When memory does not fail: familiarity-based recognition in mild cognitive impairment and Alzheimer's disease.

Abstract:

:Recognition can be guided by familiarity, a restricted form of retrieval devoid of contextual recall, or by recollection, which occurs when retrieval is sufficient to support the full experience of remembering an episode. Recollection and familiarity were disentangled by testing recognition memory using silhouette object drawings, high target-foil resemblance, and both yes-no and forced-choice procedures. Theoretically, forced-choice recognition could be mediated by familiarity alone. Alzheimer's disease and its preclinical stage, mild cognitive impairment (MCI), were associated with memory impairments that were greater on the yes-no test. Remarkably, forced-choice recognition was unequivocally normal in patients with MCI compared with age-matched controls. Neuropathology in hippocampus and entorhinal cortex, known to be present in MCI, presumably disrupted recollection while leaving familiarity-based recognition intact.

journal_name

Neuropsychology

journal_title

Neuropsychology

authors

Westerberg CE,Paller KA,Weintraub S,Mesulam MM,Holdstock JS,Mayes AR,Reber PJ

doi

10.1037/0894-4105.20.2.193

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

193-205

issue

2

eissn

0894-4105

issn

1931-1559

pii

2006-03817-007

journal_volume

20

pub_type

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