Depressive symptoms precede cognitive impairment in de novo Parkinson's disease patients: Analysis of the PPMI cohort.

Abstract:

INTRODUCTION:Nonmotor symptoms, including depression, anxiety, apathy, and cognitive dysfunction, are common in Parkinson's disease (PD). Although a link between mood symptoms and cognitive impairment in PD has been theorized vis-à-vis striatal dopamine depletion, studies have been inconsistent regarding the relationship between mood symptoms and cognitive function. Inconsistencies may reflect the cross-sectional nature of previous studies. The current study examined the bidirectional longitudinal relationship between mood and cognition. METHOD:Data were obtained from 310 individuals newly diagnosed with PD, who were followed up to 4 years (baseline, 1st, 2nd, 3rd, and 4th annual follow-ups). Apathy, anxiety, depressive symptoms, motor severity, and neurocognitive functioning were assessed at each annual assessment. The longitudinal relationship between apathy, anxiety, depressive symptoms, and cognition was analyzed with multilevel models. RESULTS:Over the 4-year period, more severe depressive symptoms were related to worse performance on tasks of processing speed, verbal learning, and verbal delayed recall. Additionally, there was a significant Depression × Time interaction, suggesting that individuals with more severe depressive symptoms experience more rapid declines in global cognitive functioning and verbal learning. Apathy and anxiety were not significantly related to performance in any cognitive test. Lagged models revealed that changes in depression precede declines in working memory, verbal learning, delayed verbal recall, and global cognition. CONCLUSION:Findings suggest depressive symptoms may be a harbinger for future cognitive decline among individuals with PD. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

journal_name

Neuropsychology

journal_title

Neuropsychology

authors

Jones JD,Kurniadi NE,Kuhn TP,Szymkowicz SM,Bunch J,Rahmani E

doi

10.1037/neu0000583

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

1111-1120

issue

8

eissn

0894-4105

issn

1931-1559

pii

2019-42962-001

journal_volume

33

pub_type

杂志文章,多中心研究
  • Multimodal cuing of autobiographical memory in semantic dementia.

    abstract:OBJECTIVE:Individuals with semantic dementia (SD) have impaired autobiographical memory (AM), but the extent of the impairment has been controversial. According to one report (Westmacott, Leach, Freedman, & Moscovitch, 2001), patient performance was better when visual cues were used instead of verbal cues; however, the...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0021005

    authors: Greenberg DL,Ogar JM,Viskontas IV,Gorno Tempini ML,Miller B,Knowlton BJ

    更新日期:2011-01-01 00:00:00

  • Faking bad: The neural correlates of feigning memory impairment.

    abstract:OBJECTIVE:The detection of malingering in cognitive performance is a challenge in clinical and legal environments. Neuroimaging may provide an objective method for delineation of malingering. METHOD:A heterogeneous with concern of gender and racial-ethnic identity of 22 healthy volunteers completed the Tombaugh Test o...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000251

    authors: Kosheleva E,Spadoni AD,Strigo IA,Buchsbaum MS,Simmons AN

    更新日期:2016-03-01 00:00:00

  • A meta-analysis on the impact of psychiatric disorders and maltreatment on cognition.

    abstract:OBJECTIVE:Few studies have attempted to describe the range of cognitive impairments in individuals with psychiatric disorders who experienced maltreatment as children. The aims of this meta-analysis were to establish the impact of maltreatment and psychiatric disorders on cognition, and to examine the change in impact ...

    journal_title:Neuropsychology

    pub_type: 杂志文章,meta分析

    doi:10.1037/neu0000228

    authors: Masson M,East-Richard C,Cellard C

    更新日期:2016-02-01 00:00:00

  • Semantic organization and verbal memory efficiency in patients with schizophrenia.

    abstract::The role of semantic organization in verbal memory efficiency in schizophrenia was investigated. Patients and healthy controls were administered a free-recall task involving 1 nonsemantically organizable list, 1 list organizable in semantic categories with typical instances, and 1 list organizable in semantic categori...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.18.2.378

    authors: Brébion G,David AS,Jones H,Pilowsky LS

    更新日期:2004-04-01 00:00:00

  • Measurement invariance of neuropsychological tests in diverse older persons.

    abstract:OBJECTIVE:Comparability of meaning of neuropsychological test results across ethnic, linguistic, and cultural groups is important for clinicians challenged with assessing increasing numbers of older ethnic minorities. We examined the dimensional structure of a neuropsychological test battery in linguistically and demog...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0021090

    authors: Mungas D,Widaman KF,Reed BR,Tomaszewski Farias S

    更新日期:2011-03-01 00:00:00

  • Examining the nature of impairment in visual paired associate learning in amnestic mild cognitive impairment.

    abstract:OBJECTIVE:Visual spatial learning is impaired in mild cognitive impairment (MCI) although the nature of this impairment is not clear. This study investigated the nature and magnitude of errors made by adults with amnestic MCI (aMCI) when learning pattern-location paired associations in a continuous manner. METHOD:Visu...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0024237

    authors: Harel BT,Darby D,Pietrzak RH,Ellis KA,Snyder PJ,Maruff P

    更新日期:2011-11-01 00:00:00

  • Relations between volumetric measures of brain structure and attentional function in spina bifida: utilization of robust statistical approaches.

    abstract:OBJECTIVE:Weak structure-function relations for brain and behavior may stem from problems in estimating these relations in small clinical samples with frequently occurring outliers. In the current project, we focused on the utility of using alternative statistics to estimate these relations. METHOD:Fifty-four children...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000166

    authors: Kulesz PA,Tian S,Juranek J,Fletcher JM,Francis DJ

    更新日期:2015-03-01 00:00:00

  • Visual short term memory related brain activity predicts mathematical abilities.

    abstract:OBJECTIVE:Previous research suggests visual short-term memory (VSTM) capacity and mathematical abilities are significantly related. Moreover, both processes activate similar brain regions within the parietal cortex, in particular, the intraparietal sulcus; however, it is still unclear whether the neuronal underpinnings...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000349

    authors: Boulet-Craig A,Robaey P,Lacourse K,Jerbi K,Oswald V,Krajinovic M,Laverdière C,Sinnett D,Jolicoeur P,Lippé S

    更新日期:2017-07-01 00:00:00

  • Advances in neurocognitive rehabilitation research from 1992 to 2017: The ascension of neural plasticity.

    abstract:OBJECTIVE:The last 25 years have seen profound changes in neurocognitive rehabilitation that continue to motivate its evolution. Although the concept of nervous system plasticity was discussed by William James (1890), the foundation for experience-based plasticity had not reached the critical empirical mass to seriousl...

    journal_title:Neuropsychology

    pub_type: 杂志文章,评审

    doi:10.1037/neu0000396

    authors: Crosson B,Hampstead BM,Krishnamurthy LC,Krishnamurthy V,McGregor KM,Nocera JR,Roberts S,Rodriguez AD,Tran SM

    更新日期:2017-11-01 00:00:00

  • Contribution of organizational strategy to verbal learning and memory in adults with attention-deficit/hyperactivity disorder.

    abstract::Statistical mediation modeling was used to test the hypothesis that poor use of a semantic organizational strategy contributes to verbal learning and memory deficits in adults with attention-deficit/hyperactivity disorder (ADHD). Comparison of 28 adults with ADHD and 34 healthy controls revealed lower performance by t...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.18.1.78

    authors: Roth RM,Wishart HA,Flashman LA,Riordan HJ,Huey L,Saykin AJ

    更新日期:2004-01-01 00:00:00

  • Cognitive performance in young adulthood and midlife: Relations with age, sex, and education-The Cardiovascular Risk in Young Finns Study.

    abstract:OBJECTIVE:Age, education, and sex associate with cognitive performance. We investigated associations between age, sex, education, and cognitive performance in young or middle-aged adults and evaluated data reduction methods to optimally capture cognitive performance in our population-based data. METHOD:This study is p...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000239

    authors: Rovio SP,Pahkala K,Nevalainen J,Juonala M,Salo P,Kähönen M,Hutri-Kähönen N,Lehtimäki T,Jokinen E,Laitinen T,Taittonen L,Tossavainen P,Viikari J,Rinne JO,Raitakari OT

    更新日期:2016-07-01 00:00:00

  • The effects of perinatal hypoxic risk on developmental outcome in early and middle childhood: a twin study.

    abstract::The goal of this study of 66 twins was to determine whether motor and cognitive functions assessed in early and middle childhood are vulnerable to perinatal hypoxic risk. In an earlier study of 76 infant and toddler twins (S. Raz, F. Shah, & C. Sander, 1996), the authors found that intrapair discrepancy on the Mental ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.12.3.459

    authors: Raz S,Glogowski-Kawamoto B,Yu AW,Kronenberg ME,Hopkins TL,Lauterbach MD,Stevens CP,Sander CJ

    更新日期:1998-07-01 00:00:00

  • Visual information processing in high-functioning individuals with autism spectrum disorders and their parents.

    abstract::The authors assessed visual information processing in high-functioning individuals with pervasive developmental disorders (PDD) and their parents. The authors used tasks for contrast sensitivity, motion, and form perception to test visual processing occurring relatively early and late in the magnocellular-dorsal and p...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.21.1.65

    authors: de Jonge MV,Kemner C,de Haan EH,Coppens JE,van den Berg TJ,van Engeland H

    更新日期:2007-01-01 00:00:00

  • Prospective memory functioning in mild cognitive impairment.

    abstract:OBJECTIVE:The present study aimed to investigate prospective memory (PM) in persons with mild cognitive impairment (MCI). METHOD:Twenty individuals with MCI (10 with an amnestic profile and 10 with a dysexecutive profile of cognitive impairment) and 20 control subjects (CS) were recruited. In the PM tasks, subjects ha...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0018015

    authors: Costa A,Perri R,Serra L,Barban F,Gatto I,Zabberoni S,Caltagirone C,Carlesimo GA

    更新日期:2010-05-01 00:00:00

  • Memory enhancement for emotional stimuli is impaired in early Alzheimer's disease.

    abstract::Emotional arousal is associated with enhanced memory in neurologically intact individuals, but it is unknown whether this effect is obtained in Alzheimer's disease (AD). The current study compared emotional memory and emotional reactions in patients with early AD and in older controls. Participants viewed emotionally ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:

    authors: Hamann SB,Monarch ES,Goldstein FC

    更新日期:2000-01-01 00:00:00

  • Reading in developmental prosopagnosia: Evidence for a dissociation between word and face recognition.

    abstract:OBJECTIVE:Recent models suggest that face and word recognition may rely on overlapping cognitive processes and neural regions. In support of this notion, face recognition deficits have been demonstrated in developmental dyslexia. Here we test whether the opposite association can also be found, that is, impaired reading...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000428

    authors: Starrfelt R,Klargaard SK,Petersen A,Gerlach C

    更新日期:2018-02-01 00:00:00

  • Longitudinal changes in odor identification performance and neuropsychological measures in aging individuals.

    abstract:OBJECTIVE:To examine changes in odor identification performance and cognitive measures in healthy aging individuals. While cross-sectional studies reveal associations between odor identification and measures of episodic memory, processing speed, and executive function, longitudinal studies so far have been ambiguous wi...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000212

    authors: Wehling EI,Wollschlaeger D,Nordin S,Lundervold AJ

    更新日期:2016-01-01 00:00:00

  • Trace eyeblink conditioning in abstinent alcoholic individuals: effects of complex task demands and prior conditioning.

    abstract::Chronic misuse of alcohol affects an integrated neural circuit supporting the formation of associative memories acquired during eyeblink classical conditioning (R. McGlinchey-Berroth et al., 1995). The authors of this study investigated single-cue trace conditioning in amnesic and nonamnesic abstinent alcoholic indivi...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.19.2.159

    authors: McGlinchey RE,Fortier CB,Capozzi SM,Disterhoft JF

    更新日期:2005-03-01 00:00:00

  • Independent effects of Alzheimer's disease on neuropsychological functioning.

    abstract::A new analytical procedure, single common factor analysis, was carried out on the data from a relatively large sample of normals (n = 101) and patients with Alzheimer's disease (AD; n = 180) to examine the extent to which there were independent effects of disease status on different neuropsychological variables. This ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.12.2.242

    authors: Salthouse TA,Becker JT

    更新日期:1998-04-01 00:00:00

  • Abnormal error-related antisaccade activation in premanifest and early manifest Huntington disease.

    abstract:OBJECTIVE:Individuals with the trinucleotide CAG expansion (CAG+) that causes Huntington's disease (HD) have impaired performance on antisaccade (AS) tasks that require directing gaze in the mirror opposite direction of visual targets. This study aimed to identify the neural substrates underlying altered antisaccadic p...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0021873

    authors: Rupp J,Dzemidzic M,Blekher T,Bragulat V,West J,Jackson J,Hui S,Wojcieszek J,Saykin AJ,Kareken D,Foroud T

    更新日期:2011-05-01 00:00:00

  • Anterior and middle cranial fossa in traumatic brain injury: relevant neuroanatomy and neuropathology in the study of neuropsychological outcome.

    abstract::The frontal and temporal lobe regions of the brain have a high vulnerability to injury as a consequence of cerebral trauma. One reason for this selective vulnerability is how the frontal and temporal regions are situated in the anterior and cranial fossa of the skull. These concavities of the skull base cup the fronta...

    journal_title:Neuropsychology

    pub_type: 杂志文章,评审

    doi:10.1037/0894-4105.21.5.515

    authors: Bigler ED

    更新日期:2007-09-01 00:00:00

  • A combined forced-attention dichotic listening - Go/Nogo task to assess response inhibition and interference suppression: An auditory event-related potential investigation.

    abstract:OBJECTIVE:Interference suppression and response inhibition are distinct effortful inhibitory processes. Yet they rely on partly overlapping neural substrates. Their independence was studied using an auditory paradigm. METHOD:Continuous EEG was recorded in 16 adults and event-related potentials (ERPs) were analyzed in ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000586

    authors: Bedoin N,Abadie R,Krzonowski J,Ferragne E,Marcastel A

    更新日期:2019-11-01 00:00:00

  • Repetition priming and recognition memory in younger and older persons: temporal stability and performance.

    abstract::The dissociation between intact priming and reduced explicit memory in aging has been called into question on the basis of limited information that suggests that priming measures are less reliable than explicit memory measures. No aging study to date, however, has offered a comprehensive examination of the reliability...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.19.6.750

    authors: Fleischman DA,Gabrieli JD,Wilson RS,Moro TT,Bennett DA

    更新日期:2005-11-01 00:00:00

  • No category specificity in Alzheimer's disease: a normal aging effect.

    abstract::The authors examined category effects on tasks of picture naming, naming to definition, and word-picture matching in 38 patients with Alzheimer's disease (AD) and 30 elderly controls. Each task was matched across category on all "nuisance" variables known to differ across domains. Standard analyses revealed significan...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.22.4.485

    authors: Moreno-Martínez FJ,Laws KR

    更新日期:2008-07-01 00:00:00

  • Developmental gender differences in children in a virtual spatial memory task.

    abstract:OBJECTIVE:Behavioral achievements are the product of brain maturation. During postnatal development, the medial temporal lobe completes its maturation, and children acquire new memory abilities. In recent years, virtual reality-based tasks have been introduced in the neuropsychology field to assess different cognitive ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000054

    authors: León I,Cimadevilla JM,Tascón L

    更新日期:2014-07-01 00:00:00

  • Phonological blocking during picture naming in dementia of the Alzheimer type.

    abstract::Individuals with dementia of the Alzheimer type (DAT; n = 53, ages 55-91), healthy older adults (n = 75, ages 59-91), and younger adults (n = 24, ages 18-24) performed a word-primed picture-naming task. Word primes were neutral (ready), semantically or phonologically related, or unrelated to the correct picture name. ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.18.3.526

    authors: Faust ME,Balota DA,Multhaup KS

    更新日期:2004-07-01 00:00:00

  • Variability in performance: identifying early signs of future cognitive impairment.

    abstract:OBJECTIVE:The current study examined whether year-to-year variability in cognitive performance differ between individuals cognitively unimpaired and individuals who subsequently develop dementia. METHOD:Analyses included a case-control sample of Baltimore Longitudinal Study of Aging (BLSA; mean [M] age = 69.90, standa...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0028686

    authors: Gamaldo AA,An Y,Allaire JC,Kitner-Triolo MH,Zonderman AB

    更新日期:2012-07-01 00:00:00

  • Patients with Parkinson's disease display a dopamine therapy related negative bias and an enlarged range in emotional responses to facial emotional stimuli.

    abstract:OBJECTIVE:The literature on emotional processing in Parkinson's disease (PD) patients shows mixed results. This may be because of various methodological and/or patient-related differences, such as failing to adjust for cognitive functioning, depression, and/or mood. METHOD:In the current study, we tested PD patients a...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000371

    authors: Lundqvist D,Svärd J,Michelgård Palmquist Å,Fischer H,Svenningsson P

    更新日期:2017-09-01 00:00:00

  • Computerized and traditional stroop task dysfunction in HIV-1 infection.

    abstract::Controlled processing, response inhibition, and set adoption were examined in 51 HIV-1 infected participants and 21 uninfected controls who were administered a vocal reaction time (RT) version of the Stroop task (Stroop-RT; J. R. Stroop, 1935) as well as the traditional 100 item paper-and-pencil version. Response set ...

    journal_title:Neuropsychology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1037//0894-4105.13.2.306

    authors: Hinkin CH,Castellon SA,Hardy DJ,Granholm E,Siegle G

    更新日期:1999-04-01 00:00:00

  • Growth mixture modeling of academic achievement in children of varying birth weight risk.

    abstract::The extremes of birth weight and preterm birth are known to result in a host of adverse outcomes, yet studies to date largely have used cross-sectional designs and variable-centered methods to understand long-term sequelae. Growth mixture modeling (GMM) that utilizes an integrated person- and variable-centered approac...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0015676

    authors: Espy KA,Fang H,Charak D,Minich N,Taylor HG

    更新日期:2009-07-01 00:00:00