Prospective and episodic memory in relation to hippocampal volume in adults with spina bifida myelomeningocele.

Abstract:

:The present study examined prospective and episodic memory in relation to age, functional independence, and hippocampal volume in younger to middle-aged adults with spina bifida myelomeningocele (SBM) and typically developing (TD) adults. Prospective and episodic memory, as well as hippocampal volume, was reduced in adults with SBM relative to TD adults. Neither memory performance nor hippocampal volume showed greater decrements in older adults. Lower hippocampal volume was associated with reduced prospective memory in adults with SBM, and this relation was specific to the hippocampus and not to a contrast structure, the amygdala. Prospective memory mediated the relation between hippocampal volume and functional independence in adults with SBM. The results add to emerging evidence for reduced memory function in adults with SBM and provide quantitative evidence for compromised hippocampal macrostructure as a neural correlate of reduced memory in this population.

journal_name

Neuropsychology

journal_title

Neuropsychology

authors

Treble-Barna A,Juranek J,Stuebing KK,Cirino PT,Dennis M,Fletcher JM

doi

10.1037/neu0000111

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

92-101

issue

1

eissn

0894-4105

issn

1931-1559

pii

2014-30819-001

journal_volume

29

pub_type

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