Diverse attention deficits in patients with neurologically symptomatic and asymptomatic Wilson's disease.

Abstract:

OBJECTIVE:Cognitive deficits in patients with Wilson's disease (WD) have been reported in several studies, but there was no detailed analysis of the various components of attention, one of the most significant factors of the executive system. Our study determined the pattern of deficits in attention subsystems in WD patients, including selective attention, divided attention, attention switching, and sustained attention. METHOD:We examined 67 WD patients using the Test of Everyday Attention (TEA)-33 participants with neurological symptoms and 34 who were neurologically asymptomatic, but most with mild hepatic dysfunctions. The results were compared with 43 matched healthy controls. RESULTS:The group of WD patients with neurological symptoms performed significantly worse (p < .05) in all components of attention: sustained attention, selective attention, divided attention, and attentional switching. WD patients without neurological symptoms exhibited significantly lower results in one component-sustained attention (p < .05). None of the TEA subtests scores were associated significantly with Unified Wilson's Disease Rating Scale scores, which may reflect that the cognitive and neurological consequences of WD are relatively independent. CONCLUSIONS:We found a deficiency in all components of attention in neurological WD patients. The most frequently disturbed function was attention switching. Relatively milder deficits concerned divided, selective, and sustained attention. These are all abilities creating the core of the executive system and are regulated by subcortical prefrontal circuits, which are usually dysfunctional in WD patients. In neurologically asymptomatic patients, an isolated deficit of sustained attention occurs; this may be a sign of mild hepatic encephalopathy.

journal_name

Neuropsychology

journal_title

Neuropsychology

authors

Iwański S,Seniów J,Leśniak M,Litwin T,Członkowska A

doi

10.1037/neu0000103

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

25-30

issue

1

eissn

0894-4105

issn

1931-1559

pii

2014-21947-001

journal_volume

29

pub_type

杂志文章
  • Characterizing multiple memory deficits and their relation to everyday functioning in individuals with mild cognitive impairment.

    abstract::The authors evaluated multiple memory processes and explored their contributions to everyday functional limitations in persons with mild cognitive impairment (MCI). Participants included individuals with amnestic MCI, nonamnestic MCI, and healthy older adults. As expected, the amnestic MCI group performed more poorly ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0014186

    authors: Schmitter-Edgecombe M,Woo E,Greeley DR

    更新日期:2009-03-01 00:00:00

  • Large sexual-orientation-related differences in performance on mental rotation and judgment of line orientation tasks.

    abstract::This study examined the performance of heterosexual and homosexual men and women on 2 tests of spatial processing, mental rotation (MR) and Benton Judgment of Line Orientation (JLO). The sample comprised 60 heterosexual men, 60 heterosexual women, 60 homosexual men, and 60 homosexual women. There were significant main...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:

    authors: Rahman Q,Wilson GD

    更新日期:2003-01-01 00:00:00

  • Independent effects of Alzheimer's disease on neuropsychological functioning.

    abstract::A new analytical procedure, single common factor analysis, was carried out on the data from a relatively large sample of normals (n = 101) and patients with Alzheimer's disease (AD; n = 180) to examine the extent to which there were independent effects of disease status on different neuropsychological variables. This ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.12.2.242

    authors: Salthouse TA,Becker JT

    更新日期:1998-04-01 00:00:00

  • The effects of perinatal hypoxic risk on developmental outcome in early and middle childhood: a twin study.

    abstract::The goal of this study of 66 twins was to determine whether motor and cognitive functions assessed in early and middle childhood are vulnerable to perinatal hypoxic risk. In an earlier study of 76 infant and toddler twins (S. Raz, F. Shah, & C. Sander, 1996), the authors found that intrapair discrepancy on the Mental ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.12.3.459

    authors: Raz S,Glogowski-Kawamoto B,Yu AW,Kronenberg ME,Hopkins TL,Lauterbach MD,Stevens CP,Sander CJ

    更新日期:1998-07-01 00:00:00

  • Anterior and middle cranial fossa in traumatic brain injury: relevant neuroanatomy and neuropathology in the study of neuropsychological outcome.

    abstract::The frontal and temporal lobe regions of the brain have a high vulnerability to injury as a consequence of cerebral trauma. One reason for this selective vulnerability is how the frontal and temporal regions are situated in the anterior and cranial fossa of the skull. These concavities of the skull base cup the fronta...

    journal_title:Neuropsychology

    pub_type: 杂志文章,评审

    doi:10.1037/0894-4105.21.5.515

    authors: Bigler ED

    更新日期:2007-09-01 00:00:00

  • A diffusion-model analysis of timing deficits among children with ADHD.

    abstract:OBJECTIVE:Deficits in the ability to perceive time have been proposed as an etiologic mechanism in the development of the cognitive and behavioral characteristics associated with ADHD. However, previous studies testing the presence of timing deficits have produced idiosyncratic results. This is in large part due to the...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000562

    authors: Shapiro Z,Huang-Pollock C

    更新日期:2019-09-01 00:00:00

  • Music training improves verbal but not visual memory: cross-sectional and longitudinal explorations in children.

    abstract::The hypothesis that music training can improve verbal memory was tested in children. The results showed that children with music training demonstrated better verbal but not visual memory than did their counterparts without such training. When these children were followed up after a year, those who had begun or continu...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.17.3.439

    authors: Ho YC,Cheung MC,Chan AS

    更新日期:2003-07-01 00:00:00

  • Relationships among age, conditioned stimulus-unconditioned stimulus interval, and neuropsychological test performance.

    abstract::To evaluate the effect of age at various conditioned stimulus (CS)-unconditioned stimulus (US) intervals, 144 young, middle-aged, and older adults were tested on eyeblink classical conditioning at CS-US intervals of 500, 1,000, or 1,500 ms. Reaction time, response timing, motor learning, declarative memory, and attent...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.13.1.90

    authors: Woodruff-Pak DS,Jaeger ME,Gorman C,Wesnes KA

    更新日期:1999-01-01 00:00:00

  • Recollection- and familiarity-based memory in healthy aging and amnestic mild cognitive impairment.

    abstract::Little is known about the cognitive mechanisms of the memory impairment associated with amnestic mild cognitive impairment (aMCI). We explored recollection and familiarity in 27 healthy young adults, 45 healthy older adults, and 17 individuals with aMCI. Relative to the younger adults, recollection was reduced in the ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.22.2.177

    authors: Anderson ND,Ebert PL,Jennings JM,Grady CL,Cabeza R,Graham SJ

    更新日期:2008-03-01 00:00:00

  • Aerobic fitness and response variability in preadolescent children performing a cognitive control task.

    abstract:OBJECTIVE:To investigate the relationship between aerobic fitness and cognitive variability in preadolescent children. METHOD:Forty-eight preadolescent children (25 males, 23 females, mean age = 10.1 years) were grouped into higher- and lower-fit groups according to their performance on a test of aerobic capacity (VO2...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0022167

    authors: Wu CT,Pontifex MB,Raine LB,Chaddock L,Voss MW,Kramer AF,Hillman CH

    更新日期:2011-05-01 00:00:00

  • Trace eyeblink conditioning in abstinent alcoholic individuals: effects of complex task demands and prior conditioning.

    abstract::Chronic misuse of alcohol affects an integrated neural circuit supporting the formation of associative memories acquired during eyeblink classical conditioning (R. McGlinchey-Berroth et al., 1995). The authors of this study investigated single-cue trace conditioning in amnesic and nonamnesic abstinent alcoholic indivi...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.19.2.159

    authors: McGlinchey RE,Fortier CB,Capozzi SM,Disterhoft JF

    更新日期:2005-03-01 00:00:00

  • Impaired implicit learning in schizophrenia.

    abstract::Schizophrenia patients consistently show deficits on tasks of explicit learning and memory. In contrast, their performance on implicit processing tasks often appears to be relatively intact, although most studies have focused on implicit learning of motor skills. This study evaluated implicit learning in 59 medicated ...

    journal_title:Neuropsychology

    pub_type: 临床试验,杂志文章

    doi:10.1037/a0012602

    authors: Horan WP,Green MF,Knowlton BJ,Wynn JK,Mintz J,Nuechterlein KH

    更新日期:2008-09-01 00:00:00

  • A functional magnetic resonance imaging study of auditory vigilance with low and high information processing demands.

    abstract::This study identified the brain activations associated with auditory vigilance tasks, using functional magnetic resonance imaging. We created auditory continuous performance tests (CPTs) in which a demanding task (working memory task) was made more difficult than a simple vigilance task by increasing working memory an...

    journal_title:Neuropsychology

    pub_type: 临床试验,杂志文章

    doi:10.1037//0894-4105.12.4.505

    authors: Seidman LJ,Breiter HC,Goodman JM,Goldstein JM,Woodruff PW,O'Craven K,Savoy R,Tsuang MT,Rosen BR

    更新日期:1998-10-01 00:00:00

  • Intraindividual variability in neuropsychological performance predicts cognitive decline and death in HIV.

    abstract:OBJECTIVE:HIV-associated neurocognitive disorder (HAND) occurs in a significant percentage of HIV-infected (HIV+) adults. Increased intraindividual variability (IIV) in cognitive function may be an early marker of emerging neurocognitive disorder, which suggests that IIV may be a sensitive measure of neurologic comprom...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000482

    authors: Anderson AE,Jones JD,Thaler NS,Kuhn TP,Singer EJ,Hinkin CH

    更新日期:2018-11-01 00:00:00

  • Individual differences in lateralization: effects of gender and handedness.

    abstract::Male and female left- and right-handers participated in 3 experiments designed to investigate 3 components of performance asymmetry in lateralized tasks. Experiment 1 used a consonant-vowel-consonant (CVC) identification task measuring quantitative differences in hemispheric abilities and hemispheric control and quali...

    journal_title:Neuropsychology

    pub_type: 临床试验,杂志文章

    doi:10.1037//0894-4105.11.4.562

    authors: Eviatar Z,Hellige JB,Zaidel E

    更新日期:1997-10-01 00:00:00

  • Can patients with schizophrenia have good mentalizing skills? Disentangling heterogeneity of theory of mind.

    abstract:OBJECTIVE:Theory of Mind (ToM) is a multifaceted construct that involves mental states attribution in social interactions. Patients with schizophrenia are impaired in ToM abilities, but recent studies showed that a non-negligible number of patients perform within normal ranges or close to normal, whereas other patients...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000456

    authors: Bechi M,Bosia M,Agostoni G,Spangaro M,Buonocore M,Bianchi L,Cocchi F,Guglielmino C,Mastromatteo AR,Cavallaro R

    更新日期:2018-09-01 00:00:00

  • Emotion perception after moderate-severe traumatic brain injury: The valence effect and the role of working memory, processing speed, and nonverbal reasoning.

    abstract:OBJECTIVE:Traumatic brain injury (TBI) impairs emotion perception. Perception of negative emotions (sadness, disgust, fear, and anger) is reportedly affected more than positive (happiness and surprise) ones. It has been argued that this reflects a specialized neural network underpinning negative emotions that is vulner...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000171

    authors: Rosenberg H,Dethier M,Kessels RP,Westbrook RF,McDonald S

    更新日期:2015-07-01 00:00:00

  • Age-related practice effects across longitudinal neuropsychological assessments in older people with schizophrenia.

    abstract:UNLABELLED:The relationship between aging and practice effects on longitudinal neuropsychological assessments was investigated in middle-aged and older people with schizophrenia and healthy controls. METHOD:Older people with schizophrenia (n = 107; M age = 56.1) and age-comparable nonpsychiatric controls (n = 107; M a...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0019560

    authors: Granholm E,Link P,Fish S,Kraemer H,Jeste D

    更新日期:2010-09-01 00:00:00

  • Decussation as an axial twist: A comment on Kinsbourne (2013).

    abstract::One of the great mysteries of the brain, which has puzzled all-time students of brain form and function, is the contralateral organization of the forebrain and the crossings of its major afferent and efferent connections. As a novel explanation, two recent studies have proposed that the rostral part of the head, inclu...

    journal_title:Neuropsychology

    pub_type: 评论,杂志文章

    doi:10.1037/neu0000163

    authors: de Lussanet MH,Osse JW

    更新日期:2015-09-01 00:00:00

  • Alzheimer disease biomarkers, attentional control, and semantic memory retrieval: Synergistic and mediational effects of biomarkers on a sensitive cognitive measure in non-demented older adults.

    abstract:OBJECTIVE:Past studies have shown that measures of attentional control and semantic memory are sensitive markers of Alzheimer's disease (AD). The effects of established biomarkers of AD (cerebrospinal fluid tau and amyloid-beta42, positron emission tomography Pittsburgh compound-B, and apolipoprotein E [APOE] genotype)...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000133

    authors: Aschenbrenner AJ,Balota DA,Tse CS,Fagan AM,Holtzman DM,Benzinger TL,Morris JC

    更新日期:2015-05-01 00:00:00

  • Cerebral lateralization and cognitive functioning in patients with congenital adrenal hyperplasia.

    abstract::A battery of tests was administered to 17 patients with congenital adrenal hyperplasia (CAH) and 17 normal controls to investigate the effect of prenatal androgen exposure on cerebral lateralization and cognitive performance. Individuals were compared on measures of hand preference, verbal and performance IQ, and temp...

    journal_title:Neuropsychology

    pub_type: 临床试验,杂志文章

    doi:10.1037//0894-4105.14.3.370

    authors: Kelso WM,Nicholls ME,Warne GL,Zacharin M

    更新日期:2000-07-01 00:00:00

  • The relation of anxiety and cognition in Parkinson's disease.

    abstract:OBJECTIVE:Parkinson's disease (PD) has long been conceptualized as a motor disorder, but nonmotor symptoms also manifest in the disease and significantly reduce quality of life. Anxiety and cognitive dysfunction are prevalent nonmotor symptoms, even in early disease stages, but the relation between these symptoms remai...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000353

    authors: Reynolds GO,Hanna KK,Neargarder S,Cronin-Golomb A

    更新日期:2017-09-01 00:00:00

  • Relations between volumetric measures of brain structure and attentional function in spina bifida: utilization of robust statistical approaches.

    abstract:OBJECTIVE:Weak structure-function relations for brain and behavior may stem from problems in estimating these relations in small clinical samples with frequently occurring outliers. In the current project, we focused on the utility of using alternative statistics to estimate these relations. METHOD:Fifty-four children...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000166

    authors: Kulesz PA,Tian S,Juranek J,Fletcher JM,Francis DJ

    更新日期:2015-03-01 00:00:00

  • Hemispheric interactions during a face--word Stroop-analog task.

    abstract::A Stroop-analog task with faces and words was developed to investigate intrahemispheric and interhemispheric Stroop effects (SEs). Lateralized faces and words were used in an attempt to invoke right- and left-hemispheric specialization, respectively. A prototypical male face, female face, and baby face and the corresp...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.14.4.579

    authors: Kavcic V,Clarke JM

    更新日期:2000-10-01 00:00:00

  • Abnormal frontal theta oscillations underlie the cognitive flexibility deficits in children with high-functioning autism spectrum disorders.

    abstract:OBJECTIVE:Deficits in cognitive flexibility have been suggested to underlie the repetitive and stereotyped behavior in individuals with autism spectrum disorders (ASD). Because cognitive flexibility is primarily mediated by the frontal lobe, where structural and functional abnormalities have been extensively found in t...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000231

    authors: Yeung MK,Han YMY,Sze SL,Chan AS

    更新日期:2016-03-01 00:00:00

  • Longitudinal analysis of phonemic clustering and switching during word-list generation in Huntington's disease.

    abstract::Two characteristics of word-list generation performance are forming clusters (i.e., contiguous words from the same subcategory) and switching among them. Patients with frontal lobe pathology show reduced switching on letter-cued word generation tasks, and clustering has been associated with temporal lobe functioning. ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.13.4.525

    authors: Rich JB,Troyer AK,Bylsma FW,Brandt J

    更新日期:1999-10-01 00:00:00

  • Chronic white matter changes detected using diffusion tensor imaging following adult traumatic brain injury and their relationship to cognition.

    abstract:: Objective: White matter (WM) changes detected using diffusion tensor imaging (DTI) are reportedly related to cognitive outcomes following traumatic brain injury (TBI), but much existing research is underpowered or has only examined general outcomes, rather than cognitive f...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000690

    authors: Wallace EJ,Mathias JL,Ward L,Pannek K,Fripp J,Rose S

    更新日期:2020-11-01 00:00:00

  • Gray matter integrity within regions of the dorsolateral prefrontal cortical-subcortical network predicts executive function and fine motor dexterity in spina bifida.

    abstract:OBJECTIVES:This study examined microstructural properties of cortical and subcortical gray matter components of the dorsolateral prefrontal (DLPFC) cortical-subcortical circuit in relation to parent-rated executive function and fine motor dexterity performance in youth with spina bifida myelomeningocele (SBM). Aberrant...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000266

    authors: Ware AL,Kulesz PA,Williams VJ,Juranek J,Cirino PT,Fletcher JM

    更新日期:2016-05-01 00:00:00

  • The mechanisms of far transfer from cognitive training: Review and hypothesis.

    abstract:OBJECTIVE:General intelligence is important for success in daily life, fueling interest in developing cognitive training as an intervention to improve fluid ability (Gf). A major obstacle to the design of effective cognitive interventions has been the paucity of hypotheses bearing on mechanisms underlying transfer of c...

    journal_title:Neuropsychology

    pub_type: 杂志文章,评审

    doi:10.1037/neu0000235

    authors: Greenwood PM,Parasuraman R

    更新日期:2016-09-01 00:00:00

  • Multimodal cuing of autobiographical memory in semantic dementia.

    abstract:OBJECTIVE:Individuals with semantic dementia (SD) have impaired autobiographical memory (AM), but the extent of the impairment has been controversial. According to one report (Westmacott, Leach, Freedman, & Moscovitch, 2001), patient performance was better when visual cues were used instead of verbal cues; however, the...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0021005

    authors: Greenberg DL,Ogar JM,Viskontas IV,Gorno Tempini ML,Miller B,Knowlton BJ

    更新日期:2011-01-01 00:00:00