Abstract:
:Twenty-seven research participants with dementia of the Alzheimer type were studied with the California Verbal Learning Test (D. C. Delis, J. H. Kramer, E. Kaplan, & B. A. Ober, 1987) and standardized volume measures of the mesial temporal cortical gray matter, neocortical gray matter, thalamus, and caudate nuclei, from magnetic resonance imaging. A pattern of atrophic brain changes in the mesial temporal lobes (MTL) and the thalamus, with relatively less severe atrophy in the neocortical gray matter, was associated with poorer learning of the word list. Similar patterns of brain atrophy were observed for measures of delayed recall and recognition hits. However, for delayed recall, neither contribution was statistically significant, and for recognition hits, MTL was only at the trend level for significance. These results provide evidence that the verbal memory deficit of Alzheimer's disease (AD) is associated not only with the mesial temporal limbic cortex, thought to be the site of earliest and most severe pathology in AD, but also with damage in the thalamus.
journal_name
Neuropsychologyjournal_title
Neuropsychologyauthors
Stout JC,Bondi MW,Jernigan TL,Archibald SL,Delis DC,Salmon DPdoi
10.1037//0894-4105.13.2.188subject
Has Abstractpub_date
1999-04-01 00:00:00pages
188-97issue
2eissn
0894-4105issn
1931-1559journal_volume
13pub_type
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