Intraductal Therapy in Breast Cancer: Current Status and Future Prospective.

Abstract:

:With our improved understanding of the biological behavior of breast cancer, minimally invasive intervention is urgently needed for personalized treatment of early disease. Intraductal therapy is one such minimally invasive approach. With the help of appropriate tools, technologies using the intraductal means of entering the ducts may be used both to diagnose and treat lesions in the mammary duct system with less trauma and at the same time avoid systemic toxicity. Traditional agents such as those targeting pathways, endocrine therapy, immunotherapy, or gene therapy can be used alone or combined with other new technologies, such as nanomaterials, through the intraductal route. Additionally, relevant mammary tumor models in rodents which reflect changes in the tumor microenvironment will help deepen our understanding of their biological behavior and heterogeneity. This article reviews the current status and future prospects of intraductal therapy in breast cancer, with emphasis on ductal carcinoma in situ.

authors

Kuang XW,Liu JH,Sun ZH,Sukumar S,Sun SR,Chen C

doi

10.1007/s10911-020-09453-4

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

133-143

issue

2

eissn

1083-3021

issn

1573-7039

pii

10.1007/s10911-020-09453-4

journal_volume

25

pub_type

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