Attentional shifting and disengagement in Rett syndrome.

Abstract:

OBJECTIVE:The purpose of the present study was to deepen our understanding of attention (a core cognitive ability) in Rett syndrome (RTT), an x-linked neurodevelopmental disorder caused by mutations in the MECP2 gene. We focused on 2 key aspects of visual orienting-shifting and disengaging attention-both of which are critical for exploring the visual world. We used gaze-based measures and eye-tracking technology to minimize demands on the limited verbal and motor abilities associated with RTT. METHOD:Shifting and disengaging attention were examined in 31 children (2-12 years) with Rett Syndrome (RTT) and 31 age-matched typically developing (TD) controls. Using the gap-overlap paradigm, the frequency and speed of shifting attention from a central to peripheral target were compared on Baseline trials, where the central stimulus disappears as the peripheral target appears, and Overlap trials, where the central stimulus remains, thus requiring disengagement. RESULTS:Our findings revealed that children with RTT had more "sticky fixations" (p < .001). That is, they had fewer saccades to the peripheral target than TD children, and this was true on both baseline (77% vs. 95%), and overlap trials (63% vs. 90%). The younger children in the RTT group also had slower saccadic RTs (SRTs) than their TD counterparts (p = .04). Within the RTT group, SRTs correlated with symptom severity. Surprisingly, disengagement cost (the relative difference between gap and overlap SRTs) did not differ across groups. CONCLUSION:Our results suggest that children with Rett have difficulty shifting attention and, to a lesser extent, disengaging attention, whereas with other disorders, problems with disengagement are paramount. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

journal_name

Neuropsychology

journal_title

Neuropsychology

authors

Rose SA,Wass S,Jankowski JJ,Feldman JF,Djukic A

doi

10.1037/neu0000515

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

335-342

issue

3

eissn

0894-4105

issn

1931-1559

pii

2019-03836-001

journal_volume

33

pub_type

杂志文章
  • Attention and memory dysfunction in posttraumatic stress disorder.

    abstract::Attention and memory performances were studied in Persian Gulf War veterans with and without posttraumatic stress disorder (PTSD) diagnoses. Veterans diagnosed with PTSD showed relative performance deficiencies on tasks of sustained attention, mental manipulation, initial acquisition of information, and retroactive in...

    journal_title:Neuropsychology

    pub_type: 临床试验,杂志文章

    doi:10.1037//0894-4105.12.1.125

    authors: Vasterling JJ,Brailey K,Constans JI,Sutker PB

    更新日期:1998-01-01 00:00:00

  • Pediatric traumatic brain injury affects multisensory integration.

    abstract:OBJECTIVE:To investigate the impact of pediatric traumatic brain injury (TBI) on multisensory integration in relation to general neurocognitive functioning. METHOD:Children with a hospital admission for TBI aged between 6 and 13 years (n = 94) were compared with children with trauma control (TC) injuries (n = 39), whi...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000302

    authors: Königs M,Weeda WD,van Heurn LW,Vermeulen RJ,Goslings JC,Luitse JS,Poll-The BT,Beelen A,van der Wees M,Kemps RJ,Catsman-Berrevoets CE,Oosterlaan J

    更新日期:2017-02-01 00:00:00

  • The relationships between apathy and executive dysfunction in multiple sclerosis.

    abstract:BACKGROUND:Neuropsychiatric symptoms are common in multiple sclerosis (MS). Among these, apathy is relatively frequent but its relationships with cognitive dysfunctions have been poorly investigated. OBJECTIVE:To explore cognitive correlates of apathy with or without depression ("pure apathy") in MS patients. MATERIA...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000279

    authors: Raimo S,Trojano L,Spitaleri D,Petretta V,Grossi D,Santangelo G

    更新日期:2016-09-01 00:00:00

  • A meta-analysis of working memory impairments in survivors of moderate-to-severe traumatic brain injury.

    abstract:OBJECTIVES:To establish the magnitude of deficits in working memory (WM) and short-term memory (STM) in those with moderate-to-severe traumatic brain injury (TBI) relative to age-matched, healthy controls and to explore the moderating effects of time since injury and age at injury on these impairments. METHOD:Twenty-o...

    journal_title:Neuropsychology

    pub_type: 杂志文章,meta分析

    doi:10.1037/neu0000285

    authors: Dunning DL,Westgate B,Adlam AR

    更新日期:2016-10-01 00:00:00

  • Profile of cognitive functioning in women with the fragile X mutation.

    abstract::Two studies tested the specificity of the neurocognitive profile of women with fragile X syndrome (FXS). First, women with an FXS full mutation were compared with women with a premutation and women without FXS who grew up in FXS families. Women with FXS had a significantly lower IQ than the other groups, and analyses ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:

    authors: Bennetto L,Pennington BF,Porter D,Taylor AK,Hagerman RJ

    更新日期:2001-04-01 00:00:00

  • Faking bad: The neural correlates of feigning memory impairment.

    abstract:OBJECTIVE:The detection of malingering in cognitive performance is a challenge in clinical and legal environments. Neuroimaging may provide an objective method for delineation of malingering. METHOD:A heterogeneous with concern of gender and racial-ethnic identity of 22 healthy volunteers completed the Tombaugh Test o...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000251

    authors: Kosheleva E,Spadoni AD,Strigo IA,Buchsbaum MS,Simmons AN

    更新日期:2016-03-01 00:00:00

  • Suboptimal decision making by children with ADHD in the face of risk: Poor risk adjustment and delay aversion rather than general proneness to taking risks.

    abstract:OBJECTIVE:Suboptimal decision making in the face of risk (DMR) in children with attention-deficit hyperactivity disorder (ADHD) may be mediated by deficits in a number of different neuropsychological processes. We investigated DMR in children with ADHD using the Cambridge Gambling Task (CGT) to distinguish difficulties...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000297

    authors: Sørensen L,Sonuga-Barke E,Eichele H,van Wageningen H,Wollschlaeger D,Plessen KJ

    更新日期:2017-02-01 00:00:00

  • A functional magnetic resonance imaging study of auditory vigilance with low and high information processing demands.

    abstract::This study identified the brain activations associated with auditory vigilance tasks, using functional magnetic resonance imaging. We created auditory continuous performance tests (CPTs) in which a demanding task (working memory task) was made more difficult than a simple vigilance task by increasing working memory an...

    journal_title:Neuropsychology

    pub_type: 临床试验,杂志文章

    doi:10.1037//0894-4105.12.4.505

    authors: Seidman LJ,Breiter HC,Goodman JM,Goldstein JM,Woodruff PW,O'Craven K,Savoy R,Tsuang MT,Rosen BR

    更新日期:1998-10-01 00:00:00

  • New directions in the study of semantic deficits: a comment on Storms et al. (2003).

    abstract::G. Storms, T. Dirikx, J. Saerens, S. Verstaeten, and P. P. De Deyn (2003) have provided an important critique of the use of multidimensional scaling (MDS) to evaluate semantic knowledge in Alzheimer's disease. If MDS is to be used with semantic proximity data (in spite of well-documented reasons for not doing so), at ...

    journal_title:Neuropsychology

    pub_type: 评论,杂志文章

    doi:10.1037/0894-4105.17.2.315

    authors: Ober BA,Shenaut GK

    更新日期:2003-04-01 00:00:00

  • Intraindividual cognitive variability before and after sports-related concussion.

    abstract:OBJECTIVE:Inconsistent performance is associated with cognitive dysfunction in a number of clinical populations. However, intraindividual cognitive variability in healthy individuals is poorly understood. Inconsistency poses a challenge to clinicians when interpreting change over time. This study examined intraindividu...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0033023

    authors: Rabinowitz AR,Arnett PA

    更新日期:2013-07-01 00:00:00

  • Examining frontotemporal connectivity and rTMS in healthy controls: implications for auditory hallucinations in schizophrenia.

    abstract:OBJECTIVE:Repetitive transcranial magnetic stimulation (rTMS) has been shown to have clinically beneficial effects in altering the perception of auditory hallucinations (AH) in patients with schizophrenia. However, the mode of action is not clear. Recent neuroimaging findings indicate that rTMS has the potential to ind...

    journal_title:Neuropsychology

    pub_type: 杂志文章,随机对照试验

    doi:10.1037/a0026603

    authors: Gromann PM,Tracy DK,Giampietro V,Brammer MJ,Krabbendam L,Shergill SS

    更新日期:2012-01-01 00:00:00

  • The role of learned irrelevance in attentional set-shifting impairments in Parkinson's disease.

    abstract::In this study, the cognitive and neurochemical factors underlying learned irrelevance, one of the mechanisms thought to be responsible for attentional set-shifting deficits in Parkinson's disease (PD), were investigated. In a visual discrimination learning task, the extent to which a target dimension was irrelevant pr...

    journal_title:Neuropsychology

    pub_type: 临床试验,杂志文章

    doi:10.1037/0894-4105.20.5.578

    authors: Slabosz A,Lewis SJ,Smigasiewicz K,Szymura B,Barker RA,Owen AM

    更新日期:2006-09-01 00:00:00

  • Preliminary evidence for differential trajectories of recovery for cognitive flexibility following sports-related concussion.

    abstract:OBJECTIVE:A critical barrier to the understanding of disruptions to cognitive flexibility following sports-related concussion is the use of assessments that conflate shifts of visuospatial attention and contextual rules. Because these dissociable forms of cognitive flexibility are subserved by distinct neural networks,...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000475

    authors: McGowan AL,Bretzin AC,Savage JL,Petit KM,Parks AC,Covassin T,Pontifex MB

    更新日期:2018-07-01 00:00:00

  • Strategy bias in the emotion regulation of high trait anxiety individuals: An investigation of underlying neural signatures using ERPs.

    abstract:OBJECTIVE:Previous studies have employed self-report measures to investigate emotion regulation (ER) strategy biases in individuals with anxiety. We investigated the neural signatures underlying ER strategy biases. METHOD:Twenty individuals with high trait anxiety (HTA) and twenty individuals with low trait anxiety (L...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000471

    authors: Pan DN,Wang Y,Li X

    更新日期:2019-01-01 00:00:00

  • Attentional networks reveal executive function deficits in posttraumatic stress disorder.

    abstract::Executive function was assessed with the Trail Making Test (Army Individual Test Battery; M. D. Lezak, 1983), the Comprehensive Trail Making Test (C. Reynolds, 2002), and a neurocognitive measure of executive control (Attentional Network Task [ANT]; J. I. Fan, B. D. McCandliss, T. Somer, A. Raz, & M. I. Posner, 2002) ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.21.3.275

    authors: Leskin LP,White PM

    更新日期:2007-05-01 00:00:00

  • When memory does not fail: familiarity-based recognition in mild cognitive impairment and Alzheimer's disease.

    abstract::Recognition can be guided by familiarity, a restricted form of retrieval devoid of contextual recall, or by recollection, which occurs when retrieval is sufficient to support the full experience of remembering an episode. Recollection and familiarity were disentangled by testing recognition memory using silhouette obj...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.20.2.193

    authors: Westerberg CE,Paller KA,Weintraub S,Mesulam MM,Holdstock JS,Mayes AR,Reber PJ

    更新日期:2006-03-01 00:00:00

  • Advances in neurocognitive rehabilitation research from 1992 to 2017: The ascension of neural plasticity.

    abstract:OBJECTIVE:The last 25 years have seen profound changes in neurocognitive rehabilitation that continue to motivate its evolution. Although the concept of nervous system plasticity was discussed by William James (1890), the foundation for experience-based plasticity had not reached the critical empirical mass to seriousl...

    journal_title:Neuropsychology

    pub_type: 杂志文章,评审

    doi:10.1037/neu0000396

    authors: Crosson B,Hampstead BM,Krishnamurthy LC,Krishnamurthy V,McGregor KM,Nocera JR,Roberts S,Rodriguez AD,Tran SM

    更新日期:2017-11-01 00:00:00

  • Verbal fluency in male and female schizophrenia patients: Different patterns of association with processing speed, working memory span, and clinical symptoms.

    abstract:OBJECTIVE:Decreased processing speed in schizophrenia patients has been identified as a major impairment factor in various neuropsychological domains. Working memory span has been found to be involved in several deep or effortful cognitive processes. We investigated the impact that these 2 cognitive functions may have ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000394

    authors: Brébion G,Stephan-Otto C,Ochoa S,Nieto L,Contel M,Usall J

    更新日期:2018-01-01 00:00:00

  • Deconstructing spatial working memory and attention deficits in multiple sclerosis.

    abstract:OBJECTIVE:To investigate whether spatial working memory (WM) is impaired in multiple sclerosis (MS), and, if it is, to localize impairment to specific cognitive subprocess(es). METHOD:In Experiment 1, MS and control participants performed computerized memory-span and visuomotor tasks. WM subprocesses were taxed by man...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0026213

    authors: Gmeindl L,Courtney SM

    更新日期:2012-01-01 00:00:00

  • Dynamic functional connectivity in bipolar disorder is associated with executive function and processing speed: A preliminary study.

    abstract:OBJECTIVE:Disturbances in functional connectivity have been suggested to contribute to cognitive and emotion processing deficits observed in bipolar disorder (BD). Functional connectivity between medial prefrontal cortex (mPFC) and other brain regions may be particularly abnormal. The goal of the present study was to c...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000317

    authors: Nguyen TT,Kovacevic S,Dev SI,Lu K,Liu TT,Eyler LT

    更新日期:2017-01-01 00:00:00

  • Semantic organization and verbal memory efficiency in patients with schizophrenia.

    abstract::The role of semantic organization in verbal memory efficiency in schizophrenia was investigated. Patients and healthy controls were administered a free-recall task involving 1 nonsemantically organizable list, 1 list organizable in semantic categories with typical instances, and 1 list organizable in semantic categori...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.18.2.378

    authors: Brébion G,David AS,Jones H,Pilowsky LS

    更新日期:2004-04-01 00:00:00

  • Relations between volumetric measures of brain structure and attentional function in spina bifida: utilization of robust statistical approaches.

    abstract:OBJECTIVE:Weak structure-function relations for brain and behavior may stem from problems in estimating these relations in small clinical samples with frequently occurring outliers. In the current project, we focused on the utility of using alternative statistics to estimate these relations. METHOD:Fifty-four children...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000166

    authors: Kulesz PA,Tian S,Juranek J,Fletcher JM,Francis DJ

    更新日期:2015-03-01 00:00:00

  • What do eye movements tell us about the visual perception of individuals with congenital prosopagnosia?

    abstract:OBJECTIVE:The lack of inversion effect for face recognition in congenital prosopagnosia (CP) is consistent with the hypothesis of a failure in holistic processing. However, although CPs' abnormal gaze behavior for upright faces has already been demonstrated, neither their scanning strategy for inverted faces, nor the p...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000362

    authors: Malaspina M,Albonico A,Toneatto C,Daini R

    更新日期:2017-07-01 00:00:00

  • Neuropsychological test performance in soldiers with blast-related mild TBI.

    abstract::This exploratory study was conducted to increase understanding of neuropsychological test performance in those with blast-related mild traumatic brain injury (mTBI). The two variables of interest for their impact on test performance were presence of mTBI symptoms and history of posttraumatic stress disorder (PTSD). Fo...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0017966

    authors: Brenner LA,Terrio H,Homaifar BY,Gutierrez PM,Staves PJ,Harwood JE,Reeves D,Adler LE,Ivins BJ,Helmick K,Warden D

    更新日期:2010-03-01 00:00:00

  • Space-based inhibition of return in children with spina bifida.

    abstract::Inhibition of return (IOR) refers to an increase in time to react to a target in a previously attended location. Children with spina bifida meningomyelocele (SBM) and hydrocephalus have congenital dysmorphology of the midbrain, a brain region associated with the control of covert orienting in general and with IOR in p...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.19.4.456

    authors: Dennis M,Edelstein K,Copeland K,Frederick JA,Francis DJ,Hetherington R,Blaser SE,Kramer LA,Drake JM,Brandt ME,Fletcher JM

    更新日期:2005-07-01 00:00:00

  • Associations of postural knowledge and basic motor skill with dyspraxia in autism: implication for abnormalities in distributed connectivity and motor learning.

    abstract::Children with autism often have difficulty performing skilled movements. Praxis performance requires basic motor skill, knowledge of representations of the movement (mediated by parietal regions), and transcoding of these representations into movement plans (mediated by premotor circuits). The goals of this study were...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0015640

    authors: Dowell LR,Mahone EM,Mostofsky SH

    更新日期:2009-09-01 00:00:00

  • Trace eyeblink conditioning in abstinent alcoholic individuals: effects of complex task demands and prior conditioning.

    abstract::Chronic misuse of alcohol affects an integrated neural circuit supporting the formation of associative memories acquired during eyeblink classical conditioning (R. McGlinchey-Berroth et al., 1995). The authors of this study investigated single-cue trace conditioning in amnesic and nonamnesic abstinent alcoholic indivi...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.19.2.159

    authors: McGlinchey RE,Fortier CB,Capozzi SM,Disterhoft JF

    更新日期:2005-03-01 00:00:00

  • Nonlinear associations between plasma cholesterol levels and neuropsychological function.

    abstract:OBJECTIVE:Although both high and low levels of total and low-density lipoprotein (LDL) cholesterol have been associated with poor neuropsychological function, little research has examined nonlinear effects. We examined quadratic relations of cholesterol to performance on a comprehensive neuropsychological battery. MET...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000298

    authors: Wendell CR,Zonderman AB,Katzel LI,Rosenberger WF,Plamadeala VV,Hosey MM,Waldstein SR

    更新日期:2016-11-01 00:00:00

  • Neuropsychological correlates of diffusion tensor imaging in schizophrenia.

    abstract::Patients with schizophrenia (n = 41) and healthy comparison participants (n = 46) completed neuropsychological measures of intelligence, memory, and executive function. A subset of each group also completed magnetic resonance diffusion tensor imaging (DTI) studies (fractional anisotropy and cross-sectional area) of th...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.18.4.629

    authors: Nestor PG,Kubicki M,Gurrera RJ,Niznikiewicz M,Frumin M,McCarley RW,Shenton ME

    更新日期:2004-10-01 00:00:00

  • Abstract reasoning in autism: a dissociation between concept formation and concept identification.

    abstract::The concept identification and concept formation aspects of abstract reasoning were examined in 90 nonmentally retarded individuals with autism and 107 normal controls. It was hypothesized that pronounced deficits would be found on concept formation tests, whereas performance on concept identification tests would be r...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.16.3.327

    authors: Minshew NJ,Meyer J,Goldstein G

    更新日期:2002-07-01 00:00:00