Prolactin as an autocrine/paracrine factor in breast tissue.

abstract：:Breast cancer development is a multi-step process in which genetic and molecular heterogeneity occurs at multiple stages. Ductal carcinoma arises from pre-invasive lesions such as atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS), which progress to invasive and metastatic cancer. The feasibility of...

journal_title：Journal of mammary gland biology and neoplasia

authors： Behbod F,Gomes AM,Machado HL

更新日期：2018-12-01 00:00:00

abstract：:Estrogen receptor-α (ERα) and transforming growth factor (TGF)-β signaling pathways are major regulators during mammary gland development, function and tumorigenesis. Predominantly, they have opposing roles in proliferation and apoptosis. While ERα signaling supports growth and differentiation and is antiapoptotic, ma...

journal_title：Journal of mammary gland biology and neoplasia

authors： Band AM,Laiho M

更新日期：2011-06-01 00:00:00

abstract：:T cell immunity in breast cancer is suggested to play a role in tumor dormancy, a period of stability which can correspond to the time interval between primary treatment and tumor recurrence. Bone marrow in breast cancer patients seems to be particularly important because it is highly enriched with cancer specific mem...

journal_title：Journal of mammary gland biology and neoplasia

authors： Schirrmacher V,Feuerer M,Beckhove P,Ahlert T,Umansky V

更新日期：2002-04-01 00:00:00

abstract：:The centrosome is the major microtubule organizing center of the cell and as such it plays an important role in cytoskeletal organization and in the formation of the bipolar mitotic spindle. Centrosome defects, characterized by abnormal size, number, and microtubule nucleation capacity, are distinguishing features of ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Salisbury JL

更新日期：2001-04-01 00:00:00

abstract：:Carcinogenesis is a complex process during which cells undergo genetic and epigenetic alterations. These changes can lead tumor cells to acquire characteristics that enable movement from the primary site of origin when conditions become unfavorable. Such characteristics include gain of front-rear polarity, increased m...

journal_title：Journal of mammary gland biology and neoplasia

authors： Howe EN,Cochrane DR,Richer JK

更新日期：2012-03-01 00:00:00

abstract：:As their name implies, the myoepithelial cells found at the epithelial-mesenchymal interface of the human mammary gland disclose features suggestive of a dual epithelial-like and muscle-like differentiation, i.e. they co-express various keratins and vimentin intermediate filaments, as well as smooth muscle-related ant...

journal_title：Journal of mammary gland biology and neoplasia

authors： Jolicoeur F

更新日期：2005-07-01 00:00:00

abstract：:Most of the development and functional differentiation in the mammary gland occur after birth. Epigenetics is defined as the stable alterations in gene expression potential that arise during development and proliferation. Epigenetic changes are mediated at the biochemical level by the chromatin conformation initiated ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Rijnkels M,Kabotyanski E,Montazer-Torbati MB,Hue Beauvais C,Vassetzky Y,Rosen JM,Devinoy E

更新日期：2010-03-01 00:00:00

abstract：:Male breast cancer is a rare disease and clinical or epidemiological data are available from only a relatively few cases. Nonetheless, both similarities and discrepancies are apparent between breast cancer in men and women. For example, lobular and mucinous carcinomas are seldom seen in men. Tumors in men more often d...

journal_title：Journal of mammary gland biology and neoplasia

authors： Olsson H

更新日期：2000-07-01 00:00:00

abstract：:Mammary gland involution, characterized by extensive apoptosis and structural remodelling of the gland, is the process by which the gland is returned to the pre-pregnant state. A key advantage of the mammary gland is the ability to synchronize involution through forced weaning, thus allowing the dissection of biochemi...

journal_title：Journal of mammary gland biology and neoplasia

authors： Sutherland KD,Lindeman GJ,Visvader JE

更新日期：2007-03-01 00:00:00

abstract：:With the discovery of an activated Notch oncogene as a causative agent in mouse mammary tumor virus induced breast cancer in mice, the potential role for Notch signaling in normal and pathological mammary development was revealed. Subsequently, Notch receptors have been found to regulate normal development in many org...

journal_title：Journal of mammary gland biology and neoplasia

authors： Callahan R,Egan SE

更新日期：2004-04-01 00:00:00

abstract：:The ErbB receptor tyrosine kinase family has often been associated with increased growth of breast epithelial cells, as well as malignant transformation and progression. In contrast, ErbB4/HER4 exhibits unique attributes from a two step proteolytic cleavage which releases an 80 kilodalton, nuclear localizing, tyrosine...

journal_title：Journal of mammary gland biology and neoplasia

authors： Muraoka-Cook RS,Feng SM,Strunk KE,Earp HS 3rd

更新日期：2008-06-01 00:00:00

abstract：:Since breast cancer and its associated metastasis are a global health problem and a major cause of mortality among women, research efforts to understand the development, morphogenesis, and functioning of the mammary gland are a high priority. Myriad signaling pathways, transcription factors, and associated transcripti...

journal_title：Journal of mammary gland biology and neoplasia

authors： Singh RR,Kumar R

更新日期：2007-09-01 00:00:00

abstract：:The Notch receptor protein and its signaling pathway have been well conserved throughout evolution and appear to be pivotal components in cell fate decisions during development. Recent studies suggest that, depending on the cellular and developmental context, Notch signaling may also affect cell proliferation and prog...

journal_title：Journal of mammary gland biology and neoplasia

authors： Callahan R,Raafat A

更新日期：2001-01-01 00:00:00

abstract：:Milk is primarily regarded as a food furnishing essential nutrients for infant growth and development, but milk can also serve as a vehicle for mother to neonate transfer of molecules that regulate development. A wide array of biologically active compounds such as hormones, cytokines and enzymes are present in milk, e...

journal_title：Journal of mammary gland biology and neoplasia

authors： Ellis LA,Mastro AM,Picciano MF

更新日期：1996-07-01 00:00:00

abstract：:The development and progression of aggressive breast cancer is characterized by genomic instability leading to multiple genetic defects, phenotypic diversity, chemoresistance, and poor outcome. Centrosome abnormalities have been implicated in the origin of chromosomal instability through the development of multipolar ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Salisbury JL,D'Assoro AB,Lingle WL

更新日期：2004-07-01 00:00:00

abstract：:We review the role of Neuregulin 3 (Nrg3) and Erbb receptor signalling in embryonic mammary gland development. Neuregulins are growth factors that bind and activate its cognate Erbb receptor tyrosine kinases, which form a signalling network with established roles in breast development and breast cancer. Studies have s...

journal_title：Journal of mammary gland biology and neoplasia

authors： Kogata N,Zvelebil M,Howard BA

更新日期：2013-06-01 00:00:00

abstract：:Colony stimulating factor 1 (CSF-1), a major regulator of the mononuclear phagocytic lineage, is expressed in more than 70% of human breast cancers and its expression is correlated with poor prognosis. Studies of CSF-1 null mutant mice demonstrated that CSF-1 plays an important role in normal mammary ductal developmen...

journal_title：Journal of mammary gland biology and neoplasia

authors： Lin EY,Gouon-Evans V,Nguyen AV,Pollard JW

更新日期：2002-04-01 00:00:00

abstract：:With our improved understanding of the biological behavior of breast cancer, minimally invasive intervention is urgently needed for personalized treatment of early disease. Intraductal therapy is one such minimally invasive approach. With the help of appropriate tools, technologies using the intraductal means of enter...

journal_title：Journal of mammary gland biology and neoplasia

authors： Kuang XW,Liu JH,Sun ZH,Sukumar S,Sun SR,Chen C

更新日期：2020-06-01 00:00:00

abstract：:Mouse modeling of human breast cancer has developed tremendously over the past ten years. Human breast cancer is characterized by enormous biological diversity and, collectively, the new models have come much closer to encompassing this diversity. They have provided a deeper understanding of the fundamental events tha...

journal_title：Journal of mammary gland biology and neoplasia

authors： Allred DC,Medina D

更新日期：2008-09-01 00:00:00

abstract：:This article illustrates the most common benign and malignant lesions in the breast, and is intended for the biologist working in the area of breast cancer and breast biology, not for the practicing pathologist. The atlas covers benign proliferative lesions, atypical lesions, variants of in situ cancer, the main types...

journal_title：Journal of mammary gland biology and neoplasia

authors： Mallon E,Osin P,Nasiri N,Blain I,Howard B,Gusterson B

更新日期：2000-04-01 00:00:00

abstract：:Much of our knowledge about the intricate pathways and molecular mechanisms involved in the conversion of a normal mammary epithelial cell to malignancy derives from studies on mammary tumorigenesis induced by the retrovirus mouse mammary tumor virus. In addition, three DNA tumor viruses, simian virus 40, polyomavirus...

journal_title：Journal of mammary gland biology and neoplasia

authors： Asch BB

更新日期：1996-01-01 00:00:00

abstract：:Premalignant breast disease in humans is a concept that admits to a broad range of elements and possible determinants predicting the likelihood of developing breast cancer. Most of these elements are relative, such as the risk of breast cancer for women that is 130 times that of men and peaks at a younger age by about...

journal_title：Journal of mammary gland biology and neoplasia

authors： Page DL,Jensen RA,Simpson JF,Dupont WD

更新日期：2000-10-01 00:00:00

abstract：:Insulin-like growth factor-I and -II (IGF-I and IGF-II) and/or the type I insulin-like growth factor receptor (IGF-IR) have been implicated in a number of human tumors including breast cancer. However, despite being implicated in breast cancer for approximately 25 years and given that transgenic technology has been av...

journal_title：Journal of mammary gland biology and neoplasia

authors： Jones RA,Moorehead RA

更新日期：2008-12-01 00:00:00

abstract：:Inflammation of the adipose tissues occurs in association with obesity. This inflammatory process leads to the induction of cyclooxygenase-2 (COX-2) expression and a consequent elevation in prostaglandin (PG) production, which, together with proinflammatory cytokines, induce aromatase expression and estrogen synthesis...

journal_title：Journal of mammary gland biology and neoplasia

authors： Vona-Davis L,Rose DP

更新日期：2013-12-01 00:00:00

abstract：:Breast development occurs through well-defined stages representing 'windows of susceptibility' to adverse environmental exposures that potentially modify breast cancer risk. Systematic characterization of morphology and transcriptome during normal breast development lays the foundation of our understanding of cancer e...

journal_title：Journal of mammary gland biology and neoplasia

authors： Gopalakrishnan K,Teitelbaum SL,Wetmur J,Manservisi F,Falcioni L,Panzacchi S,Gnudi F,Belpoggi F,Chen J

更新日期：2018-09-01 00:00:00

abstract：:The microenvironment of a tumor has emerged recently as a critical contributor to the development of cancer. Within this environment, fibroblasts and immune cells are the cell lineages that seem to be active mediators of tumour development. The activated fibroblasts that are also present during wound healing and chron...

journal_title：Journal of mammary gland biology and neoplasia

authors： Unsworth A,Anderson R,Britt K

更新日期：2014-07-01 00:00:00

abstract：:With improved screening methods, the numbers of abnormal breast lesions diagnosed in women have been increasing over time. However, it remains unclear whether these breast lesions will develop into invasive cancers. To more effectively predict the outcome of breast lesions and determine a more appropriate course of tr...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bernard S,Myers M,Fang WB,Zinda B,Smart C,Lambert D,Zou A,Fan F,Cheng N

更新日期：2018-12-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) receptor expression and signal transduction in human breast cancer are reviewed as a function of estrogen receptor (ER) expression. ER+ breast cancer cells are generally resistant to the inhibitory effects of TGF-beta. The only known exception appears to be MCF-7 early passag...

journal_title：Journal of mammary gland biology and neoplasia

authors： Brattain MG,Ko Y,Banerji SS,Wu G,Willson JK

更新日期：1996-10-01 00:00:00

abstract：:The One Health concept promotes integrated evaluation of human, animal, and environmental health questions to expedite advances benefiting all species. A recognition of the multi-species impact of mastitis as a painful condition with welfare implications leads us to suggest that mastitis is an ideal target for a One H...

journal_title：Journal of mammary gland biology and neoplasia

authors： Hughes K,Watson CJ

更新日期：2018-06-01 00:00:00

abstract：:Mammary gland involution is a period of intensive tissue remodeling. Over the course of a relatively brief period, a large proportion of the mammary gland epithelium undergoes programmed cell death and is removed by phagocytes. In addition, the gland is cleared of residual milk fat globules as well as milk and adipocy...

journal_title：Journal of mammary gland biology and neoplasia

authors： Atabai K,Sheppard D,Werb Z

更新日期：2007-03-01 00:00:00