Abstract:
:Epithelial to mesenchymal transition (EMT) and its reversion via mesenchymal to epithelial transition (MET), represent a stepwise cycle of epithelial plasticity that allows for normal tissue remodelling and diversification during development. In particular, epithelial-mesenchymal plasticity is central to many aspects of mammary development and has been proposed to be a key process in breast cancer progression. Such epithelial-mesenchymal plasticity requires complex cellular reprogramming to orchestrate a change in cell shape to an alternate morphology more conducive to migration. During this process, epithelial characteristics, including apical-basal polarity and specialised cell-cell junctions are lost and mesenchymal properties, such as a front-rear polarity associated with weak cell-cell contacts, increased motility, resistance to apoptosis and invasiveness are gained. The ability of epithelial cells to undergo transitions through cell polarity states is a central feature of epithelial-mesenchymal plasticity. These cell polarity states comprise a set of distinct asymmetric distributions of cellular constituents that are fashioned to allow specialized cellular functions, such as the regulated homeostasis of molecules across epithelial barriers, cell migration or cell diversification via asymmetric cell divisions. Each polarity state is engineered using a molecular toolbox that is highly conserved between organisms and cell types which can direct the initiation, establishment and continued maintenance of each asymmetry. Here we discuss how EMT pathways target cell polarity mediators, and how this EMT-dependent change in polarity states impact on the various stages of breast cancer. Emerging evidence places cell polarity at the interface of proliferation and morphology control and as such the changing dynamics within polarity networks play a critical role in normal mammary gland development and breast cancer progression.
journal_name
J Mammary Gland Biol Neoplasiajournal_title
Journal of mammary gland biology and neoplasiaauthors
Godde NJ,Galea RC,Elsum IA,Humbert POdoi
10.1007/s10911-010-9180-2subject
Has Abstractpub_date
2010-06-01 00:00:00pages
149-68issue
2eissn
1083-3021issn
1573-7039journal_volume
15pub_type
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
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pub_type: 杂志文章,评审
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journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
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更新日期:2013-06-01 00:00:00
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journal_title:Journal of mammary gland biology and neoplasia
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pub_type: 杂志文章,评审
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journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
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更新日期:2014-07-01 00:00:00
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
doi:10.1023/a:1026325630359
更新日期:1997-01-01 00:00:00
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journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
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更新日期:2000-07-01 00:00:00
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
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journal_title:Journal of mammary gland biology and neoplasia
pub_type: 杂志文章,评审
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更新日期:2003-10-01 00:00:00
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journal_title:Journal of mammary gland biology and neoplasia
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