

journal_title：Journal of mammary gland biology and neoplasia

authors： Finot L,Chanat E,Dessauge F

更新日期：2019-06-01 00:00:00

abstract：:The involvement of molecular mechanisms in a particular process such as embryonic mammary gland development, can be revealed by modulation of one or several factors that purportedly act in that process. If those factors or their inhibitors are soluble, their function can be tested by loading them onto small inert bead...

journal_title：Journal of mammary gland biology and neoplasia

authors： Veltmaat JM

更新日期：2013-06-01 00:00:00

abstract：:Elucidating cell hierarchy in the mammary gland is fundamental for understanding the mechanisms governing its normal development and malignant transformation. There is relatively little information on cell hierarchy in the bovine mammary gland, despite its agricultural potential and relevance to breast cancer research...

journal_title：Journal of mammary gland biology and neoplasia

authors： Rauner G,Barash I

更新日期：2016-06-01 00:00:00

abstract：:The relationship between maternal dietary intakes of energy or fat maternal body composition and the milk fat concentration is an important element in understanding the role of breast-milk in infant nutrition. In most studies in both developing and developed countries, no relation between maternal energy intake and mi...

journal_title：Journal of mammary gland biology and neoplasia

authors： Villalpando S,del Prado M

更新日期：1999-07-01 00:00:00

abstract：:Mammary gland involution is a period of intensive tissue remodeling. Over the course of a relatively brief period, a large proportion of the mammary gland epithelium undergoes programmed cell death and is removed by phagocytes. In addition, the gland is cleared of residual milk fat globules as well as milk and adipocy...

journal_title：Journal of mammary gland biology and neoplasia

authors： Atabai K,Sheppard D,Werb Z

更新日期：2007-03-01 00:00:00

abstract：:With improved screening methods, the numbers of abnormal breast lesions diagnosed in women have been increasing over time. However, it remains unclear whether these breast lesions will develop into invasive cancers. To more effectively predict the outcome of breast lesions and determine a more appropriate course of tr...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bernard S,Myers M,Fang WB,Zinda B,Smart C,Lambert D,Zou A,Fan F,Cheng N

更新日期：2018-12-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT) and its reversion via mesenchymal to epithelial transition (MET), represent a stepwise cycle of epithelial plasticity that allows for normal tissue remodelling and diversification during development. In particular, epithelial-mesenchymal plasticity is central to many aspects ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Godde NJ,Galea RC,Elsum IA,Humbert PO

更新日期：2010-06-01 00:00:00

abstract：:The insulin-like growth factors (IGFs) signaling via the type I insulin-like growth factor receptor (IGF-1R) regulate multiple aspects of malignancy. The importance of IGF-1R in regulating the malignant phenotype is currently being validated in numerous clinical trials for cancer including breast cancer. This review d...

journal_title：Journal of mammary gland biology and neoplasia

authors： Sachdev D

更新日期：2008-12-01 00:00:00

abstract：:It has long been appreciated that the estrogen receptor (ER) plays an important role in the biology of breast cancer. It is an accepted factor predicting favorable disease outcome and treatment response, and as such is generally considered to represent a "good" prognostic marker in breast cancer. In this review we pre...

journal_title：Journal of mammary gland biology and neoplasia

authors： Fuqua SA

更新日期：2001-10-01 00:00:00

abstract：:The development and progression of aggressive breast cancer is characterized by genomic instability leading to multiple genetic defects, phenotypic diversity, chemoresistance, and poor outcome. Centrosome abnormalities have been implicated in the origin of chromosomal instability through the development of multipolar ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Salisbury JL,D'Assoro AB,Lingle WL

更新日期：2004-07-01 00:00:00

abstract：:Colony stimulating factor 1 (CSF-1), a major regulator of the mononuclear phagocytic lineage, is expressed in more than 70% of human breast cancers and its expression is correlated with poor prognosis. Studies of CSF-1 null mutant mice demonstrated that CSF-1 plays an important role in normal mammary ductal developmen...

journal_title：Journal of mammary gland biology and neoplasia

authors： Lin EY,Gouon-Evans V,Nguyen AV,Pollard JW

更新日期：2002-04-01 00:00:00

abstract：:Premalignant breast disease in humans is a concept that admits to a broad range of elements and possible determinants predicting the likelihood of developing breast cancer. Most of these elements are relative, such as the risk of breast cancer for women that is 130 times that of men and peaks at a younger age by about...

journal_title：Journal of mammary gland biology and neoplasia

authors： Page DL,Jensen RA,Simpson JF,Dupont WD

更新日期：2000-10-01 00:00:00

abstract：:Breast cancer is one of the most common cancers of women in the Western world. Despite modest achievements in the treatment of this disease, there is a substantial unmet medical need to reduce the occurrence of new breast cancers. In several prospective, placebo-controlled trials, the antiestrogen tamoxifen has been s...

journal_title：Journal of mammary gland biology and neoplasia

authors： Strassmer-Weippl K,Goss PE

更新日期：2003-01-01 00:00:00

abstract：:Women are using estrogens for many purposes, such as to prevent pregnancy or miscarriage, or to treat menopausal symptoms. Estrogens also have been used to treat breast cancer which seems puzzling, since there is convincing evidence to support a link between high lifetime estrogen exposure and increased breast cancer ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Hilakivi-Clarke L,de Assis S,Warri A

更新日期：2013-03-01 00:00:00

abstract：:Various retroviral and lentiviral vectors have been used for up-the-teat intraductal injection to deliver markers, oncogenes, and other genes into mammary epithelial cells in mice. These methods along with the large number of genetically engineered mouse lines have greatly helped us learn normal breast development and...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bu W,Li Y

更新日期：2020-11-09 00:00:00

abstract：:Breast cancer is a heterogeneous disease comprised of at least five major tumor subtypes that coalesce as the second leading cause of cancer death in women in the United States. Although metastasis clearly represents the most lethal characteristic of breast cancer, our understanding of the molecular mechanisms that go...

journal_title：Journal of mammary gland biology and neoplasia

authors： Parvani JG,Taylor MA,Schiemann WP

更新日期：2011-06-01 00:00:00

abstract：:Breast cancer development is a multi-step process in which genetic and molecular heterogeneity occurs at multiple stages. Ductal carcinoma arises from pre-invasive lesions such as atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS), which progress to invasive and metastatic cancer. The feasibility of...

journal_title：Journal of mammary gland biology and neoplasia

authors： Behbod F,Gomes AM,Machado HL

更新日期：2018-12-01 00:00:00

abstract：:Most of the development and functional differentiation in the mammary gland occur after birth. Epigenetics is defined as the stable alterations in gene expression potential that arise during development and proliferation. Epigenetic changes are mediated at the biochemical level by the chromatin conformation initiated ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Rijnkels M,Kabotyanski E,Montazer-Torbati MB,Hue Beauvais C,Vassetzky Y,Rosen JM,Devinoy E

更新日期：2010-03-01 00:00:00

abstract：:Available evidence indicates that mammary gland secretions first evolved in synapsids that laid parchment-shelled eggs. Unlike the rigid-shelled eggs of birds and some other sauropsids, parchment-shelled eggs lose water very rapidly when exposed to ambient air of lower vapor pressure, whether due to differences in rel...

journal_title：Journal of mammary gland biology and neoplasia

authors： Oftedal OT

更新日期：2002-07-01 00:00:00

abstract：:The neuroendocrine hormone prolactin (PRL) stimulates breast growth and differentiation during puberty, pregnancy, and lactation. Despite extensive and convincing data indicating that PRL significantly contributes to the pathogenesis and progression of rodent mammary carcinoma, parallel observations for human breast c...

journal_title：Journal of mammary gland biology and neoplasia

authors： Clevenger CV,Plank TL

更新日期：1997-01-01 00:00:00