Adipose-depleted mammary epithelial cells and organoids.

abstract：:Women are using estrogens for many purposes, such as to prevent pregnancy or miscarriage, or to treat menopausal symptoms. Estrogens also have been used to treat breast cancer which seems puzzling, since there is convincing evidence to support a link between high lifetime estrogen exposure and increased breast cancer ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Hilakivi-Clarke L,de Assis S,Warri A

更新日期：2013-03-01 00:00:00

abstract：:The involvement of molecular mechanisms in a particular process such as embryonic mammary gland development, can be revealed by modulation of one or several factors that purportedly act in that process. If those factors or their inhibitors are soluble, their function can be tested by loading them onto small inert bead...

journal_title：Journal of mammary gland biology and neoplasia

authors： Veltmaat JM

更新日期：2013-06-01 00:00:00

abstract：:Estrogens are important for the development of the mammary gland and strongly associated with oncogenesis in this tissue. The biological effects of estrogens are mediated through the estrogen receptor (ER), a member of the nuclear receptor superfamily. The estrogen/ER signaling pathway plays a central role in mammary ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bocchinfuso WP,Korach KS

更新日期：1997-10-01 00:00:00

abstract：:Breast development occurs through well-defined stages representing 'windows of susceptibility' to adverse environmental exposures that potentially modify breast cancer risk. Systematic characterization of morphology and transcriptome during normal breast development lays the foundation of our understanding of cancer e...

journal_title：Journal of mammary gland biology and neoplasia

authors： Gopalakrishnan K,Teitelbaum SL,Wetmur J,Manservisi F,Falcioni L,Panzacchi S,Gnudi F,Belpoggi F,Chen J

更新日期：2018-09-01 00:00:00

abstract：:Colony stimulating factor 1 (CSF-1), a major regulator of the mononuclear phagocytic lineage, is expressed in more than 70% of human breast cancers and its expression is correlated with poor prognosis. Studies of CSF-1 null mutant mice demonstrated that CSF-1 plays an important role in normal mammary ductal developmen...

journal_title：Journal of mammary gland biology and neoplasia

authors： Lin EY,Gouon-Evans V,Nguyen AV,Pollard JW

更新日期：2002-04-01 00:00:00

abstract：:Obesity is a preventable risk factor for breast cancer following menopause. Regardless of menopausal status, obese women who develop breast cancer have a worsened prognosis. Breast tissue is comprised of mammary epithelial cells organized into ducts and lobules and surrounded by adipose-rich connective tissue. Studies...

journal_title：Journal of mammary gland biology and neoplasia

authors： Hillers-Ziemer LE,Arendt LM

更新日期：2020-06-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) receptor expression and signal transduction in human breast cancer are reviewed as a function of estrogen receptor (ER) expression. ER+ breast cancer cells are generally resistant to the inhibitory effects of TGF-beta. The only known exception appears to be MCF-7 early passag...

journal_title：Journal of mammary gland biology and neoplasia

authors： Brattain MG,Ko Y,Banerji SS,Wu G,Willson JK

更新日期：1996-10-01 00:00:00

abstract：:The One Health concept promotes integrated evaluation of human, animal, and environmental health questions to expedite advances benefiting all species. A recognition of the multi-species impact of mastitis as a painful condition with welfare implications leads us to suggest that mastitis is an ideal target for a One H...

journal_title：Journal of mammary gland biology and neoplasia

authors： Hughes K,Watson CJ

更新日期：2018-06-01 00:00:00

abstract：:We have reported the use of vectors based on avian leukosis virus (ALV) and ALV env pseudotyped lentivirus for stably introducing genes into somatic mammary cells in vivo for tumor modeling. These vectors require tva transgenic mice for viral infection. Here, we report, and described the method for, stably introducing...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bu W,Xin L,Toneff M,Li L,Li Y

更新日期：2009-12-01 00:00:00

abstract：:Mouse modeling of human breast cancer has developed tremendously over the past ten years. Human breast cancer is characterized by enormous biological diversity and, collectively, the new models have come much closer to encompassing this diversity. They have provided a deeper understanding of the fundamental events tha...

journal_title：Journal of mammary gland biology and neoplasia

authors： Allred DC,Medina D

更新日期：2008-09-01 00:00:00

abstract：:Mammalian cells depend on phospholipid (PL) and fatty acid (FA) transport to maintain membrane structure and organization, and to fuel and regulate cellular functions. In mammary glands of lactating animals, copious milk secretion, including large quantities of lipid in some species, requires adaptation and integratio...

journal_title：Journal of mammary gland biology and neoplasia

authors： McManaman JL

更新日期：2014-03-01 00:00:00

abstract：:Available evidence indicates that mammary gland secretions first evolved in synapsids that laid parchment-shelled eggs. Unlike the rigid-shelled eggs of birds and some other sauropsids, parchment-shelled eggs lose water very rapidly when exposed to ambient air of lower vapor pressure, whether due to differences in rel...

journal_title：Journal of mammary gland biology and neoplasia

authors： Oftedal OT

更新日期：2002-07-01 00:00:00

abstract：:Tumor spread involves degradation of various components of the extracellular matrix and blood vessel wall. Among these is heparan sulfate proteoglycan, which plays a key role in the self-assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Expression of an endoglycosidase (he...

journal_title：Journal of mammary gland biology and neoplasia

authors： Zcharia E,Metzger S,Chajek-Shaul T,Friedmann Y,Pappo O,Aviv A,Elkin M,Pecker I,Peretz T,Vlodavsky I

更新日期：2001-07-01 00:00:00

abstract：:The differentiation and function of mammary epithelial cells is dependent upon the combined action of growth factor/hormone receptors and integrin receptors, which act in concert to control the signals required for normal cell function. It is now becoming clear that integrin receptors also contribute to carcinoma cell...

journal_title：Journal of mammary gland biology and neoplasia

authors： Shaw LM

更新日期：1999-10-01 00:00:00

abstract：:The potential role of smoking in breast cancer risk has been the subject of over 100 publications, numerous scientific reviews, and animated debate. Tobacco exposure is a well-established cause of lung cancer, and is thought to account for nearly one third of all cancer deaths. Tobacco smoke contains thousands of chem...

journal_title：Journal of mammary gland biology and neoplasia

authors： Reynolds P

更新日期：2013-03-01 00:00:00

abstract：:The microenvironment of a tumor has emerged recently as a critical contributor to the development of cancer. Within this environment, fibroblasts and immune cells are the cell lineages that seem to be active mediators of tumour development. The activated fibroblasts that are also present during wound healing and chron...

journal_title：Journal of mammary gland biology and neoplasia

authors： Unsworth A,Anderson R,Britt K

更新日期：2014-07-01 00:00:00

abstract：:Much of our knowledge about the intricate pathways and molecular mechanisms involved in the conversion of a normal mammary epithelial cell to malignancy derives from studies on mammary tumorigenesis induced by the retrovirus mouse mammary tumor virus. In addition, three DNA tumor viruses, simian virus 40, polyomavirus...

journal_title：Journal of mammary gland biology and neoplasia

authors： Asch BB

更新日期：1996-01-01 00:00:00

abstract：:With the discovery of an activated Notch oncogene as a causative agent in mouse mammary tumor virus induced breast cancer in mice, the potential role for Notch signaling in normal and pathological mammary development was revealed. Subsequently, Notch receptors have been found to regulate normal development in many org...

journal_title：Journal of mammary gland biology and neoplasia

authors： Callahan R,Egan SE

更新日期：2004-04-01 00:00:00

abstract：:Breast cancer is a heterogeneous disease comprised of at least five major tumor subtypes that coalesce as the second leading cause of cancer death in women in the United States. Although metastasis clearly represents the most lethal characteristic of breast cancer, our understanding of the molecular mechanisms that go...

journal_title：Journal of mammary gland biology and neoplasia

authors： Parvani JG,Taylor MA,Schiemann WP

更新日期：2011-06-01 00:00:00

abstract：:Inflammation of the adipose tissues occurs in association with obesity. This inflammatory process leads to the induction of cyclooxygenase-2 (COX-2) expression and a consequent elevation in prostaglandin (PG) production, which, together with proinflammatory cytokines, induce aromatase expression and estrogen synthesis...

journal_title：Journal of mammary gland biology and neoplasia

authors： Vona-Davis L,Rose DP

更新日期：2013-12-01 00:00:00

abstract：:The development and progression of aggressive breast cancer is characterized by genomic instability leading to multiple genetic defects, phenotypic diversity, chemoresistance, and poor outcome. Centrosome abnormalities have been implicated in the origin of chromosomal instability through the development of multipolar ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Salisbury JL,D'Assoro AB,Lingle WL

更新日期：2004-07-01 00:00:00

abstract：:Exosomes are small extracellular vesicles secreted to the extracellular environment by several cell types, including tumor cells. It has been demonstrated that exosomes have an important role in intercellular communication, but they have recently been implicated in various tumor processes, including the oncogenic tran...

journal_title：Journal of mammary gland biology and neoplasia

authors： Villagrasa A,Álvarez PJ,Osuna A,Garrido JM,Aránega A,Rodríguez-Serrano F

更新日期：2014-12-01 00:00:00

abstract：:We review the role of Neuregulin 3 (Nrg3) and Erbb receptor signalling in embryonic mammary gland development. Neuregulins are growth factors that bind and activate its cognate Erbb receptor tyrosine kinases, which form a signalling network with established roles in breast development and breast cancer. Studies have s...

journal_title：Journal of mammary gland biology and neoplasia

authors： Kogata N,Zvelebil M,Howard BA

更新日期：2013-06-01 00:00:00

abstract：:The insulin-like growth factors (IGFs) signaling via the type I insulin-like growth factor receptor (IGF-1R) regulate multiple aspects of malignancy. The importance of IGF-1R in regulating the malignant phenotype is currently being validated in numerous clinical trials for cancer including breast cancer. This review d...

journal_title：Journal of mammary gland biology and neoplasia

authors： Sachdev D

更新日期：2008-12-01 00:00:00

abstract：:Nuclear Factor-kappaB (NF-kappaB) has been implicated in the lobuloalveolar development of the mammary gland. In breast cancer its activation has been linked to tumor progression via stimulation of cell proliferation, pro-survival, and angiogenesis pathways and metastasis. Whether NF-kappaB activation in the immune sy...

journal_title：Journal of mammary gland biology and neoplasia

authors： Haffner MC,Berlato C,Doppler W

更新日期：2006-01-01 00:00:00

abstract：:Originally adapted from the neurosphere assay, the nonadherent mammosphere assay has been utilized to assess early progenitor/stem cell frequency in a given population of mammary epithelial cells. This method has also been used to measure the frequency of tumorsphere initiating cells in both primary mammary tumors as ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Rota LM,Lazzarino DA,Ziegler AN,LeRoith D,Wood TL

更新日期：2012-06-01 00:00:00

abstract：:Mammary gland involution is a period of intensive tissue remodeling. Over the course of a relatively brief period, a large proportion of the mammary gland epithelium undergoes programmed cell death and is removed by phagocytes. In addition, the gland is cleared of residual milk fat globules as well as milk and adipocy...

journal_title：Journal of mammary gland biology and neoplasia

authors： Atabai K,Sheppard D,Werb Z

更新日期：2007-03-01 00:00:00

abstract：:The ability to produce and expel milk is important for the health and survival of all mammals. Nevertheless, our understanding of the molecular events underlying the execution of this process remains incomplete. Whilst impaired mammary gland development and lactational competence remains the subject of focused investi...

journal_title：Journal of mammary gland biology and neoplasia

authors： Stewart TA,Davis FM

更新日期：2020-11-19 00:00:00

abstract：:The ErbB receptor tyrosine kinase family has often been associated with increased growth of breast epithelial cells, as well as malignant transformation and progression. In contrast, ErbB4/HER4 exhibits unique attributes from a two step proteolytic cleavage which releases an 80 kilodalton, nuclear localizing, tyrosine...

journal_title：Journal of mammary gland biology and neoplasia

authors： Muraoka-Cook RS,Feng SM,Strunk KE,Earp HS 3rd

更新日期：2008-06-01 00:00:00

abstract：:During normal mammary gland development, the tyrosine kinase Jak2 and its main substrate, the signal transducer and activator of transcription-5 (Stat5), are critical for the growth and differentiation of alveolar progenitors as well as the survival of secretory mammary epithelial cells. Genetic studies in mouse model...

journal_title：Journal of mammary gland biology and neoplasia

authors： Wagner KU,Rui H

更新日期：2008-03-01 00:00:00