Abstract:
:Calcium is an important nutrient that is secreted into milk in quantities that put a considerable stress upon maternal calcium homeostasis. Here we summarize the evidence that two important entities, the extracellular calcium-sensing receptor (CaR) and parathyroid hormone-related protein (PTHrP) are involved in a feedback loop that regulates calcium fluxes to the mammary gland. The CaR may also play a role in regulating milk secretion, and may regulate the proliferation of normal and neoplastic mammary epithelial cells. Finally, the relationship between the CaR and PTHrP in breast cancer cells may promote the formation of osteolytic bone metastases.
journal_name
J Mammary Gland Biol Neoplasiajournal_title
Journal of mammary gland biology and neoplasiaauthors
VanHouten JNdoi
10.1007/s10911-005-5396-ysubject
Has Abstractpub_date
2005-04-01 00:00:00pages
129-39issue
2eissn
1083-3021issn
1573-7039journal_volume
10pub_type
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
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更新日期:2008-12-01 00:00:00
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journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
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更新日期:2002-04-01 00:00:00
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journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
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更新日期:2013-06-01 00:00:00
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journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
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journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
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更新日期:2008-12-01 00:00:00
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journal_title:Journal of mammary gland biology and neoplasia
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更新日期:2018-12-01 00:00:00
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journal_title:Journal of mammary gland biology and neoplasia
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更新日期:2011-12-01 00:00:00
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journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
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abstract::Breast cancer development is a multi-step process in which genetic and molecular heterogeneity occurs at multiple stages. Ductal carcinoma arises from pre-invasive lesions such as atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS), which progress to invasive and metastatic cancer. The feasibility of...
journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
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更新日期:2012-03-01 00:00:00
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
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更新日期:2001-10-01 00:00:00
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journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
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更新日期:2010-06-01 00:00:00
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journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章
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更新日期:2020-11-09 00:00:00