Memory consolidation in aging and MCI after 1 week.

Abstract:

OBJECTIVE:To assess consolidation in amnestic mild cognitive impairment (aMCI), controlling for differences in initial learning and using a protracted delay period for recall. METHOD:15 individuals with aMCI were compared with 15 healthy older adult controls on a story learning task. Subjects were trained to criteria to equalize initial learning across subjects. Recall was tested at both the 30-min typically used delay and a 1-week delay used to target consolidation. RESULTS:Using repeated measures ANOVAs adjusted for age, we found group × time point interactions across the entire task between the final trial and 30-min delay, and again between the 30-min and 1-week delay periods, with aMCI having greater declines in recall as compared with controls. Significant group main effects were also found, with aMCI recalling less than controls. CONCLUSION:Consolidation was impaired in aMCI as compared with controls. Our findings indicate that aMCI-related performance typically measured at 30 min underestimates aMCI-associated memory deficits. This is the first study to isolate consolidation by controlling for initial learning differences and using a protracted delay period to target consolidation in an aMCI sample.

journal_name

Neuropsychology

journal_title

Neuropsychology

authors

Walsh CM,Wilkins S,Bettcher BM,Butler CR,Miller BL,Kramer JH

doi

10.1037/neu0000013

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

273-80

issue

2

eissn

0894-4105

issn

1931-1559

pii

2013-38867-001

journal_volume

28

pub_type

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