Hippocampal function and spatial memory: evidence from functional neuroimaging in healthy participants and performance of patients with medial temporal lobe resections.

Abstract:

:Several strategies can be used to find a destination in the environment. Using a virtual environment, the authors identified 2 strategies dependent on 2 different memory systems. A spatial strategy involved the use of multiple landmarks available in the environment, and a response strategy involved right and left turns from a given start position. Although a probe trial provided an objective measure of the strategy used, classification that was based on verbal reports was used in small groups to avoid risks of misclassification. The authors first demonstrated that the spatial strategy led to a significant activity of the hippocampus, whereas the response strategy led to a sustained activity in the caudate nucleus. Then, the authors administered the task to 15 patients with lesions to the medial temporal lobe, showing an impaired ability using the spatial strategy. Imaging and neuropsychological results are discussed to shed light on the human navigation system.

journal_name

Neuropsychology

journal_title

Neuropsychology

authors

Bohbot VD,Iaria G,Petrides M

doi

10.1037/0894-4105.18.3.418

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

418-25

issue

3

eissn

0894-4105

issn

1931-1559

pii

2004-16644-003

journal_volume

18

pub_type

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