Abstract：
:The IGFBP family comprises six proteins with high affinity for the IGFs and several lower affinity IGFBP-related proteins. Their production in the breast is controlled by hormones, other local regulators and in tumors relates to the estrogen receptor status. Their functional activity can also be affected by various post-translational modifications. The IGFs are generally present at levels far in excess of that required for maximal receptor stimulation, and the IGFBPs are critical regulators of cellular action. IGFBPs can affect cell function in an IGF-dependent or independent manner. IGF bioactivity locally in the breast is influenced not only by local tissue expression and regulation of IGFs, IGFBPs, and IGFBP proteases, but also by these factors delivered from the circulation. Changes in the balance of the components of the IGF system may lead to a disruption of tissue homeostasis.
journal_name
J Mammary Gland Biol Neoplasiajournal_title
Journal of mammary gland biology and neoplasiaauthors
Perks CM,Holly JMdoi
10.1023/a:1009519400591subject
Has Abstractpub_date
2000-01-01 00:00:00pages
75-84issue
1eissn
1083-3021issn
1573-7039journal_volume
5pub_type
杂志文章,评审abstract：:The One Health concept promotes integrated evaluation of human, animal, and environmental health questions to expedite advances benefiting all species. A recognition of the multi-species impact of mastitis as a painful condition with welfare implications leads us to suggest that mastitis is an ideal target for a One H...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-018-9395-1
更新日期：2018-06-01 00:00:00
abstract：:Breast cancer (BC) is a leading cause of death among women with malignant diseases. The selection of adequate therapies for highly invasive and metastatic BCs still represents a major challenge. Novel combinatorial therapeutic approaches are urgently required to enhance the efficiency of BC treatment. Recently, microR...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-021-09478-3
更新日期：2021-01-21 00:00:00
abstract：:The differentiation and function of mammary epithelial cells is dependent upon the combined action of growth factor/hormone receptors and integrin receptors, which act in concert to control the signals required for normal cell function. It is now becoming clear that integrin receptors also contribute to carcinoma cell...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1018766317055
更新日期：1999-10-01 00:00:00
abstract：:Estrogens are important for the development of the mammary gland and strongly associated with oncogenesis in this tissue. The biological effects of estrogens are mediated through the estrogen receptor (ER), a member of the nuclear receptor superfamily. The estrogen/ER signaling pathway plays a central role in mammary ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1026339111278
更新日期：1997-10-01 00:00:00
abstract：:Epithelial to mesenchymal transition (EMT) and its reversion via mesenchymal to epithelial transition (MET), represent a stepwise cycle of epithelial plasticity that allows for normal tissue remodelling and diversification during development. In particular, epithelial-mesenchymal plasticity is central to many aspects ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-010-9180-2
更新日期：2010-06-01 00:00:00
abstract：:With the discovery of an activated Notch oncogene as a causative agent in mouse mammary tumor virus induced breast cancer in mice, the potential role for Notch signaling in normal and pathological mammary development was revealed. Subsequently, Notch receptors have been found to regulate normal development in many org...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/B:JOMG.0000037159.63644.81
更新日期：2004-04-01 00:00:00
abstract：:Milk production is highly dependent on the optimal development of the mammary epithelium. It is therefore essential to better understand mammary epithelial cell growth and maintenance from the related epithelial lineage during the animal life. Here, we characterized the epithelial lineage at puberty, lactation and dry...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章
doi：10.1007/s10911-019-09427-1
更新日期：2019-06-01 00:00:00
abstract：:Breast cancer is one of the most common cancers of women in the Western world. Despite modest achievements in the treatment of this disease, there is a substantial unmet medical need to reduce the occurrence of new breast cancers. In several prospective, placebo-controlled trials, the antiestrogen tamoxifen has been s...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1025727103811
更新日期：2003-01-01 00:00:00
abstract：:With our improved understanding of the biological behavior of breast cancer, minimally invasive intervention is urgently needed for personalized treatment of early disease. Intraductal therapy is one such minimally invasive approach. With the help of appropriate tools, technologies using the intraductal means of enter...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-020-09453-4
更新日期：2020-06-01 00:00:00
abstract：:During normal mammary gland development, the tyrosine kinase Jak2 and its main substrate, the signal transducer and activator of transcription-5 (Stat5), are critical for the growth and differentiation of alveolar progenitors as well as the survival of secretory mammary epithelial cells. Genetic studies in mouse model...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-008-9062-z
更新日期：2008-03-01 00:00:00
abstract：:The mammary gland is an ectodermal appendage and a defining feature of mammals. Consistent with it being a recent evolutionary novelty, many of the molecules essential for the ontogeny and morphogenesis of various vertebrate organs, including those in the fibroblast growth factor (FGF) signaling pathway, are co-opted ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-013-9278-4
更新日期：2013-06-01 00:00:00
abstract：:Exosomes are small extracellular vesicles secreted to the extracellular environment by several cell types, including tumor cells. It has been demonstrated that exosomes have an important role in intercellular communication, but they have recently been implicated in various tumor processes, including the oncogenic tran...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-015-9332-5
更新日期：2014-12-01 00:00:00
abstract：:Since breast cancer and its associated metastasis are a global health problem and a major cause of mortality among women, research efforts to understand the development, morphogenesis, and functioning of the mammary gland are a high priority. Myriad signaling pathways, transcription factors, and associated transcripti...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-007-9043-7
更新日期：2007-09-01 00:00:00
abstract：:The insulin-like growth factors (IGFs) signaling via the type I insulin-like growth factor receptor (IGF-1R) regulate multiple aspects of malignancy. The importance of IGF-1R in regulating the malignant phenotype is currently being validated in numerous clinical trials for cancer including breast cancer. This review d...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-008-9105-5
更新日期：2008-12-01 00:00:00
abstract：:Mastitis is an inflammation of the mammary gland commonly caused by bacterial infection. The inflammatory process is a normal and necessary immunological response to invading pathogens. The purpose of host inflammatory responses is to eliminate the source of tissue injury, restore immune homeostasis, and return tissue...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-011-9230-4
更新日期：2011-12-01 00:00:00
abstract：:Localised breast cancer can be cured by surgery and adjuvant treatments, but mortality remains high as some tumours metastasize early. Perlecan is a basement membrane (BM) protein involved in tumour development and progression. Here, mRNA and protein expression of perlecan, and mRNA expression of matrix degrading enzy...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章
doi：10.1007/s10911-020-09447-2
更新日期：2020-03-01 00:00:00
abstract：:The centrosome is the major microtubule organizing center of the cell and as such it plays an important role in cytoskeletal organization and in the formation of the bipolar mitotic spindle. Centrosome defects, characterized by abnormal size, number, and microtubule nucleation capacity, are distinguishing features of ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1011312808421
更新日期：2001-04-01 00:00:00
abstract：:Colony stimulating factor 1 (CSF-1), a major regulator of the mononuclear phagocytic lineage, is expressed in more than 70% of human breast cancers and its expression is correlated with poor prognosis. Studies of CSF-1 null mutant mice demonstrated that CSF-1 plays an important role in normal mammary ductal developmen...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1020399802795
更新日期：2002-04-01 00:00:00
abstract：:Mammary gland involution is a period of intensive tissue remodeling. Over the course of a relatively brief period, a large proportion of the mammary gland epithelium undergoes programmed cell death and is removed by phagocytes. In addition, the gland is cleared of residual milk fat globules as well as milk and adipocy...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-007-9036-6
更新日期：2007-03-01 00:00:00
abstract：:Calcium is an important nutrient that is secreted into milk in quantities that put a considerable stress upon maternal calcium homeostasis. Here we summarize the evidence that two important entities, the extracellular calcium-sensing receptor (CaR) and parathyroid hormone-related protein (PTHrP) are involved in a feed...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-005-5396-y
更新日期：2005-04-01 00:00:00
abstract：:The involvement of molecular mechanisms in a particular process such as embryonic mammary gland development, can be revealed by modulation of one or several factors that purportedly act in that process. If those factors or their inhibitors are soluble, their function can be tested by loading them onto small inert bead...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-013-9297-1
更新日期：2013-06-01 00:00:00
abstract：:Carcinogenesis is a complex process during which cells undergo genetic and epigenetic alterations. These changes can lead tumor cells to acquire characteristics that enable movement from the primary site of origin when conditions become unfavorable. Such characteristics include gain of front-rear polarity, increased m...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-012-9244-6
更新日期：2012-03-01 00:00:00
abstract：:Women are using estrogens for many purposes, such as to prevent pregnancy or miscarriage, or to treat menopausal symptoms. Estrogens also have been used to treat breast cancer which seems puzzling, since there is convincing evidence to support a link between high lifetime estrogen exposure and increased breast cancer ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-013-9274-8
更新日期：2013-03-01 00:00:00
abstract：:Much of our knowledge about the intricate pathways and molecular mechanisms involved in the conversion of a normal mammary epithelial cell to malignancy derives from studies on mammary tumorigenesis induced by the retrovirus mouse mammary tumor virus. In addition, three DNA tumor viruses, simian virus 40, polyomavirus...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/BF02096302
更新日期：1996-01-01 00:00:00
abstract：:Wild-type p53 is a tumor suppressor gene that plays a central role in maintaining the genetic integrity of the cell by preventing cells with damaged DNA from further proliferation. Mutation and deletion of p53 are the most common genetic defects seen in clinical cancer. About 40% of breast carcinomas show high levels ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/BF02013640
更新日期：1996-04-01 00:00:00
abstract：:Various retroviral and lentiviral vectors have been used for up-the-teat intraductal injection to deliver markers, oncogenes, and other genes into mammary epithelial cells in mice. These methods along with the large number of genetically engineered mouse lines have greatly helped us learn normal breast development and...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章
doi：10.1007/s10911-020-09469-w
更新日期：2020-11-09 00:00:00
abstract：:Nuclear Factor-kappaB (NF-kappaB) has been implicated in the lobuloalveolar development of the mammary gland. In breast cancer its activation has been linked to tumor progression via stimulation of cell proliferation, pro-survival, and angiogenesis pathways and metastasis. Whether NF-kappaB activation in the immune sy...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-006-9013-5
更新日期：2006-01-01 00:00:00
abstract：:The mouse has emerged as a primary animal model for human breast cancer because the mammary glands of the two species are very similar in structure and function. In this regard the TDLU and LA have similar morphology. The mouse, infected by MMTV, develops "spontaneous" tumors with specific but limited tumor phenotypes...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1018712905244
更新日期：1999-01-01 00:00:00
abstract：:Inflammation of the adipose tissues occurs in association with obesity. This inflammatory process leads to the induction of cyclooxygenase-2 (COX-2) expression and a consequent elevation in prostaglandin (PG) production, which, together with proinflammatory cytokines, induce aromatase expression and estrogen synthesis...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-013-9299-z
更新日期：2013-12-01 00:00:00
abstract：:The ability to produce and expel milk is important for the health and survival of all mammals. Nevertheless, our understanding of the molecular events underlying the execution of this process remains incomplete. Whilst impaired mammary gland development and lactational competence remains the subject of focused investi...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-020-09467-y
更新日期：2020-11-19 00:00:00
