The relevance of mouse models to understanding the development and progression of human breast cancer.

abstract：:Most of the development and functional differentiation in the mammary gland occur after birth. Epigenetics is defined as the stable alterations in gene expression potential that arise during development and proliferation. Epigenetic changes are mediated at the biochemical level by the chromatin conformation initiated ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Rijnkels M,Kabotyanski E,Montazer-Torbati MB,Hue Beauvais C,Vassetzky Y,Rosen JM,Devinoy E

更新日期：2010-03-01 00:00:00

abstract：:The One Health concept promotes integrated evaluation of human, animal, and environmental health questions to expedite advances benefiting all species. A recognition of the multi-species impact of mastitis as a painful condition with welfare implications leads us to suggest that mastitis is an ideal target for a One H...

journal_title：Journal of mammary gland biology and neoplasia

authors： Hughes K,Watson CJ

更新日期：2018-06-01 00:00:00

abstract：:Originally adapted from the neurosphere assay, the nonadherent mammosphere assay has been utilized to assess early progenitor/stem cell frequency in a given population of mammary epithelial cells. This method has also been used to measure the frequency of tumorsphere initiating cells in both primary mammary tumors as ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Rota LM,Lazzarino DA,Ziegler AN,LeRoith D,Wood TL

更新日期：2012-06-01 00:00:00

abstract：:Normal mammary gland development is the result of complex interactions between a number of hormones and growth factors. Normal and malignant human mammary epithelial cells are able to synthesize and to respond to various different, locally acting growth factors and growth inhibitors. Among these, the EGF-related pepti...

journal_title：Journal of mammary gland biology and neoplasia

authors： Normanno N,Ciardiello F

更新日期：1997-04-01 00:00:00

abstract：:Ductal development in the pubertal mouse mammary gland is characterized by dramatic morphological changes in the epithelium driven by proliferation of cap and body cells in the terminal endbuds. Recent experiments revealed a coincident and abundant apoptosis in the body cells of these structures. The cells undergoing ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Humphreys RC

更新日期：1999-04-01 00:00:00

abstract：:Mammary gland involution, characterized by extensive apoptosis and structural remodelling of the gland, is the process by which the gland is returned to the pre-pregnant state. A key advantage of the mammary gland is the ability to synchronize involution through forced weaning, thus allowing the dissection of biochemi...

journal_title：Journal of mammary gland biology and neoplasia

authors： Sutherland KD,Lindeman GJ,Visvader JE

更新日期：2007-03-01 00:00:00

abstract：:Insulin-like growth factor-I and -II (IGF-I and IGF-II) and/or the type I insulin-like growth factor receptor (IGF-IR) have been implicated in a number of human tumors including breast cancer. However, despite being implicated in breast cancer for approximately 25 years and given that transgenic technology has been av...

journal_title：Journal of mammary gland biology and neoplasia

authors： Jones RA,Moorehead RA

更新日期：2008-12-01 00:00:00

abstract：:Estrogens are important for the development of the mammary gland and strongly associated with oncogenesis in this tissue. The biological effects of estrogens are mediated through the estrogen receptor (ER), a member of the nuclear receptor superfamily. The estrogen/ER signaling pathway plays a central role in mammary ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bocchinfuso WP,Korach KS

更新日期：1997-10-01 00:00:00

abstract：:Human mammary epithelial cells emerge spontaneously from senescence, exhibiting eroding telomeric sequences, and ultimately enter crisis to generate the type of chromosomal abnormalities seen in early stages of breast cancer. In a mouse mammary tumor model, the spontaneous escape of senescence can be observed as an in...

journal_title：Journal of mammary gland biology and neoplasia

authors： Said TK,Medina D

更新日期：2004-01-01 00:00:00

abstract：:The ErbB receptor tyrosine kinase family has often been associated with increased growth of breast epithelial cells, as well as malignant transformation and progression. In contrast, ErbB4/HER4 exhibits unique attributes from a two step proteolytic cleavage which releases an 80 kilodalton, nuclear localizing, tyrosine...

journal_title：Journal of mammary gland biology and neoplasia

authors： Muraoka-Cook RS,Feng SM,Strunk KE,Earp HS 3rd

更新日期：2008-06-01 00:00:00

abstract：:During normal mammary gland development, the tyrosine kinase Jak2 and its main substrate, the signal transducer and activator of transcription-5 (Stat5), are critical for the growth and differentiation of alveolar progenitors as well as the survival of secretory mammary epithelial cells. Genetic studies in mouse model...

journal_title：Journal of mammary gland biology and neoplasia

authors： Wagner KU,Rui H

更新日期：2008-03-01 00:00:00

abstract：:Increased glucose requirements of the gravid uterus during late pregnancy and even greater requirements of the lactating mammary glands necessitate major adjustments in glucose production and utilization in maternal liver, adipose tissue, skeletal muscle, and other tissues. In ruminants, which at all times rely princi...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bell AW,Bauman DE

更新日期：1997-07-01 00:00:00

abstract：:We have reported the use of vectors based on avian leukosis virus (ALV) and ALV env pseudotyped lentivirus for stably introducing genes into somatic mammary cells in vivo for tumor modeling. These vectors require tva transgenic mice for viral infection. Here, we report, and described the method for, stably introducing...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bu W,Xin L,Toneff M,Li L,Li Y

更新日期：2009-12-01 00:00:00

abstract：:Localised breast cancer can be cured by surgery and adjuvant treatments, but mortality remains high as some tumours metastasize early. Perlecan is a basement membrane (BM) protein involved in tumour development and progression. Here, mRNA and protein expression of perlecan, and mRNA expression of matrix degrading enzy...

journal_title：Journal of mammary gland biology and neoplasia

authors： Jansson M,Billing O,Herdenberg C,Lundin C,Tolockiene E,Nazemroaya A,Sund M

更新日期：2020-03-01 00:00:00

abstract：:Women are using estrogens for many purposes, such as to prevent pregnancy or miscarriage, or to treat menopausal symptoms. Estrogens also have been used to treat breast cancer which seems puzzling, since there is convincing evidence to support a link between high lifetime estrogen exposure and increased breast cancer ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Hilakivi-Clarke L,de Assis S,Warri A

更新日期：2013-03-01 00:00:00

abstract：:This article illustrates the most common benign and malignant lesions in the breast, and is intended for the biologist working in the area of breast cancer and breast biology, not for the practicing pathologist. The atlas covers benign proliferative lesions, atypical lesions, variants of in situ cancer, the main types...

journal_title：Journal of mammary gland biology and neoplasia

authors： Mallon E,Osin P,Nasiri N,Blain I,Howard B,Gusterson B

更新日期：2000-04-01 00:00:00

abstract：:Available evidence indicates that mammary gland secretions first evolved in synapsids that laid parchment-shelled eggs. Unlike the rigid-shelled eggs of birds and some other sauropsids, parchment-shelled eggs lose water very rapidly when exposed to ambient air of lower vapor pressure, whether due to differences in rel...

journal_title：Journal of mammary gland biology and neoplasia

authors： Oftedal OT

更新日期：2002-07-01 00:00:00

abstract：:Breast cancer (BC) is a leading cause of death among women with malignant diseases. The selection of adequate therapies for highly invasive and metastatic BCs still represents a major challenge. Novel combinatorial therapeutic approaches are urgently required to enhance the efficiency of BC treatment. Recently, microR...

journal_title：Journal of mammary gland biology and neoplasia

authors： Petrović N,Nakashidze I,Nedeljković M

更新日期：2021-01-21 00:00:00

abstract：:Postpartum mammary gland involution is a mammalian tissue remodeling event that occurs after pregnancy and lactation to return the gland to the pre-pregnant state. This event is characterized by apoptosis and lysosomal-mediated cell death of the majority of the lactational mammary epithelium, followed by remodeling of...

journal_title：Journal of mammary gland biology and neoplasia

authors： Elder AM,Stoller AR,Black SA,Lyons TR

更新日期：2020-06-01 00:00:00

abstract：:The microenvironment of a tumor has emerged recently as a critical contributor to the development of cancer. Within this environment, fibroblasts and immune cells are the cell lineages that seem to be active mediators of tumour development. The activated fibroblasts that are also present during wound healing and chron...

journal_title：Journal of mammary gland biology and neoplasia

authors： Unsworth A,Anderson R,Britt K

更新日期：2014-07-01 00:00:00

abstract：:The development and progression of aggressive breast cancer is characterized by genomic instability leading to multiple genetic defects, phenotypic diversity, chemoresistance, and poor outcome. Centrosome abnormalities have been implicated in the origin of chromosomal instability through the development of multipolar ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Salisbury JL,D'Assoro AB,Lingle WL

更新日期：2004-07-01 00:00:00

abstract：:The involvement of molecular mechanisms in a particular process such as embryonic mammary gland development, can be revealed by modulation of one or several factors that purportedly act in that process. If those factors or their inhibitors are soluble, their function can be tested by loading them onto small inert bead...

journal_title：Journal of mammary gland biology and neoplasia

authors： Veltmaat JM

更新日期：2013-06-01 00:00:00

abstract：:The mouse model for breast cancer has developed into a most effective means of dissecting and understanding this devastating disease. The inbred transgenic mouse lends itself to biological, molecular, immunological, and genetic studies. The observation, dissection, transplantation, and subsequent amplification of prec...

journal_title：Journal of mammary gland biology and neoplasia

authors： Young LJ

更新日期：2008-09-01 00:00:00

abstract：:Since the discovery that neural tissue contains a population of stem cells that form neurospheres in vitro, sphere-forming assays have been adapted for use with a number of different tissue types for the quantification of stem cell activity and self-renewal. One tissue type widely used for stem cell investigations is ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Shaw FL,Harrison H,Spence K,Ablett MP,Simões BM,Farnie G,Clarke RB

更新日期：2012-06-01 00:00:00

abstract：:Mammary gland involution is a period of intensive tissue remodeling. Over the course of a relatively brief period, a large proportion of the mammary gland epithelium undergoes programmed cell death and is removed by phagocytes. In addition, the gland is cleared of residual milk fat globules as well as milk and adipocy...

journal_title：Journal of mammary gland biology and neoplasia

authors： Atabai K,Sheppard D,Werb Z

更新日期：2007-03-01 00:00:00

abstract：:Inflammation of the adipose tissues occurs in association with obesity. This inflammatory process leads to the induction of cyclooxygenase-2 (COX-2) expression and a consequent elevation in prostaglandin (PG) production, which, together with proinflammatory cytokines, induce aromatase expression and estrogen synthesis...

journal_title：Journal of mammary gland biology and neoplasia

authors： Vona-Davis L,Rose DP

更新日期：2013-12-01 00:00:00

abstract：:With the discovery of an activated Notch oncogene as a causative agent in mouse mammary tumor virus induced breast cancer in mice, the potential role for Notch signaling in normal and pathological mammary development was revealed. Subsequently, Notch receptors have been found to regulate normal development in many org...

journal_title：Journal of mammary gland biology and neoplasia

authors： Callahan R,Egan SE

更新日期：2004-04-01 00:00:00

abstract：:The mouse has emerged as a primary animal model for human breast cancer because the mammary glands of the two species are very similar in structure and function. In this regard the TDLU and LA have similar morphology. The mouse, infected by MMTV, develops "spontaneous" tumors with specific but limited tumor phenotypes...

journal_title：Journal of mammary gland biology and neoplasia

authors： Cardiff RD,Wellings SR

更新日期：1999-01-01 00:00:00

abstract：:With our improved understanding of the biological behavior of breast cancer, minimally invasive intervention is urgently needed for personalized treatment of early disease. Intraductal therapy is one such minimally invasive approach. With the help of appropriate tools, technologies using the intraductal means of enter...

journal_title：Journal of mammary gland biology and neoplasia

authors： Kuang XW,Liu JH,Sun ZH,Sukumar S,Sun SR,Chen C

更新日期：2020-06-01 00:00:00

abstract：:Premalignant breast disease in humans is a concept that admits to a broad range of elements and possible determinants predicting the likelihood of developing breast cancer. Most of these elements are relative, such as the risk of breast cancer for women that is 130 times that of men and peaks at a younger age by about...

journal_title：Journal of mammary gland biology and neoplasia

authors： Page DL,Jensen RA,Simpson JF,Dupont WD

更新日期：2000-10-01 00:00:00