Intraductal Injection of Lentivirus Vectors for Stably Introducing Genes into Rat Mammary Epithelial Cells in Vivo.

abstract：:Milk is primarily regarded as a food furnishing essential nutrients for infant growth and development, but milk can also serve as a vehicle for mother to neonate transfer of molecules that regulate development. A wide array of biologically active compounds such as hormones, cytokines and enzymes are present in milk, e...

journal_title：Journal of mammary gland biology and neoplasia

authors： Ellis LA,Mastro AM,Picciano MF

更新日期：1996-07-01 00:00:00

abstract：:The mouse model for breast cancer has developed into a most effective means of dissecting and understanding this devastating disease. The inbred transgenic mouse lends itself to biological, molecular, immunological, and genetic studies. The observation, dissection, transplantation, and subsequent amplification of prec...

journal_title：Journal of mammary gland biology and neoplasia

authors： Young LJ

更新日期：2008-09-01 00:00:00

abstract：:Dynamic interactions between the hormone responsive mammary gland epithelium and surrounding stromal macrophage populations are critical for normal development and function of the mammary gland. Macrophages are versatile cells capable of diverse roles in mammary gland development and maintenance of homeostasis, and th...

journal_title：Journal of mammary gland biology and neoplasia

authors： Sun X,Ingman WV

更新日期：2014-07-01 00:00:00

abstract：:The insulin-like growth factors (IGFs) signaling via the type I insulin-like growth factor receptor (IGF-1R) regulate multiple aspects of malignancy. The importance of IGF-1R in regulating the malignant phenotype is currently being validated in numerous clinical trials for cancer including breast cancer. This review d...

journal_title：Journal of mammary gland biology and neoplasia

authors： Sachdev D

更新日期：2008-12-01 00:00:00

abstract：:Analysis of genes and proteins involved in lipid biosynthesis in mammary epithelial cells (MECs) is complicated by the presence of adipose tissue in the mammary gland, which may be predominant in whole tissue lysates depending upon developmental stage. We have developed a method based on protocols used to establish pr...

journal_title：Journal of mammary gland biology and neoplasia

authors： Rudolph MC,Wellberg EA,Anderson SM

更新日期：2009-12-01 00:00:00

abstract：:Obesity is a preventable risk factor for breast cancer following menopause. Regardless of menopausal status, obese women who develop breast cancer have a worsened prognosis. Breast tissue is comprised of mammary epithelial cells organized into ducts and lobules and surrounded by adipose-rich connective tissue. Studies...

journal_title：Journal of mammary gland biology and neoplasia

authors： Hillers-Ziemer LE,Arendt LM

更新日期：2020-06-01 00:00:00

abstract：:Mouse modeling of human breast cancer has developed tremendously over the past ten years. Human breast cancer is characterized by enormous biological diversity and, collectively, the new models have come much closer to encompassing this diversity. They have provided a deeper understanding of the fundamental events tha...

journal_title：Journal of mammary gland biology and neoplasia

authors： Allred DC,Medina D

更新日期：2008-09-01 00:00:00

abstract：:Transgenic experiments using oocyte micro-injection methodology are often performed in order to target expression of a foreign gene in a specific tissue or, to a lesser extent, to study the regulation of gene expression. However, the isolation of embryonic stem cells in mice and the development of antisense and ribozy...

journal_title：Journal of mammary gland biology and neoplasia

authors： Vilotte JL,L'Huillier P,Mercier JC

更新日期：1998-07-01 00:00:00

abstract：:Since breast cancer and its associated metastasis are a global health problem and a major cause of mortality among women, research efforts to understand the development, morphogenesis, and functioning of the mammary gland are a high priority. Myriad signaling pathways, transcription factors, and associated transcripti...

journal_title：Journal of mammary gland biology and neoplasia

authors： Singh RR,Kumar R

更新日期：2007-09-01 00:00:00

abstract：:Nuclear Factor-kappaB (NF-kappaB) has been implicated in the lobuloalveolar development of the mammary gland. In breast cancer its activation has been linked to tumor progression via stimulation of cell proliferation, pro-survival, and angiogenesis pathways and metastasis. Whether NF-kappaB activation in the immune sy...

journal_title：Journal of mammary gland biology and neoplasia

authors： Haffner MC,Berlato C,Doppler W

更新日期：2006-01-01 00:00:00

abstract：:During normal mammary gland development, the tyrosine kinase Jak2 and its main substrate, the signal transducer and activator of transcription-5 (Stat5), are critical for the growth and differentiation of alveolar progenitors as well as the survival of secretory mammary epithelial cells. Genetic studies in mouse model...

journal_title：Journal of mammary gland biology and neoplasia

authors： Wagner KU,Rui H

更新日期：2008-03-01 00:00:00

abstract：:Estrogens are important for the development of the mammary gland and strongly associated with oncogenesis in this tissue. The biological effects of estrogens are mediated through the estrogen receptor (ER), a member of the nuclear receptor superfamily. The estrogen/ER signaling pathway plays a central role in mammary ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bocchinfuso WP,Korach KS

更新日期：1997-10-01 00:00:00

abstract：:Normal mammary gland development is the result of complex interactions between a number of hormones and growth factors. Normal and malignant human mammary epithelial cells are able to synthesize and to respond to various different, locally acting growth factors and growth inhibitors. Among these, the EGF-related pepti...

journal_title：Journal of mammary gland biology and neoplasia

authors： Normanno N,Ciardiello F

更新日期：1997-04-01 00:00:00

abstract：:Estrogen receptor-α (ERα) and transforming growth factor (TGF)-β signaling pathways are major regulators during mammary gland development, function and tumorigenesis. Predominantly, they have opposing roles in proliferation and apoptosis. While ERα signaling supports growth and differentiation and is antiapoptotic, ma...

journal_title：Journal of mammary gland biology and neoplasia

authors： Band AM,Laiho M

更新日期：2011-06-01 00:00:00

abstract：:Breast cancer (BC) is a leading cause of death among women with malignant diseases. The selection of adequate therapies for highly invasive and metastatic BCs still represents a major challenge. Novel combinatorial therapeutic approaches are urgently required to enhance the efficiency of BC treatment. Recently, microR...

journal_title：Journal of mammary gland biology and neoplasia

authors： Petrović N,Nakashidze I,Nedeljković M

更新日期：2021-01-21 00:00:00

abstract：:Mammalian cells depend on phospholipid (PL) and fatty acid (FA) transport to maintain membrane structure and organization, and to fuel and regulate cellular functions. In mammary glands of lactating animals, copious milk secretion, including large quantities of lipid in some species, requires adaptation and integratio...

journal_title：Journal of mammary gland biology and neoplasia

authors： McManaman JL

更新日期：2014-03-01 00:00:00

abstract：:Tight junctions (TJs), the most apical components of the cell-cell junctional complexes, play a crucial role in the establishment and maintenance of cell polarity within tissues. In secretory glandular tissues, such as the mammary gland, TJs are crucial for separating apical and basolateral domains. TJs also create th...

journal_title：Journal of mammary gland biology and neoplasia

authors： Itoh M,Bissell MJ

更新日期：2003-10-01 00:00:00

abstract：:Much of our knowledge about the intricate pathways and molecular mechanisms involved in the conversion of a normal mammary epithelial cell to malignancy derives from studies on mammary tumorigenesis induced by the retrovirus mouse mammary tumor virus. In addition, three DNA tumor viruses, simian virus 40, polyomavirus...

journal_title：Journal of mammary gland biology and neoplasia

authors： Asch BB

更新日期：1996-01-01 00:00:00

abstract：:We have reported the use of vectors based on avian leukosis virus (ALV) and ALV env pseudotyped lentivirus for stably introducing genes into somatic mammary cells in vivo for tumor modeling. These vectors require tva transgenic mice for viral infection. Here, we report, and described the method for, stably introducing...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bu W,Xin L,Toneff M,Li L,Li Y

更新日期：2009-12-01 00:00:00

abstract：:Since the discovery that neural tissue contains a population of stem cells that form neurospheres in vitro, sphere-forming assays have been adapted for use with a number of different tissue types for the quantification of stem cell activity and self-renewal. One tissue type widely used for stem cell investigations is ...

journal_title：Journal of mammary gland biology and neoplasia

authors： Shaw FL,Harrison H,Spence K,Ablett MP,Simões BM,Farnie G,Clarke RB

更新日期：2012-06-01 00:00:00

abstract：:The ErbB receptor tyrosine kinase family has often been associated with increased growth of breast epithelial cells, as well as malignant transformation and progression. In contrast, ErbB4/HER4 exhibits unique attributes from a two step proteolytic cleavage which releases an 80 kilodalton, nuclear localizing, tyrosine...

journal_title：Journal of mammary gland biology and neoplasia

authors： Muraoka-Cook RS,Feng SM,Strunk KE,Earp HS 3rd

更新日期：2008-06-01 00:00:00

abstract：:With improved screening methods, the numbers of abnormal breast lesions diagnosed in women have been increasing over time. However, it remains unclear whether these breast lesions will develop into invasive cancers. To more effectively predict the outcome of breast lesions and determine a more appropriate course of tr...

journal_title：Journal of mammary gland biology and neoplasia

authors： Bernard S,Myers M,Fang WB,Zinda B,Smart C,Lambert D,Zou A,Fan F,Cheng N

更新日期：2018-12-01 00:00:00

abstract：:With our improved understanding of the biological behavior of breast cancer, minimally invasive intervention is urgently needed for personalized treatment of early disease. Intraductal therapy is one such minimally invasive approach. With the help of appropriate tools, technologies using the intraductal means of enter...

journal_title：Journal of mammary gland biology and neoplasia

authors： Kuang XW,Liu JH,Sun ZH,Sukumar S,Sun SR,Chen C

更新日期：2020-06-01 00:00:00

abstract：:The relationship between maternal dietary intakes of energy or fat maternal body composition and the milk fat concentration is an important element in understanding the role of breast-milk in infant nutrition. In most studies in both developing and developed countries, no relation between maternal energy intake and mi...

journal_title：Journal of mammary gland biology and neoplasia

authors： Villalpando S,del Prado M

更新日期：1999-07-01 00:00:00

abstract：:The differentiation and function of mammary epithelial cells is dependent upon the combined action of growth factor/hormone receptors and integrin receptors, which act in concert to control the signals required for normal cell function. It is now becoming clear that integrin receptors also contribute to carcinoma cell...

journal_title：Journal of mammary gland biology and neoplasia

authors： Shaw LM

更新日期：1999-10-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) receptor expression and signal transduction in human breast cancer are reviewed as a function of estrogen receptor (ER) expression. ER+ breast cancer cells are generally resistant to the inhibitory effects of TGF-beta. The only known exception appears to be MCF-7 early passag...

journal_title：Journal of mammary gland biology and neoplasia

authors： Brattain MG,Ko Y,Banerji SS,Wu G,Willson JK

更新日期：1996-10-01 00:00:00

abstract：:The Notch receptor protein and its signaling pathway have been well conserved throughout evolution and appear to be pivotal components in cell fate decisions during development. Recent studies suggest that, depending on the cellular and developmental context, Notch signaling may also affect cell proliferation and prog...

journal_title：Journal of mammary gland biology and neoplasia

authors： Callahan R,Raafat A

更新日期：2001-01-01 00:00:00

abstract：:This article illustrates the most common benign and malignant lesions in the breast, and is intended for the biologist working in the area of breast cancer and breast biology, not for the practicing pathologist. The atlas covers benign proliferative lesions, atypical lesions, variants of in situ cancer, the main types...

journal_title：Journal of mammary gland biology and neoplasia

authors： Mallon E,Osin P,Nasiri N,Blain I,Howard B,Gusterson B

更新日期：2000-04-01 00:00:00

abstract：:We review the role of Neuregulin 3 (Nrg3) and Erbb receptor signalling in embryonic mammary gland development. Neuregulins are growth factors that bind and activate its cognate Erbb receptor tyrosine kinases, which form a signalling network with established roles in breast development and breast cancer. Studies have s...

journal_title：Journal of mammary gland biology and neoplasia

authors： Kogata N,Zvelebil M,Howard BA

更新日期：2013-06-01 00:00:00

abstract：:Mammary gland involution, characterized by extensive apoptosis and structural remodelling of the gland, is the process by which the gland is returned to the pre-pregnant state. A key advantage of the mammary gland is the ability to synchronize involution through forced weaning, thus allowing the dissection of biochemi...

journal_title：Journal of mammary gland biology and neoplasia

authors： Sutherland KD,Lindeman GJ,Visvader JE

更新日期：2007-03-01 00:00:00