Role of white matter lesions, cerebral atrophy, and APOE on cognition in older persons with and without dementia: the Cache County, Utah, study of memory and aging.

Abstract:

:Neuropsychological, qualitative, and quantitative magnetic resonance imaging findings were examined in subjects with Alzheimer's disease (AD), non-AD dementia or mixed neuropsychiatric disorder, subjects characterized as mild/ambiguous, and controls, all with known apolipoprotein E (APOE) genotype. Neuropsychological tasks included an expanded Consortium to Establish a Registery for Alzheimer's Disease (J. T. Tschanz et al., 2000; K. A. Welsh, J. M. Hoffman, N. L. Earl, & M. W. Hanson 1994) battery and the Mini-Mental Status Examination (M. F. Folstein, S. E. Folstein, & P. R. McHugh, 1975). Periventricular white matter lesions were the most clinically salient, and generalized measures of cerebral atrophy were the most significant quantitative indicators. APOE genotype was unrelated to imaging or neuropsychological performance. Neuropsychological relationships with neuroimaging findings depend on the qualitative or quantitative method used.

journal_name

Neuropsychology

journal_title

Neuropsychology

authors

Bigler ED,Lowry CM,Kerr B,Tate DF,Hessel CD,Earl HD,Miller MJ,Rice SA,Smith KH,Tschanz JT,Welsh-Bohmer K,Plassman B,Victoroff J

doi

10.1037/0894-4105.17.3.339

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

339-52

issue

3

eissn

0894-4105

issn

1931-1559

journal_volume

17

pub_type

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