Abstract:
:The epsilon4 allele of apolipoprotein E (APOE) is an established risk factor for Alzheimer's disease, despite uncertainty as to its effect on cognitive function in normal aging. Some evidence suggests poor episodic memory and executive functioning in epsilon4 allele carriers. Prospective memory has been overlooked in investigations of the relationship between APOE and cognition. The authors used a laboratory paradigm to examine the relationship between prospective memory and APOE status in healthy elderly adults, and they varied the association (high vs. low) between a target word and a response word. The authors found a significant deficit in prospective memory for epsilon4 allele carriers but no effect of association in either group. The results suggest the deficit was due to failure of the prospective component of the task.
journal_name
Neuropsychologyjournal_title
Neuropsychologyauthors
Driscoll I,McDaniel MA,Guynn MJdoi
10.1037/0894-4105.19.1.28subject
Has Abstractpub_date
2005-01-01 00:00:00pages
28-34issue
1eissn
0894-4105issn
1931-1559pii
2005-00128-004journal_volume
19pub_type
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