Abstract:
:Neuropsychological, qualitative, and quantitative magnetic resonance imaging findings were examined in subjects with Alzheimer's disease (AD), non-AD dementia or mixed neuropsychiatric disorder, subjects characterized as mild/ambiguous, and controls, all with known apolipoprotein E (APOE) genotype. Neuropsychological tasks included an expanded Consortium to Establish a Registery for Alzheimer's Disease (J. T. Tschanz et al., 2000; K. A. Welsh, J. M. Hoffman, N. L. Earl, & M. W. Hanson 1994) battery and the Mini-Mental Status Examination (M. F. Folstein, S. E. Folstein, & P. R. McHugh, 1975). Periventricular white matter lesions were the most clinically salient, and generalized measures of cerebral atrophy were the most significant quantitative indicators. APOE genotype was unrelated to imaging or neuropsychological performance. Neuropsychological relationships with neuroimaging findings depend on the qualitative or quantitative method used.
journal_name
Neuropsychologyjournal_title
Neuropsychologyauthors
Bigler ED,Lowry CM,Kerr B,Tate DF,Hessel CD,Earl HD,Miller MJ,Rice SA,Smith KH,Tschanz JT,Welsh-Bohmer K,Plassman B,Victoroff Jdoi
10.1037/0894-4105.17.3.339subject
Has Abstractpub_date
2003-07-01 00:00:00pages
339-52issue
3eissn
0894-4105issn
1931-1559journal_volume
17pub_type
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