Apolipoprotein E and prospective memory in normally aging adults.

Abstract:

:The epsilon4 allele of apolipoprotein E (APOE) is an established risk factor for Alzheimer's disease, despite uncertainty as to its effect on cognitive function in normal aging. Some evidence suggests poor episodic memory and executive functioning in epsilon4 allele carriers. Prospective memory has been overlooked in investigations of the relationship between APOE and cognition. The authors used a laboratory paradigm to examine the relationship between prospective memory and APOE status in healthy elderly adults, and they varied the association (high vs. low) between a target word and a response word. The authors found a significant deficit in prospective memory for epsilon4 allele carriers but no effect of association in either group. The results suggest the deficit was due to failure of the prospective component of the task.

journal_name

Neuropsychology

journal_title

Neuropsychology

authors

Driscoll I,McDaniel MA,Guynn MJ

doi

10.1037/0894-4105.19.1.28

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

28-34

issue

1

eissn

0894-4105

issn

1931-1559

pii

2005-00128-004

journal_volume

19

pub_type

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