Abstract：
:Male breast cancer is a rare disease and clinical or epidemiological data are available from only a relatively few cases. Nonetheless, both similarities and discrepancies are apparent between breast cancer in men and women. For example, lobular and mucinous carcinomas are seldom seen in men. Tumors in men more often display neuroendocrine differentiation, with an average age at diagnosis ten years later than in women. A high proportion of breast tumors in men are estrogen receptor-alpha positive (in this review 77%) and progesterone receptor positive (76%). Breast tumors in men often respond favorably to endocrine manipulation, including testicular ablation or antiestrogen therapy. Thus, the hormone receptors in these tumors can be functionally active and used for therapeutic intervention. This proposal has been questioned in some studies because estrogen dependent proteins are expressed to a lesser degree in men. Furthermore, men do not have a better overall breast cancer prognosis compared with women, after adjustments have been made for age and tumor stage. While the androgen receptor content has been assessed in a few studies, there are no studies on the estrogen receptor-beta content of breast tumors in men.
journal_name
J Mammary Gland Biol Neoplasiajournal_title
Journal of mammary gland biology and neoplasiaauthors
Olsson Hdoi
10.1023/a:1009546811429subject
Has Abstractpub_date
2000-07-01 00:00:00pages
283-7issue
3eissn
1083-3021issn
1573-7039pii
290050journal_volume
5pub_type
杂志文章,评审abstract：:Mammary gland involution is a period of intensive tissue remodeling. Over the course of a relatively brief period, a large proportion of the mammary gland epithelium undergoes programmed cell death and is removed by phagocytes. In addition, the gland is cleared of residual milk fat globules as well as milk and adipocy...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-007-9036-6
更新日期：2007-03-01 00:00:00
abstract：:Breast cancer development is a multi-step process in which genetic and molecular heterogeneity occurs at multiple stages. Ductal carcinoma arises from pre-invasive lesions such as atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS), which progress to invasive and metastatic cancer. The feasibility of...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-018-9408-0
更新日期：2018-12-01 00:00:00
abstract：:Milk is primarily regarded as a food furnishing essential nutrients for infant growth and development, but milk can also serve as a vehicle for mother to neonate transfer of molecules that regulate development. A wide array of biologically active compounds such as hormones, cytokines and enzymes are present in milk, e...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/BF02018079
更新日期：1996-07-01 00:00:00
abstract：:Calcium is an important nutrient that is secreted into milk in quantities that put a considerable stress upon maternal calcium homeostasis. Here we summarize the evidence that two important entities, the extracellular calcium-sensing receptor (CaR) and parathyroid hormone-related protein (PTHrP) are involved in a feed...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-005-5396-y
更新日期：2005-04-01 00:00:00
abstract：:The microenvironment of a tumor has emerged recently as a critical contributor to the development of cancer. Within this environment, fibroblasts and immune cells are the cell lineages that seem to be active mediators of tumour development. The activated fibroblasts that are also present during wound healing and chron...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-014-9326-8
更新日期：2014-07-01 00:00:00
abstract：:Tumor spread involves degradation of various components of the extracellular matrix and blood vessel wall. Among these is heparan sulfate proteoglycan, which plays a key role in the self-assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Expression of an endoglycosidase (he...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1011375624902
更新日期：2001-07-01 00:00:00
abstract：:The potential role of smoking in breast cancer risk has been the subject of over 100 publications, numerous scientific reviews, and animated debate. Tobacco exposure is a well-established cause of lung cancer, and is thought to account for nearly one third of all cancer deaths. Tobacco smoke contains thousands of chem...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-012-9269-x
更新日期：2013-03-01 00:00:00
abstract：:We review the role of Neuregulin 3 (Nrg3) and Erbb receptor signalling in embryonic mammary gland development. Neuregulins are growth factors that bind and activate its cognate Erbb receptor tyrosine kinases, which form a signalling network with established roles in breast development and breast cancer. Studies have s...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-013-9286-4
更新日期：2013-06-01 00:00:00
abstract：:The ErbB receptor tyrosine kinase family has often been associated with increased growth of breast epithelial cells, as well as malignant transformation and progression. In contrast, ErbB4/HER4 exhibits unique attributes from a two step proteolytic cleavage which releases an 80 kilodalton, nuclear localizing, tyrosine...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-008-9080-x
更新日期：2008-06-01 00:00:00
abstract：:Breast cancer is one of the most common cancers of women in the Western world. Despite modest achievements in the treatment of this disease, there is a substantial unmet medical need to reduce the occurrence of new breast cancers. In several prospective, placebo-controlled trials, the antiestrogen tamoxifen has been s...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1025727103811
更新日期：2003-01-01 00:00:00
abstract：:Nuclear Factor-kappaB (NF-kappaB) has been implicated in the lobuloalveolar development of the mammary gland. In breast cancer its activation has been linked to tumor progression via stimulation of cell proliferation, pro-survival, and angiogenesis pathways and metastasis. Whether NF-kappaB activation in the immune sy...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-006-9013-5
更新日期：2006-01-01 00:00:00
abstract：:Dynamic interactions between the hormone responsive mammary gland epithelium and surrounding stromal macrophage populations are critical for normal development and function of the mammary gland. Macrophages are versatile cells capable of diverse roles in mammary gland development and maintenance of homeostasis, and th...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-014-9319-7
更新日期：2014-07-01 00:00:00
abstract：:Human mammary epithelial cells emerge spontaneously from senescence, exhibiting eroding telomeric sequences, and ultimately enter crisis to generate the type of chromosomal abnormalities seen in early stages of breast cancer. In a mouse mammary tumor model, the spontaneous escape of senescence can be observed as an in...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/B:JOMG.0000023590.63974.f8
更新日期：2004-01-01 00:00:00
abstract：:Localised breast cancer can be cured by surgery and adjuvant treatments, but mortality remains high as some tumours metastasize early. Perlecan is a basement membrane (BM) protein involved in tumour development and progression. Here, mRNA and protein expression of perlecan, and mRNA expression of matrix degrading enzy...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章
doi：10.1007/s10911-020-09447-2
更新日期：2020-03-01 00:00:00
abstract：:It has long been appreciated that the estrogen receptor (ER) plays an important role in the biology of breast cancer. It is an accepted factor predicting favorable disease outcome and treatment response, and as such is generally considered to represent a "good" prognostic marker in breast cancer. In this review we pre...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1014782813943
更新日期：2001-10-01 00:00:00
abstract：:The ability to produce and expel milk is important for the health and survival of all mammals. Nevertheless, our understanding of the molecular events underlying the execution of this process remains incomplete. Whilst impaired mammary gland development and lactational competence remains the subject of focused investi...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-020-09467-y
更新日期：2020-11-19 00:00:00
abstract：:The mouse has emerged as a primary animal model for human breast cancer because the mammary glands of the two species are very similar in structure and function. In this regard the TDLU and LA have similar morphology. The mouse, infected by MMTV, develops "spontaneous" tumors with specific but limited tumor phenotypes...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1018712905244
更新日期：1999-01-01 00:00:00
abstract：:As their name implies, the myoepithelial cells found at the epithelial-mesenchymal interface of the human mammary gland disclose features suggestive of a dual epithelial-like and muscle-like differentiation, i.e. they co-express various keratins and vimentin intermediate filaments, as well as smooth muscle-related ant...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-005-9581-9
更新日期：2005-07-01 00:00:00
abstract：:Analysis of genes and proteins involved in lipid biosynthesis in mammary epithelial cells (MECs) is complicated by the presence of adipose tissue in the mammary gland, which may be predominant in whole tissue lysates depending upon developmental stage. We have developed a method based on protocols used to establish pr...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章
doi：10.1007/s10911-009-9161-5
更新日期：2009-12-01 00:00:00
abstract：:During normal mammary gland development, the tyrosine kinase Jak2 and its main substrate, the signal transducer and activator of transcription-5 (Stat5), are critical for the growth and differentiation of alveolar progenitors as well as the survival of secretory mammary epithelial cells. Genetic studies in mouse model...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-008-9062-z
更新日期：2008-03-01 00:00:00
abstract：:The Notch receptor protein and its signaling pathway have been well conserved throughout evolution and appear to be pivotal components in cell fate decisions during development. Recent studies suggest that, depending on the cellular and developmental context, Notch signaling may also affect cell proliferation and prog...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1009512414430
更新日期：2001-01-01 00:00:00
abstract：:Transgenic experiments using oocyte micro-injection methodology are often performed in order to target expression of a foreign gene in a specific tissue or, to a lesser extent, to study the regulation of gene expression. However, the isolation of embryonic stem cells in mice and the development of antisense and ribozy...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1018775729834
更新日期：1998-07-01 00:00:00
abstract：:Much of our knowledge about the intricate pathways and molecular mechanisms involved in the conversion of a normal mammary epithelial cell to malignancy derives from studies on mammary tumorigenesis induced by the retrovirus mouse mammary tumor virus. In addition, three DNA tumor viruses, simian virus 40, polyomavirus...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/BF02096302
更新日期：1996-01-01 00:00:00
abstract：:Inflammation of the adipose tissues occurs in association with obesity. This inflammatory process leads to the induction of cyclooxygenase-2 (COX-2) expression and a consequent elevation in prostaglandin (PG) production, which, together with proinflammatory cytokines, induce aromatase expression and estrogen synthesis...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-013-9299-z
更新日期：2013-12-01 00:00:00
abstract：:The involvement of molecular mechanisms in a particular process such as embryonic mammary gland development, can be revealed by modulation of one or several factors that purportedly act in that process. If those factors or their inhibitors are soluble, their function can be tested by loading them onto small inert bead...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-013-9297-1
更新日期：2013-06-01 00:00:00
abstract：:Insulin-like growth factor-I and -II (IGF-I and IGF-II) and/or the type I insulin-like growth factor receptor (IGF-IR) have been implicated in a number of human tumors including breast cancer. However, despite being implicated in breast cancer for approximately 25 years and given that transgenic technology has been av...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-008-9097-1
更新日期：2008-12-01 00:00:00
abstract：:The One Health concept promotes integrated evaluation of human, animal, and environmental health questions to expedite advances benefiting all species. A recognition of the multi-species impact of mastitis as a painful condition with welfare implications leads us to suggest that mastitis is an ideal target for a One H...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-018-9395-1
更新日期：2018-06-01 00:00:00
abstract：:The mammary gland is an ectodermal appendage and a defining feature of mammals. Consistent with it being a recent evolutionary novelty, many of the molecules essential for the ontogeny and morphogenesis of various vertebrate organs, including those in the fibroblast growth factor (FGF) signaling pathway, are co-opted ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1007/s10911-013-9278-4
更新日期：2013-06-01 00:00:00
abstract：:Estrogens are important for the development of the mammary gland and strongly associated with oncogenesis in this tissue. The biological effects of estrogens are mediated through the estrogen receptor (ER), a member of the nuclear receptor superfamily. The estrogen/ER signaling pathway plays a central role in mammary ...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1026339111278
更新日期：1997-10-01 00:00:00
abstract：:Available evidence indicates that mammary gland secretions first evolved in synapsids that laid parchment-shelled eggs. Unlike the rigid-shelled eggs of birds and some other sauropsids, parchment-shelled eggs lose water very rapidly when exposed to ambient air of lower vapor pressure, whether due to differences in rel...
journal_title：Journal of mammary gland biology and neoplasia
pub_type： 杂志文章,评审
doi：10.1023/a:1022848632125
更新日期：2002-07-01 00:00:00
