Abstract：
:The relationship between maternal dietary intakes of energy or fat maternal body composition and the milk fat concentration is an important element in understanding the role of breast-milk in infant nutrition. In most studies in both developing and developed countries, no relation between maternal energy intake and milk fat content was observed. In only one published study, in which maternal fat intake comprised a very low 5% of calories, was a short term reduction in milk lipid observed in some subjects. On the other hand, a positive relation between maternal fatness and milk fat is evident in both well-nourished and under-nourished women when appropriate methodologies have been used. Low milk fat concentrations are associated with higher milk volumes probably because infant demand determines milk intake, compensating, at least partially, for low milk fat. No impairment of infant growth was associated with low milk fat, in studies where it has been measured. The mechanism for the relationship between body fat and milk fat is a fertile field for additional investigation.
journal_name
J Mammary Gland Biol Neoplasiajournal_title
Journal of mammary gland biology and neoplasiaauthors
Villalpando S,del Prado Mdoi
10.1023/a:1018702030259subject
Has Abstractpub_date
1999-07-01 00:00:00pages
285-95issue
3eissn
1083-3021issn
1573-7039journal_volume
4pub_type
杂志文章abstract：:The One Health concept promotes integrated evaluation of human, animal, and environmental health questions to expedite advances benefiting all species. A recognition of the multi-species impact of mastitis as a painful condition with welfare implications leads us to suggest that mastitis is an ideal target for a One H...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-018-9395-1
更新日期：2018-06-01 00:00:00
abstract：:Premalignant breast disease in humans is a concept that admits to a broad range of elements and possible determinants predicting the likelihood of developing breast cancer. Most of these elements are relative, such as the risk of breast cancer for women that is 130 times that of men and peaks at a younger age by about...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1009521726605
更新日期：2000-10-01 00:00:00
abstract：:Tumor spread involves degradation of various components of the extracellular matrix and blood vessel wall. Among these is heparan sulfate proteoglycan, which plays a key role in the self-assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Expression of an endoglycosidase (he...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1011375624902
更新日期：2001-07-01 00:00:00
abstract：:Mouse modeling of human breast cancer has developed tremendously over the past ten years. Human breast cancer is characterized by enormous biological diversity and, collectively, the new models have come much closer to encompassing this diversity. They have provided a deeper understanding of the fundamental events tha...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-008-9093-5
更新日期：2008-09-01 00:00:00
abstract：:The potential role of smoking in breast cancer risk has been the subject of over 100 publications, numerous scientific reviews, and animated debate. Tobacco exposure is a well-established cause of lung cancer, and is thought to account for nearly one third of all cancer deaths. Tobacco smoke contains thousands of chem...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-012-9269-x
更新日期：2013-03-01 00:00:00
abstract：:The ability to produce and expel milk is important for the health and survival of all mammals. Nevertheless, our understanding of the molecular events underlying the execution of this process remains incomplete. Whilst impaired mammary gland development and lactational competence remains the subject of focused investi...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-020-09467-y
更新日期：2020-11-19 00:00:00
abstract：:Breast cancer development is a multi-step process in which genetic and molecular heterogeneity occurs at multiple stages. Ductal carcinoma arises from pre-invasive lesions such as atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS), which progress to invasive and metastatic cancer. The feasibility of...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-018-9408-0
更新日期：2018-12-01 00:00:00
abstract：:Milk is primarily regarded as a food furnishing essential nutrients for infant growth and development, but milk can also serve as a vehicle for mother to neonate transfer of molecules that regulate development. A wide array of biologically active compounds such as hormones, cytokines and enzymes are present in milk, e...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/BF02018079
更新日期：1996-07-01 00:00:00
abstract：:Analysis of genes and proteins involved in lipid biosynthesis in mammary epithelial cells (MECs) is complicated by the presence of adipose tissue in the mammary gland, which may be predominant in whole tissue lysates depending upon developmental stage. We have developed a method based on protocols used to establish pr...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章
doi：10.1007/s10911-009-9161-5
更新日期：2009-12-01 00:00:00
abstract：:Normal mammary gland development is the result of complex interactions between a number of hormones and growth factors. Normal and malignant human mammary epithelial cells are able to synthesize and to respond to various different, locally acting growth factors and growth inhibitors. Among these, the EGF-related pepti...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1026351730785
更新日期：1997-04-01 00:00:00
abstract：:Estrogens are important for the development of the mammary gland and strongly associated with oncogenesis in this tissue. The biological effects of estrogens are mediated through the estrogen receptor (ER), a member of the nuclear receptor superfamily. The estrogen/ER signaling pathway plays a central role in mammary ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1026339111278
更新日期：1997-10-01 00:00:00
abstract：:Insulin-like growth factor-I and -II (IGF-I and IGF-II) and/or the type I insulin-like growth factor receptor (IGF-IR) have been implicated in a number of human tumors including breast cancer. However, despite being implicated in breast cancer for approximately 25 years and given that transgenic technology has been av...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-008-9097-1
更新日期：2008-12-01 00:00:00
abstract：:Nuclear Factor-kappaB (NF-kappaB) has been implicated in the lobuloalveolar development of the mammary gland. In breast cancer its activation has been linked to tumor progression via stimulation of cell proliferation, pro-survival, and angiogenesis pathways and metastasis. Whether NF-kappaB activation in the immune sy...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-006-9013-5
更新日期：2006-01-01 00:00:00
abstract：:Localised breast cancer can be cured by surgery and adjuvant treatments, but mortality remains high as some tumours metastasize early. Perlecan is a basement membrane (BM) protein involved in tumour development and progression. Here, mRNA and protein expression of perlecan, and mRNA expression of matrix degrading enzy...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章
doi：10.1007/s10911-020-09447-2
更新日期：2020-03-01 00:00:00
abstract：:Exosomes are small extracellular vesicles secreted to the extracellular environment by several cell types, including tumor cells. It has been demonstrated that exosomes have an important role in intercellular communication, but they have recently been implicated in various tumor processes, including the oncogenic tran...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-015-9332-5
更新日期：2014-12-01 00:00:00
abstract：:Breast cancer is one of the most common cancers of women in the Western world. Despite modest achievements in the treatment of this disease, there is a substantial unmet medical need to reduce the occurrence of new breast cancers. In several prospective, placebo-controlled trials, the antiestrogen tamoxifen has been s...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1025727103811
更新日期：2003-01-01 00:00:00
abstract：:Obesity is a preventable risk factor for breast cancer following menopause. Regardless of menopausal status, obese women who develop breast cancer have a worsened prognosis. Breast tissue is comprised of mammary epithelial cells organized into ducts and lobules and surrounded by adipose-rich connective tissue. Studies...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-020-09452-5
更新日期：2020-06-01 00:00:00
abstract：:Breast cancer (BC) is a leading cause of death among women with malignant diseases. The selection of adequate therapies for highly invasive and metastatic BCs still represents a major challenge. Novel combinatorial therapeutic approaches are urgently required to enhance the efficiency of BC treatment. Recently, microR...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-021-09478-3
更新日期：2021-01-21 00:00:00
abstract：:With the discovery of an activated Notch oncogene as a causative agent in mouse mammary tumor virus induced breast cancer in mice, the potential role for Notch signaling in normal and pathological mammary development was revealed. Subsequently, Notch receptors have been found to regulate normal development in many org...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/B:JOMG.0000037159.63644.81
更新日期：2004-04-01 00:00:00
abstract：:The Notch receptor protein and its signaling pathway have been well conserved throughout evolution and appear to be pivotal components in cell fate decisions during development. Recent studies suggest that, depending on the cellular and developmental context, Notch signaling may also affect cell proliferation and prog...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1009512414430
更新日期：2001-01-01 00:00:00
abstract：:Since the discovery that neural tissue contains a population of stem cells that form neurospheres in vitro, sphere-forming assays have been adapted for use with a number of different tissue types for the quantification of stem cell activity and self-renewal. One tissue type widely used for stem cell investigations is ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-012-9255-3
更新日期：2012-06-01 00:00:00
abstract：:Transforming growth factor beta (TGF-beta) receptor expression and signal transduction in human breast cancer are reviewed as a function of estrogen receptor (ER) expression. ER+ breast cancer cells are generally resistant to the inhibitory effects of TGF-beta. The only known exception appears to be MCF-7 early passag...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/BF02017392
更新日期：1996-10-01 00:00:00
abstract：:It has long been appreciated that the estrogen receptor (ER) plays an important role in the biology of breast cancer. It is an accepted factor predicting favorable disease outcome and treatment response, and as such is generally considered to represent a "good" prognostic marker in breast cancer. In this review we pre...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1014782813943
更新日期：2001-10-01 00:00:00
abstract：:We have reported the use of vectors based on avian leukosis virus (ALV) and ALV env pseudotyped lentivirus for stably introducing genes into somatic mammary cells in vivo for tumor modeling. These vectors require tva transgenic mice for viral infection. Here, we report, and described the method for, stably introducing...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章
doi：10.1007/s10911-009-9154-4
更新日期：2009-12-01 00:00:00
abstract：:The mouse has emerged as a primary animal model for human breast cancer because the mammary glands of the two species are very similar in structure and function. In this regard the TDLU and LA have similar morphology. The mouse, infected by MMTV, develops "spontaneous" tumors with specific but limited tumor phenotypes...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1018712905244
更新日期：1999-01-01 00:00:00
abstract：:Calcium is an important nutrient that is secreted into milk in quantities that put a considerable stress upon maternal calcium homeostasis. Here we summarize the evidence that two important entities, the extracellular calcium-sensing receptor (CaR) and parathyroid hormone-related protein (PTHrP) are involved in a feed...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-005-5396-y
更新日期：2005-04-01 00:00:00
abstract：:Breast development occurs through well-defined stages representing 'windows of susceptibility' to adverse environmental exposures that potentially modify breast cancer risk. Systematic characterization of morphology and transcriptome during normal breast development lays the foundation of our understanding of cancer e...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章
doi：10.1007/s10911-018-9401-7
更新日期：2018-09-01 00:00:00
abstract：:Wild-type p53 is a tumor suppressor gene that plays a central role in maintaining the genetic integrity of the cell by preventing cells with damaged DNA from further proliferation. Mutation and deletion of p53 are the most common genetic defects seen in clinical cancer. About 40% of breast carcinomas show high levels ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/BF02013640
更新日期：1996-04-01 00:00:00
abstract：:Most of the development and functional differentiation in the mammary gland occur after birth. Epigenetics is defined as the stable alterations in gene expression potential that arise during development and proliferation. Epigenetic changes are mediated at the biochemical level by the chromatin conformation initiated ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-010-9170-4
更新日期：2010-03-01 00:00:00
abstract：:The development and progression of aggressive breast cancer is characterized by genomic instability leading to multiple genetic defects, phenotypic diversity, chemoresistance, and poor outcome. Centrosome abnormalities have been implicated in the origin of chromosomal instability through the development of multipolar ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/B:JOMG.0000048774.27697.30
更新日期：2004-07-01 00:00:00
