Recollection- and familiarity-based memory in healthy aging and amnestic mild cognitive impairment.

Abstract:

:Little is known about the cognitive mechanisms of the memory impairment associated with amnestic mild cognitive impairment (aMCI). We explored recollection and familiarity in 27 healthy young adults, 45 healthy older adults, and 17 individuals with aMCI. Relative to the younger adults, recollection was reduced in the older adults, especially among those with aMCI. Familiarity did not differ among groups. In the healthy younger and older adults, better performance on a set of clinical memory measures that are sensitive to medial temporal lobe functioning was associated with greater recollection. In addition, among the healthy older adults better executive functioning was also associated with greater recollection. These results are consistent with the notion that recollection is a product of strategic processes mediated by the prefrontal cortex that suppport the retrieval of context-dependent memories from the hippocampus. Hippocampal atrophy associated with aMCI may disrupt this brain network, and thereby interfere with recollection.

journal_name

Neuropsychology

journal_title

Neuropsychology

authors

Anderson ND,Ebert PL,Jennings JM,Grady CL,Cabeza R,Graham SJ

doi

10.1037/0894-4105.22.2.177

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

177-87

issue

2

eissn

0894-4105

issn

1931-1559

pii

2008-02526-005

journal_volume

22

pub_type

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