Abstract:
:The present study examined prospective and episodic memory in relation to age, functional independence, and hippocampal volume in younger to middle-aged adults with spina bifida myelomeningocele (SBM) and typically developing (TD) adults. Prospective and episodic memory, as well as hippocampal volume, was reduced in adults with SBM relative to TD adults. Neither memory performance nor hippocampal volume showed greater decrements in older adults. Lower hippocampal volume was associated with reduced prospective memory in adults with SBM, and this relation was specific to the hippocampus and not to a contrast structure, the amygdala. Prospective memory mediated the relation between hippocampal volume and functional independence in adults with SBM. The results add to emerging evidence for reduced memory function in adults with SBM and provide quantitative evidence for compromised hippocampal macrostructure as a neural correlate of reduced memory in this population.
journal_name
Neuropsychologyjournal_title
Neuropsychologyauthors
Treble-Barna A,Juranek J,Stuebing KK,Cirino PT,Dennis M,Fletcher JMdoi
10.1037/neu0000111subject
Has Abstractpub_date
2015-01-01 00:00:00pages
92-101issue
1eissn
0894-4105issn
1931-1559pii
2014-30819-001journal_volume
29pub_type
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