Abstract：
:Colony stimulating factor 1 (CSF-1), a major regulator of the mononuclear phagocytic lineage, is expressed in more than 70% of human breast cancers and its expression is correlated with poor prognosis. Studies of CSF-1 null mutant mice demonstrated that CSF-1 plays an important role in normal mammary ductal development as well as in mammary tumor progression to metastasis. CSF-1 regulates these processes through the recruitment and regulation of macrophages, cells that become associated with mammary tumors and the terminal end buds at the end of the growing ducts. This phenomenon suggests that the tumors subvert normal developmental processes to allow invasion into the surrounding stroma, a process that gives the tumor access to the vasculature and consequently the promotion of metastasis. In addition, soluble CSF-1 secreted from the tumor acts to divert antitumor macrophage responses and suppresses the differentiation of mature tumor-antigen-presenting dendritic cell This review discusses these observations in detail and attempts to fit them into a larger picture of CSF-1 and macrophage action in the regulation of normal mammary gland development and tumor progression.
journal_name
J Mammary Gland Biol Neoplasiajournal_title
Journal of mammary gland biology and neoplasiaauthors
Lin EY,Gouon-Evans V,Nguyen AV,Pollard JWdoi
10.1023/a:1020399802795subject
Has Abstractpub_date
2002-04-01 00:00:00pages
147-62issue
2eissn
1083-3021issn
1573-7039journal_volume
7pub_type
杂志文章,评审abstract：:The One Health concept promotes integrated evaluation of human, animal, and environmental health questions to expedite advances benefiting all species. A recognition of the multi-species impact of mastitis as a painful condition with welfare implications leads us to suggest that mastitis is an ideal target for a One H...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-018-9395-1
更新日期：2018-06-01 00:00:00
abstract：:The mammary gland is an ectodermal appendage and a defining feature of mammals. Consistent with it being a recent evolutionary novelty, many of the molecules essential for the ontogeny and morphogenesis of various vertebrate organs, including those in the fibroblast growth factor (FGF) signaling pathway, are co-opted ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-013-9278-4
更新日期：2013-06-01 00:00:00
abstract：:The mouse model for breast cancer has developed into a most effective means of dissecting and understanding this devastating disease. The inbred transgenic mouse lends itself to biological, molecular, immunological, and genetic studies. The observation, dissection, transplantation, and subsequent amplification of prec...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-008-9088-2
更新日期：2008-09-01 00:00:00
abstract：:Nuclear Factor-kappaB (NF-kappaB) has been implicated in the lobuloalveolar development of the mammary gland. In breast cancer its activation has been linked to tumor progression via stimulation of cell proliferation, pro-survival, and angiogenesis pathways and metastasis. Whether NF-kappaB activation in the immune sy...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-006-9013-5
更新日期：2006-01-01 00:00:00
abstract：:Mammary gland involution is a period of intensive tissue remodeling. Over the course of a relatively brief period, a large proportion of the mammary gland epithelium undergoes programmed cell death and is removed by phagocytes. In addition, the gland is cleared of residual milk fat globules as well as milk and adipocy...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-007-9036-6
更新日期：2007-03-01 00:00:00
abstract：:Most of the development and functional differentiation in the mammary gland occur after birth. Epigenetics is defined as the stable alterations in gene expression potential that arise during development and proliferation. Epigenetic changes are mediated at the biochemical level by the chromatin conformation initiated ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-010-9170-4
更新日期：2010-03-01 00:00:00
abstract：:As their name implies, the myoepithelial cells found at the epithelial-mesenchymal interface of the human mammary gland disclose features suggestive of a dual epithelial-like and muscle-like differentiation, i.e. they co-express various keratins and vimentin intermediate filaments, as well as smooth muscle-related ant...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-005-9581-9
更新日期：2005-07-01 00:00:00
abstract：:Tight junctions (TJs), the most apical components of the cell-cell junctional complexes, play a crucial role in the establishment and maintenance of cell polarity within tissues. In secretory glandular tissues, such as the mammary gland, TJs are crucial for separating apical and basolateral domains. TJs also create th...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/B:JOMG.0000017431.45314.07
更新日期：2003-10-01 00:00:00
abstract：:Originally adapted from the neurosphere assay, the nonadherent mammosphere assay has been utilized to assess early progenitor/stem cell frequency in a given population of mammary epithelial cells. This method has also been used to measure the frequency of tumorsphere initiating cells in both primary mammary tumors as ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-012-9258-0
更新日期：2012-06-01 00:00:00
abstract：:This article illustrates the most common benign and malignant lesions in the breast, and is intended for the biologist working in the area of breast cancer and breast biology, not for the practicing pathologist. The atlas covers benign proliferative lesions, atypical lesions, variants of in situ cancer, the main types...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1026439204849
更新日期：2000-04-01 00:00:00
abstract：:Calcium is an important nutrient that is secreted into milk in quantities that put a considerable stress upon maternal calcium homeostasis. Here we summarize the evidence that two important entities, the extracellular calcium-sensing receptor (CaR) and parathyroid hormone-related protein (PTHrP) are involved in a feed...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-005-5396-y
更新日期：2005-04-01 00:00:00
abstract：:Mammary gland involution, characterized by extensive apoptosis and structural remodelling of the gland, is the process by which the gland is returned to the pre-pregnant state. A key advantage of the mammary gland is the ability to synchronize involution through forced weaning, thus allowing the dissection of biochemi...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-007-9034-8
更新日期：2007-03-01 00:00:00
abstract：:The insulin-like growth factors (IGFs) signaling via the type I insulin-like growth factor receptor (IGF-1R) regulate multiple aspects of malignancy. The importance of IGF-1R in regulating the malignant phenotype is currently being validated in numerous clinical trials for cancer including breast cancer. This review d...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-008-9105-5
更新日期：2008-12-01 00:00:00
abstract：:Since the discovery that neural tissue contains a population of stem cells that form neurospheres in vitro, sphere-forming assays have been adapted for use with a number of different tissue types for the quantification of stem cell activity and self-renewal. One tissue type widely used for stem cell investigations is ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-012-9255-3
更新日期：2012-06-01 00:00:00
abstract：:The differentiation and function of mammary epithelial cells is dependent upon the combined action of growth factor/hormone receptors and integrin receptors, which act in concert to control the signals required for normal cell function. It is now becoming clear that integrin receptors also contribute to carcinoma cell...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1018766317055
更新日期：1999-10-01 00:00:00
abstract：:Exosomes are small extracellular vesicles secreted to the extracellular environment by several cell types, including tumor cells. It has been demonstrated that exosomes have an important role in intercellular communication, but they have recently been implicated in various tumor processes, including the oncogenic tran...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-015-9332-5
更新日期：2014-12-01 00:00:00
abstract：:Insulin-like growth factor-I and -II (IGF-I and IGF-II) and/or the type I insulin-like growth factor receptor (IGF-IR) have been implicated in a number of human tumors including breast cancer. However, despite being implicated in breast cancer for approximately 25 years and given that transgenic technology has been av...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-008-9097-1
更新日期：2008-12-01 00:00:00
abstract：:Premalignant breast disease in humans is a concept that admits to a broad range of elements and possible determinants predicting the likelihood of developing breast cancer. Most of these elements are relative, such as the risk of breast cancer for women that is 130 times that of men and peaks at a younger age by about...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1009521726605
更新日期：2000-10-01 00:00:00
abstract：:The IGFBP family comprises six proteins with high affinity for the IGFs and several lower affinity IGFBP-related proteins. Their production in the breast is controlled by hormones, other local regulators and in tumors relates to the estrogen receptor status. Their functional activity can also be affected by various po...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1009519400591
更新日期：2000-01-01 00:00:00
abstract：:The neuroendocrine hormone prolactin (PRL) stimulates breast growth and differentiation during puberty, pregnancy, and lactation. Despite extensive and convincing data indicating that PRL significantly contributes to the pathogenesis and progression of rodent mammary carcinoma, parallel observations for human breast c...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1026325630359
更新日期：1997-01-01 00:00:00
abstract：:Localised breast cancer can be cured by surgery and adjuvant treatments, but mortality remains high as some tumours metastasize early. Perlecan is a basement membrane (BM) protein involved in tumour development and progression. Here, mRNA and protein expression of perlecan, and mRNA expression of matrix degrading enzy...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章
doi：10.1007/s10911-020-09447-2
更新日期：2020-03-01 00:00:00
abstract：:It has long been appreciated that the estrogen receptor (ER) plays an important role in the biology of breast cancer. It is an accepted factor predicting favorable disease outcome and treatment response, and as such is generally considered to represent a "good" prognostic marker in breast cancer. In this review we pre...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1014782813943
更新日期：2001-10-01 00:00:00
abstract：:Increased glucose requirements of the gravid uterus during late pregnancy and even greater requirements of the lactating mammary glands necessitate major adjustments in glucose production and utilization in maternal liver, adipose tissue, skeletal muscle, and other tissues. In ruminants, which at all times rely princi...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1026336505343
更新日期：1997-07-01 00:00:00
abstract：:Mouse modeling of human breast cancer has developed tremendously over the past ten years. Human breast cancer is characterized by enormous biological diversity and, collectively, the new models have come much closer to encompassing this diversity. They have provided a deeper understanding of the fundamental events tha...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-008-9093-5
更新日期：2008-09-01 00:00:00
abstract：:During normal mammary gland development, the tyrosine kinase Jak2 and its main substrate, the signal transducer and activator of transcription-5 (Stat5), are critical for the growth and differentiation of alveolar progenitors as well as the survival of secretory mammary epithelial cells. Genetic studies in mouse model...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-008-9062-z
更新日期：2008-03-01 00:00:00
abstract：:Estrogen receptor-α (ERα) and transforming growth factor (TGF)-β signaling pathways are major regulators during mammary gland development, function and tumorigenesis. Predominantly, they have opposing roles in proliferation and apoptosis. While ERα signaling supports growth and differentiation and is antiapoptotic, ma...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-011-9203-7
更新日期：2011-06-01 00:00:00
abstract：:Obesity is a preventable risk factor for breast cancer following menopause. Regardless of menopausal status, obese women who develop breast cancer have a worsened prognosis. Breast tissue is comprised of mammary epithelial cells organized into ducts and lobules and surrounded by adipose-rich connective tissue. Studies...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-020-09452-5
更新日期：2020-06-01 00:00:00
abstract：:The Notch receptor protein and its signaling pathway have been well conserved throughout evolution and appear to be pivotal components in cell fate decisions during development. Recent studies suggest that, depending on the cellular and developmental context, Notch signaling may also affect cell proliferation and prog...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1009512414430
更新日期：2001-01-01 00:00:00
abstract：:The centrosome is the major microtubule organizing center of the cell and as such it plays an important role in cytoskeletal organization and in the formation of the bipolar mitotic spindle. Centrosome defects, characterized by abnormal size, number, and microtubule nucleation capacity, are distinguishing features of ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1011312808421
更新日期：2001-04-01 00:00:00
abstract：:T cell immunity in breast cancer is suggested to play a role in tumor dormancy, a period of stability which can correspond to the time interval between primary treatment and tumor recurrence. Bone marrow in breast cancer patients seems to be particularly important because it is highly enriched with cancer specific mem...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1020308104613
更新日期：2002-04-01 00:00:00
